ATA904881A - Verfahren zum bestimmen der stoffwechselumwandlung bestimmter chemikalien und wirkstoffe - Google Patents

Verfahren zum bestimmen der stoffwechselumwandlung bestimmter chemikalien und wirkstoffe

Info

Publication number
ATA904881A
ATA904881A AT0904881A AT904881A ATA904881A AT A904881 A ATA904881 A AT A904881A AT 0904881 A AT0904881 A AT 0904881A AT 904881 A AT904881 A AT 904881A AT A904881 A ATA904881 A AT A904881A
Authority
AT
Austria
Prior art keywords
determining
active substances
certain chemicals
metabolic conversion
metabolic
Prior art date
Application number
AT0904881A
Other languages
English (en)
Other versions
AT391145B (de
Inventor
Barbara B Knowles
David P Aden
Original Assignee
Wistar Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Inst filed Critical Wistar Inst
Publication of ATA904881A publication Critical patent/ATA904881A/de
Application granted granted Critical
Publication of AT391145B publication Critical patent/AT391145B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/82—Hepatitis associated antigens and antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT9048/81A 1980-06-12 1981-06-10 Verfahren zum bestimmen der stoffwechselumwandlung bestimmter chemikalien und wirkstoffe AT391145B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/158,685 US4393133A (en) 1980-06-12 1980-06-12 Human hepatoma derived cell line, process for preparation thereof, and uses therefor

Publications (2)

Publication Number Publication Date
ATA904881A true ATA904881A (de) 1990-02-15
AT391145B AT391145B (de) 1990-08-27

Family

ID=22569250

Family Applications (1)

Application Number Title Priority Date Filing Date
AT9048/81A AT391145B (de) 1980-06-12 1981-06-10 Verfahren zum bestimmen der stoffwechselumwandlung bestimmter chemikalien und wirkstoffe

Country Status (10)

Country Link
US (1) US4393133A (de)
EP (1) EP0053165B1 (de)
JP (1) JPH0411198B2 (de)
AT (1) AT391145B (de)
CA (1) CA1193210A (de)
CH (1) CH657456A5 (de)
DE (1) DE3152113C2 (de)
GB (1) GB2089370B (de)
IT (1) IT1171297B (de)
WO (1) WO1981003663A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721675A (en) * 1982-02-01 1988-01-26 Abbott Laboratories Production of hepatitis A virus in vitro utilizing a persistently virus infected cell culture system
US4532204A (en) * 1982-07-19 1985-07-30 Massachusetts Institute Of Technology Mutation assays involving blood cells that metabolize toxic substances
US4808532A (en) * 1985-07-01 1989-02-28 The United States Of America As Represented By The United States Department Of Energy Continuous human cell lines and method of making same
FR2585722B1 (fr) * 1985-07-31 1987-11-20 Ire Celltarg Sa Co-cultures d'hepatocytes et de cellules epitheliales de foie traitees
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5665589A (en) * 1988-12-14 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Human liver epithelial cell lines
US5529920A (en) * 1988-12-14 1996-06-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human liver epithelial cell line and culture media therefor
CA2081782C (en) * 1990-05-16 2004-08-24 James H. Kelly Permanent human hepatocyte cell line and its use in a liver assist device (lad)
US5704910A (en) * 1995-06-05 1998-01-06 Nephros Therapeutics, Inc. Implantable device and use therefor
US5994061A (en) * 1995-09-29 1999-11-30 Queen's University At Kingston DNA constructs and methods for screening for increased expression of human apo AI gene
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
ATE458039T1 (de) * 2001-07-06 2010-03-15 Inst Nat Sante Rech Med Menschliche hepatomazellinien, deren gewinung und deren verwendungen
US20050074876A1 (en) * 2003-10-03 2005-04-07 Inserm Bipotential liver cell lines from wild-type mammalian liver tissue
ES2389441T3 (es) * 2004-01-08 2012-10-26 North Carolina State University Métodos y dispositivos para el microencapsulamiento de células
EP1814981A4 (de) * 2004-10-25 2009-09-30 Baylor Res Inst Mit hitzeschock-behandelten melanomzellkörpern beladene dendritische zellen
AU2007212110A1 (en) 2006-02-02 2007-08-16 Innovative Bio Therapies An extracorporeal cell-based therapeutic device and delivery system
US20090081296A1 (en) * 2006-02-02 2009-03-26 Humes H David Extracorporeal cell-based therapeutic device and delivery system
WO2010071692A2 (en) * 2008-06-18 2010-06-24 Innovative Biotherapies, Inc. Methods for enhanced propagation of cells
KR101179171B1 (ko) 2008-08-14 2012-09-03 주식회사 운화 산삼 또는 인삼을 포함한 인삼류의 형성층 유래 식물줄기세포주를 유효성분으로 함유하는 간질환의 예방 또는 치료용 조성물
CN103087989A (zh) * 2013-02-01 2013-05-08 湖南省肿瘤医院 一种人肝癌细胞系hlcz01及其应用
WO2015116884A1 (en) * 2014-01-30 2015-08-06 The Cleveland Clinic Foundation In vitro assay systems and methods for identifying anti-cancer agents
US20200115682A1 (en) * 2017-04-03 2020-04-16 Deborah Lynn GREENE NGUYEN Use of Engineered Liver Tissue Constructs for Modeling Liver Disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1300391A (en) * 1969-08-22 1972-12-20 Nat Res Dev Cell lines and virus culture
DD109659A1 (de) * 1974-01-25 1974-11-12
DE2431918A1 (de) * 1974-07-03 1976-01-22 Bbc Brown Boveri & Cie Verfahren und vorrichtung zur kontinuierlichen bestimmung und auswertung der humantoxizitaet von fluessigkeiten
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
US4164566A (en) * 1978-08-17 1979-08-14 Merck & Co., Inc. Hepatitis a virus cell culture in vitro
FR2444713A1 (fr) * 1978-12-18 1980-07-18 Pasteur Institut Procede de production d'un adn comprenant le genome du virus de l'hepatite b et vecteur le comportant
US4209587A (en) * 1978-12-29 1980-06-24 Monsanto Company Production of tumor angiogenesis factor by cell culture
US4352880A (en) * 1979-09-17 1982-10-05 Massachusetts Institute Of Technology Diffusion bioassay for the quantitative determination of mutagenicity
US4301250A (en) * 1979-11-02 1981-11-17 Merck & Co., Inc. Method of producing hepatitis B surface antigen
PT72015B (en) * 1979-11-13 1982-06-20 Merck & Co Inc Process for preparing "invitro" cultures of hepatitis b virus
DE3162469D1 (en) * 1980-03-27 1984-04-12 Merck & Co Inc Method of growing hepatitis b surface antigen
PT73614B (en) * 1980-09-11 1983-10-19 Merck & Co Inc Method for preparing mycoplasma-free hepatoma cell line
US4416986A (en) * 1981-01-16 1983-11-22 Merck & Co., Inc. Methods of producing HBsAg

Also Published As

Publication number Publication date
DE3152113C2 (de) 1994-06-09
GB2089370A (en) 1982-06-23
AT391145B (de) 1990-08-27
DE3152113T1 (de) 1982-08-12
IT1171297B (it) 1987-06-10
WO1981003663A1 (en) 1981-12-24
EP0053165A4 (de) 1983-03-04
EP0053165A1 (de) 1982-06-09
JPH0411198B2 (de) 1992-02-27
CA1193210A (en) 1985-09-10
US4393133A (en) 1983-07-12
GB2089370B (en) 1984-09-05
EP0053165B1 (de) 1987-05-06
IT8148663A0 (it) 1981-06-11
JPS57500768A (de) 1982-05-06
CH657456A5 (de) 1986-08-29

Similar Documents

Publication Publication Date Title
ATA904881A (de) Verfahren zum bestimmen der stoffwechselumwandlung bestimmter chemikalien und wirkstoffe
FI813034L (fi) Foerfarande foer framstaellning av substituerade imino-disyror
IT1148234B (it) Metodo di saggio biologico
IT8249581A0 (it) Procedimento ed apparecchio per la separazione di isotopi mediante onde stazionarie
IT1070726B (it) Apparecchiatura e metodo per la eliminkazione di sostanze inquinanti dall acqua mediante ultrasuoni
IT1092846B (it) Apparato e metodo per il movimento di cereali contenuti in silos
BR8202959A (pt) Aparelho para a concentracao de frutas
JPS52114446A (en) Method of joining members of different materials
FI810133L (fi) Foerfarande och anordning foer bestaemning av ligninghalten i massa
IT7950008A0 (it) Metodo e procedimento per arilalchi lazione
JPS54147611A (en) Method of construction of chemicals injection
FI810935L (fi) Foerfarande foer framstaellning av substituerade triaryltiazol-foereningar
CS194222B2 (en) Method of cleaning the extracts containing the utero-evacuation substances
AT342186B (de) Gerat zum untersuchen von objekten nach dem ultraschall-schnittbildverfahren
GT198167188A (es) Formulacion anticoccidiana y metodo
FI800481A (fi) Foerfarande foer framstaellning av substituerade acylpiperidiner
AT368042B (de) Einrichtung zum quertransport von langgestreckten guetern
ATA518278A (de) Verfahren zum herstellen von musterblechen
DD131348A5 (de) Verfahren zum reinigen der innenwaende von reaktoren
IT1117328B (it) Sapone liquido e procedimento per la sua fabbricazione
IT1166754B (it) Metodo elettrofotografico ed apparato per la realizzazione pratica dello stesso
JPS54158009A (en) Method of chemicals injection construction
YU106980A (en) Nondestructive method of defining the activity of concrete
JPS52133343A (en) Method of copperizing various materials for construction
DD160115B1 (de) Aetzmittel zum aetzen von nife-duennschichten

Legal Events

Date Code Title Description
ELA Expired due to lapse of time