AR248010A1 - Process for the preparation of a biphenyl derivative - Google Patents

Process for the preparation of a biphenyl derivative

Info

Publication number
AR248010A1
AR248010A1 AR93324725A AR32472593A AR248010A1 AR 248010 A1 AR248010 A1 AR 248010A1 AR 93324725 A AR93324725 A AR 93324725A AR 32472593 A AR32472593 A AR 32472593A AR 248010 A1 AR248010 A1 AR 248010A1
Authority
AR
Argentina
Prior art keywords
preparation
formula
biphenyl derivative
halogen
biphenyl
Prior art date
Application number
AR93324725A
Other languages
Spanish (es)
Original Assignee
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Elf filed Critical Sanofi Elf
Application granted granted Critical
Publication of AR248010A1 publication Critical patent/AR248010A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DEL 4-METIL-2'-CIANO-BIFENILO DE FORMULA (I), SE HACE REACCIONAR, EN PRESENCIA DE UNA SAL MANGANOSA, UN HALOGENURO DE BENZONITRILO DE FORMULA (II) EN LA CUAL HAL REPRESENTA UN ATOMO DE HALOGENO, CON UN DERIVADO ORGANOMETALICO DE FORMULA (III), EN LA CUAL X ES HALOGENO, Y LUEGO SE HIDROLIZA EL COMPLEJO OBTENIDO, LO QUE PROVEE EL COMPUESTO DESEADO.PROCEDURE FOR THE PREPARATION OF 4-METHYL-2'-CYAN-BIPHENYL OF FORMULA (I), A HALOGENIDE OF BENZONITRILE OF FORMULA (II) IS REACTED IN WHICH IT REPRESENTS AN ATOM OF HALOGEN, WITH AN ORGANOMETALLIC DERIVATIVE OF FORMULA (III), IN WHICH X IS HALOGEN, AND THEN THE COMPLEX OBTAINED IS HYDROLYZED, WHICH PROVIDES THE DESIRED COMPOUND.

AR93324725A 1992-04-13 1993-04-13 Process for the preparation of a biphenyl derivative AR248010A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9204512A FR2689887B1 (en) 1992-04-13 1992-04-13 PROCESS FOR THE PREPARATION OF A BIPHENYL DERIVATIVE.

Publications (1)

Publication Number Publication Date
AR248010A1 true AR248010A1 (en) 1995-05-31

Family

ID=9428800

Family Applications (1)

Application Number Title Priority Date Filing Date
AR93324725A AR248010A1 (en) 1992-04-13 1993-04-13 Process for the preparation of a biphenyl derivative

Country Status (28)

Country Link
US (1) US5288895A (en)
EP (1) EP0566468B1 (en)
JP (1) JP2930827B2 (en)
KR (1) KR100283066B1 (en)
AR (1) AR248010A1 (en)
AT (1) ATE148101T1 (en)
AU (1) AU656263B2 (en)
BR (1) BR9301514A (en)
CA (1) CA2093723C (en)
CZ (1) CZ282559B6 (en)
DE (1) DE69307577T2 (en)
DK (1) DK0566468T3 (en)
ES (1) ES2097466T3 (en)
FI (1) FI103666B1 (en)
FR (1) FR2689887B1 (en)
HK (1) HK1001328A1 (en)
HU (1) HU212253B (en)
IL (1) IL105337A (en)
MX (1) MX9302123A (en)
MY (1) MY107763A (en)
NO (1) NO177637C (en)
NZ (1) NZ247372A (en)
PH (1) PH30349A (en)
RU (1) RU2102384C1 (en)
SK (1) SK280581B6 (en)
TW (1) TW225516B (en)
UA (1) UA27104C2 (en)
ZA (1) ZA932589B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2928982B2 (en) 1994-10-27 1999-08-03 住化ファインケム株式会社 Method for producing 4'-bromomethyl-2-cyanobiphenyl
DE19607135C1 (en) * 1996-02-26 1997-04-24 Great Lakes Chem Konstanz Gmbh Prodn. of asymmetric cyano-bi:phenyl cpds.
FR2753195B1 (en) * 1996-09-09 1998-11-27 Sanofi Sa PROCESS FOR THE PREPARATION OF A CYANOBIPHENYL
FR2753705B1 (en) 1996-09-20 1999-08-06 PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES
US5892094A (en) * 1997-01-08 1999-04-06 Sumika Fine Chemicals Co., Ltd. Process for preparing 4'-methyl-2-cyanobiphenyl
US5998652A (en) * 1997-01-21 1999-12-07 Sumika Fine Chemicals Co., Ltd. Process for preparing 2-cyanobiphenyl compound
US6194599B1 (en) 1997-04-08 2001-02-27 Catalytica, Inc. Process for preparing biaryl compounds
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
US6162922A (en) * 1998-01-30 2000-12-19 Bristol-Myers Squibb Co. Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst
FR2776658B3 (en) 1998-03-24 2000-05-26 Sanofi Sa METHYL-BIPHENYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE
US5874606A (en) * 1998-03-31 1999-02-23 Occidental Chemical Corporation Process for making o-arylbenzonitriles
EP0976736A1 (en) * 1998-07-29 2000-02-02 SUMIKA FINE CHEMICALS Co., Ltd. Production method of 2-(p-alkylphenyl)pyridine compound
US6962999B2 (en) * 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
ES2299616T3 (en) * 2002-06-12 2008-06-01 Sumitomo Chemical Company, Limited PROCEDURE TO PRODUCE 4'-BROMOMETIL-2-CIANOBIFELINO.
US7105467B2 (en) * 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
US7105707B2 (en) * 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
CN102964271B (en) * 2012-12-03 2014-05-14 齐鲁工业大学 Synthesis method of sartan anti-hypertensive medicament intermediate 2-cyan-4'-methyl diphenyl
CN103012201B (en) * 2012-12-03 2014-07-30 滕州市悟通香料有限责任公司 Synthetic method of 2-cyano-4'-methyl diphenyl
CN103012202B (en) * 2012-12-04 2014-10-08 山东鑫泉医药有限公司 Preparation method of sartanbiphenyl
CN103467341B (en) * 2013-08-29 2015-02-25 河南师范大学 Preparation method for 2-cyano-4'-methylbiphenyl
CN105017025B (en) * 2014-04-22 2018-06-12 浙江省化工研究院有限公司 The preparation method of one kind 4 '-chloro- 2 nitro biphenyl
CN104326938B (en) * 2014-10-22 2016-08-17 陕西煤业化工技术开发中心有限责任公司 A kind of method using benzimidazole ionic liquid to prepare sartanbiphenyl

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2590252B3 (en) * 1985-11-19 1988-09-09 Rolland Sa A NOVEL PROCESS FOR OBTAINING AMINONITRILES AND THEIR APPLICATIONS IN ORGANIC SYNTHESIS
DE3816120A1 (en) * 1988-05-11 1989-11-23 Bayer Ag METHOD FOR PRODUCING UNBALANCED BIARYL COMPOUNDS
GB9017480D0 (en) * 1990-08-09 1990-09-26 Ici Plc Chemical process
GB9017482D0 (en) * 1990-08-09 1990-09-26 Ici Plc Manufacturing process

Also Published As

Publication number Publication date
DK0566468T3 (en) 1997-07-07
DE69307577D1 (en) 1997-03-06
CZ60693A3 (en) 1994-01-19
RU2102384C1 (en) 1998-01-20
IL105337A (en) 1997-02-18
IL105337A0 (en) 1993-08-18
EP0566468A3 (en) 1995-02-15
FI103666B (en) 1999-08-13
SK280581B6 (en) 2000-04-10
NO931346L (en) 1993-10-14
MX9302123A (en) 1994-05-31
UA27104C2 (en) 2000-02-28
NO177637C (en) 1995-10-25
FR2689887B1 (en) 1995-06-23
BR9301514A (en) 1993-11-16
ES2097466T3 (en) 1997-04-01
CA2093723A1 (en) 1993-10-14
MY107763A (en) 1996-06-15
EP0566468A2 (en) 1993-10-20
AU656263B2 (en) 1995-01-27
FI931603A (en) 1993-10-14
FI931603A0 (en) 1993-04-08
HU9301070D0 (en) 1993-07-28
HK1001328A1 (en) 1998-06-12
NO931346D0 (en) 1993-04-07
JPH069536A (en) 1994-01-18
DE69307577T2 (en) 1997-07-24
CA2093723C (en) 2003-07-29
FI103666B1 (en) 1999-08-13
SK33593A3 (en) 1994-06-08
ZA932589B (en) 1994-10-13
CZ282559B6 (en) 1997-08-13
AU3676393A (en) 1993-10-14
NZ247372A (en) 1994-07-26
NO177637B (en) 1995-07-17
TW225516B (en) 1994-06-21
PH30349A (en) 1997-04-02
US5288895A (en) 1994-02-22
EP0566468B1 (en) 1997-01-22
HUT64005A (en) 1993-11-29
HU212253B (en) 1996-04-29
FR2689887A1 (en) 1993-10-15
JP2930827B2 (en) 1999-08-09
KR930021613A (en) 1993-11-22
KR100283066B1 (en) 2001-04-02
ATE148101T1 (en) 1997-02-15

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