AT269350B - Verfahren zur Herstellung von neuen, antibiotisch wirksamen Substanzen - Google Patents
Verfahren zur Herstellung von neuen, antibiotisch wirksamen SubstanzenInfo
- Publication number
- AT269350B AT269350B AT1097465A AT1097465A AT269350B AT 269350 B AT269350 B AT 269350B AT 1097465 A AT1097465 A AT 1097465A AT 1097465 A AT1097465 A AT 1097465A AT 269350 B AT269350 B AT 269350B
- Authority
- AT
- Austria
- Prior art keywords
- new
- production
- antibiotic substances
- antibiotic
- substances
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US416599A US3361742A (en) | 1964-12-07 | 1964-12-07 | 5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT269350B true AT269350B (de) | 1969-03-10 |
Family
ID=23650586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT1097465A AT269350B (de) | 1964-12-07 | 1965-12-06 | Verfahren zur Herstellung von neuen, antibiotisch wirksamen Substanzen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3361742A (de) |
| AT (1) | AT269350B (de) |
| BE (1) | BE673376A (de) |
| BR (1) | BR6575537D0 (de) |
| CH (1) | CH475997A (de) |
| DE (1) | DE1467872A1 (de) |
| ES (1) | ES320436A1 (de) |
| FR (1) | FR1553664A (de) |
| GB (1) | GB1092888A (de) |
| NL (1) | NL6515880A (de) |
| SE (1) | SE316136B (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3523941A (en) * | 1967-03-06 | 1970-08-11 | Hoffmann La Roche | Benzodiazepine compounds and process for their preparation |
| US3524849A (en) * | 1967-10-27 | 1970-08-18 | Hoffmann La Roche | Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein |
| FR2027356A1 (en) * | 1968-12-30 | 1970-09-25 | Fujisawa Pharmaceutical Co | Benzodiazepinone antibiotics |
| JPS5279082A (en) * | 1975-12-25 | 1977-07-02 | Green Cross Corp:The | Preparation of anti-tumor compound |
| JPS585916B2 (ja) | 1977-12-27 | 1983-02-02 | 株式会社ミドリ十字 | 新規ベンゾジアゼピン系化合物 |
| CA1214774A (en) * | 1983-02-10 | 1986-12-02 | Yusei Shiraga | Benzodiazepine derivative |
| AUPO470197A0 (en) * | 1997-01-21 | 1997-02-13 | Attfield, Paul Victor | Fluorescent dyes from microorganisms |
| BR112012026801B8 (pt) | 2010-04-15 | 2021-05-25 | Medimmune Ltd | conjugados de pirrolobenzodiazepina direcionados, composição farmacêutica, uso dos mesmos para tratamento de uma doença proliferativa ou autoimune e ligante de medicamento |
| NZ602933A (en) | 2010-04-15 | 2014-09-26 | Seattle Genetics Inc | Pyrrolobenzodiazepines used to treat proliferative diseases |
| CA2849039C (en) | 2011-09-20 | 2018-09-18 | Spirogen Sarl | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
| WO2013055990A1 (en) | 2011-10-14 | 2013-04-18 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| CA2850264C (en) | 2011-10-14 | 2019-11-05 | Spirogen Sarl | Pyrrolobenzodiazepines |
| AU2012322613B2 (en) | 2011-10-14 | 2016-04-21 | Medimmune Limited | Pyrrolobenzodiazepines and targeted conjugates |
| EA028457B1 (ru) | 2011-10-14 | 2017-11-30 | Медимьюн Лимитед | Пирролобензодиазепины |
| SI3470086T1 (sl) | 2012-10-12 | 2021-03-31 | Medimmune Limited | Pirolobenzodiazepini in njihovi konjugati |
| CA2885305C (en) | 2012-10-12 | 2019-11-12 | Spirogen Sarl | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
| MX364328B (es) | 2012-10-12 | 2019-04-23 | Medimmune Ltd | Conjugados del anticuerpo pirrolobenzodiazepina. |
| CN105102003B (zh) | 2012-10-12 | 2019-03-05 | Adc疗法责任有限公司 | 吡咯并苯并二氮杂卓-抗psma抗体结合物 |
| WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| EP2839860B1 (de) | 2012-10-12 | 2019-05-01 | MedImmune Limited | Pyrrolobenzodiazepine und Konjugate davon |
| CA2887895C (en) | 2012-10-12 | 2019-10-29 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine-anti-cd19 antibody conjugates |
| EP2906297B1 (de) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepin-antikörper-konjugate |
| JP6392765B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ | ピロロベンゾジアゼピン−抗体結合体 |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP3054985B1 (de) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepin-antikörper-konjugate |
| US9956299B2 (en) | 2013-10-11 | 2018-05-01 | Medimmune Limited | Pyrrolobenzodiazepine—antibody conjugates |
| EP3054983B1 (de) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepin-antikörper-konjugate |
| GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| CA2968447A1 (en) | 2014-11-25 | 2016-06-02 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates and their use to treat neoplasms |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| JP6671555B2 (ja) | 2017-02-08 | 2020-03-25 | アーデーセー セラピューティクス ソシエテ アノニム | ピロロベンゾジアゼピン抗体複合体 |
| JP2020517609A (ja) | 2017-04-18 | 2020-06-18 | メディミューン リミテッド | ピロロベンゾジアゼピン複合体 |
| CA3057748A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
| WO2018229222A1 (en) | 2017-06-14 | 2018-12-20 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-cd19 adc |
| WO2019034764A1 (en) | 2017-08-18 | 2019-02-21 | Medimmune Limited | CONJUGATES OF PYRROLOBENZODIAZEPINE |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3247187A (en) * | 1963-07-10 | 1966-04-19 | Hoffmann La Roche | Oxidation of 1, 4-benzodiazepines to 1, 4-benzodiazepin-2-ones |
-
1964
- 1964-12-07 US US416599A patent/US3361742A/en not_active Expired - Lifetime
-
1965
- 1965-12-03 FR FR1553664D patent/FR1553664A/fr not_active Expired
- 1965-12-04 DE DE19651467872 patent/DE1467872A1/de active Pending
- 1965-12-06 GB GB51119/65A patent/GB1092888A/en not_active Expired
- 1965-12-06 ES ES0320436A patent/ES320436A1/es not_active Expired
- 1965-12-06 AT AT1097465A patent/AT269350B/de active
- 1965-12-07 SE SE15830/65A patent/SE316136B/xx unknown
- 1965-12-07 BR BR175537/65A patent/BR6575537D0/pt unknown
- 1965-12-07 BE BE673376D patent/BE673376A/xx unknown
- 1965-12-07 CH CH1683365A patent/CH475997A/de not_active IP Right Cessation
- 1965-12-07 NL NL6515880A patent/NL6515880A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE673376A (de) | 1966-04-01 |
| BR6575537D0 (pt) | 1973-09-06 |
| ES320436A1 (es) | 1966-05-16 |
| NL6515880A (de) | 1966-06-08 |
| FR1553664A (de) | 1969-01-17 |
| GB1092888A (en) | 1967-11-29 |
| CH475997A (de) | 1969-07-31 |
| SE316136B (de) | 1969-10-20 |
| DE1467872A1 (de) | 1969-05-14 |
| US3361742A (en) | 1968-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT269350B (de) | Verfahren zur Herstellung von neuen, antibiotisch wirksamen Substanzen | |
| CH478156A (de) | Verfahren zur Herstellung neuartiger Antibiotika | |
| CH456636A (de) | Verfahren zur Herstellung von neuen Aminen | |
| CH475241A (de) | Verfahren zur Herstellung von neuen Pyrrolderivaten | |
| AT264136B (de) | Verfahren zur Herstellung von neuen Copolyestern | |
| CH473117A (de) | Verfahren zur Herstellung von neuen Verbindungen | |
| CH468977A (de) | Verfahren zur Herstellung von neuen Carbamaten | |
| CH471129A (de) | Verfahren zur Herstellung von neuen Noralkaloiden | |
| CH488640A (de) | Verfahren zur Herstellung von neuen Cycloheptadienen | |
| AT265515B (de) | Verfahren zur Herstellung von neuen Penicillinen | |
| AT266314B (de) | Verfahren zur Herstellung des neuen Antibiotikums Lincomycin B | |
| AT250981B (de) | Verfahren zur Herstellung von neuen alkalilöslichen Kondensationsprodukten | |
| AT254205B (de) | Verfahren zur Herstellung von neuen Azepinderivaten | |
| AT261804B (de) | Verfahren zur Herstellung von neuen wasserlöslichen, antibiotisch wirksamen Verbindungen | |
| AT264003B (de) | Verfahren zur Herstellung von neuen Penicillinen | |
| AT264711B (de) | Verfahren zur Herstellung von neuen Penicillinen | |
| AT284089B (de) | Verfahren zur herstellung von neuen substituierten beta-phenylaethanolen | |
| CH457433A (de) | Verfahren zur Herstellung von neuen basisch substituierten Pseudoindolen | |
| AT282079B (de) | Verfahren zur Herstellung von neuen 9β,10α-Steroiden | |
| AT255435B (de) | Verfahren zur Herstellung von neuen organischen Zinn-Bor-Verbindungen | |
| CH434265A (de) | Verfahren zur Herstellung von neuen Azepinderivaten | |
| AT257627B (de) | Verfahren zur Herstellung von neuen S-Amino-iso-thio-harnstoffen | |
| AT268552B (de) | Verfahren zur Herstellung von neuen α-Alkyl-thyroninen | |
| CH486421A (de) | Verfahren zur Herstellung von neuen Phenoxyaminopropanen | |
| AT270867B (de) | Verfahren zur Herstellung von neuen Penicillinen |