AT212499B - Process for the preparation of steroid compounds substituted in the 4-position - Google Patents

Process for the preparation of steroid compounds substituted in the 4-position

Info

Publication number
AT212499B
AT212499B AT614656A AT614656A AT212499B AT 212499 B AT212499 B AT 212499B AT 614656 A AT614656 A AT 614656A AT 614656 A AT614656 A AT 614656A AT 212499 B AT212499 B AT 212499B
Authority
AT
Austria
Prior art keywords
preparation
steroid compounds
compounds substituted
steroid
general formula
Prior art date
Application number
AT614656A
Other languages
German (de)
Inventor
Bianca Patelli
Bruno Camerino
Alberto Vercellone
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Application granted granted Critical
Publication of AT212499B publication Critical patent/AT212499B/en

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  • Steroid Compounds (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Herstellung von in 4-Stellung substituierten
Steroidverbindungen Zur Herstellung von in 4-Stellung substituierten Steroidverbindungen von der allgemeinen Formel 
 EMI1.1 
 (worin R (H)OCOCH3, O. (H)COCH3, (H)COCH2OCOCH3 oder (OH)COCH2OCOCH3; R' H2. (H)OH oder 0 und   R"OH, Aeyloxy, Br, Cl   oder F bedeuten), ist bereits an anderer Stelle ein Verfahren beschrieben, welches darin besteht, dass man ein 4,   5-Epoxy-3-keto-Steroid   von der allgemeinen Formel 
 EMI1.2 
 oder 
 EMI1.3 
 (in welcher R und R'die oben genannte Bedeutung haben) in einem organischen Lösungsmittel mit 
 EMI1.4 
 

 <Desc/Clms Page number 2> 

 
 EMI2.1 
 
 EMI2.2 




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  Process for the preparation of substituted in 4-position
Steroid compounds For the preparation of 4-position substituted steroid compounds of the general formula
 EMI1.1
 (where R (H) OCOCH3, O. (H) COCH3, (H) COCH2OCOCH3 or (OH) COCH2OCOCH3; R 'H2. (H) OH or 0 and R "are OH, aeyloxy, Br, Cl or F), a process has already been described elsewhere, which consists in the fact that one is a 4,5-epoxy-3-keto-steroid of the general formula
 EMI1.2
 or
 EMI1.3
 (in which R and R 'have the meaning given above) in an organic solvent with
 EMI1.4
 

 <Desc / Clms Page number 2>

 
 EMI2.1
 
 EMI2.2

Claims (1)

B.PATENTANSPRUCH : Verfahren zur Herstellung von in 4-Stellung substituierten Steroidverbindungen der allgemeinen Formel EMI3.1 (worin R (H) OH, 0, (H) COCH3, (H) COCH2OH oder (OH)COCH2OH; R' H2, (H)OH oder 0 und R"OH oder Acyloxy bedeuten), dadurch gekennzeichnet, dass man ein 4&alpha;,5&alpha;- oder 4ss,5ss-Epoxy- - 3-keto-Steroid oder ein Gemisch beider Isomeren von der allgemeinen Formel EMI3.2 in einem organischen Lösungsmittel, insbesondere Benzol mit Bortrifluorid, vorzugsweise in Form seines Ätherates umsetzt. B. PATENT CLAIM: Process for the preparation of steroid compounds of the general formula substituted in the 4-position EMI3.1 (in which R (H) OH, 0, (H) COCH3, (H) COCH2OH or (OH) COCH2OH; R 'H2, (H) OH or 0 and R "are OH or acyloxy), characterized in that one 4α, 5α - or 4ss, 5ss-epoxy- 3-keto-steroid or a mixture of both isomers of the general formula EMI3.2 in an organic solvent, in particular benzene with boron trifluoride, preferably in the form of its etherate.
AT614656A 1956-03-29 1956-10-15 Process for the preparation of steroid compounds substituted in the 4-position AT212499B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT212499X 1956-03-29

Publications (1)

Publication Number Publication Date
AT212499B true AT212499B (en) 1960-12-27

Family

ID=11179025

Family Applications (1)

Application Number Title Priority Date Filing Date
AT614656A AT212499B (en) 1956-03-29 1956-10-15 Process for the preparation of steroid compounds substituted in the 4-position

Country Status (1)

Country Link
AT (1) AT212499B (en)

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