AT34249B - Process for the preparation of 2.4.6-trioxypyrimidine and its 5-mono- and dialkyl derivatives. - Google Patents
Process for the preparation of 2.4.6-trioxypyrimidine and its 5-mono- and dialkyl derivatives.Info
- Publication number
- AT34249B AT34249B AT34249DA AT34249B AT 34249 B AT34249 B AT 34249B AT 34249D A AT34249D A AT 34249DA AT 34249 B AT34249 B AT 34249B
- Authority
- AT
- Austria
- Prior art keywords
- trioxypyrimidine
- mono
- preparation
- acid
- dialkyl derivatives
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
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Verfahren zur Darstellung von 2.4.6-Trioxypyrimidin und dessen 5-Mono-und Dialkylderivaten.
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2.4. 6-Trioxypyrimidin (Barbitursäure) bzw. dessen 5-Mono- und Dialkylderivate überzugehen. Es bietet sich hiedurch ein neuer Weg zur Darstellung dieser therapeutisch wertvollen Verbindungen.
Beispiel I : Darstellung von 2. 4.6-Trioxypyrimidin (Barbitursäure). Das als Ausgangsmaterial dienende Malonestersäureureid
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wird durch Einwirkung von Malonestersäurechlorid (Kp. 71 bei 15 mm) auf mindestens 2 Mol. Harnstoff und Trennung des Reaktionsgemisches mit Wasser erhalten. Das Ureid
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es setzt sich schwerlösliches, barbitursaures Natrium zu Boden, das mit Salzsäure reine Barbitursäure ergibt.
Beispiel II : Darstellung von 5-Monoäthyl-2. 4. 6-Trioxypyrimidin (Äthylbarbitursäure).
Das hiebei benutzte Äthylmalonestersäureureid
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Die Löslichkeit in Wasser ist gering. I. 2,2 kg Diäthylmalonäthylestersäureureid werden mit 20 l konzentriertem wässrigen Ammoniak bei gewöhnlicher Temperatur gut durchmischt. Nach 1 Stunde ist eine Lösung entstanden, die nach Abdunsten des überschüssigen Ammoniaks und
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und man kann mittels Salzsäure 1,7 kg reine Diäthylbarbitursäure ausfällen.
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Process for the preparation of 2,4,6-trioxypyrimidine and its 5-mono- and dialkyl derivatives.
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2.4. 6-trioxypyrimidine (barbituric acid) or its 5-mono- and dialkyl derivatives. This offers a new way of representing these therapeutically valuable connections.
Example I: Preparation of 2,4,6-trioxypyrimidine (barbituric acid). The malonic ester acid acid used as starting material
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is obtained by the action of malonic ester acid chloride (b.p. 71 at 15 mm) on at least 2 moles of urea and separation of the reaction mixture with water. The ureid
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sparingly soluble, barbituric acid sodium settles on the ground, which with hydrochloric acid results in pure barbituric acid.
Example II: Preparation of 5-monoethyl-2. 4. 6-trioxypyrimidine (ethyl barbituric acid).
The ethyl malonic ester acid ureid used here
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The solubility in water is low. I. 2.2 kg of diethyl malonic ester acid acid are mixed well with 20 l of concentrated aqueous ammonia at ordinary temperature. After 1 hour a solution has formed which, after the excess ammonia has evaporated, and
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and 1.7 kg of pure diethylbarbituric acid can be precipitated using hydrochloric acid.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE193447D | 1907-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT34249B true AT34249B (en) | 1908-09-10 |
Family
ID=5739142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT34249D AT34249B (en) | 1907-02-13 | 1907-12-20 | Process for the preparation of 2.4.6-trioxypyrimidine and its 5-mono- and dialkyl derivatives. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT34249B (en) |
-
1907
- 1907-12-20 AT AT34249D patent/AT34249B/en active
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