AT279633B - Verfahren zur herstellung von neuen 3-(4-r-piperazino)-terverfahren zur herstellung von neuen 10,11-dihydrodibenzo<bt.-amino-propiophenonen, ihren quaternaeren ammoniumverbin,f>-azepinderivaten sowie von deren saeureadditionssalzen dungen und salzen und quaternaeren ammoniumverbindungen - Google Patents

Verfahren zur herstellung von neuen 3-(4-r-piperazino)-terverfahren zur herstellung von neuen 10,11-dihydrodibenzo<bt.-amino-propiophenonen, ihren quaternaeren ammoniumverbin,f>-azepinderivaten sowie von deren saeureadditionssalzen dungen und salzen und quaternaeren ammoniumverbindungen

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Publication number
AT279633B
AT279633B AT04126/69A AT412669A AT279633B AT 279633 B AT279633 B AT 279633B AT 04126/69 A AT04126/69 A AT 04126/69A AT 412669 A AT412669 A AT 412669A AT 279633 B AT279633 B AT 279633B
Authority
AT
Austria
Prior art keywords
ammoniumverbines
new
production
quaternal
quaternaal
Prior art date
Application number
AT04126/69A
Other languages
English (en)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
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Publication of AT279633B publication Critical patent/AT279633B/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04126/69A 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-terverfahren zur herstellung von neuen 10,11-dihydrodibenzo<bt.-amino-propiophenonen, ihren quaternaeren ammoniumverbin,f>-azepinderivaten sowie von deren saeureadditionssalzen dungen und salzen und quaternaeren ammoniumverbindungen AT279633B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58435066A 1966-10-05 1966-10-05
US642718A US3538090A (en) 1966-10-05 1967-06-01 1-(4-tertiaryaminophenyl)-3-(piperazino)-propanols

Publications (1)

Publication Number Publication Date
AT279633B true AT279633B (de) 1970-03-10

Family

ID=27079076

Family Applications (8)

Application Number Title Priority Date Filing Date
AT901167A AT277250B (de) 1966-10-05 1967-10-04 Verfahren zur Herstellung von neuen 3-(4-R-Piperazino)-tert.amino-propiophenonen, ihren quaternären Ammoniumverbindungen und Salzen
AT00018/69A AT279625B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00017/69A AT277264B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00020/69A AT279626B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00019/69A AT277265B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT04126/69A AT279633B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-terverfahren zur herstellung von neuen 10,11-dihydrodibenzo<bt.-amino-propiophenonen, ihren quaternaeren ammoniumverbin,f>-azepinderivaten sowie von deren saeureadditionssalzen dungen und salzen und quaternaeren ammoniumverbindungen
AT00015/69A AT277262B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00016/69A AT277263B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen

Family Applications Before (5)

Application Number Title Priority Date Filing Date
AT901167A AT277250B (de) 1966-10-05 1967-10-04 Verfahren zur Herstellung von neuen 3-(4-R-Piperazino)-tert.amino-propiophenonen, ihren quaternären Ammoniumverbindungen und Salzen
AT00018/69A AT279625B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00017/69A AT277264B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00020/69A AT279626B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.-amino-propiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00019/69A AT277265B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT00015/69A AT277262B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen
AT00016/69A AT277263B (de) 1966-10-05 1967-10-04 Verfahren zur herstellung von neuen 3-(4-r-piperazino)-tert.aminopropiophenonen, ihren quaternaeren ammoniumverbindungen und salzen

Country Status (7)

Country Link
US (2) US3538090A (de)
AT (8) AT277250B (de)
BE (1) BE704696A (de)
ES (1) ES345694A1 (de)
FR (3) FR1549341A (de)
GB (1) GB1173369A (de)
NL (1) NL6713497A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933824A (en) * 1970-03-06 1976-01-20 Sumitomo Chemical Company, Limited Piperazinobutyrophenone derivatives
US4613598A (en) * 1984-03-13 1986-09-23 Mitsubishi Chemical Industries Limited Piperazine derivatives and their acid addition salts
USRE35053E (en) * 1985-09-12 1995-10-10 The Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5380839A (en) * 1985-09-12 1995-01-10 The Upjohn Company Phenylpiperazinyl steroids
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3317538A (en) * 1965-10-22 1967-05-02 American Home Prod 4, 4'-diamino-butyrophenones

Also Published As

Publication number Publication date
US3538090A (en) 1970-11-03
AT279625B (de) 1970-03-10
BE704696A (de) 1968-04-04
ES345694A1 (es) 1969-03-16
AT277265B (de) 1969-12-29
FR7253M (de) 1969-09-08
AT277262B (de) 1969-12-29
AT277263B (de) 1969-12-29
AT277250B (de) 1969-12-10
FR6943M (de) 1969-05-12
NL6713497A (de) 1968-04-08
AT277264B (de) 1969-12-29
US3538091A (en) 1970-11-03
AT279626B (de) 1970-03-10
FR1549341A (de) 1968-12-13
GB1173369A (en) 1969-12-10

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