ATE155785T1 - MITOMYCIN DERIVATIVES - Google Patents

MITOMYCIN DERIVATIVES

Info

Publication number
ATE155785T1
ATE155785T1 AT92105200T AT92105200T ATE155785T1 AT E155785 T1 ATE155785 T1 AT E155785T1 AT 92105200 T AT92105200 T AT 92105200T AT 92105200 T AT92105200 T AT 92105200T AT E155785 T1 ATE155785 T1 AT E155785T1
Authority
AT
Austria
Prior art keywords
substituted
unsubstituted
represents hydrogen
chem
together form
Prior art date
Application number
AT92105200T
Other languages
German (de)
Inventor
Hitoshi Arai
Yutaka Kanda
Motomichi Kono
Masaji Kasai
Tadashi Ashizawa
Katsushige Gomi
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE155785T1 publication Critical patent/ATE155785T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Mitomycin derivatives of formula <CHEM> wherein W represents a substituted or unsubstituted alkyl having 2 to 19 carbon atoms, a substituted or unsubstituted cycloalkylalkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted cycloalkenylalkyl or a substituted or unsubstituted aralkyl; X represents methoxy or amino, or X and W together form -W-X- shown by the formula: <CHEM> or <CHEM> wherein U und V independently represent a substituted or unsubstituted lower alkyl, lower alkenyl or lower alkoxy group, a substituted or unsubstituted aryl or lower alkenyloxy group, or U and V together form -(CH2)m-CR<3>R<4>-CH2- (wherein m represents an integer of 0 to 1; R<3> and R<4> independently represents hydrogen, a lower alkyl or a substituted or unsubstituted aryl); Y represents hydrogen or methyl; Z represents hydrogen, methyl, a lower alkanoyl or an allyloxycarbonyl; one of R<1> and R<2> represents carbamoyloxymethyl and the other represents hydrogen, or R<1> and R<2> together form methylene (=CH2). The compounds have antitumor activity.
AT92105200T 1991-03-26 1992-03-26 MITOMYCIN DERIVATIVES ATE155785T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6183891 1991-03-26

Publications (1)

Publication Number Publication Date
ATE155785T1 true ATE155785T1 (en) 1997-08-15

Family

ID=13182638

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92105200T ATE155785T1 (en) 1991-03-26 1992-03-26 MITOMYCIN DERIVATIVES

Country Status (4)

Country Link
US (2) US5256685A (en)
EP (1) EP0510373B1 (en)
AT (1) ATE155785T1 (en)
DE (1) DE69221006T2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524812B1 (en) 1993-10-07 2003-02-25 Regents Of The University Of Minnesota Genes encoding resistance to DNA alkylating agents
US6495348B1 (en) * 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
GB0418474D0 (en) 2004-08-12 2004-09-22 Pentapharm Ltd Device with novel and improved surface properties

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1003092A (en) * 1961-11-09 1965-09-02 American Cyanamid Co Novel antibacterial substances
JPS6021993B2 (en) * 1973-10-03 1985-05-30 協和醗酵工業株式会社 Novel production method for mitomycin derivatives
US4374774A (en) * 1979-03-13 1983-02-22 Kyowa Hakko Kogyo Co., Ltd. Mitomycins
DE3871836T2 (en) * 1987-03-25 1993-01-14 Kyowa Hakko Kogyo Kk MITOMYCIN DERIVATIVES.
JPS6470490A (en) * 1987-09-10 1989-03-15 Kyowa Hakko Kogyo Kk Mitomycins and production thereof
JPH02167282A (en) * 1988-09-09 1990-06-27 Kyowa Hakko Kogyo Co Ltd Mitomycin derivative

Also Published As

Publication number Publication date
EP0510373A1 (en) 1992-10-28
EP0510373B1 (en) 1997-07-23
US5334611A (en) 1994-08-02
DE69221006T2 (en) 1998-02-19
DE69221006D1 (en) 1997-08-28
US5256685A (en) 1993-10-26

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