ATE1382T1 - N-MONOHYDROXYPROPYLAMIDES, N-DIHYDROXYPROPYLAMIDES AND THEIR ACETONOIDS OF ALL-E AND 13-Z-RETINOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THEM. - Google Patents
N-MONOHYDROXYPROPYLAMIDES, N-DIHYDROXYPROPYLAMIDES AND THEIR ACETONOIDS OF ALL-E AND 13-Z-RETINOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THEM.Info
- Publication number
- ATE1382T1 ATE1382T1 AT79103682T AT79103682T ATE1382T1 AT E1382 T1 ATE1382 T1 AT E1382T1 AT 79103682 T AT79103682 T AT 79103682T AT 79103682 T AT79103682 T AT 79103682T AT E1382 T1 ATE1382 T1 AT E1382T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydroxypropylamides
- monohydroxypropylamides
- acetonoids
- preparation
- retinoic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1. N-monohydroxypropylamides and N-dihydroxypropylamides of all-E-retinic acid and 13-Z-retinic acid, of the formulae I and II see diagramm : EP0009776,P7,F1 see diagramm : EP0009776,P8,F2 where X and Y are hydrogen or hydroxyl, but an least one is hydroxyl, or X and Y together with the carbon atoms linking them form a 2,2-dimethyl-1,3-dioxolane ring, and the acetonoids of such N-dihydroxypropylamides.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782843870 DE2843870A1 (en) | 1978-10-07 | 1978-10-07 | N-HYDROXYPROPYLAMIDES OF ALL-E AND 13-Z RETINIC ACID |
EP79103682A EP0009776B1 (en) | 1978-10-07 | 1979-09-28 | N-monohydroxypropylamides, n-dihydroxypropylamides and their acetonoides of all-e and 13-z retinoic acid, process for their preparation and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE1382T1 true ATE1382T1 (en) | 1982-08-15 |
Family
ID=6051696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79103682T ATE1382T1 (en) | 1978-10-07 | 1979-09-28 | N-MONOHYDROXYPROPYLAMIDES, N-DIHYDROXYPROPYLAMIDES AND THEIR ACETONOIDS OF ALL-E AND 13-Z-RETINOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THEM. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0009776B1 (en) |
JP (1) | JPS5551059A (en) |
AT (1) | ATE1382T1 (en) |
CA (1) | CA1136638A (en) |
DE (2) | DE2843870A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4743400A (en) * | 1986-09-22 | 1988-05-10 | Mcneilab, Inc. | Process for preparing retinoyl chlorides |
DE69316027T2 (en) * | 1992-11-18 | 1998-05-14 | Hoechst Celanese Corp | METHOD OF MANUFACTURING A FIBROUS STRUCTURE WITH IMMOBILIZED PARTICULATE MATERIAL |
KR100556682B1 (en) * | 1995-09-01 | 2006-06-21 | 코스모페름 베.파우 | Retinoylamide based derivatives of sphingoid bases |
DE60010516T2 (en) * | 1999-12-24 | 2005-05-12 | Mitsubishi Rayon Co., Ltd. | METHOD FOR PRODUCING TETRAHYDROPYRANYLOXYAMINES |
US7015225B1 (en) * | 2003-06-26 | 2006-03-21 | Larry Chen | Anti-cancer agents and methods |
KR100837186B1 (en) * | 2006-09-29 | 2008-06-13 | (주)아모레퍼시픽 | Retinoic acid derivative having anti-aging activity and preparation method thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH529742A (en) * | 1970-02-02 | 1972-10-31 | Hoffmann La Roche | Process for the production of vitamin A acid amides |
-
1978
- 1978-10-07 DE DE19782843870 patent/DE2843870A1/en active Pending
-
1979
- 1979-09-28 EP EP79103682A patent/EP0009776B1/en not_active Expired
- 1979-09-28 AT AT79103682T patent/ATE1382T1/en not_active IP Right Cessation
- 1979-09-28 DE DE7979103682T patent/DE2963424D1/en not_active Expired
- 1979-09-28 CA CA000336668A patent/CA1136638A/en not_active Expired
- 1979-10-05 JP JP12811379A patent/JPS5551059A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0009776A1 (en) | 1980-04-16 |
DE2843870A1 (en) | 1980-04-24 |
JPS5551059A (en) | 1980-04-14 |
DE2963424D1 (en) | 1982-09-16 |
EP0009776B1 (en) | 1982-07-28 |
CA1136638A (en) | 1982-11-30 |
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