ATE130763T1 - COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING GRAM NEGATIVE INFECTIONS. - Google Patents

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING GRAM NEGATIVE INFECTIONS.

Info

Publication number
ATE130763T1
ATE130763T1 AT89310044T AT89310044T ATE130763T1 AT E130763 T1 ATE130763 T1 AT E130763T1 AT 89310044 T AT89310044 T AT 89310044T AT 89310044 T AT89310044 T AT 89310044T AT E130763 T1 ATE130763 T1 AT E130763T1
Authority
AT
Austria
Prior art keywords
treating
compositions
methods
gram
gram negative
Prior art date
Application number
AT89310044T
Other languages
German (de)
Inventor
J Eric Bubbers
David L Castaldi
Samia Mankarious
John A Hooper
Melanie Alpern
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Application granted granted Critical
Publication of ATE130763T1 publication Critical patent/ATE130763T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A composition effective for treating or preventing diseases of Gram-negative bacterial origin comprises polyclonal immunoglobulins containing polyclonal antibodies against antigens of Gram-negative bacteria and monoclonal antibodies capable of binding with and neutralizing an antigen common to the endotoxin region of a variety of Gram-negative bacterial lipopolysaccharides.
AT89310044T 1988-10-12 1989-10-02 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING GRAM NEGATIVE INFECTIONS. ATE130763T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25744588A 1988-10-12 1988-10-12

Publications (1)

Publication Number Publication Date
ATE130763T1 true ATE130763T1 (en) 1995-12-15

Family

ID=22976343

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89310044T ATE130763T1 (en) 1988-10-12 1989-10-02 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING GRAM NEGATIVE INFECTIONS.

Country Status (6)

Country Link
EP (1) EP0368466B1 (en)
JP (1) JP2949291B2 (en)
AT (1) ATE130763T1 (en)
CA (1) CA1341375C (en)
DE (1) DE68924963T2 (en)
ES (1) ES2082783T3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU730308B2 (en) * 1997-06-18 2001-03-01 Rockefeller University, The Methods for identifying antibodies and peptides useful in the treatment of septic shock and experimental arthritis and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4834975A (en) * 1984-05-25 1989-05-30 Genetics Corporation Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production
FI853395L (en) * 1984-09-05 1986-03-06 Cetus Corp MONOCLONAL ANTICROPPAR SOM BLOCKERAR GRAM-NEGATIVE BACTERIEENDOTOXIN.
JPS61130300A (en) * 1984-11-27 1986-06-18 ザ　ボ−ド　オブ　トラステイ−ズ　オブ　ザ　レランド　スタンフオ−ド　ジユニア　ユニバ−シテイ Human monoclonal antibody
AU5991786A (en) * 1985-06-06 1987-01-07 Genetic Systems Corporation Protective human monoclonal antibodies to pseudomonas aeruginosa exotoxin a
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
IL81370A (en) * 1986-02-07 1991-06-30 Genetic Systems Corp Pharmaceutical and diagnostic compositions comprising a plurality of human monoclonal antibodies for the treatment of bacterial diseases,methods for the preparation of the compositions and antibodies and kits containing said compositions
DK172840B1 (en) * 1986-07-03 1999-08-09 Genetic Systems Corp Monoclonal antibodies to Pseudomonas aeruginosa flagella, pharmaceutical preparations containing such antibodies, and c.

Also Published As

Publication number Publication date
JP2949291B2 (en) 1999-09-13
EP0368466A3 (en) 1991-04-17
EP0368466A2 (en) 1990-05-16
JPH02134329A (en) 1990-05-23
DE68924963D1 (en) 1996-01-11
EP0368466B1 (en) 1995-11-29
CA1341375C (en) 2002-07-09
DE68924963T2 (en) 1996-06-20
ES2082783T3 (en) 1996-04-01

Similar Documents

Publication Publication Date Title
ATE301471T1 (en) USE OF ANTIBODIES AGAINST CD45RO LEUKOCYTE ANTIGEN FOR IMMUNE MODULATION
ES2106195T3 (en) IGG AGLYCOSILATED ANTIBODY ANTI CD3.
ATE237351T1 (en) TYPE I SURFACE ANTIGENS ASSOCIATED WITH STAPHYLOCOCCUS EPIDERMIDIS
GB2128630A (en) Method of affinity purification employing monoclonal antibodies
ATE71411T1 (en) MONOCLONAL ANTIBODIES SPECIFIC FOR MEMBRANE-ASSOCIATED ANTIGENS.
ATE197506T1 (en) BROADLY REACTIVE OPSONIC ANTIBODIES THAT REACT WITH COMMON ANTIGENS OF STAPHYLOCOCCUS
FI973484A (en) A method for stimulating an immune response
ATE398137T1 (en) PORPHYROMONAS GINGIVALIS ANTIGENS FOR THE DIAGNOSIS AND TREATMENT OF PERIODONTITIS
DE3280319D1 (en) FOR ENDOTOXINE-SPECIFIC ANTIBODIES.
ATE130763T1 (en) COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING GRAM NEGATIVE INFECTIONS.
ATE111606T1 (en) A GENUS-SPECIFIC LISTERIA ANTIGEN IDENTIFIED BY MONOCLONAL ANTIBODIES.
ATE77243T1 (en) E87AG ANTIGEN OF PSEUDOMONAS AERUGINOSA, MONOCLONAL ANTIBODIES AGAINST HYBRIDOMA.
ATE209659T1 (en) BROADLY REACTIVE OPSONIC ANTIBODIES THAT REACT WITH COMMON STAPHYLOCOCCUS ANTIGENS
DE69025629D1 (en) MEDICINAL PRODUCT AND METHOD FOR TREATING ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) AND AIDS-RELATED COMPLEX USING CARBOHYDRATE-SPECIFIC ANTIBODIES
DK0513565T3 (en) Monoclonal antibodies against the plasmin-antiplasmin complex, method for their preparation and their use
FI924278A0 (en) BCRF1 ANTAGONISTER FOER SKOETSEL AV EPSTEIN-BARR VIRUSINFEKTIONER.
EP0450573A3 (en) Antibodies for the treatment and diagnosis of pseudomonas aeruginosa infections

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee