ATE150320T1 - Zusammensetzung mit verzögerter wirkstoffabgabe enthaltend ein multivalentes kation verzetztes alginat kombiniert mit einem polyacrylsäure - Google Patents
Zusammensetzung mit verzögerter wirkstoffabgabe enthaltend ein multivalentes kation verzetztes alginat kombiniert mit einem polyacrylsäureInfo
- Publication number
- ATE150320T1 ATE150320T1 AT94307259T AT94307259T ATE150320T1 AT E150320 T1 ATE150320 T1 AT E150320T1 AT 94307259 T AT94307259 T AT 94307259T AT 94307259 T AT94307259 T AT 94307259T AT E150320 T1 ATE150320 T1 AT E150320T1
- Authority
- AT
- Austria
- Prior art keywords
- alginate
- agents
- polyacrylic acid
- interaction
- consolidated
- Prior art date
Links
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 title abstract 8
- 229940072056 alginate Drugs 0.000 title abstract 8
- 229920000615 alginic acid Polymers 0.000 title abstract 8
- 235000010443 alginic acid Nutrition 0.000 title abstract 8
- 229920002125 Sokalan® Polymers 0.000 title abstract 2
- 239000004584 polyacrylic acid Substances 0.000 title abstract 2
- 230000003111 delayed effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 4
- 229940124597 therapeutic agent Drugs 0.000 abstract 4
- 239000011324 bead Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000003993 interaction Effects 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000002091 cationic group Chemical group 0.000 abstract 2
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920000447 polyanionic polymer Polymers 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/138,367 US5451411A (en) | 1993-10-15 | 1993-10-15 | Methods and compositions for the oral delivery of therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE150320T1 true ATE150320T1 (de) | 1997-04-15 |
Family
ID=22481704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94307259T ATE150320T1 (de) | 1993-10-15 | 1994-10-04 | Zusammensetzung mit verzögerter wirkstoffabgabe enthaltend ein multivalentes kation verzetztes alginat kombiniert mit einem polyacrylsäure |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5451411A (de) |
| EP (1) | EP0652015B1 (de) |
| JP (1) | JPH07258115A (de) |
| AT (1) | ATE150320T1 (de) |
| CA (1) | CA2133271A1 (de) |
| DE (1) | DE69402153T2 (de) |
| DK (1) | DK0652015T3 (de) |
| ES (1) | ES2100632T3 (de) |
| GR (1) | GR3023307T3 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9619660D0 (en) * | 1996-09-20 | 1996-11-06 | Scient Hospital Suppl Int Ltd | Prevention of gastrointestinal damage |
| US6656508B2 (en) * | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
| JP2002500201A (ja) | 1998-01-05 | 2002-01-08 | ユニバーシティ オブ ワシントン | 膜破壊剤を使用する増強された輸送 |
| GB9806530D0 (en) * | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
| JP2002527408A (ja) | 1998-10-09 | 2002-08-27 | ミシガン大学 | ドラッグデリバリー用ヒドロゲル及び水溶性ポリマーキャリアー |
| AU3556400A (en) | 1999-03-17 | 2000-10-04 | Novartis Ag | Pharmaceutical compositions |
| WO2001024812A1 (en) * | 1999-10-06 | 2001-04-12 | N.V. Nutricia | USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA |
| AU2764801A (en) | 2000-01-07 | 2001-07-24 | University Of Washington | Enhanced transport of agents using membrane disruptive agents |
| US6596310B1 (en) | 2000-08-23 | 2003-07-22 | Board Of Trustees Operating Michigan State University | Method of artificial insemination by timed release of sperm from capsules or solid beads |
| US6676958B2 (en) * | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
| US20030206957A1 (en) * | 2002-05-06 | 2003-11-06 | Scherr George H. | Orally administered medicament delivery systems |
| AU2004210964A1 (en) * | 2003-02-11 | 2004-08-26 | University Of Washington | Stimuli-responsive polymer conjugates and related methods |
| JP4822092B2 (ja) * | 2003-09-01 | 2011-11-24 | 大正製薬株式会社 | Ｗ／ｏ／ｗ型複合エマルション |
| DE10350248A1 (de) * | 2003-10-28 | 2005-06-16 | Magnamedics Gmbh | Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik |
| US7744895B2 (en) * | 2005-08-31 | 2010-06-29 | Yamanashi University | Methods of treating allergies using TGF-β1 and allergens |
| WO2007109584A1 (en) * | 2006-03-16 | 2007-09-27 | University Of Washington | Temperature-and ph-responsive polymer compositions |
| KR101396776B1 (ko) | 2006-07-04 | 2014-05-22 | 스펌바이탈 에이에스 | 정자의 보존 및 조절된 전달/방출 |
| US7981688B2 (en) | 2007-03-08 | 2011-07-19 | University Of Washington | Stimuli-responsive magnetic nanoparticles and related methods |
| US20080292663A1 (en) * | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
| DE102007059939A1 (de) | 2007-12-12 | 2009-06-18 | Müller-Schulte, Detlef, Dr. | Auflösbare, magnetische und unmagnetische Polymerträger zur Abtrennung und Wiedergewinnung von Zellen und Biosubstanzen |
| IT1392471B1 (it) * | 2008-11-25 | 2012-03-09 | Pharmafilm S R L | Collutorio in forma di sospensione stabile comprendente microsfere che incorporano un principio attivo. |
| US8426214B2 (en) * | 2009-06-12 | 2013-04-23 | University Of Washington | System and method for magnetically concentrating and detecting biomarkers |
| US20110117668A1 (en) * | 2009-11-09 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Self-powered smart diagnostic devices |
| US9080933B2 (en) | 2009-11-09 | 2015-07-14 | University Of Washington Through Its Center For Commercialization | Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates |
| WO2011152783A1 (en) * | 2010-06-03 | 2011-12-08 | Rph Pharmaceuticals Ab | Formulations preserving bioactivity and methods of their preparation |
| US9165703B2 (en) * | 2010-08-25 | 2015-10-20 | Brown University | Methods and systems for prolonged localization of drug delivery |
| US20120213856A1 (en) * | 2011-02-23 | 2012-08-23 | Po-Lun Wang | Manufacturing Method of Microcapsule |
| CA3170184A1 (en) | 2012-03-12 | 2013-09-19 | Advanced Bioadjuvants, Llc | Adjuvant and vaccine compositions |
| WO2018193337A2 (en) * | 2017-04-18 | 2018-10-25 | Actorius Innovations And Research Pvt. Ltd | Polymer based formulation for release of drugs and bioactives at specific git sites |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8323624D0 (en) * | 1983-09-02 | 1983-10-05 | Reckitt & Colmann Prod Ltd | Medicinal compositions |
| US4740365A (en) * | 1984-04-09 | 1988-04-26 | Toyo Boseki Kabushiki Kaisha | Sustained-release preparation applicable to mucous membrane in oral cavity |
| CA1215922A (en) * | 1984-05-25 | 1986-12-30 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
| US4933185A (en) * | 1986-09-24 | 1990-06-12 | Massachusetts Institute Of Technology | System for controlled release of biologically active compounds |
| CA1321048C (en) * | 1987-03-05 | 1993-08-10 | Robert W. J. Lencki | Microspheres and method of producing same |
| US4923645A (en) * | 1987-11-16 | 1990-05-08 | Damon Biotech, Inc. | Sustained release of encapsulated molecules |
| US5260066A (en) * | 1992-01-16 | 1993-11-09 | Srchem Incorporated | Cryogel bandage containing therapeutic agent |
-
1993
- 1993-10-15 US US08/138,367 patent/US5451411A/en not_active Expired - Fee Related
-
1994
- 1994-09-29 CA CA002133271A patent/CA2133271A1/en not_active Abandoned
- 1994-10-04 EP EP94307259A patent/EP0652015B1/de not_active Expired - Lifetime
- 1994-10-04 DE DE69402153T patent/DE69402153T2/de not_active Expired - Fee Related
- 1994-10-04 AT AT94307259T patent/ATE150320T1/de not_active IP Right Cessation
- 1994-10-04 DK DK94307259.5T patent/DK0652015T3/da active
- 1994-10-04 ES ES94307259T patent/ES2100632T3/es not_active Expired - Lifetime
- 1994-10-14 JP JP6249199A patent/JPH07258115A/ja not_active Abandoned
-
1997
- 1997-05-02 GR GR970400963T patent/GR3023307T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69402153D1 (de) | 1997-04-24 |
| CA2133271A1 (en) | 1995-04-16 |
| EP0652015A2 (de) | 1995-05-10 |
| EP0652015A3 (de) | 1995-08-02 |
| EP0652015B1 (de) | 1997-03-19 |
| US5451411A (en) | 1995-09-19 |
| DE69402153T2 (de) | 1997-10-09 |
| DK0652015T3 (da) | 1997-04-14 |
| ES2100632T3 (es) | 1997-06-16 |
| JPH07258115A (ja) | 1995-10-09 |
| GR3023307T3 (en) | 1997-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |