ATE14115T1 - AMIDE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL OR VETERINARY COMPOSITIONS CONTAINING THEM. - Google Patents

AMIDE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL OR VETERINARY COMPOSITIONS CONTAINING THEM.

Info

Publication number
ATE14115T1
ATE14115T1 AT81302147T AT81302147T ATE14115T1 AT E14115 T1 ATE14115 T1 AT E14115T1 AT 81302147 T AT81302147 T AT 81302147T AT 81302147 T AT81302147 T AT 81302147T AT E14115 T1 ATE14115 T1 AT E14115T1
Authority
AT
Austria
Prior art keywords
hydrogen
pharmaceutical
processes
compositions containing
carbon atoms
Prior art date
Application number
AT81302147T
Other languages
German (de)
Inventor
Neville Stanton Crossley
Alasdair Thomas Glen
Leslie Richard Hughes
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Plc filed Critical Ici Plc
Application granted granted Critical
Publication of ATE14115T1 publication Critical patent/ATE14115T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel 3,4-disubstituted-N-acylanilines of the formula: <IMAGE> wherein R1, R2 and ring A are defined in claim 1; wherein R3 is hydrogen or alkyl of up to 4 carbon atoms, or is joined to R5 as stated below; wherein R4 is alkyl of 2 to 4 carbon atoms, or has the formula -CX1X2X3 wherein X1, X2 and X3, which may be the same or different, each is hydrogen, fluorine or chlorine; wherein R5 is hydrogen, hydroxy or alkoxy or acyloxy each of up to 15 carbon atoms, or is joined to R3 to form an oxycarbonyl group such that together with the <IMAGE> part of the molecule it forms an oxazolidinedione group; and wherein R6 is hydrogen or halogen. These compounds possess antiandrogenic activity and are useful for the treatment of androgen dependent or prostatic diseases. Representative of the compounds is 3,4-dichloro-N-(2-hydroxy-2-p-nitrophenylpropionyl)aniline. Also disclosed are processes for the manufacture of the compounds and pharmaceutical and veterinary compositions containing them.
AT81302147T 1980-05-22 1981-05-14 AMIDE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL OR VETERINARY COMPOSITIONS CONTAINING THEM. ATE14115T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8016915 1980-05-22
EP81302147A EP0040932B1 (en) 1980-05-22 1981-05-14 Amide derivatives, process for their manufacture and pharmaceutical or veterinary compositions containing them

Publications (1)

Publication Number Publication Date
ATE14115T1 true ATE14115T1 (en) 1985-07-15

Family

ID=10513596

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81302147T ATE14115T1 (en) 1980-05-22 1981-05-14 AMIDE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL OR VETERINARY COMPOSITIONS CONTAINING THEM.

Country Status (19)

Country Link
US (1) US4386080A (en)
EP (1) EP0040932B1 (en)
JP (1) JPS5711951A (en)
AT (1) ATE14115T1 (en)
AU (1) AU543459B2 (en)
CA (1) CA1161850A (en)
DE (1) DE3171196D1 (en)
DK (1) DK219981A (en)
ES (2) ES8300088A1 (en)
FI (1) FI811547L (en)
GR (1) GR75659B (en)
HU (1) HU185799B (en)
IE (1) IE51201B1 (en)
IL (1) IL62873A (en)
NO (1) NO811730L (en)
NZ (1) NZ197008A (en)
PT (1) PT73079B (en)
YU (1) YU130981A (en)
ZA (1) ZA813099B (en)

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Also Published As

Publication number Publication date
ES512702A0 (en) 1983-02-01
NO811730L (en) 1981-11-23
CA1161850A (en) 1984-02-07
IE51201B1 (en) 1986-10-29
JPS5711951A (en) 1982-01-21
ES8303285A1 (en) 1983-02-01
PT73079B (en) 1982-07-15
HU185799B (en) 1985-03-28
GR75659B (en) 1984-08-02
DE3171196D1 (en) 1985-08-08
US4386080A (en) 1983-05-31
FI811547L (en) 1981-11-23
DK219981A (en) 1981-11-23
AU7029581A (en) 1981-11-26
EP0040932A1 (en) 1981-12-02
NZ197008A (en) 1984-10-19
AU543459B2 (en) 1985-04-18
ES502441A0 (en) 1982-10-01
PT73079A (en) 1981-06-01
IE811010L (en) 1981-11-22
IL62873A (en) 1985-05-31
EP0040932B1 (en) 1985-07-03
YU130981A (en) 1983-10-31
ZA813099B (en) 1982-05-26
ES8300088A1 (en) 1982-10-01

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REN Ceased due to non-payment of the annual fee