AT218522B - Process for the preparation of the new 2- (4-pyridyl) ethyl hydrazine - Google Patents
Process for the preparation of the new 2- (4-pyridyl) ethyl hydrazineInfo
- Publication number
- AT218522B AT218522B AT328460A AT328460A AT218522B AT 218522 B AT218522 B AT 218522B AT 328460 A AT328460 A AT 328460A AT 328460 A AT328460 A AT 328460A AT 218522 B AT218522 B AT 218522B
- Authority
- AT
- Austria
- Prior art keywords
- pyridyl
- new
- preparation
- ethyl hydrazine
- hydrazine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 6
- HMCWZAZLRFMRPY-UHFFFAOYSA-N 2-pyridin-4-ylethylhydrazine Chemical compound NNCCC1=CC=NC=C1 HMCWZAZLRFMRPY-UHFFFAOYSA-N 0.000 title description 4
- 238000002360 preparation method Methods 0.000 title description 2
- 239000011541 reaction mixture Substances 0.000 claims description 2
- KFDVPJUYSDEJTH-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C=CC1=CC=NC=C1 KFDVPJUYSDEJTH-UHFFFAOYSA-N 0.000 description 4
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 3
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pyridine Compounds (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Herstellung des neuen
2- (4-Pyridyl)-äthylhydrazins
EMI1.1
EMI1.2
EMI1.3
system beeinflussenden Arzneimitteln steigert.
Das erfindungsgemässe Verfahren ermöglicht die Herstellung des neuen 2- (4-Pyridyl)-äthylhydrazins in einfacher Weise und unter Erzielung guter Ausbeuten ; das Verfahren ist dadurch gekennzeichnet, dass Hydrazinhydrat mit 4-Vinylpyridin umgesetzt wird. Bei Durchführung der Umsetzung kann das Reaktionsgemisch während eines kurzen Zeitraumes erhitzt werden.
Beispiel : Es wurden zu 225 cms (4, 5 Mol) auf dem Wasserbad auf 930C erhitztem Hydrazinhydrat (1000/0) während 7 Minuten 159 g (1,5 Mol) 4-Vinylpyridin hinzugegeben, und dann das Gemisch weitere 2 Stunden erhitzt. Die Innentemperatur erreichte 3 Minuten nach beendetem Zusetzen und vollständiger Lösung des 4-Vinylpyridins eine maximale Höhe von etwa 104, 5 C. Nach der Heizperiode wurde über- schussiges Hydrazin bei verringertem Druck destilliert und dann das Verfahrensprodukt im Vakuum destil-
EMI1.4
bei 6 - 7 mm erhalten.
PATENTANSPRÜCHE :
1. Verfahren zur Herstellung des neuen 2- (4-Pyridyl)-äthylhydrazins, dadurch gekennzeichnet, dass Hydrazinhydrat mit 4-Vinylpyridin umgesetzt wird.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
Method of making the new
2- (4-pyridyl) ethyl hydrazine
EMI1.1
EMI1.2
EMI1.3
system-influencing drugs increases.
The process according to the invention enables the new 2- (4-pyridyl) ethylhydrazine to be prepared in a simple manner and with good yields being achieved; the process is characterized in that hydrazine hydrate is reacted with 4-vinylpyridine. In carrying out the reaction, the reaction mixture can be heated for a short period of time.
Example: 159 g (1.5 mol) of 4-vinylpyridine were added to 225 cms (4.5 mol) of hydrazine hydrate (1000/0) heated to 930C on a water bath over 7 minutes, and then the mixture was heated for a further 2 hours. The internal temperature reached a maximum of about 104.5 C 3 minutes after the addition was complete and the 4-vinylpyridine had completely dissolved. After the heating period, excess hydrazine was distilled under reduced pressure and the process product was then distilled in vacuo.
EMI1.4
at 6 - 7 mm.
PATENT CLAIMS:
1. Process for the preparation of the new 2- (4-pyridyl) ethylhydrazine, characterized in that hydrazine hydrate is reacted with 4-vinylpyridine.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US218522XA | 1958-05-07 | 1958-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT218522B true AT218522B (en) | 1961-12-11 |
Family
ID=21806509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT328460A AT218522B (en) | 1958-05-07 | 1959-05-02 | Process for the preparation of the new 2- (4-pyridyl) ethyl hydrazine |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT218522B (en) |
-
1959
- 1959-05-02 AT AT328460A patent/AT218522B/en active
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