AT516999A1 - cap - Google Patents

Abstract

The invention relates to a cap (10) for the detection and administration of substances. According to the invention, at least one wall of the covering cap (10) is superficially deposited and / or embedded in the material of the wall, one of the covering material (10) forming material or composite material of different indicator (11) for a substance to be indexed (20 ) is sensitive and in the presence of the substance (20) permanently or temporarily changes its state from an initial state, arranged such that the substance (20) passes from the outer region of the covering cap (10) to the indicator (11).

Description

The invention relates to a cap for the detection of substances, in particular for placement on a skin analyzer and for insertion into body openings, according to the preamble of claim 1, a cap according to the preamble of claim 27 and a cap for administering one or more administration substances, according to the preamble 33. Furthermore, the invention relates to a combination of a measuring device with a cap according to claim 51, a combination of a measuring device with a cap according to claim 56 and a combination of a measuring device with a cap according to claim 57. The invention further relates to a hygiene article according to claim 61 and a robot arm according to claim 62. Furthermore, the invention relates to a method for producing a cap according to the preamble of claim 63, a method for producing a cap gem ß the preamble of claim 64 and a method for manufacturing a cover cap according to the preamble of claim 66th

In this context, skin is understood to mean any body surface, in particular skin surfaces, mucous membranes, conjunctivae, organic skins, etc.

Background of the invention is the use of caps, also called hygienic caps, for covering sensors of a measuring device. Cover caps are essential for sterile or non-sterile, clean human, animal or material measurements, without contaminating the sensor covered by the cap or the meter covered by the cap. Such caps are used in the prior art, for example in an infrared thermometer, the infrared sensor is covered to protect against contamination with a cap. The use of caps is designed not to spread disease to other people or body parts or objects.

However, the caps available from the prior art have disadvantages in many respects. Since substances are difficult or impossible to detect due to the hygienically shielding design of the hygiene caps, for example, the detection of gases with a measuring device covered by a hygiene cap is virtually impossible.

From the prior art it is known that hygiene caps are made of a uniform and equally thick material, preferably polyethylene or polypropylene, wherein the surface area of the respective cap is thinned by means of a Mikrotonmeters or by laser in the front wall, through which the respective temperature characterizing infrared beam penetrates. Thus, the temperature can be measured, but the presence of substances such as inflammation or certain gases, but can not be detected. The invention solves this disadvantage in a cap of the type mentioned above with the characterizing feature of claim 1 and a combination of a cap with a measuring device according to claim 51.

In the case of a cover cap for the detection of substances, it is provided that at least one wall of the covering cap is superficially deposited or incorporated in the material of the wall, one of which the covering cap forming material or composite material is arranged different administration substance, such that - by mechanical, chemical or thermal action on the cap or - by irradiation of the cap, the administration substance, preferably completely, from the cap (10) detachable or ausbringbare from the cap.

The indicator allows detection of substances while providing hygienic shielding of the meter and can detect substances such as gases or other parameters of the skin of a person or an object.

Another known problem is the measurement of pH values or other parameters determined by electrodes with a high hygiene standard or to perform electrostimulation in hygienically sensitive areas. The invention solves this problem with a cap of the type mentioned above with the characterizing feature of claim 27 and a combination of a cap with a measuring device according to claim 56.

In such a cap is provided - that the wall defines an interior, wherein the cap facing the interior and an inner side facing the outer region of the cap and on the wall of the inside has the opposite outer side - that deposited on at least one wall of the cap on the surface or embedded in the material of the wall at least one of which the cap forming

Material or composite material consisting of conductive material conductor material is arranged such that a) from the interior to the outside at least one electrical contact can be produced and / or b) within the interior of the cap at least one electrical contact can be produced and / or c) along the outside the cover at least one electrical contact can be produced and / or d) Within the wall at least one electrical contact can be produced.

The prior art also has the problem of achieving administration of drugs or other substances under hygienic conditions. The invention solves this problem with a cap of the type mentioned above with the characterizing feature of claim 33 and a combination with a measuring device according to the characterizing feature of claim 57. In such a cap is provided - that superficially deposited on at least one wall of the cap or embedded in the material of the wall one of the cap forming material or composite material different administration substance is arranged so -dass by mechanical, chemical or thermal action on the cap or - by irradiation of the cap, the administration substance, preferably completely, detachable from the cap or from the cap is ausbringbar.

The cap according to the invention makes it possible to administer administering substances under a high standard of hygiene.

Another object of the invention is to provide an advantageous method for producing these caps. The invention solves this problem in the method of the type mentioned above with the characterizing feature of claims 63, 64 and 66.

Particularly advantageous embodiments of the invention are defined in more detail by the features of the dependent claims:

An improved embodiment of the invention is achieved in that the cover cap has a peripheral wall bounded by an end wall and a peripheral edge of the

The end wall adjoining the shell wall, wherein the end wall and the shell wall bound an interior, wherein the cap facing the interior and an inner side facing the outer region of the cap and on the wall of the inside facing the outside has and that a) the indicator in or on one or a plurality of the surfaces - the outside of the end wall and / or - the inside of the end wall and / or - the outside of the shell wall and / or - the inside of the shell wall is arranged and / or b) the indicator in the material of the end wall and / or the shell wall is arranged.

A simple detection of the substance is achieved by the indicator upon contact with the substance changes at least one physical, chemical, thermal or electrical property, and that this change in the characteristic of the indicator from a, in particular within the cap can be arranged measuring device, detectable.

A determination of the number of uses, i. a single use of the cap or a repeated use of the cap, is achieved by the indicator on contact with the substance its physical, chemical, thermal or electrical property - irreversibly changes or - or that the indicator reversibly changes and returns to its initial state, wherein the duration of the reaction of the indicator with the substance to be indexed is much shorter than the cooldown in which the indicator returns to its original state.

In order to bind the fabric and to keep available for further evaluation, it is provided that on at least one wall, in particular the end wall and / or the shell wall, the cap superficially or embedded in the material one of the covering cap forming material or Material verbünd arranged various additional binding substance, which binds, in particular volatile, substances for which the indicator is sensitive.

An optical detection of the presence of the substance is achieved by the indicator on contact with the substance changes its optical properties compared to the initial state and in particular for certain, in particular visible, wavelength components, its transparency, opacity or its reflective or absorbing behavior changes.

By an increased contrast effect of the indicator when the substance with the material of the cap is achieved by the material of the cap is provided with a dye and that the contrast between the indicator and the dye in detection of the substance by the indicator of the contrast between the indicator and the dye is different in the initial state.

Another way to increase the contrast between the indicator and the cap is achieved by part of the wall of the cap, in particular the shell wall and / or parts of the end wall, free of the indicator, the parts of the wall containing a free dye from the indicator.

In order to be able to detect the substance only above a certain concentration threshold, it is provided that the indicator changes its physical, chemical or thermal property only after exceeding a concentration threshold of the substance.

A larger number of substances or more substances can be detected by at least one wall of the cap on the surface or incorporated in the material of the wall more of the covering cap forming material or composite material has different, in particular different from each other, indicators.

A different detection of the substance or a detection of several different substances is achieved by the indicators are different in their chemical, physical, thermal or optical properties.

A local distribution of the substance can be detected by arranging the indicators at different regions of the covering cap, in particular at different regions within or superficially on the end wall and / or the jacket wall.

A detection of different volatile substances is achieved by different indicators in different layer depths of the wall, in particular the shell wall and / or the end wall, the cap are arranged.

A substance which is difficult to detect can be detected by conversion into a messenger by a) the indicators are in a reaction relationship to each other, b) the first indicator - changes its physical, chemical, thermal or electrical property when reacting with the substance or - with the substance (20) reacts and forms a messenger substance (23), c) a further indicator is arranged closer to the inside of the wall than the first indicator, and d) the further indicator - if the physical, chemical, thermal or electrical property of the first indicator changes - When the messenger substance is produced by the first indicator changes its physical, chemical, thermal or electrical property.

The reaction of an object on a reaction substance can be detected by - on the outside of the wall, in particular the shell wall and / or the end wall, a reaction substance is arranged, wherein the substance is formed when applying the reaction substance to an object to be examined, - preferably on the surface of the wall facing the interior, in particular the casing wall and / or the end wall, the indicator is arranged and - the region of the cap covering the substance between the reaction substance and the indicator is permeable to the substance.

It is preferably provided that the reaction substance contains or is an allergen.

Contamination of a measuring device arranged in the interior of the covering cap can be prevented by forming part of the wall of the covering cap, in particular the casing wall and / or the end wall, permeable to the substance, the wall of the covering cap, in particular the casing wall and / or the End wall, impermeable to contamination, especially body secretions such as faeces, urine, blood, pus and saliva, is.

Targeted activation or formation of the indicator is achieved by the indicator comprising at least one auxiliary substance which can be converted into the indicator substance by external excitation, in particular by heat, light and / or chemical methods, and / or by the indicator having a plurality of auxiliary substances, wherein the auxiliary substances by external excitation, in particular by heat, light and / or chemical processes, is convertible into an indication substance. the indicator comprises an indicator substance and an auxiliary substance and - that by external excitation, in particular by heat, light and / or chemical methods, the indicator substance is activated by the auxiliary substance.

An incorporation of the indicator in a carrier is provided by the indicator comprises an indicator substance and a carrier, wherein the indicator substance is incorporated in the carrier and formed such that the indicator for the substance in the initial state is not sensitive and that the carrier the indicator to mechanical , chemical or thermal action activated.

Premature detection of the substance or contamination of the indicator is prevented by the indicator comprising an indicator substance, the indicator being separated or encapsulated by a barrier from the environment of the cap, the barrier being disrupted or permeable to the substance upon external stimulation, and wherein in particular by an acting on the cap pressure, the indicator substance is pressed out.

A preferred embodiment of the cap is achieved by the indicator consists of one of the following indicators or substances or a mixture thereof: -pH-Indicators (acid-base titrations), in particular litmus, Bromthymolblau or phenolphthalein, redox indicators, complex indicators, Solvatochrome indicators, thermoindicators, mixed indicator, contrast indicator, moisture indicators, - fluorescent indicator, enzymes, biochemical catalyst, in particular • group I: oxidoreductases • group II; Transferases • group IN; Hydrolases • group IV: lyases (syntheses) • group V: isomerases • group VI: ligases (synthetases),

Allergen, zymase, cofactor nicotinamide adenine dinucleotide, yeast, oxygen, enzyme glucose oxidase (GOx), yeast and / or boronic acid, carbon dioxide, urea, enzyme

Urease, catalase, hexachlorobenzene, bay leaf oil, pomegranate, potash oil, medium, rice extract, tetra-ethyl-ammonium-hydroxide, acids or alkalis or acid-alkali combinations, alkalis (oxides, soda-lime).

The carrier preferably consists of one of the following substances or substances or a mixture thereof: colloidal vehicle systems such as microemulsions, active ingredient molecules having sufficient lipophilicity, small hydrophilic molecules, in particular urea or propylene glycol, enhancers, in particular oleic acid, terpenes, glycolipids, medium-chain triglycerides, Waxes, in particular isopropyl myristate, branched-chain fatty alcohols, in particular eutanol G, urea, propylene glycol, azone, dimethyl sulfoxide, taurine, 1,2-pentylene glycol, galenic vehicle systems, in particular microemulsions, penetration retarders or reducers.

The auxiliary substance preferably consists of one of the following substances or substances or a mixture thereof:

Gases, liquids, solids, air constituents in particular C02 or 02, water, water vapor, substances that degenerate into or on the surface of the skin, bacteria, viruses.

In order to facilitate the application of the cap or the effect of the application of the cap and to reduce or repair any damage, it is provided that on the outside of the cap, a lubricant and / or care agent is applied and the lubricant and / or care agent is arranged on the outside of the cap so that the indicator, in particular the indicators, is covered by the lubricant and / or care agent.

In order to take samples of the object or a person to be examined, it is provided that the covering cap and / or the indicator comprises an adhesive substance, wherein the adhesive substance is arranged such that the adhesive substance comes into contact with the object when the covering cap is applied to an object - that the adhesive substance binds to itself parts of the article, in particular skin flakes or DNA, and - that the parts of the article adhere to the adhesive substance when the cover cap is removed.

In order to detect whether a first substance is present and a second substance can not analyze or detect more complex substances or substance mixtures, the covering cap comprises: a first indicator, which changes its state in the presence of a first substance, at least a second one Indicator, in particular a number of further indicators, which changes state in the presence of a second substance, a calculator comprising a calculator substance, which changes its state depending on the state of the first indicator and second indicator, wherein preferably the calculator of one of the substances or a mixture consists of indicator substances.

A particular embodiment of the invention is provided in that the cover cap comprises an end wall bounded by a peripheral edge and a lateral wall adjoining the peripheral edge of the end wall, the end wall and the jacket wall defining an interior space, wherein the cover cap has an inner side facing the inner space and an outer area a) the conductor substance in or on one or more of the surfaces - the outside of the end wall and / or - the inside of the end wall and / or - the outside of the shell wall and / or the outer side facing the cap - The inside of the jacket wall is arranged and / or b) the conductor substance in the material of the end wall and / or the jacket wall is arranged.

In order to conduct electrical impulses from the interior of the cap to the outside and to deliver by means of electrodes to the object or a person, it is provided that on the outside, in particular the end wall, the cap electrodes are arranged, wherein by the conductor substance, between the interior of the Cover and the electrodes an electrical contact is formed.

Electrodes or other electrical components or lines can be connected to the cap by electrically conductive contact surfaces are formed on the outside, in particular on the end wall, wherein an electrical contact is formed by the conductor substance, between the interior of the cap and the contact surfaces.

A particular embodiment of the invention is provided in that the conductor substance, the electrodes and / or the contact surfaces consist of or comprise a conductive, in particular the same adhesive.

Preferred embodiments of the conductive substance are achieved by: - the conductive substance, the electrodes and / or the contact surfaces of one of the following materials or a mixture thereof: plant starch, stearin (biodegradable), palm fat, vegetable fat, paraffin, beeswax, capillary beeswax Separating acids, - conductive substances such as: carbon (graphite and graphene), silver (eg silver nanoparticles) eg 200 mQ / rnrn ^, Carbon, Tin oxide, Copper, Silver, Gold, Aluminum, Sodium, Tungsten, Salt, Tungsten, Zinc, Brass, Iron, Chromium, Lead, Titanium, Stainless steel, Mercury, Gadolinium, Graphite, Conductive polymers, Doped Germanium, doped silicon and tellurium; embedded in the material and / or - that the material comprises binders for binding the conductive substances.

Preferably, the administering substance is a medicament, painkillers, disinfectant care products, a barrier opening substance or supplement, in particular a food supplement, or a combination of the aforementioned substances.

A preferred embodiment of the cap is achieved by the cap comprises an end wall bounded by a peripheral edge and a mantle wall adjoining the peripheral edge of the end wall, wherein the end wall and the shell wall define an interior space, the cap having an inner side facing the inner space and an outer area a) the administration substance in or on one or more of the surfaces - the outside of the end wall and / or - the inside of the end wall and / or - the outside of the shell wall and / or - The inside of the jacket wall is arranged and / or b) the administering substance in the material of the end wall and / or the jacket wall is arranged.

A defined dose or a defined volume of the administration substance is achieved by the end wall in particular being completely folded over the peripheral edge into the interior of the covering cap and forming an indentation, which in particular has a definable volume, wherein the administering substance is arranged in the indentation and the administration substance, in particular by a within the interior of the cap, can be arranged ausbringable Ausbringelement from the indentation.

An easy way to deploy the administration substance from the indentation or bring them completely out of the bulge is made possible by the end wall is flexible and the indentation over the peripheral edge, in particular completely, can be folded out.

In order to be able to dispose residues of the administration substance completely out of the cover cap after use or to render the cover cap and / or the administration substance ineffective, it can be provided that the administration substance can be arranged by a heat source, in particular a measuring device which can be arranged in the interior of the cover cap comprising a heat source , destructible and especially combustible. Thus, it is also achieved that the cap can be disposed of easily on a simple landfill, or that already decomposition of the cap or the material of the cap is initiated by the action of the heat source and thereby the decomposition is accelerated. The substances contained in the cap, such as indicators, auxiliary substances, etc., can be permanently disabled by irradiation, heating, light, etc., so that the cap can be disposed of without environmental impact. In particular, enzymes or hormones disintegrate even with moderate irradiation or heating, for example even between 50 ° C and 60 ° C, so that the cap disposed of residue and possibly even can be composted.

Hygienic coverage of the delivery substance and shielding of germs or contaminants is achieved by covering the delivery substance by a sealing cap, in particular the sigla lid covering the bulge completely and extending along the peripheral edge.

Another possibility of sealing and encapsulating the administration substance and thus preventing contamination is achieved by the

Administering substance is separated or encapsulated by a barrier from the environment of the cap, wherein the barrier is destructible or permeable by external excitation and in particular by a pressure acting on the cap, the administration substance is auspressbar.

A particular embodiment of the invention provides that the jacket wall has at least one peripheral portion whose thickness is less than the thickness of the jacket wall in the portion of the end wall remote from the end wall of the shell wall. By this measure, a certain flexibility is given in the region of the circumferential section, with the optimal adaptation of the cap is made possible to the respective measuring device.

In principle, it is advantageous in the case of any type of covering cap, in particular in all the abovementioned developments of the invention, if the end wall has a thickness in the range of less than 100 μm, preferably between 0.1 μm and 20 μm, at least at one point. in particular between 5 pm and 10 pm. This makes it possible to create an end wall, can diffuse through the gases and a cap is also possible to protect the sensor from harmful substances, without affecting the entire function of the meter, as through the formation of the end wall to be measured substances through this can diffuse.

In particular, it can be provided that the end wall in particular has a constant thickness. As a result, a particularly accurate measurement is possible.

Another preferred aspect of the invention provides that the end wall is radiation, vapor, moisture, particle, and / or translucent and / or has a number of, in particular vapor-permeable or gas-permeable, micro-holes. This makes it possible to make the thus formed cover for a variety of different measuring devices applicable.

A particularly adaptable, robust and resistant embodiment of the invention provides that the cap is made of the same material and / or in one piece, and in particular of thermoplastic or plastically deformed or deformable plastic, preferably from one of the following materials or a mixture thereof: PETG ( Polyethylene terephthalate glycol), PP (polypropylene), PE (polyethylene), PC (polycarbonate), PVC (polyvinyl chloride), PS (polystyrene), ABS (acrylonitrile butadiene styrene), HOPE (high density polyethylene), LDPE (low density polyethylene), PET (Polyethylene terephthalate), PMMA (Poymethylmethacrylate), ECOTERM S 900 T1, PETG / Copolyester 67639, the matehai of the covering cap (10), in particular additionally, containing one or more of the following constituents: Additives,

Stabiiisatoren, Farbmittei, Füiistoffe, reinforcing materials, in particular the Matehai the cap has a dye and the end wall for certain, especially visible Weiieniängenanteiie is opaque or absorbent.

A particular Weitererbiidung of the invention provides that the cap is materiaieinheitiich and / or in one piece ausgeiidet, and in particular thermopiastic or piastically deformed or deformable bioplastic based on Ceiiusiose, Poiymiichsäure or starch, the Materiai the cap, in particular additionally, one or several of the following constituents include binders, additives, stabilizers, colorants, excipients, reinforcing agents.

A simple production is made possible by the fact that the thickness of the Manteiwand, in particular in axiaier or radiaier direction, a continuous over the shell wall, kink and edging-free course, and / or thickness is the respective average thickness in each section of the shell wall applies, and / or that the jacket wall, in particular with the exception of the region of the latching projections and / or latching recesses, is rotationally symmetrical.

In order to achieve a hygienic packaging and sealing of the cap, the administration substance, the electrode substance, it is provided that the cap has a seal, wherein the seal the cap, in particular the indicator, the administration substance, the electrode substance, or the wall, in particular the end wall, partially, in particular completely, surrounds and seals.

The invention relates by means of a combination of a measuring device, in particular for skin analysis, which is covered with a cap according to one of claims 1 to 50, characterized in that the measuring device comprises at least one detector for the change of state of at least one indicator upon contact with the substance is sensitive.

In order to be able to activate the auxiliary substance by means of a measuring device, it is provided that the measuring device, in particular the detector, comprises at least one activation element, wherein the indicator can be activated by the activation element or the auxiliary substance can be converted into the indicator substance of the indicator or activated.

A simplified application of a cap with a barrier or a carrier and in combination with a meter can be achieved by the barrier by the meter, in particular the detector, is breakable or causes the carrier to release the indicator.

A preferred positioning of the combination of the cap with the measuring device to the object to be examined or a person is achieved by the distance of the detector from the cap during detection is a maximum of 10 mm.

A particular embodiment of the invention is achieved in that the detector has a photomultiplier, in particular embodied as μΡΜΤ.

The invention further relates to a combination of a measuring device, in particular according to claim 51 to 56, which is covered with a cap, which is formed according to one of claims 1 to 50, in particular according to one of claims 33 to 50, characterized in that the measuring device a dispensing element, wherein the administration substance, in particular by expressing the bulge of the cap over the peripheral edge, by the dispensing element is detachable or ausbringbar.

In order to be able to record or record the duration of administration of an administration substance, it is provided that the measuring device comprises a timer, wherein the duration of administration of the administration substance with the timer can be detected, and the timer in particular after a predetermined period of time a signal or the administration of the administration substance interrupts. This interruption can be done, for example, by making the Verarbreichungssubstanz by inactivation or heating inactive.

In order to prevent unauthorized operation of the measuring device, it is provided that the measuring device has an identification unit, wherein the identification unit allows the use of the measuring device only after entering an authorization key, in particular a password or a fingerprint.

In order to be able to irradiate the auxiliary substance with heat or a special radiation, it is provided that the measuring device comprises a heat source and / or radiation source which is directed in particular to the auxiliary substance, the indicator, the carrier of the covering cap or to the heating or irradiation of the measuring object, Object or a person is trained.

A particular embodiment and application of the cap according to the invention is provided with a hygiene article according to claim 61. For this purpose, it is provided that the absorbent hygiene article, in particular diaper or sanitary napkin, is covered with a cap according to the invention, wherein the cap or the cap is arranged in combination with a measuring device, in particular on the waistband of the diaper and is preferably integrated in a holder with clip.

Furthermore, the invention relates to a method for producing a cap, in particular according to one of claims 1 to 50, a) wherein a plastic film, in particular a film consisting of PETG (polyethylene terephthalate glycol), is used as starting material for a deep-drawing process, which preferably has a thickness between 0.04 mm and 0.5 mm, - wherein in a molding step b) the cap is formed from the plastic film and - wherein in an application step c) one of the cap forming material or composite materials of various indicator, which in the presence of a substance its state changes, in the plastic film or on the surface of the plastic film, - is applied or introduced before the formation of the cap in or on the plastic film or - applied or introduced after the formation of the cap on the cap. With this method caps according to the invention can be produced with indicators advantageous.

Furthermore, the invention relates to a method for producing a cap, in particular according to one of claims 27 to 50, a) wherein a plastic film, in particular a film consisting of PETG, is used as starting material for a deep-drawing process, which preferably has a thickness between 0.04 mm and 0.5 mm, - wherein in a molding step b) the cap is formed from the Kunststofffoiie and - wherein in an Appiktionsschritt c) one of the cover cap forming material or composite material consisting of conductive material electrode substance, in the plastic film or on the surface of the plastic film, - is applied or introduced prior to the formation of the cap in or on the plastic film or applied or introduced after the formation of the cap on the cap. Cover caps with electrodes according to the invention can advantageously be produced with this method.

A special manufacturing method of the cap is provided by the manufacturing method provides that - in a admixing step d) before the application or introduction of the conductive substance on or in the plastic film or on or in the formed of the plastic film cap of the conductor substance magnetic or magnetizable elements, in particular graphite powder is added, - wherein in a magnetization step e) at least one magnet or an electric field is applied to a surface of the plastic film or the cap, in particular the end wall, - in a positioning step f) before or after the magnetization step e) the electrode substance is applied to the plastic film or to the formed from the plastic film cap, in particular the end wall and is brought by the magnet or the electric field, the electrode substance in a defined position and - in one Fixing step g) the positioned electrode substance in or on the plastic film or cap, in particular by local heating of the plastic film or the cap, is incorporated or sealed and fixed by application of a particular non-conductive material to the surface of the plastic film or the cap.

An inventive manufacturing method of a cap with administration substance provides that a plastic film, in particular a film consisting of PETG (polyethylene terephthalate glycol), is used as starting material for a deep drawing process, which preferably has a thickness between 0.04 mm and 0.5 mm. - wherein in a molding step b) the cap is formed from the plastic film, - wherein in an application step c) one of the cap forming material or composite material different administration substance in the plastic film or on the surface of the plastic film, - before the formation of the cap in or applied to the plastic film or is introduced or applied or introduced after the formation of the cap on the cap.

In order to easily form the bulge of the cap and to achieve a particular embodiment of the cap is provided - that in the plastic film prior to the formation of the cap indentation is formed or - that in the cap after the formation of the cap indentation is formed and - that one of the cap or the material forming material composite composite administration substance is introduced into the bulge or applied to the surface of the bulge.

A particular possibility to attach the electrode substance, the administration substance or the indicator to the plastic film or cap provides that the indicator, the electrode substance and / or the administration substance by a stamp on the plastic film or on the formed from the plastic film cap, in particular the end wall is printed.

A cap with a particularly thin end wall can be produced by the method according to the invention. It is provided that a) that a plastic film, in particular a film consisting of PETG (polyethylene terephthalate glycol), is used as starting material for a deep drawing process, which preferably has a thickness between 0.04 mm and 0.5 mm, b) that a punch is pressed with a number of separately movable, abutting sub-stamps on the plastic film, wherein the individual part punches are moved normal to the plane of the plastic film and wherein the plastic film (31) is pressed by the pressure of the part punches in a counter-mold and is deformed into a cap shape , c) that the individual partial stamps of the stamp during or after step b) are spaced from each other, each of the sub-stamp is moved from the position of the punch from radially outward, whereby in the plastic film, an end wall, in particular with a thickness in the range of less than 100 pm, preferably between 3 pm and 20 pm, in particular between 5 pm and 10 pm.

A particularly adaptable, robust and resistant development of the invention provides that the plastic film consists of thermoplastic or plastically deformed or deformable plastic, preferably one of the following materials or a mixture thereof: PETG (polyethylene terephthalate glycol), PP (polypropylene), PE (Polyethylene), PC (Polycarbonate), PVC (Polyvinylchloride), PS (Polystyrene), ABS (Acrylonitrile butadiene styrene), HOPE (High Density Polyethylene), LDPE (Low Density Polyethylene), PET (Polyethylene terephthalate), PMMA (Polymethyl methacrylate), ECOTERM S 900 T1, PETG / copolyester 67639, wherein the material of the cap, in particular in addition, one or more of the following ingredients: additives, stabilizers, colorants, fillers, reinforcing agents, in particular the material of the cap has a dye and the end wall for certain wavelength components opaque or absorbent au is formed.

A particular embodiment of the invention provides that the plastic film of thermoplastic or plastically deformed or deformable bioplastic based on cellulose, polylactic acid or starch, wherein the material of the cap, in particular in addition, one or more of the following components: - binders, additives , Stabilizers, colorants, fillers, reinforcing agents.

To create caps with circular end walls can be provided that the part of the punch during their radially directed away from its center movement in step c) along a about a central axis spirally outwardly extending and widening curve are rotated.

In order to enable an improved diffusion of substances through the end wall, it can be provided that, in particular by means of a laser or a heated microneedle or nanoneedle or by means of etching, holes, in particular microholes or nanoholes, are formed in the end wall.

Further advantages and embodiments of the invention will become apparent from the description and the accompanying drawings. The invention is illustrated schematically below with reference to particularly advantageous, but not limiting exemplary embodiments in the drawings and is described by way of example with reference to the drawings:

Fig. 1 shows a first embodiment of a cap according to the invention in cross section. Fig. 2 shows the cap shown in Fig. 1 from above. Fig. 3 shows a cap according to a particularly simple embodiment of the invention in cross section. Fig. 4 is a first embodiment of a cap according to the invention in section. Fig. 5 shows a second embodiment of a cover according to the invention in section. Fig. 6 shows a third embodiment of a cap according to the invention in section. Fig. 7 shows a fourth embodiment of a cap according to the invention in section. 8 and 9 show several variants of the arrangement of the indicator in the wall of a cap. 10 shows a fifth embodiment of a cap according to the invention for this purpose. Fig. 11 shows a sixth embodiment of a cap according to the invention with a view towards the end wall. Fig. 12 shows a seventh embodiment of a cap according to the invention. Fig. 13 shows an eighth embodiment of a cap according to the invention. Fig. 14 shows a ninth embodiment of a cap according to the invention. Fig. 15 shows a preferred embodiment of the ninth embodiment of a cap according to the invention. Fig. 16 shows a tenth embodiment of the invention with a barrier. Fig. 17 shows an eleventh embodiment of a cap according to the invention with a carrier. Fig. 18 shows a twelfth embodiment of a cap according to the invention with an excipient. Fig. 19 shows a thirteenth embodiment of a cap according to the invention. Fig. 20 shows a fourteenth embodiment of a cap according to the invention. FIG. 21 shows a first combination of a measuring device with a cap according to the invention. FIG. 22 shows a second embodiment of the inventive combination of a measuring device with a cap according to the invention. Fig. 23 shows a third embodiment of the inventive combination of a measuring device with a cap according to the invention. Fig. 24. shows an application of the combination of a measuring device with a cap according to the invention. Fig. 25 shows a further application of the cover caps according to the invention. Fig. 26 shows a fifteenth embodiment of the cap of the present invention for administration of an administering substance. Fig. 27 shows a sixteenth embodiment of a measuring device with an inventive

Cap. Fig. 28a to 28c show a seventeenth embodiment of the cap according to the invention in section. Fig. 29 shows an eighteenth embodiment of the cap according to the invention. Fig. 30 shows a nineteenth embodiment of the cap according to the invention. Figures 31a and 31b show a twentieth embodiment of the cap. Fig. 32 shows a fourth combination of a measuring device with a cap according to the invention. Fig. 33 shows a fifth combination of a cap according to the invention with a measuring device. Fig. 34 shows a twenty-first embodiment of the cap according to the invention. FIGS. 35a to 35c show variants of a twenty-second embodiment of a covering cap according to the invention in section. Fig. 36 shows a twenty-third embodiment of a cap according to the invention. Fig. 37 shows a twenty-fourth embodiment of a cap according to the invention. Fig. 38 shows a twenty-fifth embodiment of a cap according to the invention. Fig. 39a shows a twenty-sixth embodiment of a cap according to the invention in section. Fig. 40 shows a plastic film with which the cap is formed. Fig. 41 shows the end face of the punch and its part punches. Fig. 42 shows the penetration of the partial punch in the plastic film. Fig. 43 shows the expansion of the partial punch and the formation of the end face of the cap. Fig. 44 shows the movement of the partial punch for forming a circular end face. Fig. 45 shows the movement of the part punches for forming a rectangular end face. Fig. 46 and 47 show the formation of different thickness shell wall sections of the cap. Fig. 48 shows the completion of the cap by separating from the plastic film. FIGS. 49a and 49b show a production variant or the application of the indicator 11. Fig. 50 shows a further manufacturing variant of the cap 10. Fig. 51 shows another method of manufacturing the application of the indicator on the plastic film.

In Fig. 1, a first embodiment of a cap according to the invention 10 in cross section (section line I a in Fig. 2) is shown. The same cap 10 is shown in Fig. 2 from below according to the indicated in Fig. 1 section line I b. This cap 10 has a wall which separates the environment of the cap from an interior 37. The wall of the cap 10 comprises a circular end wall 1, which is bounded by a peripheral edge 4 and a jacket wall 2. At the peripheral edge 4 of the end wall 1, the shell wall 2 connects, which is continued at its end facing away from the end wall 1 of a base wall 3 , The casing wall 2 is formed in the following embodiment, approximately widening conically and is in the region of the peripheral edge 4 at an angle α of 75 ° from the end wall 1 to the outside. 1. The interior space 37 is bounded by the casing wall 2 and the end wall 1 adjoining the casing wall 2. The interior 37 with its inner surface which extends over the casing wall 2 and end wall 1 is separated from the outer region of the cap 10 by the wall and shields the interior 37 from the environment of the cap 10. At the outer region of the cap or the environment facing Side of the cap 10, an outer side 35 of the cap 10 extends over the surface of the shell wall 2 and the end wall 1. The outer side 35 is located on the opposite side of the wall seen from the inside of the interior 35 or the shell wall 2 and the end wall 1 of Cover cap 10.

The end wall 1 has a very small wall thickness ds of 10 pm, advantageously the wall thickness ds may be in a range between 0.01 μm and 20 μm, in particular in a range from 3 μm to 20 μm. The end wall 1 has in the present case a diameter of 5 mm. Basically, this diameter can be in a very wide range, particularly advantageous are diameters in the range between 2 mm and 20 mm, which, depending on the application, even larger diameters of up to 100 mm may well find application.

An alternative, not shown embodiment of the invention has, instead of a circular structure of the end wall 1 a square end wall 1, which has a substantially equal wall surface, as in the embodiment shown in FIG. 1 and has an edge length of about 10 mm. Alternatively, the end wall 1 may also be rectangular, square or elliptical, wherein the side edges of the end wall 1 may have a length between 2 mm and 40 mm, in particular between 5 mm and 8 mm.

In the illustrated in Fig. 1 the first embodiment of the invention, the jacket 2 of the cap 10 is formed in three parts and includes in the vicinity of the end wall 1 adjoining the peripheral edge 4, first thickening portion 7 having a thickness di, in the present embodiment, a thickness di was Range selected between 150 and 250 pm for the first thickening section. The thickness di of the casing wall 2 in the first thickening section 7 exceeds the thickness ds of the end wall 1 and in the present embodiment is 5 pm to 8 pm. The first thickening portion 7 is formed circumferentially, wherein the first thickening portion 7 is limited circularly on the end remote from the end wall 1, and wherein in this

Bounding an intermediate portion 8 connects to the first thickening portion 7.

In the intermediate section 8, the casing wall 2 has a thickness d2 which is smaller than the thickness di of the casing wall 2 in the first thickening section 7. In the present embodiment, a thickness of 50 to 150 μm is selected as the thickness d2 of the casing wall 2 in the intermediate section 8. The intermediate section 8 is circularly delimited on its end remote from the first thickening section 7, with a second thickening section 9 adjoining this circular boundary, in which the thickness ds of the casing wall 2 is greater than the thickness d2 of the casing wall 2 in the intermediate section 8. In the present exemplary embodiment a thickness was chosen in the range between 150 and 250 pm for the first thickening section. In the present case, the second thickening section 9 adjoins the end wall of the casing wall 2 remote from the end wall 1; in particular, the second thickening section 9 directly adjoins the base wall 3.

As a result of this special design, the jacket wall 2 has a circumferential section 8 in the form of the intermediate section 8, in which the thickness d2 is less than the thickness da of the jacket wall 2 in the region of the end of the jacket wall 2 facing away from the end wall 1. The thickness of the jacket wall 2 decreases in the axial or radial direction, starting from the thickness di in the first thickening region 7 continuously or continuously and reaches in the intermediate section 8 a minimum, then the thickness of the shell wall 2 takes in the second thickening region 9 to the end wall 1 far end the lateral surface too.

The thickness of the casing wall 2 has a continuous over the casing wall 2, kink and edging free course. As far as necessary for the following considerations, the average thickness in this section is understood in each case as the thickness of the casing wall 2 in the respective section 7, 8, 9 of the casing wall 2.

The base wall 3, which continues the jacket wall 2 at the end remote from the end wall 1, extends in the present embodiment parallel to the end wall 1. Alternatively, the base wall 3 but also at an angle of 10 ° to the end wall 1 to the outside and from the end wall. 1 gone away. Preferably, the base wall 3 is from the casing wall 2 to the outside, with increasing the radial distance of the normal distance of the base wall 3 rises from the end wall.

The base wall 3 is annular in the present embodiment and formed parallel to the end wall 1 and has an outer diameter of 21 mm and an inner diameter of 18 mm. The circular ring width is 1.5 mm in the present case.

Furthermore, the cover cap 10 has latching recesses 5a (FIG. 3) on the inside of the casing wall 2, which allow a detachable attachment to a measuring device 100 (FIGS. 21 to 24). In the present embodiment, two locking recesses 5 b are arranged so that they are opposite to each other on the casing wall 2 of the cap 10. Alternatively, instead of latching recesses 5a also not shown latching projections 5b may be provided. Basically, the purpose of the latching recesses 5a and latching projections 5b is therein, a latching with a measuring device 100 or with arranged on the measuring device 100

To achieve latching recesses 125a and / or latching projections 125b.

The two recesses 5a are formed in the present embodiment as recesses on the inside of the casing wall 2 in the region of the second thickening portion 9 and extend approximately at an angle ßi, 82 of 20 ° relative to the casing wall 2. The recesses 5a protrude about 60 pm in the second Thickening area 9 into it.

In the present embodiment, the entire cap 10 is formed of the same material and made of plastic. In the present case PETG was used, which is mixed with a small amount of dyes. The use of dyes for the caps 10 allows the distinction of different caps with different material properties, in particular with different thickness ds the end wall 1. However, it is also possible to make by adding dyes, the end wall for certain wavelength components opaque or absorbent.

Instead of PETG (polyethylene terephthalate glycol) it is also possible to use plastics known from the prior art, such as polyethylene or polypropylene or mixtures thereof.

In alternative embodiments of the invention, the cap consists of one of the following substances or a mixture of the following substances: PETG (polyethylene terephthalate glycol), PP (polypropylene), PE (polyethylene), PC (polycarbonate), PVC (polyvinyl chloride), PS (polystyrene ), ABS (Acrylonitrile butadiene styrene), HOPE (High Density Polyethylene), LDPE (Low Density Polyethylene), PET (Polyethylene terephthalate), PMMA (Polymethyl methacrylate), ECOTERM S 900 T1. In this case, one or more of the following constituents may additionally be added to the material of the covering cap 10: additives, stabilizers, colorants, fillers, reinforcing materials, PETG / copolyester 6763.

Furthermore, a suitable choice of material from the prior art known bioplastics or compostable or degradable plastics based on cellulosic, polylactic acid or starch, and mixtures thereof is suitable. In this case, in particular one or more of the following constituents may additionally be added to the material of the covering cap 10: binders, additives, stabilizers, colorants, fillers, reinforcing materials.

By the concrete selection of the chain length of the individual molecular chains of the polyethylene, polypropylene or PETG it can be determined for which chemical compounds the front wall 1 is permeable or for which chemical compounds the end wall 1 is impermeable. For example, it is possible to measure certain samples such as blood, urine, sweat or faeces and living samples, such as skin, whereby only certain, desired for the measurement ingredients can diffuse through the end wall 1, such as sodium, potassium, chlorine, magnesium Vitamins, hormones, glycose, alcohol, trace elements and water vapor, but other components of the sample can not or only after a very long time in the range of hours by the front wall 1 diffuse, such as water, saliva, blood, urine, feces or pus. By choosing shorter chains, holes are formed in the respective plastic or in the respective plastic structure, so that larger molecules can diffuse through the end wall 1. The longer the chain molecules are selected, the closer the plastic structure runs and the smaller must molecules be to penetrate the end wall 1 can. Furthermore, the thickness ds of the end wall 1 also determines the permeability, since molecules can diffuse more easily through a thinner end wall 1, than through a thicker end wall 1. If a certain thickness is required due to specifications regarding the stability of the end wall 1, microholes may alternatively be used or nanoholes 6 with a diameter of 0.1 nm to 5 pm, at most up to 400 pm, in the end wall 1, for example with a microneedle or a laser beam created.

Alternatively, it is also possible to achieve holes 6 in the end face 1 with chemical processes, such as etching. In order to avoid further damage to the end face 1, this is cleaned after the creation of the holes of the respective etchant, in particular rinsed.

Since the molecular size of water is 0.3 nm and the molecular size of water vapor is 0.1 nm, by providing holes having a diameter of less than 0.3 nm, water can not permeate through the end surface. From a diameter of the holes or pores of 1 nm, water passes slowly through the end face 1 into the interior of the hygiene cap. With a measurement time of 3 seconds, the holes or pores can also be selected with 3 to 4 nm, since the water diffuses less rapidly through the face than the vapor. If a cap 10 with holes having a thickness of about 3 to 4 nm with the end face 1 first immersed in water, this requires depending on the thickness of the end face for about 1 minute until it has penetrated the end face 1.

Due to the uniformity of the material, the individual parts of the cap 10 have substantially the same properties. Only through the respective thickness ds of the end wall 1, the shell wall 2 and the base wall 3 special permeabilities for certain substances or radiations can be achieved. Thus, the end wall 1 can be made particularly thin in the course of the manufacturing process, so that it allows the diffusion or flow of certain materials, such as gases, liquids, atoms, molecules, compounds.

The exemplary embodiment illustrated in FIG. 3 essentially corresponds to the exemplary embodiment illustrated in FIGS. 1 and 2, so that only the differences between the two illustrated exemplary embodiments will be discussed in detail. The height hi of the adjoining the end wall 1 section 8 corresponds approximately to the height h2 of the end wall 1 distant thickening section. 7

The shell wall 2 is divided in the present embodiment into two sections 7, 8, wherein both sections 7, 8 are formed circumferentially and the sections 7, 8 adjacent to each other and between these two sections 7, 8 a circular boundary line extends, whose points each to the end wall 1 have the same normal distance. The thickness of the casing wall 2 decreases from the end wall 1, viewed in the axial or radial direction, to the end of the casing wall 2 remote from the end wall 1 continuously.

FIGS. 4 to 16 show detailed views of embodiments of covering caps 10 according to the invention, wherein the area of the end wall 1 is shown enlarged.

4, the first embodiment of a cap 10 according to the invention is shown. On the surface of the wall of the cap 10 in detail, an indicator 11 is superficially arranged in the region of the end wall 1 on the outwardly facing outer side 35. The indicator 11 changes its chemical, electrical, optical, or thermal properties or state in the presence of a substance 20 and thus indicates the presence of the substance 20. The indicator 11 can permanently or temporarily change its chemical, electrical, optical or thermal properties. The indicator 11 is different from the material of the cap 10 and the end wall 1.

Fig. 5 shows a second embodiment of the invention, in which the indicator 11 is disposed within the wall of the cap 10. The indicator 11 is in this case integrated into the wall of the end wall 1 in the surface of the outside 5 facing the environment. The substance 20 comes with the indicator 11 when placing the cap on the object to be tested in contact and the indicator 11 detects the presence of the substance 20 its chemical, electrical, optical or thermal properties.

Fig. 6 shows a third embodiment of the invention. In this embodiment, the indicator 11 is integrated within the wall of the cap 10, in particular in this embodiment, within the wall of the end wall 1. The substance 20 penetrates into the cap 10 on the end wall 1 and passes through diffusion through the permeable to the fabric 20 formation of the end wall 1, as described in FIGS. 1 and 2, in the cap 10 and thus passes to the indicator 11th The indicator 11, upon contact with the fabric 20, changes its physical, chemical, thermal or electrical property.

As an alternative to the arrangements of the indicator 11 shown in FIGS. 4 to 6, the indicator 11 can also be positioned within the wall of the covering cap 10 at other positions, for example inside the shell wall 2 or superficially at the latter.

Fig. 7 shows a fourth embodiment of the cap 10 for the detection of substances 20, while the indicator 11 is arranged such that it is disposed within the end wall 1 and the end wall 1 from the outside facing to the environment 35 to the through the wall of the cap formed interior 37 completely penetrated.

Fig. 8 shows several variants of the alternative arrangement of the indicator 11. The indicator 11 may be integrated, for example, in the wall of the cap 10 and the surface 37 to point superficially, or be arranged on the surface of the interior 37. The outer surface 35 facing surface of the cap 10 can be connected to the indicator 11 via channels or micro-holes 6, as described for Fig. 1 and Fig. 2, whereby the substance 20 passes from the outside 35 of the cap 10 to the indicator 11 , Furthermore, there is the possibility that the indicator 11 is integrated on or within the surface of the cap, wherein from the indicator to the interior 37 of the cap 10 micro holes 6 can lead. Furthermore, it is possible that the indicator 11 is disposed within the wall of the cap 10 and is connected in each case by a channel 6 with the outside facing the environment 35 and the interior 37 of the cap 10 is connected to a further channel, nanoholes or micro holes 6 , The fabric 20 thus reaches the indicator 11 to different variants, wherein the indicator 11 changes one of its physical, electrical, chemical or thermal property. The change in the characteristic of the indicator 11 can be detected by a measuring device 100 (see FIGS. 21 to 24) which can be arranged within the covering cap 10, and thus the presence of the substance 20 can be detected by the measuring device 100 via the indicator 11. By way of the size of the microholes 6, as described with reference to FIG. 1, a selection or filtering of the substances 20 can take place, which are to be detected by the indicator 11. It is also possible, through the thickness of the wall, in particular the front wall 1, as already described for Fig. 1, to adjust the fusion or the knitting of the plastic structure to detect smaller molecules of the substances 20 with the indicator 11, but larger molecules or to shield contaminants such as feces, saliva, urine, blood or pus by the wall of the cap 10.

FIG. 9 shows further variants of indicators 11a, 11b, 11c, 11d arranged within the wall or on its surface. If these indicators are in the same wall, a plurality of substances 20 can be detected by differently configured indicators 11a to 11d. The indicator 11a is integrated within the wall of the cap 10 and detects a substance 20a. The indicator 11b detects another substance 20b and is disposed on the surface of the wall. The indicator 11b is connected to the internal space 37 through microholes. Another indicator 11 c is disposed within the wall of the cap near the surface of the Innraum 37 facing part of the wall. A substance 20c diffuses through the wall of the cap 10 to the substance 11c, where it is again detected. A further indicator 11d is arranged on the surface of the environment-facing outer side 35 of the cap 10 and delektiert another substance 20d. The indicator 11d is connected to the inner space 35 of the cap 10 through microholes 6. Alternatively it can be provided that a plurality of indicators, for example the indicator 11a and the indicator 11d detect the same substance 20a or 20d and indicate a local presence of the substance 20 by the local arrangement of the detectors 11a, 11b,.

Fig. 10 shows a fifth embodiment of the cap 10, wherein the cap 10 is square and a plurality of similar indicators 11 delektieren a local presence of a substance 20. Thus, a local distribution of the substance 20 can be detected within the object to be examined.

Fig. 11 shows a sixth embodiment of the cap 10, wherein two indicators 11a, 11b are superficially arranged on the wall or within the wall of the cap 10, wherein the first indicator 11a is disposed in the center of the circular-shaped end wall 1 and another indicator 11b concentric with the first indicator 11a is arranged annularly around this.

The indicators shown in FIGS. 1 to 11 can change their physical, chemical, thermal or electrical property either irreversibly or for a limited time. However, if the characteristic of the indicator 11 changes over time, the indicator 11 is designed in such a way that the duration of the reaction Tr of the indicator 11 with the substance 20 to be indexed is substantially shorter than the decay time Ta in which the indicator 11 returns to its initial state ,

The indicator 11 can change its property in different ways, for example by chemical reaction with the substance 20. It is also possible that the indicator 11 detects the substance 20 by changing the color. In a color change of the indicator 11, an embodiment of the cap according to the invention provides that the wall, in particular the end wall 1 or the casing wall 2 is colorless in the environment of the indicator or is colored in a contrasting color corresponding to the indicator 11. As a result, an optical detection of the indication of the substance 20 by the indicator 11 can be detected more easily. Furthermore, it is provided that the indicators 11a, 11b,... Or the indicator 11, only after exceeding a concentration threshold of the substance 20, the physical. chemical, optical or thermal properties changes. It is also possible that the indicator 11 changes its optical property upon contact with the substance 20 and changes its properties for certain wavelength components compared to the initial state transparent or opaque or reflective or absorbent. This is particularly advantageous if the change of the optical property takes place in a wavelength range of the visible light. Furthermore, it is provided that a plurality of indicators 11a, 11b, ... are disposed within or superficially on the wall of the cap 10, wherein the indicators 11a, 11b, ... also on different walls, for example, the indicator 11a on the end wall 1 and on the jacket wall 2 of the indicator 11 b, are arranged. For the indicator 11, all indicators suitable from the prior art can be used. A selection of suitable indicators is given in Table 1, the purpose of which is indicated in the second column for the individual indicators.

Table 1

FIG. 12 shows a seventh embodiment of the cover cap 10. In the end wall 1 of the cover cap 10, a first indicator 11a is arranged close to the outer side 35 of the end wall 1 facing the surroundings, and a further indicator 11b is arranged on the surface facing the interior 37 of the cover cap 10 , The first indicator 11a changes its property upon contact with a substance 20 and forms a messenger substance 23 upon contact with the substance 20. The messenger substance 23 is guided by the indicator 11a via microchannels 6 or by diffusion through the wall of the end wall 1 to the second indicator 11b, this second indicator 11b reacts with the messenger substance 23 and indicates its presence or indexed. For example, a substance which is difficult to detect may be converted into a more readily detectable messenger 23 by contact with the first indicator 11a and reaction with the first indicator 11a, and its concentration may be indicated by the second indicator 11b.

Fig. 13 shows an eighth embodiment of the cap 10 for the detection of substances. In the front wall 1 of the cap 10, two indicators 11a and 11b are arranged on the surface facing the environment of the end wall. At the interior 37 facing surface of the end wall 1 of the cap 10, a calculator 22 is arranged, which comprises a calculator substance. The calculator 22 is connected via micro channels 6 or through a permeable for the Soff 20 wall portion of the wall with the indicator 11a and the indicator 11b. The indicator 11a now detects the presence of a substance 20a and changes its chemical, thermal, optical or physical property, the indicator 11b changes its chemical, physical, thermal or optical property in the presence of another substance 20b. The calculator substance of the calculator 22 is sensitive to the changes of the indicator 11a and the indicator 11b and can indicate the presence of both substances 20a and 20b by changing its chemical, thermal, optical or physical properties. Furthermore, the indicators 11a, 11b can also form messenger substances 23a and 23b upon contact with the substances 20a or 20b which the calculator then detects. Alternatively, it is possible for the calculator 22 to also indicate the presence of the substance 20 or the change in the characteristic of the indicator 11a, analogously to a logic circuit, on the condition that the substance 20b does not undergo any change in properties by the indicator 11b or the indicator 11b or vice versa , This principle can also be applied to several other combinations and indicators 11a, 11b, 11c, etc. With the help of the indicators and the calculator 22 or more calculators 22a, 22b, ... a logical circuit can be built. Thus, a complex composition of matter can be analyzed by detecting individual substances 20a, 20b,... By means of different or similar indicators 11a, 11b,... And logically linking them to the calculator 22 or the calculators 22a, 22b,... are displayed.

Fig. 14 shows a ninth embodiment of the cap 10. In the wall of the cap 10, in this embodiment in the end wall 1, an indicator 11 is disposed on the interior 35 facing surface. On the environment-facing outer side 35 of the cap 10, a reaction substance 13 is arranged. By the reaction substance 13, a chemical reaction or a different kind of reaction can be caused on the object to be measured, which causes the production of a substance 20. This substance 20 diffuses through the wall of the cap 10 to the indicator 11 and is detected by this. For example, allergic reactions to allergens can be tested by reacting substance 13 as an allergen and triggering an allergic reaction on the skin of a subject or patient by detecting substance 20 formed by the allergic reaction using indicator 11 or a meter becomes. The excreted by application of the allergen to the skin substance 20 is especially water vapor. This can be determined either by the indicator 11 of the cap or a covered by the cap gauge.

FIG. 15 shows a preferred embodiment of the covering cap 10 for this embodiment, wherein a plurality of reaction substances 13, in particular allergens, are arranged within the wall or on its surface. This can include a variety of foods or allergenic substances analogous to the common allergy testing. A selection of suitable allergens is given in Table 2.

Table 2

In a tenth embodiment of the invention, which is shown in Fig. 16, it is provided that the indicator 11 or parts of the wall of the cap 10 are separated with a barrier 21 from the environment of the cap 10 or encapsulated. The barrier 21 is destructible by external excitation, such as pressure or friction, or becomes permeable to the substance 20 by external excitation. Thus, for example, it is only when the covering cap is applied to the object to be tested that the barrier 21 is broken and the indicator 11 becomes accessible to the substance 20. This prevents a contamination of the indicator 11 or an unwanted indication of the substance 20 takes place early. Furthermore, it is possible that the indicator 11, in particular by pressure on the cap 10, is pressed out beyond the barrier 21. For example, substances which melt on contact with the skin, such as e.g. Beeswax, emulsions, waxes, oils, fats. After melting, the indicator is exposed and sensitive.

Fig. 17 shows an eleventh embodiment of the cap for detecting substances. In this embodiment, the indicator 11 is bound non-contacting in a carrier 16 in its initial state of the substance. The carrier 16 allows for mechanical, chemical or thermal action, the contact of the substance 20 with the indicator. The carrier 16 thus prevents premature contacting of the substance 20 with the indicator 11 and an unwanted indication of the substance 20. The carrier 16 may be arranged, for example, on the surface of the wall of the cap 10 and the indicator 11 embedded in the carrier 16 or be arranged under the support 16 in the wall or on the surface of the wall of the cap 10.

Carriers which release the indicator when exposed to mechanical action are, for example, activated carbon and ash.

The indicator may be exposed due to the conversion of the carrier by chemical processes. This can be achieved, for example, by fermentation, e.g. Lactic acid fermentation, alcoholic fermentation, propionic acid fermentation, butyric acid fermentation, formic acid fermentation, 2,3-butanediol fermentation, malolactic fermentation, non-glycolytic fermentation, fermentation of nitrogen-containing compounds. Here, organic substances are decomposed by microbial degradation.

Carriers that release the indicator when exposed to heat include, for example, oils, fats, waxes, ...

FIG. 18 shows a twelfth embodiment of the covering cap 10, wherein the indicator 11 is arranged on the outer side 35 of the covering cap 10 facing the surroundings. The indicator 11 comprises two auxiliary substances 15a, 15b. In the present case, bacteria are contained in the first auxiliary substance 15a, which can be activated by means of external excitation by heat and convert the second auxiliary substance 15b into an indicator substance. Alternatively, however, it is also possible to isolate the bacteria by other types of external stimulation, e.g. Light, irradiation or addition of other substances to activate.

The external excitation can be effected for example by a measuring device 100 arranged in the interior 37 of the covering cap with an integrated activating element 102 or externally by heat sources, excitation means, radiation sources or the like.

Alternatively, only a single auxiliary substance is present, which is a precursor to the indicator substance. This can be converted into the indicator substance by electrical, chemical, thermal excitation or irradiation.

At best, it is also possible to deactivate the indicator substance after the measurement carried out by external electrical, chemical, thermal excitation or irradiation.

A selection of suitable auxiliary substances 15 are the following substances or substances or a mixture thereof: gases, liquids, solids, air constituents, in particular CO 2 or O 2, water, water vapor, substances which occur in or on the surface of the skin, bacteria, viruses.

To activate the indicator, it is also advantageous to use gases, liquids, solids contained in the skin, e.g. get into the skin from the bloodstream.

Auxiliary substances that can be activated by heat and converted into the indicator or emerge from the indicator are: fragrances, adhesives, passivants. This can be exploited in particular, that such substances expand when heated, enlarge their pores and become permeable. Waxes become more permeable, oils dissolve, etc.

A thirteenth embodiment of the invention is shown in Fig. 19 in a sectional view. On the wall of the cap 10, a lubricant 18 or care agent 19 is applied in particular to the jacket wall 2 of the cap 10. A arranged on the jacket wall 2 lubricant 18 allows easier insertion of the

Cap 10 in, for example, body openings of a person or a simpler measurement or application of the cap 10 on a measurement object. A care agent 19 allows the application of a care agent 19 during the measurement or application of the cap 10 and thus allows damage or caused by the application of irritants by the care agent 19 to reduce or counteract this. The care agent 19 or lubricant 18 may optionally be arranged along the entire outer surface of the cap 10 or partially cover the surfaces of the cap 10. Furthermore, it is possible that the care agent 19 or the lubricant 18 partially or completely cover the indicator 11, so that in applications of the cap 10, the lubricant 18 or care agent 19 is stripped from the cap 10 on the measurement object or the skin of the person and so the access to the indicator 11 for the substance 20 is released.

Algae, phototrophic, aerophilic organisms e.g. terrestrial cyanobacteria, because of their large biotechnological potential due to their secondary metabolite spectrum, absorption, scattering, fluorescence substances undergoing a change with light.

In Fig. 20, a fourteenth embodiment of the invention is shown. The covering cap 10 comprises a binding substance 12 in addition to the indicator 11. In the embodiment shown, the binding substance 12 is arranged on the surface of a wall of the covering cap 10, here on the end wall 1. The binding substance 12 captures the substance 20 and stores it in it. Furthermore, as shown, it is also possible to arrange the binding substance 12 inside or around the microholes 6 or channels and thus to bind or catch the substance 20 during transport through the capillary action in the microholes 6 towards the indicator 11. The binding substance 12 allows a preservation of substances 20 for a later evaluation or in the case of volatile substances 20, a preservation of these and controlled delivery and delivery to the indicator 11. Here, the binding substance 12 also defines the trapped volatile substance 20 piecemeal again to the indicator 11 out. This is particularly advantageous if the reaction of the volatile substance 20 with the indicator 11 would take longer than the substance 20 is available or the substance 20 evaporates too quickly to be detected by the indicator 11.

Suitable binding substances 12 are: oils, wax, salts e.g. NaCl water, steam, Epsom salts, coal e.g. Activated carbon, filters (e.g., mechanical), mineral salt, sugary substances e.g. Dextrose, tannins e.g. Tanner extract, herbal

Tanning agents, starch e.g. vegetable, emulsions, creams, albuminous substances, resins, fillers and finishing agents, e.g. dissolve substances; Crom complexes: breakage by alkaline perspiration; Stimulants for decay, fat, lime, gypsum, acid, bases, glues, cartilage, sediments, molluscs substances, shell substances, lophotrochocins, slug mucus, ..., periostracum, i. Peel skin from the glycoprotein conchine, ostracum, i.e. outer prism layer of vertical lime prisms, hypostracum, i. inner mother-of-pearl layer of lime aragonite, lophotrochozoa.

As an alternative to the embodiments described above, it is possible that the indicator 11 on the outer surface of the cap 10 at different sections, such. the end wall 1 or the jacket wall 2, is arranged. Furthermore, it is possible that a plurality of indicators 11 a, 11 b, ... are arranged at different locations of the cap 10. It is also possible that a plurality of indicators 11a, 11b, ... different substances 20a, 20b, ... detect or sensitive to different substances 20a, 20b, ... and thus different substances or different concentrations at different positions and Sections of the wall of the cap 10 can detect.

Combination meter and detector cap

FIG. 21 shows a first embodiment of the combination of a measuring device 100 with a covering cap 10 according to the invention according to one of the previously described embodiments. This measuring device 100 has a housing 126, which comprises a tapered housing part 121, which is covered by a cap 10. At the end of the tapered housing part 121, an end face 122 is arranged at or behind which a sensor or detector 101 is located. In the present embodiment, the tapered housing part 121 in the region of the end face 122 has an opening leading to the detector 101, so that the substances to be measured 20a, 20b, ..., gases and / or substances, as described above, through the cap 10 to the indicator 11 and the indicators 11a, 11b, ... and optionally further to the detector 101 can flow. With a cap 10 placed on the conical housing part 121, it can be ensured that the detector 101 is kept free from soiling, such as excrement, saliva, blood, urine or pus. The detector 101 is sensitive to the change in state of the indicator 11 of the cap 10 and thus registers a change in the state of the indicator 11 in contact with the fabric 20th

On the tapered housing 121 there are a number of latching projections 125b, alternatively or additionally, a number of latching projections 125a may be arranged on the lateral surface of the conically tapered Gehäuseteilsl 21. As shown in Fig. 21, the cap 10 can be placed on the tapered housing part 121, so that the projecting from the conically tapered housing part 121 latching projections 125b engage in the recesses 5a of the cap 10. In order to achieve this covered state of the measuring device 100, the cap 10 is advantageously gripped with two fingers in the lower thickening region 9 and placed on the tapered housing part 121, so that the latching projections 125 b of the tapered housing part 121 of the measuring device 100 in the Engaging recesses 5a, 5b of the jacket wall 2 of the cap 10 engage. The cap 10 is adapted to the tapered housing part 121 such that the latching projections or recesses 5a, 5b, 25a, 25b are at mutually adapted locations, so that the cap 10 and the tapered housing part 121 arranged in the latched state are that the end wall 1 of the cap 10 is slipped over the end face 122 and the recess located on the end face 122 of the tapered housing part 121 is completely covered or covered by the front wall 1 in front of the detector 101. This is achieved in particular in that the cover cap 10 is subject to a particularly strong elastic deformation in its respective section 8 with a small thickness d2 and thus forms an optimum fit for the respective measuring device 100 or its conically tapering housing part 121.

The position and position of the recesses 125a and latching projections 125b on the tapered housing portion 121 corresponds to the position of the recesses 5a and / or latching projections 5b on the cap 10. In particular, the recesses 125a and the latching projections 125b each with the same normal distance to the end face 122 on the arranged conically tapered housing part 121 and distributed advantageously evenly in the circumferential direction. The total number of latching recesses and / or latching projections 125a, 125b in the present embodiment is two, but alternatively, three or four or even more latching recesses and / or latching projections may be provided. The shape of the latching recesses or latching projections 125a, 125b is in each case adapted to the shape of the cover caps 10 or of the latching recesses 5a or latching projections 5b of the cover cap 10. The latching projections 125a and 125b are at an angle of 10 ° to 30 °, at most 1 mm, in particular at most 0.5 mm from the outer wall of the tapered housing part 121 from.

The meter 100 also has an ejection element 124 disposed in the end of the tapered housing portion 121 remote from the front end surface 122. This ejection element 124 is farther away from the front end wall 122 than the latching projections 125 of the tapered housing part 121. In the present exemplary embodiment, the ejection element 124 is annular, namely circular-cylindrical, and surrounds the tapered housing part 121. As can be seen in FIG , The base wall 3 of the cap 10 is flat on the ejection element 124. Pressing the ejection element 124 toward the end face 122 causes the cover cap 10 to be pushed out of its latching position, wherein the cover cap 10 is subject to elastic deformation in the region of its latching recess 5a during the displacement from the latching. Due to the angled structure of the latching recess 5a and the latching projection 125b, the energy expended during elastic deformation of the cover cap 10 is converted into kinetic energy of the cover cap 10 during disengagement, which accelerates the cover cap in a direction from the ejection element 124 towards the end surface 122.

FIG. 22 shows a second embodiment of the combination according to the invention of an embodiment of the cover cap 10 with a measuring device 100. As described with reference to FIG. 18, the measuring device 100 has an additional activation element which has an auxiliary substance 15 arranged in the cover cap 10 as described for FIG excited by heat or radiation and this activates the indicator substance of the indicator 11 or forms from the auxiliary substance 15, the indicator substance. The activation element may be a heat source, a light source or a radiation source for different radiations, for example UVA or radioactive radiation.

23 shows a third embodiment of the inventive combination of a measuring device 100 with a cap 10 according to the invention. The cap 10 has a plurality of indicators 11a, 11b,... (See FIG. 9) on the tip of the measuring device 100 are in the region of the end face 122 a plurality of detectors 101a, 101b, ... arranged which are each sensitive to the change of state of the indicators 11a, 11b, .... The detectors 101a, 101b, ... may be optical, chemical, temperature, gas, or humidity sensors or detectors or other sensors or detectors known in the art. Furthermore, it is possible that in addition to or instead of the detectors 101a, 101b, ... a photomultiplier or

Photoelectron multiplier (PMT) is arranged on the measuring device 100 or integrated into the measuring device 100. Also known from the state of the art are so-called μΡΜΤ, which are photomultipliers of a very small size and, with a compact design of the measuring device 100 used in accordance with the invention, are particularly preferably integrated therein.

With the aid of a PMT or μΡΜΤ, the messenger substances 23 emitted by the indicator 11 or the indicators 11a, 11b,... Can be analyzed particularly well or the substance 20 can be detected by the measuring device 100 after diffusion through the covering cap 10. In accordance with the change in state of the indicator 11 through the substance 20, for example, a preselection of the appropriate setting on the measuring device 100 can be made and thus the measurement can be improved or accelerated. The substance 100 can also be detected in its absolute concentration by the measuring device 100 and the respective concentration or concentration differences of the substance 20 or 20 can be detected by the indicators 11a, 11b,... Of the covering cap 10 arranged at different locations on the covering cap 10 several substances 20a, 20b, ... are examined along a surface or a region of the object to be measured or an area of the skin of a person.

FIG. 24 shows an application of the combination of a measuring device 100 with a covering cap 10 according to the invention. The measuring object 90 in this case separates the skin surface of a person from the substance 20. The measuring device 100 is arranged at a distance of at most 10 mm or can advantageously rest completely with the covering cap 10 on the skin or the measuring object 90. The fabric 20 travels through the end wall 1 of the cap 10, comes into contact with the indicator 11 and the indicator 11 changes its example optical property. The measuring device 100 registers this change, for example a discoloration of the indicator 11, and thus registers the presence of the substance 20. The measuring device 100 can optionally store this or, depending on the degree of discoloration of the indicator 11, indicate the concentration of the substance 20 on a display.

Alternatively, the meter 100 may include, for example, tines or other formations that open or pierce the barrier 23 of the cap 10 and render the barrier 23 permeable to the fabric 20. Also, the carrier 16 may be e.g. Beeswax, in which the indicator substance is integrated, are softened by a heat source integrated in the measuring device 100 and thus enable the contact of the substance 20 with the indicator 11 or the indicator substance.

FIG. 25 shows a further application of the cover caps 10 according to the invention or the combination of the cover caps 10 with measuring devices. The combinations of the measuring devices 100a,..., 100e with covering caps 10a and 10e are placed on the fingers of a robot hand 300. With the help of a robot hand 300, different substances 20 can be detected at different locations or openings and thus a fast and reliable evaluation of substances 20 to be indexed can be made. Furthermore, the use of a robot reduces the risk of transmission of infections and simplifies examinations in places that are life-threatening for humans. As an alternative to the embodiment described in FIG. 25, different arrangements of the covering cap or different combinations are also possible. For example, only one cap on a finger of the robot hand 300 or on each finger, a combination of a measuring device 100 with a cap 10 may be arranged.

In all previously mentioned embodiments of the invention, the cap 10, for example on the end wall 1 or the shell wall 2, and / or the indicator 11 comprise an adhesive substance. Now, when the cap 10 is applied to the front wall 1 on the skin of a person or an article comes the adhesive substance when attaching the cap 10 on the object to be examined or the skin of a person in contact and binds parts of the article or parts of the skin itself. If the covering cap 10 is now removed, the parts bound to the adhesive substance continue to adhere and are detached from the object or the person as a sample. In particular, such a sample may be a dander or part of the skin containing DNA. The sample may then be further examined without the need for the object or person to be present, or exposed to it in examinations with radiation such as X-rays. Adhesives, in particular glues, starch-containing adhesives, can generally be used as adhesive substances.

Several areas of application of the cap 10 according to the invention are briefly explained below: 1. Allergy measurement

The reaction substance 13 is an allergen as described for Fig. 14, e.g. Grass. This is finely ground or immediately immediately completely dissolved in a water vessel filled with water. This water with the allergen grass is now concentrated defined so that water and allergen is present in the vessel. For example, By evaporation, the concentration of the allergen can be increased and the concentration of the water can be reduced accordingly. This allergen liquid is applied to a portion of the cap 10 as a reaction substance 13 by means of a pipette and then evaporated. Remains the allergen on and in the cap 10 depending on the concentration and pore design of the cap 10. Now, the cap is placed on the skin acts on a portion of the skin, the allergen. Since the allergen has been deprived of water, the water vapor of the skin can pass unimpeded through the allergen and be measured. The allergen may cause a skin reaction in which a substance 20 is produced. This substance 20 is then detected by the indicator 11 and optionally evaluated by a measuring device 100.

Alternatively, the substance 20 can also be evaluated directly by a measuring device 100. If the substance 20 is, for example, water vapor, it can diffuse through a part of the cap which is permeable to water vapor and is detected by the measuring device 100 covered by the cap 10. 2. Blood sugar measurement

There are several ways to measure blood sugar, especially glucose, over the skin, with or without reagent in the cap. In addition, it may be necessary in each of the following methods to obtain or remove oxygen from the ambient air and / or from the meter for the reaction. In this case, the cap is permeable to the oxygen molecule. One or more substances or enzymes may be used as an indicator to convert the substances removed from the skin into one or more gases, respectively. As a result, sugar type determinations are possible. As a result, the measurement of any substances contained in the air can be made independently. In particular, it can be determined on the basis of the measurement how the carbon dioxide content in the covering cap changes due to the reaction or measurement carried out.

By incorporating zymase and / or cofactor and / or nicotinamide adenine dinucleotide and / or yeast as indicator 11 or indicator substance, the glucose exiting the skin is converted to ethanol and carbon dioxide. This may be due to an alcohol sensor and a carbon dioxide sensor in the meter or equivalent

Indicator 11 is registered and its concentration determined. Furthermore, an oxidation by oxygen supply and a conversion into carboxylic acid can take place. The carboxylic acid can in turn be converted by pH indicators into a color code, which in turn can be determined by means of an optical sensor.

If the enzyme glucose oxidase GOx is used as the indicator substance, glucose is produced while consuming oxygen to form gluconic acid and hydrogen peroxide. The article or organism protects itself against the toxic effect of hydrogen peroxide by means of enzymes, in the present case, catalases and peroxidases, which decompose the hydrogen peroxide back to non-toxic O 2 and H 2 O. The indicator substance of the indicator 11 in this catalase is CAT, which converts hydrogen peroxide H2O2 into oxygen O2 and water H2O.

This oxygen can be measured. By adding additional enzymes, other gases can be generated and used for detection. The reduction of oxygen is a direct indicator of glucose. The measurement is possible as long as there is oxygen. Therefore, oxygen is constantly supplied during permanent measurements.

By using yeast and / or boronic acid as an indicator substance, however, glucose can also be measured by measuring carbon dioxide. 3. Measurement of ammonia

Due to the temperature of the skin, the reaction occurs by diffusing the gases through the cap as well as by the heat flow due to the temperature difference. If the substance leaving the skin and e.g. lighter than air it rises up as gas e.g. Ammonia on. By incorporation of an indicator substance, e.g. Oxygen at the inner end of the cap, the gas is brought in oxidation of the ammonia to elemental nitrogen with the formation of water: 4 NH3 + 3 02 ^ 2 N2 + 6 H20 decomposes. The nitrogen is e.g. measured by gas sensor and the additional water vapor rate due to the formation of water can be measured by a water vapor sensor.

Ammonia reacts with the carbon dioxide CO2 inside the cap 10 to form ammonium carbonate NH ;, f CO 2 - [H2N-CO, which in turn decomposes into urea and water [HiN-CJO-OjNHi -> HsN - CX-l -Niis f H-jO. A second optical acid-base indicator, such as phenolphthalein, can now determine the concentration of urea. Thus, ammonia can be detected by optical detection.

Medically, the Amoniakgehalt of the blood and thus the protein turnover and the liver function is measurable. Thus, diseases such as chronic hepatitis, brain damage, liver tissue destruction, e.g. as a result of cirrhosis of the liver, increased protein breakdown as in the case of chemotherapy of tumors or the ingestion of medication, function of the detoxification apparatus.

By targeted temperature increase by e.g. at 60 ° C, a denaturation of the enzyme can be achieved. The reaction is thereby stopped.

In addition, it is of course also possible to split urea into carbon dioxide and ammonia by means of the enzyme urease in aqueous solution. As a result, reaction chains are possible one behind the other.

Referring to Fig. 13, in the measurement of urea and ammonia secretions from the skin, excretion calculation can be made. For this purpose, the ammonia is converted into urea by a first indicator 11a according to the reaction described above. Furthermore, the urea excreted from the skin and the urea produced by the first indicator 11a of ammonia reach the optical acid-base indicator, which in the present case acts as a calculator substance 22. 4. HBC measurement HBC is excreted through the skin. If there is an HBC excretion this means there is HBC poisoning at the site where HBC excretion occurs. By oils e.g. Hexachlorobenzene, laurel oil, pomegranate, calander oil, can stimulate HBC excretion. As a substance, this oil is applied in whole or in part to the cap 10 as an indicator 11. By difference measurement then takes place a recognition whether HBC is present. The oil is adjusted to the substance that is to be eliminated from the skin. Optionally, 11 n can be used as an additional indicator.

Hexane are placed on the cap 10 which detects the excreted HCB. Alternatively, the spectrum of HBC can also be measured directly by means of PMT.

Fig. 26 shows a fifteenth embodiment of the cap 10 according to the invention for administration of an administration substance 50. On the cap 10 is in the region of the end wall 1 of the cap 10 forming material or material composite different administration substance 50 is arranged. The wall of the cap 10 comprises a bounded by a peripheral edge 4 end wall 1 and a subsequent to the peripheral edge 4 of the end wall 1 shell wall 2. The end wall 1 and the shell wall 2 define the interior 37. The cap 10 further includes an interior 37 facing the inside and an outer side of the cap 10 facing and on the wall of the inner side opposite outer side 35, which extend over the casing wall 2 and the end wall 1. The administering substance 50 is disposed on a surface of the outside 35 of the end wall 1. When the cap 10 is applied to the skin of a person or to an object, the administering substance 50 is released from the end wall 1 by friction, pressure, stripping, or the temperature of the body or article and is thus administered.

Referring to Fig. 27, a sixteenth embodiment of the cap 10 for administration of an administering substance 50 is shown. In the outer side 35 of the end wall 1, the administration substance 50 is incorporated superficially in the material of the end wall 1. As an alternative to the embodiments shown in FIGS. 26 and 27, the administration substance 50 can also be arranged on the outer side 35 of the casing wall 2, the inside of the casing wall 2 or incorporated or arranged in the material of the end wall 1 and / or the casing wall 2 be.

Fig. 28a to 28c show a seventeenth embodiment of the cap 10 according to the invention in section. In this embodiment, the cap 10, the end wall 2 is formed like a dome and folded over the peripheral edge 4 in the limited by the casing wall 2 interior 37 of the cap 10. The end wall 1 is completely folded into the interior space 37 beyond the peripheral edge 4 and forms a bulge 51. In the bulge 51 is the

Administration substance 50 is arranged on the surface of the outer side 35 of the end wall 1. The end wall 1 is flexible and can be folded out of the interior 37 over the peripheral edge 4 addition.

Fig. 28b shows a possibility of application of the administration substance 50 from the bulge 51 of the cap 10. In the interior 37, a dispensing element 105 is mounted on the inside of the end wall 1. The dispensing element 105 may, for example, be a slider of a measuring device 100 (see FIG. 32) or a finger positioned in the interior 37 of the covering cap 10. If now applied by the Ausbringelement 105 pressure against the end wall 1 as the end wall 1 works piecewise beyond the peripheral edge 4 of the cap 10 and the administration substance 50 is detached from the front wall 1, applied and thus optionally administered to a person. By way of the size of the bulge 51, its defined volume or the depth X (FIG. 28 c), which the end wall 1 is introduced into the interior 35, the maximum amount of the administration substance 50 can be determined. Depending on the length that the end wall 1 is unfolded beyond the peripheral edge 4, the administered amount of the administering substance 50 can be determined.

Fig. 29 shows an eighteenth embodiment of the cap 10 according to the invention with the end wall 1 which is folded into the interior 37 of the cap 10 over the peripheral edge 4 into and the indentation 51 forms. In the indentation 51, the administering substance 50 is arranged on its surface and thus on the outer side 35 of the end wall 1. The indentation 51 is completely covered with a sealing cover 52. The sealing cap 52 completely spans the indentation 51 and extends over the entire peripheral edge 4. The sealing cap 52 prevents contamination of the administration substance 50 during its storage or transport. Prior to the administration of the administration substance 50 with the cap 10, the sealing lid 52 is removed or torn off and thus removed. The sealing lid 52 may be glued to the peripheral edge 4 with an adhesive or welded or otherwise releasably attached thereto.

Fig. 30 shows a nineteenth embodiment of the cap 10 according to the invention in the wall of the cap 10 more precisely in the material of the end wall 1 of the cap 10, the administering substance 50 is incorporated. The end wall 1 is permeable to the administration substance 50, whereby it diffuses upon application from the end wall 1 to the outside 35 of the end wall 1 and then released to the environment or, for example, the skin of a person.

In Fig. 31a and 31b, a twentieth embodiment of the cap 10 is shown. The cap 10 has an administration substance 50, which is incorporated in the material of the end wall 1 to the outside 35. The administration substance 50 is completely covered by a barrier 21, which also partially covers the end wall 1. (Figure 31a) Upon application of the cap 10, for example to the skin of a person or to an object, the barrier 21 becomes permeable to the administration substance 50, for example by pressure or rupture, reaching the skin or article and reaching there the desired effect (Figure 31b). The barrier 21 may, for example, also melt due to the higher temperature of a person's skin or dissolve or become permeable upon contact with the water of the skin or perspiration, thus releasing the administration substance 50.

The barrier 21 may for example consist of wax. Wax has an adjustable melting point of e.g. 55 ° C. At 34 ° C, which corresponds to the temperature of the human skin, the wax becomes flowable and the delivery substance 50 penetrates through the wax. However, the administration substance 50 can also be integrated in the barrier 21, eg wax, itself and become fluid or liquid when applied by the pressure between the cap 10 and the skin and the resulting heat and the administration substance 50 can be released in this way.

Alternatively, the sealing lid 52 described with reference to FIG. 29 may also be designed as a barrier 21, and become permeable or dissolve completely or partially when applied to the administration substance 50. For example, the sealing cap 52 may be made of a photosensitive polymer that is then irradiated by a radiation source 108 or light source integrated in the meter 100 (FIG. 33), thereby becoming more porous and permeable to the administration substance 50.

FIG. 32 shows a fourth combination of a measuring device 100 with a cap 10 according to the invention. The cap 10 is placed on the measuring device 100 and lies against the end face 122 of the measuring device 100 with the end wall 1 folded into the interior 37 of the cap 10. In the indentation 51, the administration substance 50 is arranged. In the end face 122 of the measuring device 100, a dispensing element 109, in this embodiment, a slider controlled by the measuring device 100, sunk. The dispensing element 109 is in contact with the end wall 1. If the dispensing element 109 or the slide then moves out, the end wall 1 is unfolded or everted beyond the peripheral edge 4 and the administration substance 50 exits from the indentation 51 and thus the cover cap 10. Depending on the duration of the process or extension path of the slide or dispensing element 109, the dose of the administration substance 50 can be set or metered.

As shown in FIG. 32, the meter 100 may further include a timer 105. The timer 105 may notify the user of the meter 100 how long the application of the delivery substance 50 has already lasted, thus indicating the amount of the administered administration substance 50. Furthermore, after a preset time, the timer may give a signal indicating the attainment of a pre-set dose or administration time. These values can then be stored in a memory arranged in the measuring device 100 and / or displayed on a display.

Furthermore, the measuring device 100 can also include an identification unit 106 with the aid of which the identity of the user can be detected and, if necessary, the function is blocked if the authorization is not authorized. Thus, unauthorized dosing or use by an unauthorized person can be prevented, which is a preferred application, especially in the case of intoxicant therapy. Furthermore, the dosage of the administration substance 50 or which administration substance 50 was administered to which user can be checked, thus preventing, for example, exceeding a maximum daily dose. Here, for example, a special key used by each user or the fingerprint of the user can be used or the use be released only after entering a password.

FIG. 33 shows a fifth embodiment of the combination of the covering cap 10 with the measuring device 100; the measuring device 100 may comprise a heat source 107 or a radiation source 108 as shown in FIG. If now the administration substance 50 arranged in or on the cap 10 is delivered to an object or a person, for example the skin of a person. The effect or the uptake of the administration substance 50 can be selectively increased by the radiation source 108 or the heat source 107, or the administration substance 50 can first be activated.

Furthermore, a combinatorial treatment may be performed by a radiation source 108 or heat source 107 integrated in the meter 100, for example, the delivery substance 50 may be a painkiller and prevent or reduce the perception of radiation emitted by the radiation source 108 or reduce the perception or pain of a temperature treatment ,

In Fig. 34, a twenty-first embodiment of a cap 10 according to the invention is shown. The end wall 1 is folded over the peripheral edge 4 in the interior 35 of the cap 10 and forms the indentation 51 from. In the indentation 51, a plurality of administration substances 50a, 50b and 50c are arranged in layers. For example, different drugs that have a combinatorial effect on each other can be administered simultaneously or sequentially.

Further, the delivery substance 50a may be a barrier opening material that opens or pervades the skin barrier of a subject or the surface of an article. Thereafter, the subsequent administering substance 50b can better penetrate through the skin of the person or into the object and thus perform an increased effect or just its action. The finally applied administration substance 50c can then be, for example, a care product which closes or restores the skin or is another medicament or the like.

The individual delivery substances 50a, 50b, ... may be separated by a defined layer of wax, which then causes a delay in the administration and thus, for example, bridges an exposure time of the administration substance 50a and only then enables the contact of the second administration substance 50b with the skin after the skin barrier enough was opened by the administration substance 50.

In a further development of the embodiment of the invention shown in FIG. 34, a barrier opening substance 50a is present in the indentation 51, which additionally causes the skin to dispense substances 20. In this cap further indicators 11 are available, which identify the discharged substances 20 and qualify.

Suitable administration substances 50a and barrier opening substances are: colloidal vehicle systems such as microemulsions, in particular containing zinc pyrion clotrimazole or cyclosporin A. Microemulsions are optically isotropic, because of their very low interfacial tension they are thermodynamically stable and highly dynamic. They consist of a surfactant, a cosurfactant, an oil and a water phase. The radii of the colloidal phase are between 10 and 50 nm. ME systems are variable from 0 / W to W / 0. By means of the surfactant system it is possible to determine whether an aqueous hydrophilic phase W / O-ME or an oily lipophilic phase O / WME is colloidal. It has been shown that the 0 / W-ME in dermal application enormously promotes the penetration of an incorporated drug. This should be in the oily colloidal phase. The W / O microemulsions, in whose aqueous colloidal phase peptides and nucleic acids are incorporated - active ingredient molecules with sufficient lipophilicity, for example glucocorticoids,

Betamethasone valerate, dithranol; - active substances such as the organic nitrates and estradiol; small hydrophilic molecules such as urea, propylene glycol; Enhancer e.g. Oleic acid, terpenes, glycolipids, medium-chain triglycerides, synthetic; - waxes (eg (isopropyl myristate)), branched chain fatty alcohols (Eutanol G), urea, propylene glycol, azone, dimethylsulfoxide, taurine, 1,2-pentyleneglycol, - galenic vehicle systems (microemulsions) - Penetrantsretarder or reducer: These are substances containing the Minimize or prevent the penetration of substances through the skin. - drug molecules with sufficient lipophilicity, for example glucocorticoids,

Betamethasone valerate, dithranol - active ingredients such as organic nitrates and estradiol - small hydrophilic molecules such as urea, propylene glycol enhancers, especially oleic acid, terpenes, glycolipids, medium chain triglycerides, synthetic waxes, for example isopropyl myristate, branched chain fatty alcohols (Eutanol G), urea, propylene glycol, azone , Dimethyl sulfoxide, taurine, 1,2-pentylene glycol, enhancers such as oleic acid, fluidize the SC lipid bilayers and thus increase the penetration of drugs across the non-polar route. - galenic suspensory systems (microemulsions) - iontophoresis and other electrochemical methods - penetration retarders or reducers: These are substances, in particular natural and synthetic ceramides, which reduce or prevent the penetration of substances through the skin. These can be used for example in the field of cosmetics, for sunscreen as well as for the treatment of diseases such as psoriasis.

With the help of the fifteenth to twenty-first embodiment of the cap 10 described in FIGS. 26 to 34 and a combination according to FIGS. 31 a to 33, an automated administration of an administration substance 50 can also be achieved. For this purpose, a cap with an administration substance 50 in combination with a measuring device 100 or another electronic device, for example a wristwatch, is applied to the skin or other places of a person and fastened, for example, over a longer period of time. The measuring device 100 can now at defined time intervals, for example every 3 hours, spread the delivery substance 50 with the aid of the delivery element 109 out of the covering cap 10 and deliver it to the person.

Further, the first to fourteenth embodiments may be combined with the embodiments fifteen to twenty-one, and thus have one indicator or a plurality of indicators 11a, 11b,... And simultaneously one or more

Administering substances 50a, 50b, ....

Furthermore, a combined cap 10 then cover a meter 100 and thus the reaction of the object or a person on the

Detect delivery substances 50 through the indicator 11 and / or the meter 100. Thus, for example, a precisely required dose with the help of pharmacodynamics (dose-response relationships of drugs) can be determined or the dose-response relationship of a single subject or patient can be specifically determined.

Furthermore, the measuring device 100 can be combined with other sensors, for example a heart rate sensor arranged externally on a chest belt. For example, a person's response to a heartbeat-enhancing drug (e.g., isoproterol) may be determined or targeted. With the help of arranged on the cap 10 crime substance 50 a targeted dose of the drug is administered to increase the heartbeat. The meter 100 detects the increase in the heart rate and determines, by the increase in the heart rate and / or by means of the dose-response relationship known for this drug, which dose of the administering substance 50 is still required or must be tracked by the heart rate to one specific value or in a targeted area. A delay in effect is known for all approved drugs and is 5-25 minutes, depending on the drug and dosage. Usually these details are already indicated on the package leaflet. Thus, this delay can be supplied to the meter 100 and the administration of the administration substance 50 adjusted accordingly.

The data of the dosage and the response, e.g. The heart rate of the person can then be recorded by means of the meter 100 and used for monitoring the therapy or for scientific or statistical purposes to be available and evaluated.

Furthermore, for example, the threshold of a drug in the bloodstream or at a focal point can be determined and, if appropriate, a new dose of the administration substance 50 administered.

The administering substance 50 may be a medicament, a painkiller, an anesthetic agent, a disinfectant, a conditioner, a barrier agent, or a supplement, particularly a nutritional supplement, or a combination thereof.

As medicaments which may be contained in the administering substance, there may be considered, in particular: Drugs acting on the nervous system, e.g. Acetyichoiin, carbachol, muscarine, pilocarpine, arecoline, oxotremorir, physostigmine, edrophonium, neostigmine, pyridostigmine, distigmine, atropine, scopoiamine, homatropine, tropicamide, N-methyiscopoiamine, N-butyiscopoiamine, methantelin, oxyphenonium, camylofine, pirenzepine, nicotine, dimethylphenylpiperazinium, etc., - Histamine, histamine antagonists and drugs with influence on the immune response, such as Chloropyramine, diphenhydramine, chlorphenoxamine, chlorphenamine, burimamide, metiamide, antiparkinson agents, in particular I-dopa, carbidopa, benserazide, amantadine, biperiden, trihexyphenidyl, phenglutarimide, metixene, levodopa, amantadine-HCl, etc., - muscle relaxants, in particular D - tubocurarine, alcuronium, gailamine, pancuronium, decamethonium, suxamethonium, hexacarbacholine, suxamethonium chloride (example: 0.5-1.2 mg / kg, duration of action 3-5 minutes), - local anesthetics, in particular procaine, tetracaine, lidocaine, butane-silicate, Mepivacaine, prilocaine, bupivacaine, etidocaine, carticain, etc., - antidotes to the central nervous system (sedatives, hypnostics, narcotics) anticonvulsants, especially diazepam, nitrazepam, flunitrazepam, lormetazepam, triazolam, barbital, phenobarbital, amobarbital, cyclobarbital, heptabarbital, pentobarbital , Vinylbital, hexobartital, chloral hydrate, paraldehyde, methylpentynol, glutethimide, methyprylon, ethinamate, carbrmal, bromoisoval, methaqual on, halothane, enflurane, methoxyflurane, nitrous oxide (nitrous oxide), diethyl ether ("ether"),

Barbiturates, thiopental sodium, hexobarbital sodium, methohexital sodium, propanidide, ketamine, etomidate, γ-hydroxybutyric acid, fentanyl, droperidol, etc., - analeptics and convulsants, especially anticonvulsants: phenytoin, phenobarbital, primidone, carbamazepine, epoxide, valproic acid , Ethosuximide, diazepam, clonazepam, analeptics and convulsants: pentetrazole, bemegrid, nicethamide, doxapram,

Psychotropic drugs, in particular chlorpromazine, perphenazine, trifluoperazine, fluphenazine, triflupromazine, thioridazine, clorprothixene, clopenthixol, flupenthixol, prothipendyl, clozapine, loxapine, benperidol, trifluperidol, haloperidol, moperone, fluanison, pipamperone, pimozide,

Imipramine, desipramine, clomipramine, lofepramine, trimipramine, amitriptyline, nortriptyline, noxiptilin, protriptyline, dibenzepine, dimetacrine, doxepin, melitracene, maprotiline, mianserin, nomifensine, viloxazine, triazolam, oxazepam, temazepam, bromazepam, lorazepam, chlordiazepoxide, medazepam, ketazolam, Lormetazepam, flunitrazepam, nitrazepam, clonazepam, flurazepam, diazepam, chlorazepate, prazepam, clotiazepam, clobazam, methylpentynol, meprobamate, phenprobamate, hydroxyzine, benzoctamine, opipramol, cocaine, amphetamine, methamphetamine, phenmetrazine, methylphenidate, norephedrine, ephedrine, mazindol, propylhexedrine, Amfepramone diethylpropion, mefenorex, fenfluramine, pemoline, fenproporex, pentorex, anhalonium, myristica fragrans, psilocybe, - analgesics - antiphlogistics - antirheumatics, especially morphine, hydromorphone, codeine, diamorphine, pentazocine, phenazocine, cyclazocine, pethidine, diphenoxylate, cetobemidone, fentanyl, Levomethadone, acetylmethadol, dextromoramide, dextropropoxyphene, acetylsa licilic acid, diflunisal, ibuprofen, ketoprofen, naproxen, tolmetin, diclofenac, indomethacin, piroxicam, phenylbutazone, gold sodium thiomalate, aurothioglucose, aurothiopolypeptide, D-penicillamine, chloroquine diphosphate, chloroquine sulfate, hydroxychloroquine, etc., - antitussives - expectorants, especially codeine , Dihydrocodeine, dextromethorphan, noscapine, pipetate, clobutinol, pentoxyverine, N-acetylcysteine, guaifenesin, ambroxol, etc., - heart-action drugs, in particular lidocaine, phenytion, mexiletine, tocainide, quinidine, procainamide, disopyramide, ajmaline, pravmalium , Aprindin, lorcainide, flecainide, propafenone, amiodarone, verapamil, glyceryl trinitrate, isosorbide dinitrate, amyl nitrite, verapamil, nifedipine, diltiazem, prenylamine, perhexiline, - anemia treatment agent, blood substitute, haemostatic disorder treatment agent, Blood, in particular dextran 70, 60, 40, hydroxyethyl starch, gelatin derivatives Oxypolygelatin e, plasma proteins, electrolyte solutions, acetylsalicylic acid, sulfinpyrazone, dipyridamole, ticlopidine, ethylbiscumacetate, acenocoumarol, warfarin sodium, phenprocoumone,, aminocaproic acid, tranexamic acid, etc .. - Pharmaceuticals with influence on the kidneys, the water, electrolytes and acids / bases household , in particular chlorothiazide, hydrochlorothiazide, cyclopenthiazide, chlorthalidone, mefrusid, furosemide, bumetanide, ethacrynic acid, etozolin, ozolinone, triamterene, amiloride, etc., - drugs with effect on the gastrointestinal tract, in particular histamine, cimetidine, ranitidine, carbenoxolone, aldosterone, loperamide, Diphenoxylate, pethidine, dioctylsulfosuccinate, dantrone, bisacodyl, phenolphthalein, mannitol, sorbitol, lactulose, apomorphine, morphine, - X-ray contrast media, in particular sodium biopodate, lotalaminic acid, locarminsäure, adipiodone, loxaglinsäure, metrizamide, - drugs for the treatment of endocrine disorders, in particular hormones , Hormone analogs, hormone antagonists etc, such as gonadorelin, protirelin, clomifene, cyclofenil, chorionic gonadotropin, bromocriptine, corticotropin, testracosactide, thyrotropin, somatotropin, oxytocin, vasopressin, lypressin, desmopressin, glucagon, diazoxide, streptozotocin, insulin, sulfonylureas, carbutamide, chlorpropamide, glibenclamide, glibornuride, Gliclazide, glipizide. Gliquidone, Glisoxepid, Tolazamide, Glymidine, Metformin, Propylthiouracil, Methylthioucacil, Carbimazole, Thiamazole, Iodides, Ergocalciferol, Colecaldiferol, Aldosterone, Desoxycorton, Fludrocortisone, Glucocorticoids, Dexamethasone, Prednisone, Testosterone, Clostebol, Mesterolone, Medrogestone, Cyproterone Acetate, Dienestrol, Estriol, Epimestrol, quinestrol, tamoxifen, danazol, chlormadonone, hydroxyprogesterone, medrogestone, megestrol, progesterone, levonorgestrel, lynestrenol, norgestrel, etc. - Drugs for the treatment of metabolic diseases, especially clofibric acid. Clofibrate, fenofibrate, bezafibrate, etofibrate, nicotinic acid, D-thyrixine, probucol, allopurinol, oxypurinol, probenecid, sulfinpyrazone, benzbromarone, colchicine, fluoride, etc. - Pharmaceuticals for the treatment and prevention of infections in particular

Chemotherapeutics, antibiotics, disinfectants, such as benzylpenicillin, propicillin, oxacillin, amoxicillin, epicillin, aziocillin, piperacillin, streptomycin, neomycin, kanamycin, dibekacin, gentamycin, sisomycin, tetracycline, cloramohenicol,

Thiamphenicol, macrolides, erythromycin-estolate, lincomycin, polymyxin, vancomycin, enolpyruvate, fosfomycin, folic acid, sulfanilamide, nitrofurantione, nalidixic acid,

Methenamine, isoniazid, protionamide, pyrazinamide, ethambutol, para-aminosalicylic acid, rifampicin, cycloserine, nystatin, imidazole derivatives, bifonazole, chlormidazole, griseofulvin, quinine, chloroquine, dihydrofolic acid, proguanil, pyrimethamine, clioquinol, metronidazole, niclosamide, piperazine, pyrvinium, Pyrantel, Mebendazole, Hydrogen Peroxide, Potassium Permanganate, Halogens, Alcohols, Aldehydes, Phenol Derivatives, Surfactants, Heavy Metals, Chlorhexidine, Hexetidine, etc. - Cytostatics, Anti Toxicological Drugs, Especially Anti Snake Venom, Anti Toxicants, Actinomycins, Anthracyclines, Mithramycin, Methotrexate, Purine antagonists, bleomycins, - toxicology: eg Active against: deferoxamine, cysteine-penicillamine-disulfide,

Calcium edetate sodium, ferric hexacyanoferrate, salicylic acid, lead, mercury, cadmium, arsenic, thallium,, acids, alkalis, surfactants, gases: carbon monoxide hemoglobin, cyanide, hydrogen sulphide, irritating gases: nitrogen oxides, ozone, phosgene, hydrogen chloride, ammonia, sulfur dioxide, methemoglobin , Solvents: benzene, benzines, aliphatic halogenated hydrocarbons, ethanol, clomethiazole, methanol; Pesticides: herbicides: dichlorophenoxyacetic acid, trichlorophenoxyacetic acid, tetrachloridibenzo-p-dioxin, sodium chlorate; Insecticides: DDT, chlorphenotane, aldrin, dieldrin, HCH, lindane; Alkyl phosphates: diethylparanitrophenyl thiophosphate, fluostigmine, carbamic acid ester; Animal Poisons: Snake Poisons, Cnidarian Poisons, Hymenoptera Poisons; Mycotoxins:

Tuber-leaved fungus, gyromitrin, muscarine, muscimol, ibotenic acid, aflatoxin; Spring Chlorella Muscarin-containing fungi, fly and panther fungi, gastrointestinal tract irritant fungal toxins, mycotoxins; Tobacco: nicotine; Chemical carcinogens: benzopyrene, 3-methylcholanthrene, nitrosamine, dimethylnitrosamine.

Furthermore, the cap may also include a hemorrhage-loading agent as the administration substance 50 and may be formed as haemorrhoidal capsules.

In particular, the following care products can be used as care products: oils: in particular argan oil, fat, especially shea butter, acids, in particular AHAS (a-HYDROXYLIC ACIDS), glycolic acid, citric acid or malic acids, butter, in particular cocoa butter, active substance cocoheal, baobab, tiger grass, turmeric , Sesame oil, orchid, bamboo, papaya, - vegetable substances and plant products, in particular horsetail, silicic acid (5-8%), flavonoids, glucosides (kaempferol, quercetin, luteolin and apigenin glycosides), pyridine alkaloids, potassium, calcium, magnesium, Aluminum, iron - aloe; In the entire sheet: amino acids, alkyl chromomas (inter alia C-glucosyl-chromone), anthracene derivatives, mucopolysaccharides, resins, bitter substances, polysaccharides.

Aloe gel with: primarily polysaccharides (galactose, glucose, arabinose (aloin sugar, aloinose), xylose and uronic acids), including aloverose (also called accemannan, which is considered to be a value-determining and dermatologically active component of the aloe vera gel), low in amounts water-soluble vitamins, amino acids, amylase and the like a. - eyebright aucubin (a glycoside), flavonoids, tannins, bitter substances;

Bearded lichen, Usnic acid - centella - marshmallow, true: up to 15% mucilage (polysaccharides) in the root and up to 10% in leaves and flowers, tannins, sugar, starch (about 35%), asparagine. - Essential oils - Water-binding substances: glycerine, panthenol, hyaluronic acid - Fats: oils, butters, waxes. Depending on the oil, these fatty acids are present as triglycerides or wax esters or a mixture of both. I would most likely differentiate fatty acids by size, there are shorter, saturated fatty acids such as caprolic acid, capric acid, lauric acid. - Proteins and related (keratin etc.): Hydrolyzed Wheat Protein, Hydrolyzed Silk Protein, Hydrolyzed Soy Protein, Hydrolized Keratin, etc., Cationic surfactants, In the KK area, these are the priority, Quaternium-xy, Polyquaternium-xy, Behentrimonium Chloride, Stearamidopropyl Betaine, lecithin, hair guar. - silicones; Acids and tannins: vinegar and citric acid etc., extracts with tannins (for example witch hazel)

A selection of particularly noteworthy supplements in particular

Food supplement center are:

Vitamin D, omega-3 fatty acids, probiotics, astaxanthin, aronia, bitter substances, grass juices, magnesium, algae, bentonite, psyllium, curcumin, sulforaphane, vitamin B complex, protein powder, vitamins, trace elements, ...

A selection of particularly noteworthy barrier opening substances are: Barrier-impairing substances, in particular milking fat, acids, bases, (aggressive) skin cleansing agents, emulsifiers.

In particular, acids, bases, etchants, lacquers can be used as barrier-destroying substances.

As sweat-forming substances fats, milking fats, insulating substances can be used to apply to the skin. Alternatively, a polymer seal or temperature increase is possible.

In FIGS. 35 a to 35 c, variants of a twenty-second embodiment of the covering cap 10 according to the invention are shown in section. FIG. 35a shows a variant of the twenty-second embodiment of the cap 10 according to the invention. On the cap 10, in the region of the end wall 1, a material or composite of material forming the cap 10 is arranged. The wall of the cap 10 comprises a bounded by a peripheral edge 4 end wall 1 and a subsequent to the peripheral edge 4 of the end wall 1 shell wall 2. The end wall 1 and the shell wall 2 define the interior 37. The cap 10 further includes an interior 37 facing the inside and an outer side of the cap 10 facing and on the wall of the inside opposite outer side 35 which extends over the casing wall 2 and the end wall 1. The conductor substance 40 is arranged on the surface 37 of the interior facing the end wall 1. With this variant, a contact within the interior 37 of the cap 10 can be made.

35b shows a variant of the twenty-second embodiment of the cap 10, in which the conductor substance 40 is embedded and arranged in the material of the end wall 1. In this case, a part of the conductive substance 40, the end wall 1 to enforce the inside and thus form an electrical contact within the material of the end wall 1.

In Fig. 35c, another variant of the twenty-second embodiment of the cap 10 is shown. In this variant, the conductor substance 40 is integrated in the material of the end wall 1 and formed from the inside of the end wall 1 to the outside 35, the end wall 1 completely penetrating. In this variant, an electrical contact through the end wall 1, ie from the interior 37 to the outside 35 of the cap 10, is produced by the conductor substance 40.

Alternatively, to the variants shown in FIGS. 35a to 35c, the conductive substance 40 may be arranged on the surface of the outside 35 of the end wall 1, the outside 35 of the shell wall 2 and / or the inside of the shell wall and / or in the material of the shell wall 2.

The conductor substance 40 can take on different shapes in the different variants of the embodiments of the cover cardboard 10. It may be formed, for example, as a continuous line or as individual electrodes 41 or be designed as a plurality of different separate lines or line system or as a circuit.

FIG. 36 shows a twenty-third embodiment of the cap 10 according to the invention. In the material of the cap 10, the conductor substance 40 is arranged on the end wall 1, as described with reference to FIG. 35 c. The conductor substance 40 passes completely through the end wall 1 and establishes an electrical contact from the interior 37 to the outside 35. On the outer side 35 of the end wall 1, two contact surfaces 42 are formed. The contact surfaces 42 are made electrically conductive from the same material as the conductor substance 40 and allow the connection of electrodes 41, not shown, or lines to the cap 10.

In a twenty-fourth embodiment of the cap 10 shown in Fig. 37, it is provided that on the outer side 35 of the end wall 1 electrodes 41 a, 41 b are arranged. As shown in FIG. 36, the conductor substance 40 is integrated in the material of the end wall 1 and penetrates it completely. The electrodes 41a, 41b may be formed from the same material as the conductor substance 40 and be formed by the conductor substance 40 in the manufacturing process or subsequently glued, for example, with a conductive adhesive. Suitable conductive adhesives include, for example: conventional adhesives such as e.g. Electrically conductive epoxy resin based resin; Starch pastes, gum, celluloses, bitumen or rubber glue containing conductive ingredients; Resins, tree resin or mastic with conductive ingredients; Silicone adhesive with conductive ingredients; or anisotropic conductive adhesive.

The electrode 41a is round and arranged centrally on the rounded end wall 1. The electrode 41b is concentrically arranged around the electrode 41a at a distance therefrom and is annular. The conductor substance 40 has two separate parts, which are not conductively connected to each other, wherein each part is respectively connected to one of the electrodes 41a, 41b and thus produces a separate connection of the electrodes 41a, 41b in the interior 37 of the cap 10.

Fig. 38 shows a twenty-fifth embodiment of the cap 10. The electrodes 41a, 41b are formed in the form of circular portions covering a part of the outside 35 of the end wall 1. The electrodes 41a, 41b are arranged at a distance from each other and are each connected by the conductor substance 40 with the interior 37 separated from each other.

Fig. 39a shows a twenty-sixth embodiment of the cap 10, which is shown in section. The cap 10 has on the outer side 35 two contact surfaces 42 which are each conductively connected by the conductor substance 40 with the interior 37 of the cap 10. On the inside of the end wall 1 electronic components 45 are arranged, which are conductively connected to the conductor substance 40. The conductor substance 40 forms with the electronic components a circuit system with which the control of the application of not shown

Electrodes or the introduction of electrical stimulation in an object or a person are allowed.

39b shows a sixth combination of a cap 10 with a measuring device 100. The cap 10 is formed as described in FIG. 35c, wherein the conductor substance 40 completely penetrates the end wall 1 of the cap 10 in two points. The measuring device 100 is covered by the cap 10, wherein the end face 122 is in contact with the inside of the end wall 1. At the end face 122, the measuring device 100 has two electrically conductive electrode connections 104 which are connected to the conductive substance 40 in a conductive manner. The measuring device 100 furthermore has a circuit, not shown, on which it makes it possible to make electrical contact via the connections 104 to the conductor substance 40 and thus to the outer region or the outer side 35 of the covering cap 10. By means of this combination of the cap 10 with the measuring device 100, it is possible, for example, to make measurements of the conductivity of the test object or to deliver targeted electrical impulses to a person.

The conductive substance 40, the electrodes 41 and / or the contact surfaces 42 are made of a matrix comprising the following constituents or a mixture thereof: plant starch, stearin (biodegradable), palm fat, vegetable fat, paraffin,

Beeswax, beeswax with capillary separating acids. In this matrix, the following are incorporated with conductive substances such as: carbon (graphite and graphene), silver (e.g., silver nanoparticles) e.g. 200 mQ / mn, carbon, tin oxide, copper, silver, gold, aluminum, sodium, tungsten, salt, tungsten, zinc, brass, iron, chromium, titanium, stainless steel, mercury, gadolinium, graphite, conductive polymers, doped germanium, doped silicon and tellurium; or incorporated in the material and / or further comprise materials such as binders for binding the conductive substances. Alternatively, the conductive substance 40, the electrodes 41 and / or the contact surfaces 42 may consist of or comprise a conductive, in particular the same, adhesive.

As an alternative to the embodiments of the covering cap 10 shown in FIGS. 35a to 39b, the covering cap 10 may additionally have defined holes, filters, pores, braids, etc., so that an electrical conduction can also take place within the material.

Alternatively, through-plating through the cap 10, in addition to the embodiments shown, can also be achieved by the conductive substance 40 introduced into the pores of the material or by holes produced by etchant, sputtering, vapor deposition, heat input, punching, needles, mandrels.

A cap 10 with a conductor substance 40, as shown in FIGS. 35a to 39b, can be used in combination with a measuring device designed according to the purpose of the prior art, in particular for the following applications: For the measurement of particles, molecules and conductivities of substances; - For stimulation, stimulation of the object or a person; For pore opening the skin or an article e.g. by temperature introduction; - To measure on an object or a person by substances in the interior of the object are measured electrically, magnetic field generation or generation of an electric field; - For measuring the pH value with a pH meter, measuring the impedance, measuring the liquid or measuring the liquid content of a DUT,

In the case of electrical components 42 integrated in the cover cap 10, as shown in FIG. 39 a, it may be provided that the electrical or electronic components 45 are designed as disposable components which are destroyed after an application. Thus, a multiple use and thus a possible spread of germs or diseases or viruses can be prevented.

An application of the cap 10 of the invention or the cap 10 in combination with a meter 100 is the arrangement of the combination on or in an absorbent hygiene article, such as a diaper or a sanitary napkin. The cap 10 is arranged in a holder which has a clip. This holder is then clipped, for example, on the waistband of the diaper with the clip, wherein the holder is arranged in the interior of the diaper.

The cap 10 may alternatively be bent hackenförmig even at the end of the interior 37 and be attached without mounting on the diaper.

When placed in a diaper, e.g. Salts disposed between the electrodes 42 of the embodiments of FIGS. 35a to 39a undergo an impedance change when water vapor or water reaches the cap 10. The meter 100 covered by the sanitary cap 10 can detect this impedance change without being contaminated. By way of example, the measuring device makes it possible to transmit a message by radio to a static device and continuously transmits the status or moisture level of the diaper.

Indicators 11a, 11b, ..., as described in embodiments 1 to 14 of the cap 10, are coptic on the cap 10, a simultaneous analysis of the diaper wearing person or the skin of this person on substances 20, such as inflammatory germs or inflammatory substances is possible ,

The twenty-six embodiments of the cap 10 or six combinations shown in FIGS. 1 to 39b can also be combined with one another. For this purpose, for example, an administration substance can be arranged next to a conductor substance and an indicator 11 on the end wall in order to cover combinatorial applications.

A further aspect of the present invention is the disposal of the cover caps 10 according to the invention. For this purpose, bioplastics can be used for this purpose or the plastics used can be designed for a specific service life. Furthermore, it is envisaged that the caps are heated after use before they are removed from the meter by a heat source integrated in the meter, that the criminal substance 50 of the indicator 11 or the ladder subassembly and other substances and substances arranged on the cap 10 are burned or rendered harmless become.

The advantage lies in the defined short-term use of the caps within 10 years, in particular use of 3-5 years (storage) or defined only by a year or less. For comparison, most caps will not rot after more than 100 years, which is a major challenge for storage, especially when the caps have been used in the medical sector. These must then be disposed of usually on special landfills for dangerous goods.

In the following, an embodiment of a method according to the invention for producing a covering cap 10 made of a plastic film 31 is shown, wherein the production of the embodiments of a cap 10 according to the invention shown in FIGS. 1 to 39b is explained concretely.

Fig. 40 shows a plastic film 31 as a starting material with which the cap 10 is to be formed. The plastic film 31 has a thickness df of 0.4 mm in the initial state and consists of polyethylene terephthalate glycol (PETG).

For forming an end face 1 with a thickness ds of about 1 .mu.m to 10 .mu.m, a stamp 32 comprising a number of a plurality of partial stamps 33 is used. In the present embodiment, the punch 32 comprises four part punches 33. The punch 32 is cylindrical and has a circular end face with a radius of 1 mm. Each partial punch 33 has a circular segment-shaped end face in the form of a quadrant with a radius of 1 mm. All sub-stamps 33 are arranged separately from one another and can be pivoted. In FIG. 41, a view of the partial punches 33 from the plastic film 31 is shown, as indicated by the section line V a.

In a first forming step, the partial punches 33 abut each other, the quarter-circular end faces of the temples 33 together form a circular end face. The Tellstempel 33 are advanced in this position in the area of the plastic film 31. As shown in Fig. 42, the plastic film 31 is thereby deformed. A volume 39 which is bounded by the plastic film 31 except for the side from which the partial punches 33 have penetrated into the plastic film 31 is blanked out. The outer shape of the formed from the plastic film 31 shape is determined by a first counter-mold, not shown, which rests against the outer casing wall 2 and on the end wall 1 of the formed from the plastic film 31 cap 10.

In the next step, shown in FIG. 43, the partial punches 33 are moved radially outward. In the present case, the plastic film 31 is heated simultaneously in the region of the partial punch 33 to a temperature of 40 ° C. As a result, the plastic film 31 is strongly pulled and thinned in the intermediate region between the partial punches 33, so that an end face 1 with a thickness ds of approximately 4 μm results.

In principle, it is provided that the partial punches 33 first perform an axial movement normal to the plane of the plastic film 31 (FIG. 42) and only when the partial punches 33 have assumed an end position in this direction, the partial punches 33 are displaced in the radial direction (FIG are to form the end face 1.

Alternatively, it is of course possible to combine the axial movement axial movement normal to the plane of the plastic film 31 and the radial displacement of the partial punch 33 to the outside with each other, so that a superposition of the two movements of the partial punch 33 is present.

If a rectangular or square end face 1 is to be created, it is sufficient if the individual partial punches 33 are each guided to a trainee corner of the end face 1, as shown in FIG. 45. However, if a circular end face 1 is to be created, the part punches 33 can additionally, as shown in FIG. 44, be set in rotary motion about the common axis X. The rotational movement is superimposed by the radially outward movement of the partial punch 33. The individual partial punches 33 thus move along a helical movement path, wherein the circular cylindrical lateral surfaces of the partial punches 33 are in each case in contact with the plastic foil 31.

As previously described in connection with the formation of rectangular or square end faces 1, a combined axial and radial movement of the partial punch 33 in the formation of circular end faces 1 is possible. In this case, the partial punches 33 perform a movement along a spiral path of motion which extends helically and widening downward in a spiral shape and represents a superposition of an axial and a radial movement and a rotational movement about the axis X.

As shown in FIG. 43, a volume 39 is formed, which has a height hi in relation to an imaginary continuation of the upper edge of the plastic film 31. This height is determined by the feed length of the individual part punches 33 axially in the direction of the axis X. By the feed rate of the partial punch 33 and by fixing the temperature of the partial punch 33 and the plastic film 31 in the axial direction, the thickness of the volume 39 laterally bounding shell wall 2 is set, in particular the thickness in the region in which the plastic film 31 in the Mantle wall 2 passes particularly strongly on the respective feed rate and the respective temperature is dependent.

The thickness of the jacket wall 2 can be determined by selecting the temperature of the plastic film 31 and the partial punch 33 and by the feed rate of the partial punch 33 in the axial direction. The thickness di of the shell wall 2 in the formed shell wall portion 7 can be continuously examined, wherein in the event that the thickness di is too low, the feed rate of the partial punch 33 is reduced in the axial direction or the temperature of the plastic film 31 or the partial punch 33 is reduced becomes. If, however, the thickness di is too large, the feed rate of the partial punch 33 in the axial direction is increased or the temperature of the plastic film 31 or the partial punch 33 is increased.

In the present embodiment, a plastic film 31 is used with a thickness of 0.4 mm, which was heated to 40 ° C during processing. The partial punches 33 have a temperature of 45 ° C and form a volume 39 with a height hi of 4 mm. Subsequently, the partial punches 33, as shown in Fig. 45, moved radially outward, initially a rectangular end face is formed with a side length of about 4 mm. In a further step, shown in FIG. 44, the partial punches 33 are set in a rotational movement, wherein the partial punches rotate about the axis X. The circular cylindrical lateral surfaces of the partial punch 33 rest against the inner wall of the formed casing wall.

In Fig. 46 and Fig. 47, the formation of further casing wall sections 8, 9 of the cap 2 with different thickness d2, as shown. Instead of the partial punch 33, a further punch 36 or a plurality of further punches is used in the following steps, whose outer shape corresponds to the shape of the respective cap 10.

As shown in Fig. 46, the further punch 36 is advanced into the formed volume 39, wherein the respective wall thickness da of the formed in this process step area of the shell wall 2, hereinafter called intermediate section 8, is thinner than the wall thickness di of the region of the shell wall 2, hereinafter called the first thickening section 7. The thickness since the jacket wall 2 in the intermediate section 8, as already done in the preparation of the first thickening portion 7, determined by the feed rate of the other punch 36 and by the temperature of the further punch 36 and the temperature of the plastic film 31.

The outer shape of the formed from the plastic film 31 portion of the cap 10, in particular of the intermediate portion 8 is defined by a second counter-mold, not shown, which rests against the outer shell wall 2 and on the end wall 1 of the formed from the plastic film 31 cap 10.

In the present embodiment, the plastic film 31 remains at its deformation at a temperature of about 40 ° C to 50 ° C, then the further punch 36 is introduced into the second counter-mold. The second counter-mold is heated to a temperature of about 40 ° C to 50 ° C. The intermediate region between the further punch 36 and the second counter-mold corresponds to the desired shape of the cap 10 in the first

Thickening section 7 and in the intermediate section 8, in the present embodiment, the wall thickness in the intermediate section 8 is less than in the first thickening section. 7

Subsequently, as shown in Fig. 47, the further punch 36 is further advanced, wherein a second thickening portion 9 is formed, whose thickness da is larger than the thickness da in the intermediate portion.

The outer shape of the formed of the plastic film 31 portion of the cap 10, in particular of the adjoining the intermediate portion 8 second thickening portion 9 is defined by a third counter-mold, not shown, which formed on the outer shell wall 2 and on the end wall 1 of the plastic film 31 Cover cap 10 is present.

In the present embodiment, the plastic film 31 remains at its deformation at a temperature of about 40 ° C to 50 ° C, then the further punch 36 is introduced into the second counter-mold. The third counter-mold is heated to a temperature of about 40 ° C to 50 ° C. The intermediate region between the further punch 36 and the third counter-mold corresponds to the desired shape of the cap 10 in the first thickening section 7, in the intermediate section 8, as well as in the second thickening section.

Fig. 48 shows the completion of the cap by separating from the plastic film. After shaping and profiling of the entire casing wall 2, the jacket wall is still connected to the plastic film 31. In a final step, the plastic film 31 is separated along a predetermined cutting line 37, in the present embodiment, the plastic film 31 is punched along the shell wall. As a result, the cap 10 is separated from the rest of the plastic film 31.

By cutting along the cutting line 37, a base wall 3 of the cap 10 is formed, which extends parallel to the end surface radially from the end face 1 far end of the lateral surface 2 to the outside , Alternatively, it is also possible, by a further deformation process, the base wall 3 facing away from the end wall 1 and projecting radially outwardly from the lateral surface 2 at an angle of up to 20 °, in particular of up to 10 °.

After the end of the molding, either before or after cutting off the cap 10 along the cutting line 37, the plastic film 31 forming the cap 10 is heated to a temperature of between 50 and 120 ° C for a predetermined period of 3 to 4 seconds, depending on the plastic used , heated in the present case to 75 ° C. In the course of this process, the plastic film 31 forming plastic is transformed by the heating. The plastic film 31 loses its thermoplastic properties. Due to the effect of heat, the plastic film 31 forming molecular chains are split, whereby a greater permeability of the cap 10, in particular in the region of the end face 1 is created. The longer the heat action on the plastic film 31 lasts and the more intense it is, in particular the higher the selected temperature, the shorter the molecular chains forming the plastic film 31 become and the greater the permeability of the end face 1 becomes.

Alternatively, instead of heating the cap, it is also possible to form holes 6 in the form, in this case microholes or nanoholes, in the end wall 1, preferably exclusively in the end wall 1, in order to achieve increased permeability to molecules of a specific size. The formation of the micro and nanoholes can be done by using a laser beam and perforation by puncturing with a heated microneedle.

It is particularly advantageous if the covering cap 10 has a very high rigidity in the region remote from the peripheral edge 4, which serves for the stability of the covering cap. The rigidity of the cap 10 increases towards the center on the casing wall 2, wherein the casing wall 2 again has a greater rigidity in the area surrounding the end wall 1. The elasticity of the jacket wall 4 is greatest in the region of its thinnest point or in the region of its location with the lowest rigidity.

Preferably, the rigidity or elasticity of the casing wall 4 is distributed homogeneously around the circumference and varies only with the distance to the end wall 1.

In Fig. 49a and 49b is a production variant or the application of the indicator 11 is shown. On a stamp 250, the indicator 11 is applied. After the forming step as described above, the cap 10, the stamp 250 is pressed onto the end wall 1 of the molded cap 10 and the indicator 11 on the outside 35 of the end wall 1 is applied (Fig. 49b). The indicator 11 is introduced by the pressure of the punch 250 in the material of the end wall 1 and connected to this example by heat. For this purpose, the plunger 250 and / or the cap 10 may be heated to a temperature at which the indicator 11 remains stable.

Alternatively, the indicator 11 can be applied as a solid by means of the stamp 250 and by multiple stamping layers are introduced over layers of indicator substances. By pressure, temperature and gravity, and porosity of the cap 10 of the indicator 11 or the indicator substance is superficially or in deeper layers of the cap 10 installed. Due to the access from both sides of the plastic film 31 and the cap 10, different inputs and porosities can be achieved. The polymer chains are temporarily changed by a suitable temperature and the pressure pushes the indicator 11 into the cap 10 or plastic film 31.

FIG. 50 shows a further production variant of the covering cap 10, in which case the indicator 11 is applied and fixed on the plastic film 31 before the shaping step by means of punches 250. The plastic film 31 can then be further formed as described in FIGS. 42 to 48. The attachment of the indicator 11 on the plastic film 31 is positioned according to the later position of the indicator 11, on the part of the plastic film 31, which later corresponds to the end wall 1, the shell wall 2 or other parts of the wall.

Alternatively, the conductive substance 40 or the administration substance 50 can be applied analogously to the application of the indicator 11 by means of a punch 250 before (FIG. 50) or after (FIG. 40 a and 49 b) the shape of the cap 10.

The bulge may be introduced into the plastic film 31 or the end wall 1 of the molded cap 10 before or after forming the cap 10, and then administering the delivery substance 50 therein prior to molding or after molding.

Alternatively to the attachment by means of a punch 250, the

Administration substance 50, the indicator 11 and / or the conductive substance 40 may be dissolved in a liquid and dropped onto the plastic film 31 or the wall of the molded cap 10 in the region of the end wall 1 or the shell wall 2. By heat, the solvent is evaporated or the plastic is superficially melted and the administration substance 50, the indicator 11 and / or the conductive substance 40 are introduced into it.

Alternatively, the administering substance 50, the indicator 11 and / or the conductive substance 40 may also be dropped onto the cap 10 and be drawn into and thus held in the wall by the porosity of the plastic of the wall. It is also possible to print the administration substance 50 and / or the indicator 11 and / or the conductive substance 40 onto the covering cap 10.

Furthermore, the administration substance 50, the indicator 11 and / or the

Conductor substance 40 by encapsulation with the aid of a barrier 21 or a carrier substance 16, e.g. in wax, oil, fat, etc. encapsulated as an emulsion.

Furthermore, the administration substance 50, the indicator 11 and / or the

Conductor substance 40 be dissolved in gases that is passed through the cap 10 or the plastic film 31 and accumulate as particles in the material.

Another manufacturing method is shown in FIG. 51. On the opposite side of the plastic film 31 or the wall of the cap 10 to which the conductor substance 30 is to be deposited, a magnet 251 is attached. The conductive substance 40, for example graphite powder, is then applied and pulled or held by the magnet 251 in the desired position or to the point to be applied. For example, beeswax having a melting point of 62 ° C.-65 ° C. is dripped onto the graphite powder and thus fixed on the plastic film 31 or the covering cap 10, thus forming the conductive substance 40. The beeswax can be dissolved in heated alcohol or dissolved in turpentine oil and applied to the graphite fine powder.

Alternatively, the graphite powder may be stirred into the beeswax and then applied to the plastic film 31 or cap 10. The magnet 251 then pulls or fixes the conductive substance 40 until it is dry until the wax cools down at the desired position.

Claims (74)

claims: 1. cap (10) for the detection of substances, characterized in that deposited on at least one wall of the cap (10) superficially and / or embedded in the material of the wall one of which the cap (10) forming material or composite material of various indicator (11 ), which is sensitive to a substance (20) to be indexed and in the presence of the substance (20) permanently or temporarily changes its state from an initial state, is arranged such that the substance (20) is bound from the outer region of the covering cap (10) Indicator (11) arrives. 2. Cover cap (10) according to claim 1, characterized in that the cover cap (10) by a peripheral edge (4) limited end wall (1) and at the peripheral edge (4) of the end wall (1) subsequent shell wall (2) wherein the end wall (1) and the casing wall (2) delimit an interior space (37), the cap (10) facing an inner space (37) and an outer area of the cap (10) facing the inner wall and (a) the indicator (11) in or on one or more of the surfaces - the outside (35) of the end wall (1) and / or - the inside of the end wall (1) and / or - Outside (35) of the jacket wall and / or - the inside of the jacket wall (2) is arranged and / or b) the indicator (11) in the material of the end wall (1) and / or the jacket wall (2) is arranged. 3. cap (10) according to any one of the preceding claims, characterized in that the indicator (11) upon contact with the substance (20) changes at least one physical, chemical, thermal or electrical property, and that this change in the property of the indicator ( 11) of a, in particular within the cap (10) can be arranged measuring device (100) detectable. 4. cap (10) according to any one of the preceding claims, characterized in that the indicator (11) upon contact with the substance (20) its physical, chemical, thermal or electrical property - irreversibly changes or - or that the indicator (11) reversibly changes and returns to its initial state, wherein the duration of the reaction (tp) of the indicator (11) with the material to be indexed (20) is substantially shorter than the decay time (tA), in which the indicator (11) returns to its initial state , 5. cap (10) according to one of the preceding claims, characterized in that on at least one wall, in particular the end wall (1) and / or the jacket wall (2), the cap (10) superficially or embedded in the material one of which Cover cap (10) forming material or composite material is arranged various additional binding substance (12) which binds, in particular volatile, substances (20) for which the indicator is sensitive. 6. cap (10) according to any one of the preceding claims, characterized in that the indicator (11) upon contact with the substance (20) changes its optical properties compared to the initial state and in particular for certain, especially visible, wavelength components its transparency, opacity or its reflective or absorbing behavior changes. 7. cap (10) according to claim 6, characterized in that the material of the cap (10) is provided with a dye and that the contrast between the indicator (11) and the dye upon detection of the substance (20) by the indicator ( 11) is different from the contrast between the indicator (11) and the dye in the initial state. 8. cap (10) according to any one of the preceding claims, characterized in that a part of the wall of the cap (10), in particular the jacket wall (2) and / or parts of the end wall (1), is free of the indicator (11) wherein the parts of the wall containing a dye are free from the indicator (11). 9. cap (10) according to any one of the preceding claims, characterized in that the indicator (11) only after exceeding a concentration threshold of the substance (20) changes its physical, chemical or thermal property. 10. cap (10) according to one of the preceding claims, characterized in that at least one wall of the cap (10) superimposed or incorporated in the material of the wall more of the cap (10) forming material or composite materials different, in particular different from each other, indicators (11a, 11b, ...). 11. cap (10) according to claim 10, characterized in that the indicators (11a, 11b, ...) are unterschiediich in their chemical, physikaiischen, thermal or optical properties. 12. Cover cap (10) according to any one of claims 10 or 11, characterized in that the indicators (11a, 11b, ...) at different areas of the cap (10), in particular at different areas within or superficially on the end wall (1 ) and / or the jacket wall (2) are arranged. 13. cap (10) according to claim 10 to 12, characterized in that different indicators (11a, 11b, ...) in different layer depths of the wall, in particular the jacket wall (2) and / or the end wall (1), the cap (10) are arranged. 14. cap (10) according to claim 13, characterized in that a) the indicators (11a, 11b, ...) are in a reaction relationship to each other, b) that the first indicator (11a) - in reaction with the substance (20 ) changes its physical, chemical, thermal or electrical property or - reacts with the substance (20) and forms a messenger substance (23), c) that a further indicator (11b) is arranged closer to the inside of the wall than the first indicator (11a) and d) that the further indicator (11b) - changes its physical, chemical, thermal or electrical property of the first indicator (11a) or - when the messenger (23) is produced by the first indicator (11a) its physical, chemical, thermal or electrical property changes. 15. cap (10) according to any one of claims 10 to 14, characterized in that - on the outside (35) of the wall, in particular the jacket wall (2) and / or the end wall (1), a reaction substance (13) is arranged in which the substance (20) can be formed upon application of the reaction substance (13) to an object to be examined, that preferably at the surface of the wall facing the interior (37), in particular the jacket wall (2) and / or the end wall (1 ), the indicator (11) is arranged, and - that between the reaction substance (13) and the indicator (11) lying region of the cap (10) for the substance (20) is permeable. 16. cap (10) according to claim 15, characterized in that the reaction substance (13) includes or is an allergen. 17. cap (10) according to one of the predisposing claims, characterized in that a part of the wall of the cap (10), in particular the jacket wall (2) and / or the end wall (1), permeable to the substance (20) is formed , wherein the wall of the cap (10), in particular the jacket wall (2) and / or the end wall (1), impermeable to impurities, in particular body secretions such as faeces, urine, blood, pus and saliva, is. 18, cap (10) according to any one of the preceding claims, characterized in that the indicator (11) comprises at least one auxiliary substance (15) which is convertible by external excitation, in particular by heat, light and / or chemical processes in the indicator substance and / or that the indicator (11) comprises a plurality of auxiliary substances (15a, 15b), wherein the auxiliary substances (15a, 15b) can be converted into an indication substance by external excitation, in particular by heat, light and / or chemical methods. 19. Cover cap (10) according to one of the preceding claims, characterized in that the indicator (11) comprises an indicator substance and a carrier (16), wherein the indicator substance in the carrier substance (16) is embedded and formed such that the indicator (11 ) is not sensitive to the substance (20) in the initial state and that the carrier (16) activates the indicator (11) after mechanical, chemical or thermal action. 20. Cover (10) according to one of the preceding claims, characterized in that the indicator (11) comprises an indicator substance, wherein the indicator (11) by a barrier (21) from the environment of the cap (10) is separated or encapsulated, wherein the barrier (21) is destroyed by external excitation or is permeable to the substance (20) and wherein in particular by an acting on the cap (10) pressure, the indicator substance is pressed out. 21, cap (10) according to any one of the preceding claims, characterized in that the indicator (11) consists of one of the following indicators or substances or a mixture thereof: -pH-Indicators (acid-base titrations), in particular litmus, Bromothymol blue or phenolphthalein, redox indicators, complex indicators, solvatochrome indicators, thermal indicators, mixed indicator, contrast indicator, moisture indicators, - fluorescence indicator, enzymes, biochemical catalyst, in particular • group I: oxidoreductases • group II: transferases • group IN: hydrolases • group IV: lyases (Syntheses) • Group V: isomerases • Group VI: ligases (synthetases), allergen, zymase, cofactor nicotinamide adenine dinucleotide, yeast, oxygen, enzyme glucose oxidase (GOx), yeast and / or boronic acid, carbon dioxide, urea, enzyme urease, catalase , Hexachlorobenzene, laurel oil, pomegranate, kaliander oil, medium, rice extract, tetra-ethyl-ammonium-hydroxide, Acids or alkalis or acid lye combinations, alkalis (oxides, soda-lime). 22. Cover cap (10) according to one of the preceding claims, characterized in that the carrier (16) consists of one of the following substances or substances or a mixture thereof: - colloidal vehicle systems such as microemulsions (ME), - active substance molecules with sufficient lipophilicity, small hydrophilic molecules, in particular urea or propylene glycol, enhancers, in particular oleic acid, terpenes, glycolipids, medium-chain triglycerides, waxes, in particular isopropyl myristate, branched-chain fatty alcohols, in particular eutanol G, urea, propylene glycol, azone, dimethyl sulfoxide, taurine, 1,2-pentylene glycol, galenic vehicle systems, in particular microemulsions, penetration retarders or reducers. 23. Cover (10) according to one of the preceding claims, characterized in that the auxiliary substance (15) consists of one of the following substances or substances or a mixture thereof: gases, liquids, solids, air constituents in particular C02 or 02, water, water vapor , Substances that degenerate into or on the surface of the skin, bacteria, viruses. 24. Cover (10) according to one of the preceding claims, characterized in that on the outer side (35) of the cap (10) a lubricant (18) and / or care agent (19) is applied and the lubricant (18) and / or Care means (19) on the outside (35) of the cap (10) is arranged such that the indicator (11), in particular the indicators (11, 11b ...), by the lubricant (18) and / or care means (19 ) is covered. 25. Cover cap (10) according to claim 24, characterized in that the cover cap (10) and / or the indicator (11) comprises an adhesive substance, wherein the adhesive substance is arranged such that the adhesive substance when applying the cap (10) on a The article comes into contact with the article, - that the adhesive substance binds to itself parts of the article, in particular skin flakes or DNA, and - that the parts of the article adhere to the adhesive substance when the cover cap (10) is removed. 26. Cover cap (10) according to one of the preceding claims, comprising a first indicator (11a) which changes state in the presence of a first substance (20a) and at least one second indicator (11b), in particular a number of further indicators (11c, 11d , ...), which changes state in the presence of a second substance (20b) and a calculator (22) comprising a calculator substance which changes state depending on the state of the first indicator (11a) and second indicator (11b), preferably the calculator (22) consists of one of the substances or a mixture of substances according to claim 21. 27. Cover cap (10), in particular according to one of the preceding claims, characterized in that - the wall delimits an interior space (37), wherein the cover cap (10) has an interior (37) facing inside and an outside area of the cap (10 ) and on the wall of the inner side opposite outer side (35) and - that at least one wall of the cap (10) superficially deposited or embedded in the material of the wall at least one of the cap (10) forming material or material allied together Conductive material existing conductor substance (40) is arranged such that a) from the interior (37) to the outside (35) at least one electrical contact can be produced and / or b) within the interior (37) of the cap (10) at least one electrical contact can be produced and / or c) along the outer side (35) of the cap (10) at least one electrical contact can be produced and / o the d) within the wall at least one electrical contact can be produced. 28. Cover cap (10) according to claim 27, characterized in that the cover cap (10) by a peripheral edge (4) limited end wall (1) and at the peripheral edge (4) of the end wall (1) adjoining shell wall (2) wherein the end wall (1) and the casing wall (2) delimit an interior space (37), the cap (10) facing an inner space (37) and an outer area of the cap (10) facing the inner wall has opposite outer side (35) and that a) the conductor substance (40) in or on one or more of the surfaces - the outer side (35) of the end wall (1) and / or - the inside of the end wall (1) and / or - the Outside (35) of the jacket wall and / or - the inside of the jacket wall (2) is arranged and / or b) the conductor substance (40) in the material of the end wall (1) and / or the jacket wall (2) is arranged. 29, cap (10) according to any one of claims 27 or 28, characterized in that on the outer side (35), in particular the end wall (1), the cap (10) electrodes (41) are arranged, wherein by the conductor substance (40 ), between the interior (37) of the cap (10) and the electrodes (41) is formed an electrical contact. 30. Cover cap (10) according to one of claims 27 to 29, characterized in that on the outer side (35), in particular on the end wall (1), electrically conductive contact surfaces (42) are formed, wherein by the conductor substance (40), between the interior (37) of the cap (10) and the contact surfaces (42) is formed an electrical contact. 31, cap (10) according to any one of claims 27 to 30, characterized in that the conductor substance (40), the electrodes (41) and / or the contact surfaces (42) consist of a conductive, in particular the same adhesive or include such. 32. Cover cap (10) according to one of claims 27 to 31, characterized in that - the conductor substance (40), the electrodes (41) and / or the contact surfaces (42) consists of one of the following materials or a mixture thereof: Plant starch, stearin (biodegradable), palm fat, vegetable fat, paraffin, beeswax, beeswax with capillary separating acids, - that conductive substances such as: carbon (graphite and graphene), silver (eg silver nanoparticles) eg 200 mQ / mn, carbon, tin oxide, copper, silver, gold, aluminum, sodium, tungsten, salt, tungsten, zinc, brass, iron, chromium, lead, titanium, stainless steel, mercury, gadolinium, graphite, conductive polymers, doped Germanium, doped silicon and tellurium; embedded in the material and / or - that the material comprises binders for binding the conductive substances. 33. Cover cap (10) for administering one or more administration substances, in particular according to one of the preceding claims, characterized in that deposited on at least one wall of the cap (10) superficially or embedded in the material of the wall one of which the cap (10) forming material or composite material, different administration substance (50), is arranged such that - by mechanical, chemical or thermal action on the cap (10) or - by irradiation of the cap (10), the administration substance (50), preferably completely, of the cap (10) detachable or ausbringbarer from the cap (10). 34. A cap (10) according to claim 33, characterized in that the administering substance (50) is a medicament, painkiller, disinfectant, an indicator substance to be administered, conditioner, barrier barrier (50a) or supplement, especially a food supplement, or a combination of the above In particular, the cap (10) is designed according to one of claims 1 to 26 and has an indicator (11) for the detection of substances, in particular of those substances on exposure to the barrier opening material (50a) the skin is released from this. 35. Cover cap (10) according to claim 33 or 34, characterized in that the cover cap (10) of a peripheral edge (4) limited end wall (1) and at the peripheral edge (4) of the end wall (1) adjoining shell wall (2 ), wherein the end wall (1) and the jacket wall (2) delimit an interior space (37), the cover cap (10) facing the interior (37) inside and the outside of the cap (10) facing and on the wall a) the administration substance (50) in or on one or more of the surfaces - the outside (35) of the end wall (1) and / or - the inside of the end wall (1) and / or - The outer side (35) of the jacket wall (2) and / or - the inside of the jacket wall (2) is arranged and / or b) the administration substance (50) in the material of the end wall (1) and / or the jacket wall (2) is. 36. cap (10) according to claim 35, characterized in that the end wall (1) in particular completely, over the peripheral edge (4) out into the interior (37) of the cap (10) is folded and a recess (51) is formed, which in particular has a definable volume, wherein the administration substance (50) is arranged in the indentation (51) and the administering substance (50), in particular by a within the interior (37) of the cap (10), disposable dispensing element (109), from the indentation (51) can be brought out. 37. Cover cap (10) according to claim 36, characterized in that the end wall (1) is flexible and the indentation (51) over the peripheral edge (4), in particular completely, can be folded out. 38. Cover cap (10) according to one of claims 33 to 37, characterized in that the administration substance (50) can be arranged by a heat source, in particular a measuring device (100) which can be arranged in the interior (37) of the cover cap (10) and comprises a heat source (107 ), destructible and, in particular, is combustible. 39. Cover (10) according to any one of claims 33 to 38, characterized in that the administration substance (50) is covered by a sealing cover (52), wherein in particular the sigla cover (52) completely covers the bulge (51) and extends along the peripheral edge (4) extends. 40. A cap (10) according to any one of claims 33 to 39, characterized in that the administration substance (51) by a barrier (21) from the environment of the cap (10) is separated or encapsulated, wherein the barrier (21) by external Excitation is destructible or becoming permeable and wherein in particular by a force acting on the cap (10) pressure, the administering substance (50) is pressed out. 41. cap (10) according to any one of claims 2 to 40, wherein at least a portion of the cap (10) has a thickness (d2) which is less than that thickness (da) of the shell wall (2) in a section (9) the jacket wall (2) lying in the region or end of the jacket wall (2) facing away from the end wall (1). 42. cap (IO) according to claim 41, characterized in that the jacket wall (2) has at least one circumferential portion (8) whose thickness (d2) is less than that thickness (da) of the jacket wall (2) in a section ( 9) of the jacket wall (2) which lies in the region or end of the jacket wall (2) facing away from the end wall (1). 43. cap (10) according to claim 2 to 42, characterized in that the end wall (1) at least one point a thickness (ds) in the range of less than 100 pm, preferably between 0.01 pm and 20 pm, in particular between 5 pm and 10 pm, the end wall (1) in particular having a constant thickness over its course (ds). 44. Cover cap (10) according to one of the preceding claims, characterized in that the wall, in particular the end wall (1), is gas-permeable. 45. Cover cap (10) according to one of the preceding claims, characterized in that the wall, in particular the end wall (1), radiation, vapor, moisture, particle, and / or translucent is formed and / or a number of , in particular vapor-permeable or gas-permeable microholes (14). 46. Cover cap (10) according to any one of the preceding claims, characterized in that the cover (10) is formed of the same material and / or in one piece, and in particular of thermoplastic or plastically deformed or deformable plastic, preferably from one of the following materials or a mixture thereof , consists of: PETG (polyethylene terephthalate glycol), PP (polypropylene), PE (polyethylene), PC (polycarbonate), PVC (polyvinyl chloride), PS (polystyrene), ABS (acrylonitrile butadiene styrene), HOPE (high density polyethylene), LDPE ( Low Density Polyethylene), PET (polyethylene terephthalate), PMMA (polymethyl methacrylate), ECOTERM S 900 T1, PETG / copolyester 67639, wherein the material of the cap (10), in particular in addition, contains one or more of the following components: - Additives, Stabilizers, colorants, fillers, reinforcing agents. 47. Cover cap (10) according to any one of the preceding claims, characterized in that the cover (10) is formed of the same material and / or in one piece, and in particular of thermoplastic or plastically deformed or deformable bioplastic based on cellulose, polylactic acid or starch, wherein the material of the cap (10), in particular in addition, contains one or more of the following components: - binders, additives, stabilizers, colorants, fillers, reinforcing agents. 48. Cover cap (10) according to claim 46 or 47, characterized in that the end wall (1), a defined distance of the braiding of the polymer chains, wherein the thickness of the end wall (1) at least one point a thickness (ds) in the range of less than 100 nm. 49. Cover (10) according to one of the preceding claims, characterized in that the cover (10) in the end wall (1) facing away from the end wall of the jacket wall (2) latching recesses (5a) and / or latching projections (5b) for releasable attachment a measuring device are provided. 50. Cover cap (10) according to one of the preceding claims, characterized in that the cover cap (10) has a seal (51), wherein the seal (51), the cap (10), in particular the indicator (11), the administration substance ( 50), the electrode substance (40), or the wall, in particular the end wall (1), partially, in particular completely, surrounds and seals. 51. Combination of a measuring device (100), in particular for skin analysis, which is covered by a covering cap (10) according to one of claims 1 to 50, characterized in that the measuring device (100) comprises at least one detector (101) suitable for the Change in state of at least one indicator (11, 11b, ...) on contact with the substance (20) is sensitive. 52. Combination according to claim 51, comprising a covering cap (10), which is designed according to one of claims 18 to 50, characterized in that the measuring device (100), in particular the detector (101), comprises at least one activation element (102), wherein the indicator (11) can be activated by the activation element (102) or the auxiliary substance (15) can be converted into the indicator substance of the indicator (11) or activated. 53. Combination according to one of claims 51 or 52, comprising a covering cap (10), which is designed according to one of claims 19 to 32, characterized in that the barrier (21) is formed by the measuring device (100), in particular the detector (101). , is rupturable or causes the carrier (16) to release the indicator (11). 54. Combination according to one of claims 51 to 53, characterized in that the distance of the detector (101) from the cap (10) during detection is a maximum of 10 mm. 55. Combination according to one of claims 51 to 54, characterized in that the detector (101) has a photomultiplier tube (PMT), in particular embodied as μΡΜΤ. 56. Combination of a measuring device (100), in particular according to claims 51 to 55, which is covered with a covering cap (10) according to one of claims 1 to 50, in particular according to claims 27 to 32, characterized in that the measuring device (100) at least one electrode terminal (104), wherein in particular the electrode terminal (104) with the conductor substance (40) or the Leitersubstanzen (40a, 40b, ...) is electrically connected. 57. Combination of a measuring device (100), in particular according to claim 51 to 56, which is covered with a covering cap (10), which is formed according to one of claims 1 to 50, in particular according to one of claims 33 to 50, characterized the measuring device (100) has a dispensing element (109), wherein the administration substance (50) can be removed or expelled, in particular by expressing the bulge (51) of the covering cap (10) over the peripheral edge (4) by the dispensing element (109) , 58. A combination according to any one of claims 51 to 57 with a cap (10) according to any one of claims 33 to 50, characterized in that the measuring device (100) comprises a timer (105), wherein the duration of application of the administering substance (50) with the timer (105) is detectable, and the timer (105) in particular after a predetermined period of time (tA) emits a signal or the administration of the administration substance (50) interrupts. 59. A combination according to any one of claims 51 to 58 with a cap (10) according to one of claims 1 to 50, characterized in that the measuring device (100) has an identification unit (106), wherein the identification unit (106) the use of the measuring device (100) only after entering an authorization key, in particular a password or a fingerprint enabled. 60. Combination according to one of claims 51 to 57 with a cap (10) according to one of claims 1 to 50, characterized in that the measuring device (100) comprises a heat source (107) and / or radiation source (108), in particular the auxiliary substance (15), the indicator (11), the carrier (16) of the cap (10) is directed or is designed for heating or irradiation of the test object, object or a person. 61. Absorbent hygiene article, in particular diaper or sanitary napkin, characterized in that a combination according to one of claims 51 to 60 is arranged on the hygiene article, in particular the diaper or sanitary napkin, wherein the combination is arranged in particular on the waistband of the diaper and preferably in one Holder with clip is integrated. 62. Robot arm, in particular robot hand (300), comprising a number of combinations according to one of claims 50 to 58, and / or a number of caps according to any one of claims 1 to 50, wherein the combinations and / or caps each on individual fingers the robot hand (300) are arranged. 63. A method for producing a cap (10), in particular according to one of claims 1 to 50, a) wherein a plastic film (31), in particular a film consisting of PETG (polyethylene terephthalate glycol), is used as starting material for a deep-drawing process, preferably a thickness between 0.04 mm and 0.5 mm, - wherein in a molding step b) the cap (10) from the plastic film (31) is formed and - wherein in an application step c) one of which the cap (10) forming material or composite material of various indicator (11), which changes its state in the presence of a substance (20), in the plastic film (31) or on the surface of the plastic film (31), - before the formation of the cap (10) in or on the plastic film (31) is applied or introduced or - after the formation of the cap (10) on the cap (10) is applied or introduced. 64. A method for producing a cap (10), in particular according to one of claims 27 to 50, a) wherein a plastic film (31), in particular a film consisting of PETG (polyethylene terephthalate glycol), is used as starting material for a deep drawing process, preferably a thickness between 0.04 mm and 0.5 mm, - wherein in a molding step b) the cap (10) from the plastic film (31) is formed and - wherein in an application step c) one of which the cap (10) forming material or composite material consisting of various conductive material electrode substance (40), in the plastic film (31) or on the surface of the plastic film (31), - applied or introduced before the formation of the cap (10) in or on the plastic film (31) is or - after the formation of the cap (10) on the cap (10) is applied or introduced. 65. The method according to claim 64, characterized in that - in a admixing step d) before the application or introduction of the conductive substance (40) onto or into the plastic film (31) or onto or into the plastic film (31) molded cap ( 10) of the conductor substance (40) magnetic or magnetizable elements, in particular graphite powder is added, - wherein in a magnetization step e) on a surface of the plastic film (31) or the cap (10), in particular the end wall (1), at least one magnet (251) or an electric field is applied, - in a positioning step f) before or after the magnetization step e) the electrode substance (40) onto the plastic film (31) or onto the covering cap (10) formed from the plastic film (31) , in particular the end wall (1) is applied and by the magnet (251) or the electric field, the electrode substance (40) is brought into a defined position u nd - wherein in a fixing step g) the positioned electrode substance (40) in or on the plastic film (31) or cap (10), in particular by local heating of the plastic film (31) or the cap (10) is incorporated or by application of a , in particular non-conductive, material (43) on the surface of the plastic film (31) or the cap (10) is sealed and fixed. 66. A method for producing a cap (10), in particular according to one of claims 33 to 50, - wherein a plastic film (31), in particular a film consisting of PETG (polyethylene terephthalate glycol), is used as starting material for a deep-drawing process, preferably a Thickness between 0.04 mm and 0.5 mm, - wherein in a molding step b) the cap (10) from the plastic film (31) is formed, - wherein in an application step c) one of which the cap (10) forming Material or composite material, different administration substance (50) in the plastic film (31) or on the surface of the plastic film (31), - applied or introduced before the formation of the cap (10) in or on the plastic film (31) or - after the molding the cap (10) is applied or inserted onto the cap (10). 67. The method according to claim 66, characterized in that - a recess (51) is formed in the plastic film (31) prior to the shaping of the covering cap (10) or - that in the covering cap (10) after the shaping of the covering cap (10) a recess (51) is formed, and - that one of the cap (10) forming material or material verbünd different administration substance (50) introduced into the bulge (51) or applied to the surface of the bulge (51). 68. The method according to any one of claims 63 to 67, wherein the indicator (11), the electrode substance (40) and / or the administration substance (50) by a stamp on the plastic film (31) or on the formed of the plastic film (31) Cover (10), in particular the end wall (1) is printed. 69. The method according to any one of claims 63 to 68, characterized in that - after step a) in the forming step b) a punch (32) with a number of separately movable, abutting sub-stamps (33) pressed onto the plastic film (31) and - that the individual partial punches (33) are moved normal to the plane of the plastic film (31) and wherein the plastic film (31) is pressed by the pressure of the partial punch (33) in a counter-shape and is deformed into a cap shape. 70. The method according to any one of claims 63 to 69, characterized in that after the shaping step b) in a further Teilausformungsschritt bl), the individual partial punch (33) of the punch (32) during or after the forming step b) are spaced from each other, each the partial punch (33) is moved radially outwards from the position of the punch (32), whereby an end wall (1), in particular with a thickness in the range of less than 100 μm, preferably between 0.01, is provided in the plastic foil (31) pm and 20 pm, in particular between 5 pm and 10 pm. 71. The method according to any one of claims 63 to 70, characterized in that the plastic film (31) consists of thermoplastic or plastically deformed or deformable plastic, preferably from one of the following materials or a mixture thereof: PETG (polyethylene terephthalate glycol), PP ( Polypropylene), PE (Polyethylene), PC (Polycarbonate), PVC (Polyvinylchloride), PS (Polystyrene), ABS (Acrylonitrile butadiene styrene), HDPE (High Density Polyethylene), LDPE (Low Density Polyethylene), PET (Polyethylene terephthalate), PMMA (polymethyl methacrylate), ECOTERM S 900 T1, PETG / copolyester 67639, wherein the material of the cap (10), in particular in addition, contains one or more of the following components: - Additives, stabilizers, colorants, fillers, reinforcing agents. 72. The method according to any one of claims 63 to 70, characterized in that the plastic film (31) consists of thermoplastic or plastically deformed or deformable bioplastic based on celluslose, polylactic acid or starch, wherein the material of the cap (10), in particular additionally, contains one or more of the following components: - binders, additives, stabilizers, colorants, fillers, reinforcing agents. 73. The method according to any one of claims 63 to 72, characterized in that the partial punches (33) during their radially directed away from their center movement in step c) along a about a central axis (X) spirally outwardly extending and widening curve be moved in rotation. 74. Method according to one of claims 63 to 73, characterized in that, in particular by means of a laser or a heated microneedle or nanoneedle, holes (6), in particular microholes or nanoholes (6), are formed in the end wall (1).