ATE148699T1 - PRODUCTION OF 2-(2-THIENYL)ETHYLAMINE AND SYNTHESIS OF THIENO(3,2-C)PYRIDINE DERIVATIVES THEREOF - Google Patents

PRODUCTION OF 2-(2-THIENYL)ETHYLAMINE AND SYNTHESIS OF THIENO(3,2-C)PYRIDINE DERIVATIVES THEREOF

Info

Publication number
ATE148699T1
ATE148699T1 AT92401954T AT92401954T ATE148699T1 AT E148699 T1 ATE148699 T1 AT E148699T1 AT 92401954 T AT92401954 T AT 92401954T AT 92401954 T AT92401954 T AT 92401954T AT E148699 T1 ATE148699 T1 AT E148699T1
Authority
AT
Austria
Prior art keywords
thieno
thienyl
ethylamine
pyridine derivatives
synthesis
Prior art date
Application number
AT92401954T
Other languages
German (de)
Inventor
Peter J Harrington
Ignacio H Sanchez
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE148699T1 publication Critical patent/ATE148699T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compounds of the formulae: <CHEM> and <CHEM> wherein: R<1>, R<2>, R<3> and R<4> are independently hydrogen, lower alkyl of one to six carbon atoms, aryl or substituted aryl; are advantageously converted to isocyanurate compounds, 2-(2-thienyl)ethylamine compounds and thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.
AT92401954T 1991-07-08 1992-07-07 PRODUCTION OF 2-(2-THIENYL)ETHYLAMINE AND SYNTHESIS OF THIENO(3,2-C)PYRIDINE DERIVATIVES THEREOF ATE148699T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72647691A 1991-07-08 1991-07-08

Publications (1)

Publication Number Publication Date
ATE148699T1 true ATE148699T1 (en) 1997-02-15

Family

ID=24918761

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401954T ATE148699T1 (en) 1991-07-08 1992-07-07 PRODUCTION OF 2-(2-THIENYL)ETHYLAMINE AND SYNTHESIS OF THIENO(3,2-C)PYRIDINE DERIVATIVES THEREOF

Country Status (9)

Country Link
EP (1) EP0522956B1 (en)
AT (1) ATE148699T1 (en)
AU (1) AU1947992A (en)
CA (1) CA2073317A1 (en)
DE (1) DE69217282T2 (en)
DK (1) DK0522956T3 (en)
ES (1) ES2097295T3 (en)
GR (1) GR3023276T3 (en)
MX (1) MX9203996A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI101150B (en) * 1991-09-09 1998-04-30 Sankyo Co Process for the preparation of tetrahydrothione nopyridine derivatives useful as a drug
US5599986A (en) * 1994-09-29 1997-02-04 Hoechst Marion Roussel Inc. Process for the preparation of alkali metal salts of diformylamide
US6043368A (en) * 1996-09-04 2000-03-28 Poli Industria Chimica, S.P.A. Method of making thieno-pyridine derivatives
CN102432590B (en) * 2011-11-23 2013-04-17 洛阳师范学院 Method for synthesizing thiophene ethylamine
CN107056801B (en) * 2016-11-14 2018-12-28 太原理工大学 A kind of synthetic method of 4,5,6,7- thiophane simultaneously [3,2-c] pyridine hydrochloride

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300090A1 (en) * 1975-02-07 1976-09-03 Parcor Tetrahydro-thieno-pyridine derivs. prepn. - by cyclizing 2-(2-aminoethyl)thiophenes with formaldehyde (BE060876)
US4128561A (en) * 1975-12-12 1978-12-05 Parcor Process for the preparation of 2-(2-thienyl)-ethylamine and derivatives thereof
LU74545A1 (en) * 1976-03-12 1976-09-01
US4906756A (en) * 1988-05-10 1990-03-06 Syntex (U.S.A.) Inc. 2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives
US4997945A (en) * 1990-01-25 1991-03-05 Syntex (U.S.A.) Inc. Carbamate salts of 2-(2'-thienyl)alkylamines
ATE129496T1 (en) * 1990-01-25 1995-11-15 Sanofi Sa PRODUCTION OF 2-(2'-THIENYL)ALKYLAMINES AND THEIR DERIVATIVES FOR THE SYNTHESIS OF 4,5,6,7-THIENO(3,2-C>PYRIDINE DERIVATIVES.

Also Published As

Publication number Publication date
EP0522956A2 (en) 1993-01-13
MX9203996A (en) 1993-02-01
DE69217282D1 (en) 1997-03-20
DE69217282T2 (en) 1997-07-03
AU1947992A (en) 1993-01-14
DK0522956T3 (en) 1997-07-28
ES2097295T3 (en) 1997-04-01
EP0522956B1 (en) 1997-02-05
EP0522956A3 (en) 1993-04-07
GR3023276T3 (en) 1997-07-30
CA2073317A1 (en) 1993-01-09

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Legal Events

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UEP Publication of translation of european patent specification