AT6932U1 - COMBINATION PREPARATION, CONTAINING MINERALS, VITAMINS, CARBOHYDRATES AND AMINO ACIDS - Google Patents

Abstract

The invention relates to a combination preparation containing minerals, vitamins, carbohydrates and amino acids, which differs from already known preparations in that the absorption of the individual components and active substances is improved. In contrast to similar, known products, the present preparation is distinguished in particular by the following Ingredients from: - Gamma Oryzanol- Octacosanol- Alpha Lipoic Acid.

Description

       

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  There are currently a wide variety of supplements, especially for athletes, that contain either vitamins, amino acids, carbohydrates, etc., either alone or in various combinations.



  The aim of the present invention was to develop a completely new combination preparation which differs from already known preparations in that the absorption of the individual components and active substances is improved.



  This object could be achieved by the combination preparation according to the invention. Surprisingly, the combination and interaction of the various individual components in a combination preparation increases the uptake of the individual components compared to separate administration of the individual components and active ingredients, and an improved uptake in the cells is ensured, while when the individual components and active ingredients are administered, the Recording is significantly worse or even impeded.



  This effect is based on the fact that different components of the combination preparation have "carrier function" and thus a kind of synergistic effect (increased uptake and improved uptake in the cells) when combining different active ingredients and components according to the combination preparation according to the invention compared to separate administration of the individual components or Administration of other combinations of vitamins, amino acids, carbohydrates etc. arises.



  This synergistic effect is brought about both by the specific composition of the individual components of the combination preparation and by the specific amounts of the individual components.



  In contrast to similar, known products, the present preparation is characterized in particular by the following ingredients: gamma oryzanol-octacosanol-alpha lipoic acid These three components in particular control the improved absorption of the components of the combination preparation according to the invention in the cells.



  So far, essentially the following is known from these 3 ingredients of the combination preparation according to the invention: Gamma Orvzanol is obtained from rice bran oil. This substance is said to have an impact on testosterone production in the human body. But the cholesterol-lowering property is important.

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   The main active ingredient in the sugar cane extract policosanol PPG5 is octacosanol, a waxy substance that is contained in various vegetable fats and oils.



   Many studies have shown that daily doses of 20 mg of policosanol reduce the LDL
Lower cholesterol levels and generally leave the HDL levels unchanged.



   Octacosanol is also beneficial for endurance, responsiveness and physical
Loading capacity. It also has an effect on male sexual power
Potency and erection problems.



   Alpha lipoic acid (thioctic acid) is a physiological substance with a vitamin-like effect, which was isolated from liver tissue as early as the 1950s and was described in detail in terms of structure, chemical properties and physiological functions.



   The components of the combination preparation according to the invention can be any
Be origin that allows their use in food supplements.



   The preparation according to the invention can be used to improve the release of energy in the human body, in particular with increased performance such as. B. in sporty
Effort.



   The preparation also contains the following ingredients: #, minerals
Calcium: Normal functioning of the skeletal and cardiac muscles is only guaranteed if different z. T. complex substances such as calcium and
Magnesium are in balance. 99% of the calcium contained in the body is in the bones, so it is considered the most important structural element.



   Magnesium: Magnesium is involved in all metabolic reactions in which phosphorylated substrates (ATP, ADP) play a role. Magnesium forms a stable ATP complex with ATP. A low intracellular magnesium concentration therefore slows down the energy supply and all ATP-dependent enzyme reactions (glycolysis, protein metabolism). As a physiological "calcium counterpart", magnesium prevents calcium overload in the mitochondria. Further tasks of magnesium: building up
Bones and teeth, membrane stabilization, regulation of muscle contractions and central nervous system function. 60% of the magnesium in our body is in the bones, almost 30% in the connective tissue, especially in the liver and muscles. About 2% of the magnesium can be found in the body fluids.

   It is important for energy metabolism, heart muscle, and bones
Teeth, membrane stabilization and nervous system.

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   @
Phosphorus is an important building block for bones and teeth, it also regulates the acid / base balance, is also of eminent importance for the structure of cell membranes and is considered an energy carrier. Without phosphorus there would be none
Energy, no "burning" and no muscle work!
Zinc:
So far, participation in over 200 enzymes has been demonstrated for zinc. It is involved in both their synthesis and their catalytic function, i.e. it is absolutely necessary for the metabolic process in question, but is not consumed even in the process. Zinc can also inhibit or accelerate the metabolic processes.

   For example, the release of
Zinc neurotransmitter substances involved. An important point is the central role in cell division. Insufficient activity of this enzyme has a disturbance in the acid / base balance as well as an increased sodium and
Water excretion. Zinc is important for the oxidative degradation of the
Body-made but also from the alcohol supplied from outside, it offers cell protection from damage caused by free radicals and protects against
Heavy metal poisoning. Zinc plays an important role in the metabolism of sex hormones, thyroid hormones and growth hormones
Insulins and prostaglandins. Zinc is found in many throughout the body
Body functions involved. It is an important antioxidant. Zinc is a heavy metal
Opponent.

   Without zinc, mental illnesses, inflammatory tendencies and a disturbed acid base balance are inevitable.



    .?., Vitamins:
Vitamin E is the main fat-soluble antioxidant. It protects the fat-like
Substances in the cell membrane against the influence of free radicals as well as substances and structures in the body that are sensitive to oxidation, such as polyunsaturated fatty acids. Pituitary, adrenal and hormones
Sex glands (gonads) and various vitamins such. B. Vitamin A and individual B vitamins. Vitamin E also reduces the tendency of blood platelets to
Clumping in the vessels and can thus also be described as a type of antithrombotic agent.



   Vitamin B1 (thiamine) in its active form TPP (thiamine pyrophosphate) is a vital coenzyme for energy production. Thiamine is also involved in the transmission of nerve impulses to the brain and peripheral nerve cells. Thiamine also plays a role in the synthesis of collagen (the body's main and building protein), which is why thiamine deficiency diminishes
Production of collagen and deteriorated wound healing has been linked.

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   Increased alcohol consumption can reduce the absorption of thiamine and its
Impair conversion to active forms. Since the storage capacity of thiamine is not particularly pronounced, heavy physical training, stress,
Fever, burns, hyperthyroidism, liver disease, a lack of thiamine during breastfeeding and growth can be expected.



   An external intake of vitamin B1 is therefore advisable in a preventive and supportive manner. The body has only a small storage capacity for thiamine (B1), for example
30 mg, so regular, daily intake of this vitamin is necessary to
To avoid deficiency symptoms.



  Vitamin B6: its main function is the conversion of tryptophan to niacin. Vitamin B6 is neuroprotective, significantly increases the formation of
Hemoglobin and thereby contributes to oxygen transport through the red
Blood cells. This vitamin also plays a central role in the synthesis of new proteins. Pyridoxine hydrochloride (vitamin B6) is derived from the
Food ingested and active in the body, coenzyme pyridoxyl-5-
Phosphate (PLP), reshaped. PLP is the most common form of vitamin B6 in the
Bloodstream and acts as a coenzyme in more than 100 metabolic processes in the
Body.



   Vitamin B12
Vitamin B12 is a group of water-soluble vitamins whose common structural feature is a corrin ring system with a central cobalt
Atom is. A protein (intrinsic factor) that is excreted in the stomach becomes one
Compound with vitamin B12 from food and is for the absorption of the
Vitamins necessary (important for nerve cells, cell development and amino acid and
Fat metabolism).



   Biotin:
Biotin is an essential component of many enzymes that are important for cell metabolism. The greatest amount of biotin comes from food. little one
Quantities are synthesized by bacteria in the intestinal tract and complement those with the
Food ingested amount of biotin.



    -Amino acids 3rd, carnitine:
 EMI4.1
   which serves to generate energy, more than 9.5% of the carnitine content of our body is contained in the heart and skeletal muscles. These are tissues that are particularly dependent on sufficient energy production.

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  4, Awiuocoureu
Leucine:
Leucine, a branched chain amino acid, is essential for maintaining and building
Muscle tissue essential. It supports protein synthesis in muscle and
Liver, inhibits the breakdown of muscle protein and supports healing processes.



   isoleucine:
Isoleucine serves as a source of energy in the muscle cells and has an excessive effect
Counteracts serotonin formation in the brain by inhibiting tryptophan uptake.



   Isoleucine is a branched chain amino acid (BCAA) so called because of its specific molecular structure. A lack of isoleucine manifests itself in a loss
Muscle mass (age-related, athletic overexertion and healing processes).



   Valin:
Valine is the third branched chain amino acid. It works together with isoleucine and leucine and, like these, can provide energy for the muscle cells and counteract excessive serotonin formation. A deficiency is either due to an insufficient supply of vitamin B6 or high-quality proteins (containing all essential amino acids).



   creatine:
Creatine is a derivative of the amino acid glycine. Creatine in the form of
Creatine monohydrate is considered a highly effective nutritional supplement. Creatine is considered an alternative to because of its efficiency in building muscle and building strength
Known steroids.



  51 carbohydrates:
Lactose:
Lactose is a double sugar (1 molecule of glucose + 1 molecule of galactose). It is broken down into these molecules in the intestine by enzyme lactase and only then reabsorbed. Lactose is a good "carrier" for calcium. Warning: about 10% of adults in Europe have lactose deficiency.



   inositol
Although a certain amount of inositol is synthesized in our body (the largest
Part in the brain, kidneys, liver and testes), man needs under certain
Circumstances of inositol from food or in the form of nutritional supplements. to
Synthesis of inositol requires a lot of niacin and magnesium.

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 The combination preparation according to the invention contains the following composition per 100 g:

   0.8-2 g alpha-lipoic acid, 0.01-0.05 g octacosanol 6.0-7.5 g gamma oryzanol
 EMI6.1
   5-20a 15-30 g carbohydrates 5-20 g
Calcium 7000-11000 mg
Phosphorus 5000-10000 mg
Magnesium 1000 - 5000 mg zinc 50 - 200 mg vitamin E 100 - 300 mg vitamin B6 5 - 20 mg vitamin B1 5-25 mg biotin 800-1800 g vitamin B12 20 - 100 g When, preferably lactose is used, as amino acids L leucine, L-lsoleucinyL-valine and L are used. The amino acids are individually added to the powder so that, in contrast to amino acid mixtures obtained from lactalbumin, any contamination is avoided.



  The powder also contains: 10-24 g creatine monohydrate 1.8-3g inositol 0.1-1.0 g alpha-tocopherol acetate Calcium, magnesium and zinc are used in the form of any physiologically acceptable salts or oxides. Calcium is preferably used in the form of calcium phosphate, zinc in the form of zinc gluconate and magnesium in the form of magnesium oxide.

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 The combination preparation preferably contains per 100 g: 1.1-1.7 g alpha-lipoic acid, 0.02-0.04 g octacosanol 6.5-7.1 g gamma oryzanol
 EMI7.1
 Calcium 8000-10000 mg phosphorus 6000-8000 mg magnesium 2000-4000 mg zinc 100-150 mg vitamin E 180-280 mg vitamin B6 10-20 mg vitamin B1 10-15 mg biotin 1000-1500 g vitamin B12 40-80 15- 19 g creatine monohydrate 2.0-2.6 g inositol 0.3-0.7 g alpha-tocopherol acetate. The combination preparation according to the invention particularly preferably contains per 100 g:

   1.36 g alpha-lipoic acid, 0.03 g octacosanol 6.8 g gamma oryzanol
 EMI7.2
 Calcium 8800-9100 mg phosphorus 6500-7400 mg magnesium 2700-3100 mg zinc 110-140 mg vitamin E 200-240 mg vitamin B6 15-19 mg vitamin B1 9-13 mg biotin 1150-1300 g vitamin B12 50-70 g 17 , 0 g creatine monohydrate 2.25 g inositol 0.48 g alpha-tocopherol acetate

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 The combination preparation according to the invention is preferably in solid form, in particular in the form of capsules.



  Embodiment 1.36 g alpha-lipoic acid, 0.03 g octacosanol 6.8 g gamma oryzanol
 EMI8.1
 
Calcium 9000-9060 mg
Phosphorus 6900-7010 mg
Magnesium 2950-3010 mg zinc 125-129 mg vitamin E 210-220 mg vitamin B6 16-18 mg vitamin B1 10-12 mg
Biotin 1200-1250 g vitamin B12 60-62 g
17.0 g creatine monohydrate 2.25 g inositol 0.48 g alpha-tocopherol acetate The components are intended for administration in the form of hard gelatin capsules. The capsule shell is preferably of synthetic origin, e.g. B. from hydroxypropylmethyl cellulose.



  Tests were carried out with these capsules in order to demonstrate the effect of the preparation according to the invention: 12 test subjects were administered the product according to the invention, 12 comparison subjects received placebo capsules which contained only pharmaceutically acceptable filler. The duration of the experiment was 12 weeks, one capsule at 9:00 and one at 12:00. The test subjects were asked about their physical condition at irregular intervals.

   In comparison to the untreated condition, the following results were shown: after 3 days: In 6 control subjects (placebo) a significantly reduced feeling of tiredness and improved concentration were found. after 5/6 days In 6 control subjects (placebo), in addition to a significantly reduced feeling of tiredness and improved concentration, an improvement in the overall physical condition was also found.

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 after 7-12 days 9 test persons showed less fatigue from midday, better physical condition immediately after getting up, improvement in the ability to concentrate (especially in the afternoon), no physical tension, better concentration when working on the screen, especially after 3 p.m. from 4 weeks:

   All of the comparators (placebo) showed that those of some of the people who had previously noticed improvements had generally decreased the previously described improvements. From 6 weeks: All comparators (placebo) described a physical condition as before the start of the test series (including all symptoms that they had at the start) In contrast, the following improvements were found in all 12 test subjects: - less tiredness in the afternoon, - easier getting up - Improved concentration, especially from the afternoon - less tension - very good overall physical feeling from 10 weeks All test subjects showed increased sporting ambitions and performance in addition to the positive physical improvements already found.



  No effects on the comparison subjects (placebo)


    

Claims (10)

 Expectations : 1. Combination preparation for supplementing the amino acid, mineral and vitamin supply, containing minerals, vitamins, carbohydrates and amino acids, characterized in that in 100 g powder 0.8-2 g alpha-lipoic acid, 0.01-0.05 g octacosanol, 6.0-7.5 g gamma oryzanol, 15-30 g amino acids, and / or Coruiliu 5-20 g disaccharides, especially lactose, 7000-11000 mg calcium, 5000-10000 mg phosphorus, 1000 - 5,000 mg magnesium, 50 - 200 mg zinc, 100 - 300 mg vitamin E, 5 - 20 mg vitamin B6, 5-25 mg vitamin B1, 800-1800 g biotin, 20-100 g vitamin B12, 10-24 g creatine monohydrate, 1.8-3g inositol and 0.1-1.0g alpha-tocopherol acetate are included. 2. Combination preparation according to claim 1, characterized in that in 100 g powder 1.1-1.7 g alpha-lipoic acid, 0.02-0.04 g octacosanol, 6.5-7.1 g gamma oryzanol, 20- 28 g amino acids, and / or @ 8-15 g disaccharides, especially lactose 8000-10000 mg calcium, 6000-8000 mg phosphorus, 2000-4000 mg magnesium, 100-150 mg zinc, 180-280 mg vitamin E, 10-20 mg vitamin B6, 10-15 mg vitamin B1, 1000-1500 g biotin, 40-80 g vitamin B12, 15-19 g creatine monohydrate, 2.0-2.6 g inositol and 0.3-0.7 g alpha-tocopherol acetate.  <Desc / Clms Page number 11>    3. Combination preparation according to one of claims 1 or 2, characterized in that in 100 g of powder 1.36 g alpha-lipoic acid, 0.03 g octacosanol, 6.8 g gamma oryzanol, 23-25 g amino acids, and / or courihu 10-12 g disaccharides, especially lactose, 8800-9100 m calcium, 6500-7400 mg phosphorus, 2700-3100 mg magnesium, 110-140 mg zinc, 200-240 mg vitamin E, 15-19 mg vitamin B6, 9-13 mg vitamin B1, 1150-1300 g biotin, 50-70 g vitamin B12, 17.0 g creatine monohydrate, 2.25 g inositol and 0.48 g alpha-tocopherol acetate are included. 4. Combination preparation according to one of claims 1-3, characterized in that in 100 g powder 1.36 g alpha-lipoic acid, 0.03 g octacosanol, 6.8 g gamma oryzanol, 24-24.5g amino acids, and / or @ 11-11.5 g disaccharides, especially lactose, 9000-9060 mg calcium, 6900-7010 mg phosphorus, 2950-3010 mg magnesium, 125-129 mg zinc, 210-220 mg vitamin E, 16-18 mg vitamin B6, 10-12 vitamin B1, 1200-1250 g biotin, 60-62 g vitamin B12, 17.0 g creatine monohydrate, 2.25 g inositol and 0.48 g alpha-tocopherol acetate are included. 5. Preparation according to one of claims 1-4, characterized in that the calcium is in the form of calcium phosphate. 6. Preparation according to one of claims 1-5, characterized in that the  EMI11.1  available.  <Desc / Clms Page number 12>     7. Preparation according to one of claims 1-6, characterized in that is used as lactose. 8. Preparation according to one of claims 1-7, characterized in that zinc is present in the form of zinc gluconate. 9. Use of a preparation according to any one of claims 1-8 to increase physical performance, especially when exercising. 10. A preparation according to any one of claims 1-9 as a means of increasing physical performance, especially during exercise