AT244944B

AT244944B - Process for the preparation of new, basic substituted phenylacetonitriles and their salts

Info

Publication number: AT244944B
Application number: AT1000163A
Authority: AT
Original assignee: Knoll Ag
Priority date: 1962-12-19
Filing date: 1963-12-12
Publication date: 1966-02-10

Description

  

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  Verfahren zur Herstellung von neuen, basisch substituierten
Phenylacetonitrilen und deren Salzen 
Gegenstand der Erfindung ist ein Verfahren zur Herstellung von neuen, basisch substituierten Phenylacetonitrilen der allgemeinen Formel 
 EMI1.1 
 in welcher A, B und C Wasserstoff- oder Halogenatome niedermolekulare Alkyl-bzw. Alkoxygruppen, wobei in letzterem Falle zwei benachbarte Gruppen auch gemeinsam eine Methylendioxygruppe bilden können, R einen niedermolekularen aliphatischen Rest, R einen niedermolekularen Alkylrest, einen gesättigten oder ungesättigten, cyclischen oder bicyclischen Kohlenwasserstoffrest oder die Benzyl- bzw. 



  Phenylgruppe, n die Zahl 2,3 oder 4 und m die   Zahl l,   2 oder 3 bedeuten, sowie von Salzen dieser neuen Verbindungen. 



   Es wurde nun gefunden, dass man diese Verbindungen dadurch herstellen kann, dass man Phenylacetonitrile der allgemeinen Formel 
 EMI1.2 
 worin A, B, C, R und n die oben angegebene Bedeutung haben und X einen reaktionsfähigen Säurerest darstellt, mit Verbindungen der allgemeinen Formel 
 EMI1.3 
 

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 worin A, B, C und m die oben angegebene Bedeutung haben und R ein Wasserstoffatom oder einen niedermolekularen aliphatischen Rest bedeutet, zur Reaktion bringt, in die dabei erhaltenen Verbindungen der allgemeinen Formel 
 EMI2.1 
 
 EMI2.2 
 
 EMI2.3 
 
 EMI2.4 
 

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 EMI3.1 




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  Process for the production of new, basic substituted
Phenylacetonitriles and their salts
The invention relates to a process for the preparation of new, basic substituted phenylacetonitriles of the general formula
 EMI1.1
 in which A, B and C are hydrogen or halogen atoms, low molecular weight alkyl or. Alkoxy groups, where in the latter case two adjacent groups can also jointly form a methylenedioxy group, R a low molecular weight aliphatic radical, R a low molecular weight alkyl radical, a saturated or unsaturated, cyclic or bicyclic hydrocarbon radical or the benzyl or benzyl radical.



  Phenyl group, n is the number 2, 3 or 4 and m is the number 1, 2 or 3, and salts of these new compounds.



   It has now been found that these compounds can be prepared by using phenylacetonitriles of the general formula
 EMI1.2
 in which A, B, C, R and n have the meanings given above and X is a reactive acid radical, with compounds of the general formula
 EMI1.3
 

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 in which A, B, C and m have the meaning given above and R is a hydrogen atom or a low molecular weight aliphatic radical, brings about the reaction in the compounds of the general formula obtained thereby
 EMI2.1
 
 EMI2.2
 
 EMI2.3
 
 EMI2.4
 

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 EMI3.1

Claims

<Desc / Clms Page number 4> EMI4.1 in which A, B and C are hydrogen or halogen atoms, low molecular weight alkyl or alkoxy groups, whereby in the latter case two adjacent groups can also jointly form a methylenedioxy group, R a low molecular weight aliphatic radical, R a low molecular weight alkyl radical, a saturated or unsaturated, cyclic radical or bicyclic hydrocarbon radical or the benzyl or.

Phenyl group, n is the number 2, 3 or 4 and m is the number 1, 2 or 3, and salts thereof, characterized in that phenylacetonitriles of the general formula EMI4.2 wherein A, B, C, R and n have the meaning given above and X is a reactive acid radical, with compounds of the general formula EMI4.3 in which A, B, C and m have the meaning given above and IL is a hydrogen atom or a low molecular weight aliphatic radical, brings about the reaction, in compounds of the general formula obtained thereby EMI4.4 in which A, B, C, R, n and m have the meanings given above, then a radical R is introduced by alkylation and, if desired, the phenylacetonitriles of the general formula (I) obtained are converted into their salts.