ATE119532T1 - 7-oxabicycloheptyl-substituierte, heterocyclische amid-prostaglandin-analoge, verwendbar bei der behandlung von vasospastischen und thrombotischen krankheiten. - Google Patents
7-oxabicycloheptyl-substituierte, heterocyclische amid-prostaglandin-analoge, verwendbar bei der behandlung von vasospastischen und thrombotischen krankheiten.Info
- Publication number
- ATE119532T1 ATE119532T1 AT92108848T AT92108848T ATE119532T1 AT E119532 T1 ATE119532 T1 AT E119532T1 AT 92108848 T AT92108848 T AT 92108848T AT 92108848 T AT92108848 T AT 92108848T AT E119532 T1 ATE119532 T1 AT E119532T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted heterocyclic
- vasospastic
- usable
- treatment
- heterocyclic amide
- Prior art date
Links
- DYWAPFDKPAHSED-UHFFFAOYSA-N 2-cycloheptyloxepane Chemical group C1CCCCCC1C1OCCCCC1 DYWAPFDKPAHSED-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title 1
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001732 thrombotic effect Effects 0.000 title 1
- 230000002455 vasospastic effect Effects 0.000 title 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 abstract 2
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 229940123987 Thromboxane A2 receptor antagonist Drugs 0.000 abstract 1
- 108010069102 Thromboxane-A synthase Proteins 0.000 abstract 1
- -1 heterocyclic amide prostaglandin Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 239000003769 thromboxane A2 receptor blocking agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/713,898 US5158967A (en) | 1991-06-12 | 1991-06-12 | 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE119532T1 true ATE119532T1 (de) | 1995-03-15 |
Family
ID=24867989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92108848T ATE119532T1 (de) | 1991-06-12 | 1992-05-26 | 7-oxabicycloheptyl-substituierte, heterocyclische amid-prostaglandin-analoge, verwendbar bei der behandlung von vasospastischen und thrombotischen krankheiten. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5158967A (de) |
| EP (1) | EP0518118B1 (de) |
| JP (1) | JPH05194524A (de) |
| AT (1) | ATE119532T1 (de) |
| CA (1) | CA2070895A1 (de) |
| DE (1) | DE69201596T2 (de) |
| DK (1) | DK0518118T3 (de) |
| ES (1) | ES2069345T3 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5347007A (en) * | 1992-03-06 | 1994-09-13 | E. R. Squibb & Sons, Inc. | Method of preparing 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
| US5260448A (en) * | 1992-03-06 | 1993-11-09 | E. R. Squibb & Sons, Inc. | Method for preparing 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
| US5260449A (en) * | 1992-08-12 | 1993-11-09 | E. R. Squibb & Sons, Inc. | Method for preparing 7-oxabicycloheptyl substituted bromooxazole amide prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds |
| EP0621273B1 (de) * | 1992-09-18 | 1998-12-09 | Toray Industries, Inc. | Sulfonsäure derivat und deren pharmazeutische verwendung |
| CA2145192A1 (en) * | 1992-09-22 | 1994-03-31 | Gail Underiner | Novel epoxide-containing compounds |
| US5866576A (en) * | 1992-12-16 | 1999-02-02 | Cell Therapeutics, Inc. | Epoxide-containing compounds |
| US5849766A (en) * | 1996-05-31 | 1998-12-15 | Eli Lilly And Company | Carbamoyl substituted heterocycles |
| US5849922A (en) * | 1996-05-31 | 1998-12-15 | Eli Lilly And Company | Preparation of substituted alkenoic acids |
| WO2009089098A1 (en) | 2008-01-03 | 2009-07-16 | Musc Foundation For Research Development | Methods for the treatment of cancers |
| CN111432817B (zh) | 2017-11-29 | 2023-10-31 | 凡德贝尔大学 | 抑制肿瘤移转的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3922301A (en) * | 1973-06-19 | 1975-11-25 | Ono Pharmaceutical Co | Sulphonic acid derivatives of prostaglandins |
| US4418076A (en) * | 1982-05-03 | 1983-11-29 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane hydrazone prostaglandin analogs useful in treating thrombolytic diseases |
| US4416896A (en) * | 1982-05-17 | 1983-11-22 | E. R. Squibb & Sons, Inc. | 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease |
| US4556675A (en) * | 1982-05-17 | 1985-12-03 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene compounds |
| US4463015A (en) * | 1982-08-18 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation |
| US4474804A (en) * | 1983-09-19 | 1984-10-02 | E. R. Squibb & Sons, Inc. | 7-Oxabicyclo substituted prostaglandin phenyl carboxylic acid derivatives useful as cardiovascular agents |
| US4522949A (en) * | 1983-10-20 | 1985-06-11 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular agents |
| US4536513A (en) * | 1984-03-14 | 1985-08-20 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful in the treatment of thrombolytic disease |
| US4663336A (en) * | 1985-07-01 | 1987-05-05 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease |
| US4663337A (en) * | 1986-04-18 | 1987-05-05 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease |
| PH27413A (en) * | 1988-12-23 | 1993-06-21 | Squibb & Sons Inc | 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasopastic |
| US5100889A (en) * | 1989-04-03 | 1992-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
| NZ232897A (en) * | 1989-04-03 | 1992-12-23 | Squibb & Sons Inc | Interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogues, preparation and pharmaceutical compositions thereof |
-
1991
- 1991-06-12 US US07/713,898 patent/US5158967A/en not_active Expired - Lifetime
-
1992
- 1992-05-26 EP EP92108848A patent/EP0518118B1/de not_active Expired - Lifetime
- 1992-05-26 ES ES92108848T patent/ES2069345T3/es not_active Expired - Lifetime
- 1992-05-26 DK DK92108848.0T patent/DK0518118T3/da active
- 1992-05-26 DE DE69201596T patent/DE69201596T2/de not_active Expired - Fee Related
- 1992-05-26 AT AT92108848T patent/ATE119532T1/de not_active IP Right Cessation
- 1992-06-09 JP JP4149366A patent/JPH05194524A/ja not_active Withdrawn
- 1992-06-10 CA CA002070895A patent/CA2070895A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2070895A1 (en) | 1992-12-13 |
| US5158967A (en) | 1992-10-27 |
| JPH05194524A (ja) | 1993-08-03 |
| DK0518118T3 (da) | 1995-05-22 |
| ES2069345T3 (es) | 1995-05-01 |
| DE69201596T2 (de) | 1995-09-07 |
| DE69201596D1 (de) | 1995-04-13 |
| EP0518118A1 (de) | 1992-12-16 |
| EP0518118B1 (de) | 1995-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |