AT345480B - PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF DIGITOXIGENIN-ALFA-L-ARABINOSIDE - Google Patents
PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF DIGITOXIGENIN-ALFA-L-ARABINOSIDEInfo
- Publication number
- AT345480B AT345480B AT895175A AT895175A AT345480B AT 345480 B AT345480 B AT 345480B AT 895175 A AT895175 A AT 895175A AT 895175 A AT895175 A AT 895175A AT 345480 B AT345480 B AT 345480B
- Authority
- AT
- Austria
- Prior art keywords
- arabinoside
- digitoxigenin
- preparation
- new derivatives
- alfa
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Description
<Desc/Clms Page number 1>
Die Erfindung betrifft ein Verfahren zur Herstellung von neuen Derivaten des Digitoxigenin-a-L-arabi- nosids der allgemeinen Formel
EMI1.1
EMI1.2
<Desc/Clms Page number 2>
; R,thylsulfat in 1, 6 ml Toluol zu. 30 min nach der letzten Zugabe wird mit 300 ml Chloroform verdünnt, über Kieselgur filtriert und mit Chloroform nachgewaschen. Zum Gesamtfiltrat gibt man 18 ml Pyridin, engt im
EMI2.1
aus, trocknet über Natriumsulfat und bringt die Chloroform-Äthanol-Phase zur Trockne. Das Rohprodukt enthält neben Monomethyläther verschiedene Dimethyläther und wird zur Reinigung, in Benzol-Chloroform (l : l) gelöst, über 20 g Aluminiumoxyd fraktioniert.
Die Fraktionen mit 65 bis 70% Chloroform liefern nach Einengen und Kristallisation aus Chloroform-Äther 390 mg 3'-O-Methyldigitoxigenin-α-arabinosid.
Fp. = 186 bis 1900C. hRF : 19.
<Desc / Clms Page number 1>
The invention relates to a process for the preparation of new derivatives of digitoxigenin-a-L-arabinoside of the general formula
EMI1.1
EMI1.2
<Desc / Clms Page number 2>
; R, methyl sulfate in 1.6 ml of toluene. 30 minutes after the last addition, it is diluted with 300 ml of chloroform, filtered through kieselguhr and washed with chloroform. To the total filtrate is added 18 ml of pyridine, concentrated in
EMI2.1
out, dried over sodium sulfate and brought the chloroform-ethanol phase to dryness. In addition to monomethyl ether, the crude product contains various dimethyl ethers and is dissolved in benzene-chloroform (l: l) for purification and fractionated over 20 g of aluminum oxide.
The fractions with 65 to 70% chloroform give, after concentration and crystallization from chloroform-ether, 390 mg of 3'-O-methyldigitoxigenin-α-arabinoside.
Mp = 186 to 1900C. hRF: 19.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT895175A AT345480B (en) | 1973-04-19 | 1975-11-25 | PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF DIGITOXIGENIN-ALFA-L-ARABINOSIDE |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2319874A DE2319874C2 (en) | 1973-04-19 | 1973-04-19 | Novel derivatives of digitoxigenin-α-L-arabinoside, processes for their preparation and medicaments containing them |
AT321174A AT334550B (en) | 1973-04-19 | 1974-04-18 | PROCESS FOR THE PRODUCTION OF NEW DERIVATIVES OF DIGITOXIGENIN-ALPHA-L -ARABINOSID |
AT895175A AT345480B (en) | 1973-04-19 | 1975-11-25 | PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF DIGITOXIGENIN-ALFA-L-ARABINOSIDE |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA895175A ATA895175A (en) | 1978-01-15 |
AT345480B true AT345480B (en) | 1978-09-25 |
Family
ID=27149270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT895175A AT345480B (en) | 1973-04-19 | 1975-11-25 | PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF DIGITOXIGENIN-ALFA-L-ARABINOSIDE |
Country Status (1)
Country | Link |
---|---|
AT (1) | AT345480B (en) |
-
1975
- 1975-11-25 AT AT895175A patent/AT345480B/en active
Also Published As
Publication number | Publication date |
---|---|
ATA895175A (en) | 1978-01-15 |
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