ATE159759T1 - Heterobifunktionelle antikörper mit sowohl katalytischen eigenschaften als auch spezifischen antigenbindungseigenschaften und verfahren zu deren verwendung - Google Patents

Heterobifunktionelle antikörper mit sowohl katalytischen eigenschaften als auch spezifischen antigenbindungseigenschaften und verfahren zu deren verwendung

Info

Publication number
ATE159759T1
ATE159759T1 AT92401242T AT92401242T ATE159759T1 AT E159759 T1 ATE159759 T1 AT E159759T1 AT 92401242 T AT92401242 T AT 92401242T AT 92401242 T AT92401242 T AT 92401242T AT E159759 T1 ATE159759 T1 AT E159759T1
Authority
AT
Austria
Prior art keywords
antibody
catalytic
properties
methods
antigen binding
Prior art date
Application number
AT92401242T
Other languages
English (en)
Inventor
Karel Newman
Jane Schmidt
Original Assignee
Pasteur Sanofi Diagnostics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Sanofi Diagnostics filed Critical Pasteur Sanofi Diagnostics
Application granted granted Critical
Publication of ATE159759T1 publication Critical patent/ATE159759T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/10—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases p-Nitrophenol derivatives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/901—Antibodies with enzymatic activity; e.g. abzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT92401242T 1991-05-03 1992-04-30 Heterobifunktionelle antikörper mit sowohl katalytischen eigenschaften als auch spezifischen antigenbindungseigenschaften und verfahren zu deren verwendung ATE159759T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69498491A 1991-05-03 1991-05-03
US80713091A 1991-12-16 1991-12-16

Publications (1)

Publication Number Publication Date
ATE159759T1 true ATE159759T1 (de) 1997-11-15

Family

ID=27105485

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401242T ATE159759T1 (de) 1991-05-03 1992-04-30 Heterobifunktionelle antikörper mit sowohl katalytischen eigenschaften als auch spezifischen antigenbindungseigenschaften und verfahren zu deren verwendung

Country Status (7)

Country Link
EP (1) EP0512905B1 (de)
JP (1) JPH05252986A (de)
AT (1) ATE159759T1 (de)
AU (1) AU656181B2 (de)
CA (1) CA2067919C (de)
DE (1) DE69222884T2 (de)
ES (1) ES2109323T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024630A1 (en) * 1992-05-22 1993-12-09 Agen Limited Reagent for agglutination assays
DE4314556A1 (de) 1993-05-04 1994-11-10 Behringwerke Ag Modifizierte Antikörperenzymkonjugate und Fusionsproteine sowie ihre Anwendung zur tumorselektiven Therapie
DE19852905A1 (de) * 1998-11-09 2000-05-11 Basf Ag Verfahren zur Selektion von katalytischen Antikörpern
CA2501581A1 (en) * 2002-10-09 2004-04-22 Integrigen, Inc. Recombinant catalytic polypeptides and their uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444878A (en) * 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
US5229272A (en) * 1989-04-25 1993-07-20 Igen, Inc. Catalytic antibody components
GB8616174D0 (en) * 1986-07-02 1986-08-06 Antibody Technology Ltd Monoclonal antibodies
DE3920358A1 (de) * 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung

Also Published As

Publication number Publication date
AU656181B2 (en) 1995-01-27
DE69222884D1 (de) 1997-12-04
EP0512905A3 (en) 1993-07-21
AU1523192A (en) 1992-11-05
JPH05252986A (ja) 1993-10-05
CA2067919C (en) 2002-09-17
EP0512905A2 (de) 1992-11-11
EP0512905B1 (de) 1997-10-29
CA2067919A1 (en) 1992-11-04
DE69222884T2 (de) 1998-05-20
ES2109323T3 (es) 1998-01-16

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