FR2753705B1 - PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES - Google Patents

PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES

Info

Publication number
FR2753705B1
FR2753705B1 FR9611514A FR9611514A FR2753705B1 FR 2753705 B1 FR2753705 B1 FR 2753705B1 FR 9611514 A FR9611514 A FR 9611514A FR 9611514 A FR9611514 A FR 9611514A FR 2753705 B1 FR2753705 B1 FR 2753705B1
Authority
FR
France
Prior art keywords
preparation
methyl
formula
group
biphenyl derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9611514A
Other languages
French (fr)
Other versions
FR2753705A1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9611514A priority Critical patent/FR2753705B1/en
Application filed filed Critical
Priority to CA002265559A priority patent/CA2265559C/en
Priority to DE69709773T priority patent/DE69709773T2/en
Priority to JP51435398A priority patent/JP3604702B2/en
Priority to EP97919122A priority patent/EP0931057B1/en
Priority to AU43064/97A priority patent/AU4306497A/en
Priority to PCT/FR1997/001648 priority patent/WO1998012174A1/en
Priority to BRPI9713208-0A priority patent/BR9713208B1/en
Priority to US09/269,101 priority patent/US6407253B1/en
Priority to ES97919122T priority patent/ES2166990T3/en
Priority to AT97919122T priority patent/ATE209181T1/en
Publication of FR2753705A1 publication Critical patent/FR2753705A1/en
Priority to NO19991355A priority patent/NO326192B1/en
Application granted granted Critical
Publication of FR2753705B1 publication Critical patent/FR2753705B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The subject-matter of the invention is a process for the preparation of substituted 4-methylbiphenyls of general formula:in which R is a cyano group or a protected tetrazolyl group of formula:in which R1, situated at the 1 or 2 position of the tetrazolyl group, is a protective group, characterized in that a halobenzene of formula:in which Hal is a halogen atom and R has the same meaning as above, is reacted with a p-tolylmagnesium halide in the presence of a linear or branched polyether and of a catalyst comprising a transition metal.
FR9611514A 1996-09-20 1996-09-20 PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES Expired - Fee Related FR2753705B1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR9611514A FR2753705B1 (en) 1996-09-20 1996-09-20 PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES
US09/269,101 US6407253B1 (en) 1996-09-20 1997-09-17 Method for preparing 4-methyl-biphenyl derivatives
JP51435398A JP3604702B2 (en) 1996-09-20 1997-09-17 Method for producing 4-methyl-biphenyl derivative
EP97919122A EP0931057B1 (en) 1996-09-20 1997-09-17 Method for preparing 4-methyl-biphenyl derivatives
AU43064/97A AU4306497A (en) 1996-09-20 1997-09-17 Method for preparing 4-methyl-biphenyl derivatives
PCT/FR1997/001648 WO1998012174A1 (en) 1996-09-20 1997-09-17 Method for preparing 4-methyl-biphenyl derivatives
CA002265559A CA2265559C (en) 1996-09-20 1997-09-17 Method for preparing 4-methyl-biphenyl derivatives
DE69709773T DE69709773T2 (en) 1996-09-20 1997-09-17 METHOD FOR PRODUCING 4-METHYL-BIPHENYL DERIVATIVES
ES97919122T ES2166990T3 (en) 1996-09-20 1997-09-17 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 4-METHYL-BIFENYL.
AT97919122T ATE209181T1 (en) 1996-09-20 1997-09-17 METHOD FOR PRODUCING 4-METHYL-BIPHENYL DERIVATIVES
BRPI9713208-0A BR9713208B1 (en) 1996-09-20 1997-09-17 process for the preparation of 4-methyl biphenyl derivatives.
NO19991355A NO326192B1 (en) 1996-09-20 1999-03-19 Process for the preparation of 4-methyl-biphenyl derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9611514A FR2753705B1 (en) 1996-09-20 1996-09-20 PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES

Publications (2)

Publication Number Publication Date
FR2753705A1 FR2753705A1 (en) 1998-03-27
FR2753705B1 true FR2753705B1 (en) 1999-08-06

Family

ID=9495937

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9611514A Expired - Fee Related FR2753705B1 (en) 1996-09-20 1996-09-20 PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES

Country Status (12)

Country Link
US (1) US6407253B1 (en)
EP (1) EP0931057B1 (en)
JP (1) JP3604702B2 (en)
AT (1) ATE209181T1 (en)
AU (1) AU4306497A (en)
BR (1) BR9713208B1 (en)
CA (1) CA2265559C (en)
DE (1) DE69709773T2 (en)
ES (1) ES2166990T3 (en)
FR (1) FR2753705B1 (en)
NO (1) NO326192B1 (en)
WO (1) WO1998012174A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7332516B2 (en) * 2003-01-14 2008-02-19 Merck + Co., Inc. Geminally di-substituted NSAID derivatives as Aβ42 lowering agents
CN114733575B (en) * 2022-04-25 2024-04-09 浙江天宇药业股份有限公司 Palladium-supported molecular sieve catalyst and preparation method and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5270317A (en) 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
FR2689887B1 (en) 1992-04-13 1995-06-23 Sanofi Elf PROCESS FOR THE PREPARATION OF A BIPHENYL DERIVATIVE.
JPH08109143A (en) * 1994-08-17 1996-04-30 Asahi Glass Co Ltd Production of biphenyl compound
EP0788487B1 (en) * 1994-10-27 2001-07-25 Novartis AG Process for the preparation of tetrazoles
JP3763869B2 (en) * 1994-12-26 2006-04-05 東ソー・ファインケム株式会社 Method for producing biphenyl compound

Also Published As

Publication number Publication date
NO991355L (en) 1999-03-19
NO326192B1 (en) 2008-10-13
AU4306497A (en) 1998-04-14
JP3604702B2 (en) 2004-12-22
EP0931057A1 (en) 1999-07-28
BR9713208A (en) 2000-04-04
ES2166990T3 (en) 2002-05-01
BR9713208B1 (en) 2010-06-15
DE69709773T2 (en) 2002-08-08
EP0931057B1 (en) 2001-11-21
US6407253B1 (en) 2002-06-18
JP2000503025A (en) 2000-03-14
NO991355D0 (en) 1999-03-19
WO1998012174A1 (en) 1998-03-26
CA2265559A1 (en) 1998-03-26
DE69709773D1 (en) 2002-02-21
FR2753705A1 (en) 1998-03-27
CA2265559C (en) 2003-06-03
ATE209181T1 (en) 2001-12-15

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse