ATE111354T1 - 2,3-DIHYDROERGOLINES TO INCREASE SEROTONERGIC FUNCTIONS. - Google Patents

2,3-DIHYDROERGOLINES TO INCREASE SEROTONERGIC FUNCTIONS.

Info

Publication number
ATE111354T1
ATE111354T1 AT88307751T AT88307751T ATE111354T1 AT E111354 T1 ATE111354 T1 AT E111354T1 AT 88307751 T AT88307751 T AT 88307751T AT 88307751 T AT88307751 T AT 88307751T AT E111354 T1 ATE111354 T1 AT E111354T1
Authority
AT
Austria
Prior art keywords
dihydroergolines
disclosed
serotonergic functions
increase serotonergic
increase
Prior art date
Application number
AT88307751T
Other languages
German (de)
Inventor
Leander Merritt
John Stanley Ward
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE111354T1 publication Critical patent/ATE111354T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A therapeutic method employing 2,3-dihydroergolines is disclosed. Said method enhances serotonergic function in the nervous system of a mammal in need thereof, thereby finding application in serotoninmediated physiological manifestations including memory, depression, anxiety, pain and appetite. Also disclosed are pharmaceutical compositions containing said 2,3-dihydroergolines in admixture with pharmaceutically acceptable diluents and carriers.
AT88307751T 1987-08-31 1988-08-22 2,3-DIHYDROERGOLINES TO INCREASE SEROTONERGIC FUNCTIONS. ATE111354T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/091,462 US4798834A (en) 1987-08-31 1987-08-31 Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement

Publications (1)

Publication Number Publication Date
ATE111354T1 true ATE111354T1 (en) 1994-09-15

Family

ID=22227911

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88307751T ATE111354T1 (en) 1987-08-31 1988-08-22 2,3-DIHYDROERGOLINES TO INCREASE SEROTONERGIC FUNCTIONS.

Country Status (6)

Country Link
US (1) US4798834A (en)
EP (1) EP0306191B1 (en)
JP (1) JPS6468322A (en)
AT (1) ATE111354T1 (en)
DE (1) DE3851497T2 (en)
ES (1) ES2058293T3 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674875A (en) * 1993-05-04 1997-10-07 Eli Lilly And Company Method of blocking human 5-hydroxytryptamine-2 receptors
US20070243240A9 (en) * 2000-08-24 2007-10-18 Fred Windt-Hanke Transdermal therapeutic system
DE10066158B4 (en) * 2000-08-24 2007-08-09 Neurobiotec Gmbh Use of a transdermal therapeutic system for the treatment of Restless Legs Syndrome
DE10053397A1 (en) * 2000-10-20 2002-05-02 Schering Ag Use of a dopaminergic active ingredient for the treatment of dopaminerg treatable diseases
DE10064453A1 (en) * 2000-12-16 2002-07-04 Schering Ag Use of a dopaminergic active ingredient for the treatment of dopaminerg treatable diseases
US7091232B2 (en) * 2002-05-21 2006-08-15 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7276522B2 (en) * 2002-05-21 2007-10-02 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7358269B2 (en) * 2002-05-21 2008-04-15 Allergan, Inc. 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
US7323485B2 (en) 2002-05-21 2008-01-29 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
CN101044120B (en) * 2004-09-28 2011-06-15 阿勒根公司 Unsubstituted and substituted 4-benzyl-1,3-dihydro-imidazole-2-thiones acting as specific or selective alpha2 adrenergic agonists and methods for using the same
WO2018076019A1 (en) * 2016-10-21 2018-04-26 Far Biotech, Inc. Ergot derivative compounds and their use in african sleeping sickness and related disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH344731A (en) * 1956-05-18 1960-02-29 Sandoz Ag Process for the production of new derivatives of the lysergic acid series alkylated on the indole nitrogen
US3580916A (en) * 1969-02-20 1971-05-25 Lilly Co Eli Hydroxyesters of hexa- and octahydroindoloquinolines
IE41533B1 (en) * 1974-03-14 1980-01-30 Sandoz Ltd Thiomethyl ergolene derivatives
US3992385A (en) * 1975-01-20 1976-11-16 Eli Lilly And Company 2,3-Dihydroergolines
DE2656344A1 (en) * 1975-12-23 1977-07-07 Sandoz Ag ERGOLIN DERIVATIVES, THEIR USE AND MANUFACTURING
CH628049A5 (en) * 1977-03-25 1982-02-15 Sandoz Ag Process for the preparation of ergolene derivatives
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4201862A (en) * 1979-03-16 1980-05-06 Eli Lilly And Company 2-Azaergolines and 2-aza-8(or 9)-ergolenes
CH649998A5 (en) * 1982-08-09 1985-06-28 Sandoz Ag ERGOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND HEALING AGENTS, CONTAINING THESE ERGOL DERIVATIVES AS AN ACTIVE SUBSTANCE.
DE3411981A1 (en) * 1984-03-28 1985-10-10 Schering AG, Berlin und Bergkamen, 1000 Berlin METHOD FOR PRODUCING 2.3-DIHYDROERGOLINES
DE3445784A1 (en) * 1984-12-13 1986-06-26 Schering AG, Berlin und Bergkamen, 1000 Berlin METHOD FOR PRODUCING ERGOLIN DERIVATIVES

Also Published As

Publication number Publication date
DE3851497D1 (en) 1994-10-20
US4798834A (en) 1989-01-17
ES2058293T3 (en) 1994-11-01
EP0306191A2 (en) 1989-03-08
EP0306191A3 (en) 1991-11-06
JPS6468322A (en) 1989-03-14
EP0306191B1 (en) 1994-09-14
DE3851497T2 (en) 1995-02-16

Similar Documents

Publication Publication Date Title
MX9203543A (en) MEDICINE.
DE3779500D1 (en) LEVODOPA METHYL ESTER CONTAINING PHARMACEUTICAL COMPOSITIONS, THEIR PRODUCTION AND THERAPEUTIC USE.
IT1197038B (en) PHARMACEUTICAL COMPOSITION WITH ANALGESIC ACTIVITY
DE3674906D1 (en) SELF-CLAMPING MEDICAL PROSTHESIS AND THEIR PRODUCTION.
ATE61523T1 (en) MEANS FOR ADMINISTRATION OF HYALURONIC ACID TO MAMMALS.
LU90829I2 (en) Tepoxalin-zubrin and its pharmaceutically acceptable derivatives
FI872917A (en) PHARMACEUTICAL BAERARE, VILKA FRIGOER AKTIVAEMNET REGLERBART.
GR3005447T3 (en)
DK0687266T3 (en) Heterocyclic compounds and their preparation and use
ATE111354T1 (en) 2,3-DIHYDROERGOLINES TO INCREASE SEROTONERGIC FUNCTIONS.
FR2623806B1 (en) ESTERS OF 3,6-DIHYDRO-1,5 (2H) -PYRIMIDINECARBOXYLIC ACIDS WITH THERAPEUTIC ACTION
LU88790I2 (en) Moxidectin and its pharmaceutically acceptable derivatives
ATE113207T1 (en) BENZAMIDE AGAINST COGNITIVE DISEASES.
NO165071C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 7- (3-AMINO-1-PYRROLIDINYL) -8-CHLORO-1-CYCLOPROPYL-6-FLUORO-1,4, -DIHYDRO-4-OXO-3-CHINOLINE-CARBOXYL.
ATE107168T1 (en) USE OF GEPIRON IN THE MANUFACTURE OF A PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF ATYPICAL DEPRESSION.
EP0329401A3 (en) Bipolar transistors and methods of production
FI864570A0 (en) THERAPEUTIC ANVAENDBAR FOERENING.
ES2153842T3 (en) DERIVATIVES OF 3-OXO-PIRIDO (1,2-A-) BENCIMIDAZOL-4-CARBOXYL AND 4-OXO-AZEPINO (1,2-A) BENCIMIDAZOL-5-CARBOXYL USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM.
DE58904383D1 (en) SOLID MEDICINE, CONTAINING GALLOPAMIL.
FR2624008B1 (en) EXTRA-THORACIC PROSTHESIS OF VENTILATORY SUPPORT MOLDABLE BY DEPRESSION
ES2094757T3 (en) A MEGACARIOCITOPOYETIC FACTOR.
IT1224250B (en) ASSOCIATION OF DEPIPRAZOLE WITH MORFINA
IT1258315B (en) FLAVONE DERIVATIVES
FR2625507B1 (en) PROCESS FOR THE PREPARATION OF A COPOLYMER OF TWO ACIDS (ALPHA) -AMINES AND COPOLYMER THUS OBTAINED
DE68919593D1 (en) Use of zofenopril for the manufacture of medications for rheumatoid arthritis.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee