ATE140389T1 - HEMOGLOBIN OLIGOMER BASED COMPOSITION AND ITS PRODUCTION - Google Patents

HEMOGLOBIN OLIGOMER BASED COMPOSITION AND ITS PRODUCTION

Info

Publication number
ATE140389T1
ATE140389T1 AT91914918T AT91914918T ATE140389T1 AT E140389 T1 ATE140389 T1 AT E140389T1 AT 91914918 T AT91914918 T AT 91914918T AT 91914918 T AT91914918 T AT 91914918T AT E140389 T1 ATE140389 T1 AT E140389T1
Authority
AT
Austria
Prior art keywords
hemoglobin
production
based composition
oligomer based
modified
Prior art date
Application number
AT91914918T
Other languages
German (de)
Inventor
Deanna J Nelson
Ton That Hai
Ana Srnak
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24274925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE140389(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Int filed Critical Baxter Int
Application granted granted Critical
Publication of ATE140389T1 publication Critical patent/ATE140389T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A non-immunogenic mixture of hemoglobin based modified monomers and oligomers produced by the polymerization of a hemoglobin based solution in the presence of a three membered heterocyclic ring, i.e. polyether oxirane. The modified hemoglobin composition has a P50 of at least equivalent to the P50 of human red blood cell hemoglobin.
AT91914918T 1990-08-17 1991-08-15 HEMOGLOBIN OLIGOMER BASED COMPOSITION AND ITS PRODUCTION ATE140389T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56931690A 1990-08-17 1990-08-17

Publications (1)

Publication Number Publication Date
ATE140389T1 true ATE140389T1 (en) 1996-08-15

Family

ID=24274925

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91914918T ATE140389T1 (en) 1990-08-17 1991-08-15 HEMOGLOBIN OLIGOMER BASED COMPOSITION AND ITS PRODUCTION

Country Status (8)

Country Link
EP (1) EP0496866B1 (en)
JP (1) JP2689023B2 (en)
AT (1) ATE140389T1 (en)
CA (1) CA2067241A1 (en)
DE (1) DE69120925T2 (en)
DK (1) DK0496866T3 (en)
ES (1) ES2091940T3 (en)
WO (1) WO1992003153A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650388A (en) * 1989-11-22 1997-07-22 Enzon, Inc. Fractionated polyalkylene oxide-conjugated hemoglobin solutions
US5312808A (en) * 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
DK145092D0 (en) * 1992-12-03 1992-12-03 Novo Nordisk As
US6242417B1 (en) * 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
DE69912375T2 (en) * 1998-04-24 2004-08-19 Cv Therapeutics, Palo Alto COMPOSITION CONTAINING ADENOSINE A1 RECEPTOR ANTAGONISTS AND METHOD FOR RESTORING DIURETIC AND KIDNEY FUNCTION
US8084581B1 (en) * 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
JPS60258126A (en) * 1984-06-02 1985-12-20 Teruo Tomota Production of polymerized hemoglobin
US4598064A (en) * 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
IL87708A (en) * 1988-09-08 1994-04-12 Technion Inst For Research And Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof
IL87707A (en) * 1988-09-08 1994-06-24 Technion Inst For Research And Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof

Also Published As

Publication number Publication date
ES2091940T3 (en) 1996-11-16
JP2689023B2 (en) 1997-12-10
WO1992003153A1 (en) 1992-03-05
DE69120925T2 (en) 1997-02-13
EP0496866B1 (en) 1996-07-17
CA2067241A1 (en) 1992-02-18
JPH05502240A (en) 1993-04-22
DE69120925D1 (en) 1996-08-22
EP0496866A1 (en) 1992-08-05
DK0496866T3 (en) 1996-08-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
RZN Patent revoked