AT308728B - Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen - Google Patents

Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen

Info

Publication number
AT308728B
AT308728B AT890471A AT890471A AT308728B AT 308728 B AT308728 B AT 308728B AT 890471 A AT890471 A AT 890471A AT 890471 A AT890471 A AT 890471A AT 308728 B AT308728 B AT 308728B
Authority
AT
Austria
Prior art keywords
cycl
subst
benzonitriles
hexafluoro
tetrafluoro
Prior art date
Application number
AT890471A
Other languages
German (de)
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of AT308728B publication Critical patent/AT308728B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/18—Preparation of halogenated hydrocarbons by replacement by halogens of oxygen atoms of carbonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/52—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition by dehydration and rearrangement involving two hydroxy groups in the same molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT890471A 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen AT308728B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71261668A 1968-03-13 1968-03-13
US79994569A 1969-02-17 1969-02-17

Publications (1)

Publication Number Publication Date
AT308728B true AT308728B (de) 1973-07-25

Family

ID=27108860

Family Applications (4)

Application Number Title Priority Date Filing Date
AT890471A AT308728B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen
AT248469A AT308729B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen subtituierten Phenalkylaminen
AT890571A AT310726B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-halogenbenzolen und deren Homologen
AT890671A AT310727B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor-(cycl.subst.)-äthyl]- oder [Hexafluor-(cycl.subst.)-propyl]-phenalkyl-N-acylaminen und entsprechenden N-Alkylderivaten

Family Applications After (3)

Application Number Title Priority Date Filing Date
AT248469A AT308729B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen subtituierten Phenalkylaminen
AT890571A AT310726B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-halogenbenzolen und deren Homologen
AT890671A AT310727B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor-(cycl.subst.)-äthyl]- oder [Hexafluor-(cycl.subst.)-propyl]-phenalkyl-N-acylaminen und entsprechenden N-Alkylderivaten

Country Status (5)

Country Link
JP (4) JPS4910669B1 (xx)
AT (4) AT308728B (xx)
CH (1) CH527161A (xx)
GB (1) GB1265051A (xx)
PH (1) PH10298A (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0672112B2 (ja) * 1987-04-24 1994-09-14 セントラル硝子株式会社 新規なビスベンゾトリフルオリド誘導体およびその製造法
JP4612974B2 (ja) * 2001-08-09 2011-01-12 大鵬薬品工業株式会社 ベンジルアミン誘導体の製造法
KR20160062117A (ko) * 2013-10-02 2016-06-01 다이킨 고교 가부시키가이샤 불소 함유 착체 화합물, 및 이것을 사용하는 불소 함유 유기 화합물의 제조 방법

Also Published As

Publication number Publication date
GB1265051A (xx) 1972-03-01
AT310726B (de) 1973-10-10
CH527161A (de) 1972-08-31
PH10298A (en) 1976-11-10
JPS4911693B1 (xx) 1974-03-19
AT308729B (de) 1973-07-25
JPS4910669B1 (xx) 1974-03-12
JPS4911694B1 (xx) 1974-03-19
JPS4911695B1 (xx) 1974-03-19
AT310727B (de) 1973-10-10

Similar Documents

Publication Publication Date Title
AT292202B (de) Verfahren zur Herstellung von neuen 2-Amino-adenosinderivaten
AT303254B (de) Verfahren zur Herstellung von neuen 5-Halogen-salicylsäurederivaten
AT289754B (de) Verfahren zur herstellung der neuen dl-trans-3,3-dimethyl-2-cyclopropylidenmethyl-1-cyclopropancarbonsaeure und der neuen dl-trans-3,3-dimethyl-2-cyclobutylidenmethyl-1-cyclopropancarbonsaeure sowie von deren dl-allethrolonestern
AT286262B (de) Verfahren zur Herstellung von neuen 1-(subst.Phenoxy)-2-hydroxy-3-aminopropanen und von deren Säureadditionssalzen
AT302272B (de) Verfahren zur Herstellung von neuen Biphenylderivaten
AT299220B (de) Verfahren zur Herstellung von neuen 7-Amino-8-oxo-5-thia-1-azabicyclo[4,2,0,]oct-2-en-2-carbonsäureverbindungen
AT308728B (de) Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen
CH542849A (de) Verfahren zur Herstellung von 3,5-Diphenyl-4-pyrazolessigsäure
AT301534B (de) Verfahren zur Herstellung von neuen [(Thernylidenamino)-oxyd]-alkylcarbonsäurederivaten
CH500189A (de) Verfahren zur Herstellung von neuen, substituierten Phenylalkansäuren
AT284096B (de) Verfahren zur Herstellung von neuen Aryl-substituierten, teilweise gesättigten Bicycloaryloxyalkancarbonsäuren und Derivaten davon
CH508645A (de) Verfahren zur Herstellung von neuen 5-substituierten y-Carbolinderivaten
AT293634B (de) Verfahren zur Herstellung von neuen 17α-Acyloxy-11β-methyl-19-norpregn-4-en-3,20-dionen
AT278789B (de) Verfahren zur Herstellung von neuen 2,6-Dichlor-3,5-dicyan-pyridin-4-thioäthern
CH502297A (de) Verfahren zur Herstellung von alkoholischen Monomaleinatlösungen
CH487826A (de) Verfahren zur Herstellung von Bicylo-(2,2,2)-oct-7-en-2,3,5,6-tetracarbonsäure-dianhydrid
CH531513A (de) Verfahren zur Herstellung von neuen 2-Indolylessigsäurederivaten
CH531012A (de) Verfahren zur Herstellung von cis-Propenylphosphonsäure und deren Derivaten
AT311312B (de) Verfahren zur Herstellung von neuen, tricyclischen Aminoketonen und von deren Säureadditionssalzen
AT286997B (de) Verfahren zur Herstellung von neuen Derivaten des 5H-Dibenz[b,f]azepins sowie deren Salzen
CH551451A (de) Verfahren zur herstellung von 5-arylphenylphosphorigesaeure- und 5-arylphenylunterphosphorigesaeure-verbindungen.
AT279818B (de) Verfahren zur Herstellung von neuen 17-Hydroxy- und 17-Acyloxy-6β,7β-epoxy-1α,2α-methylen-4-pregnen-3,20-dionen
AT280987B (de) Verfahren zur Herstellung von neuen Bicyclo[2,2,2]oct-2-en-1-ylmethylaminen sowie deren Säureadditionssalzen
AT299170B (de) Verfahren zur Herstellung von neuen substituierten Phenylalkansäuren und deren Derivaten
AT299450B (de) Verfahren zur Herstellung von neuen Aminopenam- und Aminocephemverbindungen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee