AT308728B - Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen - Google Patents

Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen

Info

Publication number
AT308728B
AT308728B AT890471A AT890471A AT308728B AT 308728 B AT308728 B AT 308728B AT 890471 A AT890471 A AT 890471A AT 890471 A AT890471 A AT 890471A AT 308728 B AT308728 B AT 308728B
Authority
AT
Austria
Prior art keywords
cycl
subst
benzonitriles
hexafluoro
tetrafluoro
Prior art date
Application number
AT890471A
Other languages
German (de)
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of AT308728B publication Critical patent/AT308728B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/18—Preparation of halogenated hydrocarbons by replacement by halogens of oxygen atoms of carbonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/52—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition by dehydration and rearrangement involving two hydroxy groups in the same molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT890471A 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen AT308728B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71261668A 1968-03-13 1968-03-13
US79994569A 1969-02-17 1969-02-17

Publications (1)

Publication Number Publication Date
AT308728B true AT308728B (de) 1973-07-25

Family

ID=27108860

Family Applications (4)

Application Number Title Priority Date Filing Date
AT890471A AT308728B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen
AT248469A AT308729B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen subtituierten Phenalkylaminen
AT890671A AT310727B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor-(cycl.subst.)-äthyl]- oder [Hexafluor-(cycl.subst.)-propyl]-phenalkyl-N-acylaminen und entsprechenden N-Alkylderivaten
AT890571A AT310726B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-halogenbenzolen und deren Homologen

Family Applications After (3)

Application Number Title Priority Date Filing Date
AT248469A AT308729B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen subtituierten Phenalkylaminen
AT890671A AT310727B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor-(cycl.subst.)-äthyl]- oder [Hexafluor-(cycl.subst.)-propyl]-phenalkyl-N-acylaminen und entsprechenden N-Alkylderivaten
AT890571A AT310726B (de) 1968-03-13 1969-03-13 Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-halogenbenzolen und deren Homologen

Country Status (5)

Country Link
JP (4) JPS4910669B1 (https=)
AT (4) AT308728B (https=)
CH (1) CH527161A (https=)
GB (1) GB1265051A (https=)
PH (1) PH10298A (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0672112B2 (ja) * 1987-04-24 1994-09-14 セントラル硝子株式会社 新規なビスベンゾトリフルオリド誘導体およびその製造法
JP4612974B2 (ja) * 2001-08-09 2011-01-12 大鵬薬品工業株式会社 ベンジルアミン誘導体の製造法
CN112047913A (zh) * 2013-10-02 2020-12-08 大金工业株式会社 含氟络合化合物及使用其的含氟有机化合物的制造方法

Also Published As

Publication number Publication date
CH527161A (de) 1972-08-31
GB1265051A (https=) 1972-03-01
AT308729B (de) 1973-07-25
AT310727B (de) 1973-10-10
JPS4911695B1 (https=) 1974-03-19
JPS4911694B1 (https=) 1974-03-19
AT310726B (de) 1973-10-10
JPS4911693B1 (https=) 1974-03-19
JPS4910669B1 (https=) 1974-03-12
PH10298A (en) 1976-11-10

Similar Documents

Publication Publication Date Title
AT282835B (de) Verfahren zur Herstellung von neuen 2-Amino-adenosinderivaten
AT304473B (de) Verfahren zur Herstellung von neuen substituierten 1-Amino-2-hydroxy-3-[2'-cyclopentyl- bzw. (δ<2>-cyclopentenyl)-phenoxy]-propanen, deren optisch aktiven Isomeren und Salzen
AT303254B (de) Verfahren zur Herstellung von neuen 5-Halogen-salicylsäurederivaten
AT289754B (de) Verfahren zur herstellung der neuen dl-trans-3,3-dimethyl-2-cyclopropylidenmethyl-1-cyclopropancarbonsaeure und der neuen dl-trans-3,3-dimethyl-2-cyclobutylidenmethyl-1-cyclopropancarbonsaeure sowie von deren dl-allethrolonestern
AT286262B (de) Verfahren zur Herstellung von neuen 1-(subst.Phenoxy)-2-hydroxy-3-aminopropanen und von deren Säureadditionssalzen
AT299220B (de) Verfahren zur Herstellung von neuen 7-Amino-8-oxo-5-thia-1-azabicyclo[4,2,0,]oct-2-en-2-carbonsäureverbindungen
AT308728B (de) Verfahren zur Herstellung von neuen [Tetrafluor(cycl.subst.)-äthyl]- oder [Hexafluor(cycl.subst.)-propyl]-benzonitrilen und deren Homologen
CH542849A (de) Verfahren zur Herstellung von 3,5-Diphenyl-4-pyrazolessigsäure
AT283333B (de) Verfahren zur Herstellung von neuen Aryl-substituierten, teilweise gesättigten Bicycloaryloxyalkancarbonsäuren und Derivaten davon
AT289821B (de) Verfahren zur Herstellung von neuen 1-nied.Alkyl-3-azetidinolen und deren Salzen
CH508645A (de) Verfahren zur Herstellung von neuen 5-substituierten y-Carbolinderivaten
AT293354B (de) Verfahren zur Herstellung von neuen 2-Aminomethyladamantanen, sowie deren Säureadditionssalzen
CH500189A (de) Verfahren zur Herstellung von neuen, substituierten Phenylalkansäuren
AT273949B (de) Verfahren zur Herstellung der neuen Tetrahydrofuran-2,3,4,5-tetracarbonsäure
AT293634B (de) Verfahren zur Herstellung von neuen 17α-Acyloxy-11β-methyl-19-norpregn-4-en-3,20-dionen
CH531012A (de) Verfahren zur Herstellung von cis-Propenylphosphonsäure und deren Derivaten
AT288362B (de) Verfahren zur Herstellung von neuen 2-hydroxy-3,5,6,-trichlormandelsäure
CH502297A (de) Verfahren zur Herstellung von alkoholischen Monomaleinatlösungen
AT294797B (de) Verfahren zur Herstellung der neuen N-Propionyl-ɛ-aminocapronsäure und von deren Salzen
CH487826A (de) Verfahren zur Herstellung von Bicylo-(2,2,2)-oct-7-en-2,3,5,6-tetracarbonsäure-dianhydrid
CH531513A (de) Verfahren zur Herstellung von neuen 2-Indolylessigsäurederivaten
AT311312B (de) Verfahren zur Herstellung von neuen, tricyclischen Aminoketonen und von deren Säureadditionssalzen
AT286997B (de) Verfahren zur Herstellung von neuen Derivaten des 5H-Dibenz[b,f]azepins sowie deren Salzen
AT297006B (de) Verfahren zur Herstellung von neuen 10-Piperazino-10,11-dihydrodibenzo[b,f]thiepinen und deren Salzen
AT279818B (de) Verfahren zur Herstellung von neuen 17-Hydroxy- und 17-Acyloxy-6β,7β-epoxy-1α,2α-methylen-4-pregnen-3,20-dionen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee