AT32569B - Process for the preparation of methylenzitric acid dihalides. - Google Patents

Process for the preparation of methylenzitric acid dihalides.

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Publication number
AT32569B
AT32569B AT32569DA AT32569B AT 32569 B AT32569 B AT 32569B AT 32569D A AT32569D A AT 32569DA AT 32569 B AT32569 B AT 32569B
Authority
AT
Austria
Prior art keywords
methylenzitric
preparation
acid dihalides
acid
parts
Prior art date
Application number
Other languages
German (de)
Original Assignee
Farbenfab Vorm Bayer F & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1906186659D external-priority patent/DE186659C/de
Application filed by Farbenfab Vorm Bayer F & Co filed Critical Farbenfab Vorm Bayer F & Co
Application granted granted Critical
Publication of AT32569B publication Critical patent/AT32569B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Darstellung   von Methylenzitronensäuredihalogeniden.   



   Bekanntlich ist die Methylenzitronensäure ein relativ leicht zersetzlicher Körper und beruht ja auch ihre therapeutische Wirkung auf der leichten Abspaltbarkeit des Formaldehyds im Organismus. Es musste daher zweifelhaft erscheinen, ob es   möglich   sein würde, das Diehlorid 
 EMI1.1 
 sind wertvolle Zwischenprodukte   für   die Darstellung von Arzneimitteln. 



   Beispiel   I : 204   Teile Methylenzitronensäure werden mit 420 Teilen Phosphorpentachlorid 
 EMI1.2 
   Beendigung   der Reaktion destilliert man entweder das entstandene Phosphoroxychlorid ah und kristallisiert den Rückstand aus Benzol und Ligroin um, oder man giesst das füssige Reaktions- 
 EMI1.3 
 
 EMI1.4 
 
 EMI1.5 
 dann, wie in Beispiel 1 beschrieben, weiter verarbeitet. Das Chlorid kann auch in der Weise isoliert werden, dass   man   nach dem Abdestillieren des Phosphoroxychlorids unter vermindertem Druck den Rückstand in Petroläther giesst, wobei das Chlorid mit den oben angegebenen   Eigenschaften ausfällt.   



   Beispiel 3 :   204   Teile Methylenzitronensäure werden mit 862 Teilen   Phosphorpentabromid   auf dem Wasserbade erwärmt, bis alles gelöst ist, Man destilliert darauf das   Phosphoroxy-   
 EMI1.6 
 Wasser zersetzt es sich sehr leicht in die freie Säure und Bromwasserstoff. 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of methylenzitric acid dihalides.



   As is well known, methyl citric acid is a relatively easily decomposable body and its therapeutic effect is based on the ease with which formaldehyde can be split off in the body. It must therefore appear doubtful whether it would be possible to use the Diehlorid
 EMI1.1
 are valuable intermediate products for the preparation of pharmaceuticals.



   Example I: 204 parts of methylene citric acid are mixed with 420 parts of phosphorus pentachloride
 EMI1.2
   When the reaction is complete, either the phosphorus oxychloride formed is distilled and the residue is recrystallized from benzene and ligroin, or the liquid reaction mixture is poured
 EMI1.3
 
 EMI1.4
 
 EMI1.5
 then, as described in Example 1, processed further. The chloride can also be isolated in such a way that, after the phosphorus oxychloride has been distilled off, the residue is poured into petroleum ether under reduced pressure, the chloride precipitating with the properties given above.



   Example 3: 204 parts of methylene citric acid are heated with 862 parts of phosphorus pentabromide on the water bath until everything has dissolved. The phosphorus oxy-
 EMI1.6
 In water, it decomposes very easily into the free acid and hydrogen bromide.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Darstellung von Methylenzitronensäuredihalogeniden, darin bestehend, dass man Fünffachhalogenphosphor auf Methylenzitronensäure oder ihre Salze einwirken lässt. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. PATENT CLAIM: Process for the preparation of methylenzitric acid dihalides, consisting in that quintuple halophosphorus is allowed to act on methylenzitric acid or its salts. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT32569D 1906-03-22 1907-06-03 Process for the preparation of methylenzitric acid dihalides. AT32569B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1906186659D DE186659C (en) 1906-03-22

Publications (1)

Publication Number Publication Date
AT32569B true AT32569B (en) 1908-04-10

Family

ID=5720039

Family Applications (1)

Application Number Title Priority Date Filing Date
AT32569D AT32569B (en) 1906-03-22 1907-06-03 Process for the preparation of methylenzitric acid dihalides.

Country Status (1)

Country Link
AT (1) AT32569B (en)

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