AT331257B - PROCESS FOR MANUFACTURING NEW IMIDAZO (1,2-A) S-TRIAZINE - Google Patents
PROCESS FOR MANUFACTURING NEW IMIDAZO (1,2-A) S-TRIAZINEInfo
- Publication number
- AT331257B AT331257B AT650075A AT650075A AT331257B AT 331257 B AT331257 B AT 331257B AT 650075 A AT650075 A AT 650075A AT 650075 A AT650075 A AT 650075A AT 331257 B AT331257 B AT 331257B
- Authority
- AT
- Austria
- Prior art keywords
- triazine
- formula
- new imidazo
- manufacturing new
- meaning given
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
Die Erfindungbetrifft ein Verfahren zur Herstellung von neuen Imidazol[l, 2-a]s-triazinen der allgemeinen Formel
EMI1.1
in der R1 einen unsubstituierten oder durch Halogenatome, vorzugsweise Fluor-, Chlor- oder Bromatome, Methyl-, Methoxy- oder Trifluormethylgruppen gleich oder verschieden ein-bis dreifach substituierten Phenylrest und R2 ein Wasserstoffatom oder einen unsubstituierten oder ein- bis mehrfach durch Halogenatome, vorzugsweise Chloratome, substituierten Phenylrest bedeutet, welche wertvolle therapeutische Eigenschaften besitzen.
Die Herstellung der Verbindungen der Formel (I) erfolgt durch Umsetzung einer Verbindung der allgemeinen Formel
EMI1.2
in welcher R1 die angegebene Bedeutung besitzt, mit einem Orthoester der Formel
EMI1.3
inder R2 die oben angegebene Bedeutung besitzt und R eine Niederalkylgruppe mit 1 bis 3 Kohlenstoffatomen bedeutet.
Diese Kondensationen werden vorzugsweise thermisch mit oder ohne Anwendung von Lösungsmitteln bei Temperaturen zwischen 80 und 1800C durchgeführt.
Verbindungen der Formel (II) sind durch Umsetzung von Verbindungen der Formel
EMI1.4
worin R1 die obige Bedeutung besitzt, mit Carbaminsäureestern herstellbar.
Ausgangsverbindungen der Formel (IV) sind z. B. in den belgischen Patentschriften Nr. 623. 305, Nr. 687. 656, Nr. 687. 657 und Nr. 705. 944 beschrieben.
Die neuen Verbindungen zeichnen sich durch wertvolle therapeutische Eigenschaften aus. Sie entfalten insbesondere eine ausgesprochen antidepressive Wirkung, die von einer Anti-Ulcus-Wirkung, Anti-Odem-
EMI1.5
<Desc/Clms Page number 2>
EMI2.1
EMI2.2
<Desc/Clms Page number 3>
EMI3.1
EMI3.2
<Desc / Clms Page number 1>
The invention relates to a process for the preparation of new imidazole [1,2-a] s-triazines of the general formula
EMI1.1
in which R1 is an unsubstituted or by halogen atoms, preferably fluorine, chlorine or bromine atoms, methyl, methoxy or trifluoromethyl groups, identically or differently mono- to trisubstituted phenyl and R2 is a hydrogen atom or an unsubstituted or mono- or polysubstituted by halogen atoms, preferably Chlorine atoms, substituted phenyl radical means which have valuable therapeutic properties.
The compounds of the formula (I) are prepared by reacting a compound of the general formula
EMI1.2
in which R1 has the meaning given, with an orthoester of the formula
EMI1.3
in which R2 has the meaning given above and R denotes a lower alkyl group having 1 to 3 carbon atoms.
These condensations are preferably carried out thermally with or without the use of solvents at temperatures between 80 and 1800C.
Compounds of formula (II) are obtained by reacting compounds of formula
EMI1.4
where R1 has the above meaning, producible with carbamic acid esters.
Starting compounds of the formula (IV) are, for. Described in Belgian patents No. 623,305, No. 687,656, No. 687,657 and No. 705,944.
The new compounds are characterized by valuable therapeutic properties. In particular, they develop a pronounced antidepressant effect, which consists of an anti-ulcer effect, anti-edema
EMI1.5
<Desc / Clms Page number 2>
EMI2.1
EMI2.2
<Desc / Clms Page number 3>
EMI3.1
EMI3.2
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT650075A AT331257B (en) | 1973-03-23 | 1975-08-22 | PROCESS FOR MANUFACTURING NEW IMIDAZO (1,2-A) S-TRIAZINE |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2314488A DE2314488C3 (en) | 1973-03-23 | 1973-03-23 | 8- (2,6-Dichlorophenyl) -7- (4-chlorophenyl) -5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazine, process for its preparation and medicament containing it |
AT193674A AT331256B (en) | 1973-03-23 | 1974-03-08 | PROCESS FOR PREPARING NEW IMIDAZO- (1,2-A) S-TRIAZINE |
AT650075A AT331257B (en) | 1973-03-23 | 1975-08-22 | PROCESS FOR MANUFACTURING NEW IMIDAZO (1,2-A) S-TRIAZINE |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA650075A ATA650075A (en) | 1975-11-15 |
AT331257B true AT331257B (en) | 1976-08-10 |
Family
ID=27148047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT650075A AT331257B (en) | 1973-03-23 | 1975-08-22 | PROCESS FOR MANUFACTURING NEW IMIDAZO (1,2-A) S-TRIAZINE |
Country Status (1)
Country | Link |
---|---|
AT (1) | AT331257B (en) |
-
1975
- 1975-08-22 AT AT650075A patent/AT331257B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATA650075A (en) | 1975-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELJ | Ceased due to non-payment of the annual fee |