AT369737B - Verfahren zur herstellung von 6,11-dihydro-11oxodibenz(b,e)-oxepin-2-essigsaeure - Google Patents

Verfahren zur herstellung von 6,11-dihydro-11oxodibenz(b,e)-oxepin-2-essigsaeure

Info

Publication number
AT369737B
AT369737B AT0747878A AT747878A AT369737B AT 369737 B AT369737 B AT 369737B AT 0747878 A AT0747878 A AT 0747878A AT 747878 A AT747878 A AT 747878A AT 369737 B AT369737 B AT 369737B
Authority
AT
Austria
Prior art keywords
oxepin
dihydro
producing
acetic acid
acetic
Prior art date
Application number
AT0747878A
Other languages
English (en)
Other versions
ATA747878A (de
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ATA747878A publication Critical patent/ATA747878A/de
Application granted granted Critical
Publication of AT369737B publication Critical patent/AT369737B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT0747878A 1977-10-19 1978-10-18 Verfahren zur herstellung von 6,11-dihydro-11oxodibenz(b,e)-oxepin-2-essigsaeure AT369737B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/843,482 US4118401A (en) 1977-10-19 1977-10-19 Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor

Publications (2)

Publication Number Publication Date
ATA747878A ATA747878A (de) 1982-06-15
AT369737B true AT369737B (de) 1983-01-25

Family

ID=25290114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0747878A AT369737B (de) 1977-10-19 1978-10-18 Verfahren zur herstellung von 6,11-dihydro-11oxodibenz(b,e)-oxepin-2-essigsaeure

Country Status (9)

Country Link
US (4) US4118401A (de)
JP (1) JPS5461189A (de)
AR (2) AR223329A1 (de)
AT (1) AT369737B (de)
CA (1) CA1110636A (de)
ES (2) ES474162A1 (de)
HU (1) HU180245B (de)
NL (1) NL7810456A (de)
SE (2) SE7810895L (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4118401A (en) * 1977-10-19 1978-10-03 American Hoechst Corporation Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor
US4515946A (en) * 1981-12-23 1985-05-07 Hoechst-Roussel Pharmaceuticals Inc. 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives
US4576960A (en) * 1981-12-23 1986-03-18 Hoechst Roussel Pharmaceuticals Incorporated 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives
US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
US9815815B2 (en) 2013-01-10 2017-11-14 Pulmokine, Inc. Non-selective kinase inhibitors
CN111743901B (zh) 2013-10-11 2023-09-12 普尔莫凯恩股份有限公司 喷雾干燥制剂
CN106518833A (zh) * 2015-09-15 2017-03-22 江苏吉贝尔药业股份有限公司 一种新的6，11-二氢-11-氧代二苯并［b，e］噁庚因-2-乙酸制备方法
AU2017348354B2 (en) 2016-10-27 2023-06-15 Pulmokine, Inc. Combination therapy for treating pulmonary hypertension

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1409411A (fr) * 1964-07-16 1965-08-27 Imprimerie Darboy Perfectionnements apportés aux moyens pour l'élaboration d'emballages transparents étanches et aux emballages correspondants
FR1409441A (fr) * 1964-07-17 1965-08-27 France Ministre Des Armees Perfectionnements au procédé de préparation d'acides para-alkoxy-phénylalkylène-carboxyliques
DE2600768C2 (de) * 1975-02-04 1983-10-27 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von 6,11-Dihydro-11-oxodibenz[b,e]-oxepin-alkansäuren
US4118401A (en) * 1977-10-19 1978-10-03 American Hoechst Corporation Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor

Also Published As

Publication number Publication date
JPS5461189A (en) 1979-05-17
SE8301997L (sv) 1983-04-11
US4153790A (en) 1979-05-08
US4160781A (en) 1979-07-10
SE8301997D0 (sv) 1983-04-11
HU180245B (en) 1983-02-28
ES474162A1 (es) 1979-09-01
CA1110636A (en) 1981-10-13
SE7810895L (sv) 1979-04-20
ATA747878A (de) 1982-06-15
NL7810456A (nl) 1979-04-23
US4118401A (en) 1978-10-03
AR224905A1 (es) 1982-01-29
AR223329A1 (es) 1981-08-14
ES474975A1 (es) 1980-02-16
US4153791A (en) 1979-05-08

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee