AT44373B - Process for the preparation of basic purine derivatives. - Google Patents
Process for the preparation of basic purine derivatives.Info
- Publication number
- AT44373B AT44373B AT44373DA AT44373B AT 44373 B AT44373 B AT 44373B AT 44373D A AT44373D A AT 44373DA AT 44373 B AT44373 B AT 44373B
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- purine derivatives
- derivatives
- basic
- basic purine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title claims 2
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title claims 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 claims 2
- 150000003230 pyrimidines Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- -1 barythydrate Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 239000000395 magnesium oxide Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 claims 1
- 238000006798 ring closing metathesis reaction Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 150000004992 toluidines Chemical class 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Description
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300 Teilen einer Bprozentigen Natriumäthylatlösung zwei Stunden auf dem Wasserbad erhitzt. Nach dem Erkalten gibt man vorsichtig die aem Natrium entsprechende Menge konzentrierte Salzsäure zu, filtriert das ausgeschiedene Kochsalz ab, entfernt den Alkohol durch Abdestillieren und kristallisiert den Rückstand aus absolutem Alkohol um. Das so erhaltene 1. 3-Dimethyl- 8-piperidhylmethylxanthin bildet farblose Nadeln, die bei 203"C schmelzen. Sie sind leicht löslich in Wasser, Alkalien und Säuren, löslich in Alkohol und fast unlöslich in Äther.
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300 parts of a B per cent sodium ethylate solution heated on a water bath for two hours. After cooling, the amount of concentrated hydrochloric acid corresponding to the sodium is carefully added, the precipitated common salt is filtered off, the alcohol is removed by distillation and the residue is recrystallized from absolute alcohol. The 1,3-dimethyl-8-piperidhylmethylxanthine thus obtained forms colorless needles which melt at 203 ° C. They are easily soluble in water, alkalis and acids, soluble in alcohol and almost insoluble in ether.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE44373X | 1908-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT44373B true AT44373B (en) | 1910-10-10 |
Family
ID=5624642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT44373D AT44373B (en) | 1908-02-22 | 1909-02-13 | Process for the preparation of basic purine derivatives. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT44373B (en) |
-
1909
- 1909-02-13 AT AT44373D patent/AT44373B/en active
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