ATE119147T1 - Verbindungen und zusammensetzungen zur anwendung bei methoden zur behandlung und prophylaxe von pneumocystis carinii pneumonia und anderen krankheiten. - Google Patents

Verbindungen und zusammensetzungen zur anwendung bei methoden zur behandlung und prophylaxe von pneumocystis carinii pneumonia und anderen krankheiten.

Info

Publication number
ATE119147T1
ATE119147T1 AT89119720T AT89119720T ATE119147T1 AT E119147 T1 ATE119147 T1 AT E119147T1 AT 89119720 T AT89119720 T AT 89119720T AT 89119720 T AT89119720 T AT 89119720T AT E119147 T1 ATE119147 T1 AT E119147T1
Authority
AT
Austria
Prior art keywords
prophylaxis
diseases
compositions
compounds
treatment
Prior art date
Application number
AT89119720T
Other languages
English (en)
Inventor
Richard R Tidwell
J Dieter Geratz
Kwasi A Ohemeng
James Edwin Hall
Dennis E Kyle
Max Grogl
Original Assignee
Univ North Carolina
Us Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/262,535 external-priority patent/US4933347A/en
Priority claimed from US07/262,324 external-priority patent/US4963589A/en
Priority claimed from US07/334,730 external-priority patent/US5202320A/en
Application filed by Univ North Carolina, Us Army filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE119147T1 publication Critical patent/ATE119147T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT89119720T 1988-10-25 1989-10-24 Verbindungen und zusammensetzungen zur anwendung bei methoden zur behandlung und prophylaxe von pneumocystis carinii pneumonia und anderen krankheiten. ATE119147T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/262,535 US4933347A (en) 1988-10-25 1988-10-25 Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia
US07/262,324 US4963589A (en) 1988-10-25 1988-10-25 Methods for treating Giardia lamblia
US33459089A 1989-04-06 1989-04-06
US07/334,730 US5202320A (en) 1989-04-06 1989-04-06 Method for treating leishmaniasis

Publications (1)

Publication Number Publication Date
ATE119147T1 true ATE119147T1 (de) 1995-03-15

Family

ID=27500733

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89119720T ATE119147T1 (de) 1988-10-25 1989-10-24 Verbindungen und zusammensetzungen zur anwendung bei methoden zur behandlung und prophylaxe von pneumocystis carinii pneumonia und anderen krankheiten.

Country Status (13)

Country Link
EP (1) EP0366066B1 (de)
JP (1) JP2887397B2 (de)
AR (1) AR248011A1 (de)
AT (1) ATE119147T1 (de)
AU (1) AU626033B2 (de)
BR (1) BR8905441A (de)
CA (1) CA2001359C (de)
CH (1) CH679857A5 (de)
DE (1) DE68921413T2 (de)
DK (1) DK526689A (de)
FI (1) FI895039A7 (de)
IL (1) IL92101A (de)
NO (1) NO894222L (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246965A (en) * 1991-06-11 1993-09-21 Ciba-Geigy Arylethers, their manufacture and methods of treatment
US5488160A (en) * 1991-06-11 1996-01-30 Ciba-Geigy Corporation Amidino compounds, their manufacture and method of treatment
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
ATE125791T1 (de) * 1991-06-11 1995-08-15 Ciba Geigy Ag Amidino-verbindungen, ihre herstellung und verwendung als arzneimittel.
DK0902013T3 (da) * 1992-02-05 2002-03-25 Boehringer Ingelheim Pharma Hidtil ukendte amidinderivater, deres fremstilling og anvendelse som lægemidler med LTB4-antagonistisk virkning
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
US5637621A (en) * 1994-11-14 1997-06-10 Nzym, Inc. Methods and compositions for treating Botrytis infections
WO1996015104A2 (en) * 1994-11-14 1996-05-23 Nzym, Inc. Methods and compositions for treating phytopathogenic fungi infections
US5629348A (en) * 1994-11-14 1997-05-13 Nzym, Inc. Methods and compositions for treating septoria infections
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
US6635668B1 (en) * 1998-07-22 2003-10-21 The University Of North Carolina At Chapel Hill Imidazoline receptor binding compounds
US6172104B1 (en) 1998-08-20 2001-01-09 The University Of North Carolina At Chapel Hill Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof
DE19853944A1 (de) * 1998-11-24 2000-05-25 Bourdichon Alain Jacques Verwendung von Diminazen-di-aceturat zur Behandlung von Malaria
EP1732527A2 (de) * 2004-03-17 2006-12-20 Mpex Pharmaceuticals, Inc. Verwendung und verabreichung von bakteriellen ausfluss-pumpenhemmern
RU2620016C1 (ru) * 2016-03-28 2017-05-22 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ профилактики пневмоцистной пневмонииии у реципиентов сердца в раннем послеоперационном периоде после трансплантации сердца

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2277861A (en) * 1937-12-10 1942-03-31 May & Baker Ltd Process for the preparation of diamidine derivatives
FR925999A (fr) * 1945-03-22 1947-09-18 May & Baker Ltd Procédé de préparation d'amidines

Also Published As

Publication number Publication date
AR248011A1 (es) 1995-05-31
EP0366066A1 (de) 1990-05-02
NO894222L (no) 1990-04-26
CA2001359C (en) 1997-05-06
NO894222D0 (no) 1989-10-24
DE68921413D1 (de) 1995-04-06
DK526689A (da) 1990-04-26
CH679857A5 (de) 1992-04-30
AU626033B2 (en) 1992-07-23
IL92101A (en) 1995-11-27
AU4366789A (en) 1990-05-03
EP0366066B1 (de) 1995-03-01
CA2001359A1 (en) 1990-04-25
FI895039A0 (fi) 1989-10-24
JPH02243666A (ja) 1990-09-27
FI895039A7 (fi) 1990-04-26
BR8905441A (pt) 1990-10-23
DE68921413T2 (de) 1995-06-29
JP2887397B2 (ja) 1999-04-26
DK526689D0 (da) 1989-10-24

Similar Documents

Publication Publication Date Title
ATE119147T1 (de) Verbindungen und zusammensetzungen zur anwendung bei methoden zur behandlung und prophylaxe von pneumocystis carinii pneumonia und anderen krankheiten.
EP0693928A4 (de) Aminozucker- und glykosaminoglykanzusammensetzung zur behandlung und reparatus von bindegewebe
ATE270556T1 (de) Verwendung von synergistischen zusammensetzungen von il-12 und ifn-alpha für die behandlung von infektiösen krankheiten
DE3579113D1 (de) Zusammensetzungen zur milderung, behandlung und bestimmungung von arthritschen krankheiten und aehnlichen zustaenden.
DE68916036D1 (de) Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.
ATE207759T1 (de) Aktivierter faktor viii als ein therapeutisches mittel und verfahren zur behandlung eines faktor viii mangels
DE3482754D1 (de) Medikament und medikamentoese zusammensetzung zur behandlung und/oder verhinderung von hautkrankheiten, verursacht durch eine entzuendung.
ATE126433T1 (de) Verwendung von gamma-hydroxy-buttersäuresalzen zur herstellung von pharmazeutischen zusammensetzungen zur verwendung bei der behandlung von alkoholismus und die hergestellten zusammensetzungen.
DE3884200D1 (de) Verfahren zur Behandlung von Mastitis und anderen Staphylokokkeninfektionen.
DE69018457D1 (de) Gegenstände zur behandlung von periodontitis und knochendefekten.
DE3785388D1 (de) Antivirale peptide und mittel zur behandlung von herpes.
ATA11989A (de) Mittel zur vorbeugung gegen und behandlung von parodontopathien
DE58908740D1 (de) Pilzart Tolypocladium varium und Verfahren zur Herstellung des Antibioticumkomplexes Cyclosporin und/oder seiner Bestandteile.
MX18106A (es) Compuesto amidinicos y composiciones usadas para el tratamiento de pneumonia por pneumocystis carinii y otras enfermedades.
ATE190843T1 (de) Zubereitungen zur behandlung von impotenz, die ein alpha-1 inhibitor und ein alpha-2 inhibitor enthalten
DE69110713D1 (de) 7-Oxabicycloheptan-imidazol-prostaglandin-Analoge, verwendbar bei der Behandlung von thrombotischen und vasospastischen Erkrankungen.
DE3582594D1 (de) Proglumid und dessen pharmazeutische zusammensetzungen zur anwendung bei der behandlung von neoplastischen affektionen.
ATE120645T1 (de) Verfahren und therapeutische zubereitungen für die behandlung von gerinnungsstörungen.
ATE143804T1 (de) Zusammensetzung zur behandlung von mastitis und metritis
ATE180277T1 (de) Zur behandlung von tumoren und hiv-infektionen nützliches pflanzliches protein
ATE81455T1 (de) (s)-emopamil zur anwendung bei der behandlung von migraene.
DE69014501D1 (de) Verfahren zur Behandlung von Titanlegierung und damit hergestelltes Stück.
DE68908404D1 (de) Lang haltende zusammensetzung von propafenon und chinidin zur behandlung des zustandes des herzens.
DE3881377D1 (de) Mittel zur prophylaxe und behandlung von thrombocytopenie.
DE3769497D1 (de) Mittel zur bekaempfung von phytopathogenen mikroben.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee