ATE1382T1 - N-MONOHYDROXYPROPYLAMIDES, N-DIHYDROXYPROPYLAMIDES AND THEIR ACETONOIDS OF ALL-E AND 13-Z-RETINOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THEM. - Google Patents

N-MONOHYDROXYPROPYLAMIDES, N-DIHYDROXYPROPYLAMIDES AND THEIR ACETONOIDS OF ALL-E AND 13-Z-RETINOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THEM.

Info

Publication number
ATE1382T1
ATE1382T1 AT79103682T AT79103682T ATE1382T1 AT E1382 T1 ATE1382 T1 AT E1382T1 AT 79103682 T AT79103682 T AT 79103682T AT 79103682 T AT79103682 T AT 79103682T AT E1382 T1 ATE1382 T1 AT E1382T1
Authority
AT
Austria
Prior art keywords
dihydroxypropylamides
monohydroxypropylamides
acetonoids
preparation
retinoic acid
Prior art date
Application number
AT79103682T
Other languages
German (de)
Inventor
Joachim Dr. Paust
Axel Dr. Nuerrenbach
Horst Dr. Koenig
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Application granted granted Critical
Publication of ATE1382T1 publication Critical patent/ATE1382T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. N-monohydroxypropylamides and N-dihydroxypropylamides of all-E-retinic acid and 13-Z-retinic acid, of the formulae I and II see diagramm : EP0009776,P7,F1 see diagramm : EP0009776,P8,F2 where X and Y are hydrogen or hydroxyl, but an least one is hydroxyl, or X and Y together with the carbon atoms linking them form a 2,2-dimethyl-1,3-dioxolane ring, and the acetonoids of such N-dihydroxypropylamides.
AT79103682T 1978-10-07 1979-09-28 N-MONOHYDROXYPROPYLAMIDES, N-DIHYDROXYPROPYLAMIDES AND THEIR ACETONOIDS OF ALL-E AND 13-Z-RETINOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THEM. ATE1382T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782843870 DE2843870A1 (en) 1978-10-07 1978-10-07 N-HYDROXYPROPYLAMIDES OF ALL-E AND 13-Z RETINIC ACID
EP79103682A EP0009776B1 (en) 1978-10-07 1979-09-28 N-monohydroxypropylamides, n-dihydroxypropylamides and their acetonoides of all-e and 13-z retinoic acid, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE1382T1 true ATE1382T1 (en) 1982-08-15

Family

ID=6051696

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79103682T ATE1382T1 (en) 1978-10-07 1979-09-28 N-MONOHYDROXYPROPYLAMIDES, N-DIHYDROXYPROPYLAMIDES AND THEIR ACETONOIDS OF ALL-E AND 13-Z-RETINOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THEM.

Country Status (5)

Country Link
EP (1) EP0009776B1 (en)
JP (1) JPS5551059A (en)
AT (1) ATE1382T1 (en)
CA (1) CA1136638A (en)
DE (2) DE2843870A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743400A (en) * 1986-09-22 1988-05-10 Mcneilab, Inc. Process for preparing retinoyl chlorides
JP2818693B2 (en) * 1992-11-18 1998-10-30 ヘキスト・セラニーズ・コーポレーション Fibrous structure containing immobilized particulate matter and method for producing the same
US5792794A (en) * 1995-09-01 1998-08-11 Gist-Brocades, N.V. Retinoylamide based derivatives of sphingoid bases
JP4104863B2 (en) * 1999-12-24 2008-06-18 三菱レイヨン株式会社 Method for producing tetrahydropyranyloxyamine
US7015225B1 (en) * 2003-06-26 2006-03-21 Larry Chen Anti-cancer agents and methods
KR100837186B1 (en) * 2006-09-29 2008-06-13 (주)아모레퍼시픽 Retinoic acid derivative having anti-aging activity and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH529742A (en) * 1970-02-02 1972-10-31 Hoffmann La Roche Process for the production of vitamin A acid amides

Also Published As

Publication number Publication date
DE2963424D1 (en) 1982-09-16
EP0009776B1 (en) 1982-07-28
CA1136638A (en) 1982-11-30
DE2843870A1 (en) 1980-04-24
JPS5551059A (en) 1980-04-14
EP0009776A1 (en) 1980-04-16

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