FR2753705B1 - PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES - Google Patents
PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVESInfo
- Publication number
- FR2753705B1 FR2753705B1 FR9611514A FR9611514A FR2753705B1 FR 2753705 B1 FR2753705 B1 FR 2753705B1 FR 9611514 A FR9611514 A FR 9611514A FR 9611514 A FR9611514 A FR 9611514A FR 2753705 B1 FR2753705 B1 FR 2753705B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- methyl
- formula
- group
- biphenyl derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The subject-matter of the invention is a process for the preparation of substituted 4-methylbiphenyls of general formula:in which R is a cyano group or a protected tetrazolyl group of formula:in which R1, situated at the 1 or 2 position of the tetrazolyl group, is a protective group, characterized in that a halobenzene of formula:in which Hal is a halogen atom and R has the same meaning as above, is reacted with a p-tolylmagnesium halide in the presence of a linear or branched polyether and of a catalyst comprising a transition metal.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9611514A FR2753705B1 (en) | 1996-09-20 | 1996-09-20 | PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES |
AU43064/97A AU4306497A (en) | 1996-09-20 | 1997-09-17 | Method for preparing 4-methyl-biphenyl derivatives |
ES97919122T ES2166990T3 (en) | 1996-09-20 | 1997-09-17 | PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 4-METHYL-BIFENYL. |
US09/269,101 US6407253B1 (en) | 1996-09-20 | 1997-09-17 | Method for preparing 4-methyl-biphenyl derivatives |
CA002265559A CA2265559C (en) | 1996-09-20 | 1997-09-17 | Method for preparing 4-methyl-biphenyl derivatives |
BRPI9713208-0A BR9713208B1 (en) | 1996-09-20 | 1997-09-17 | process for the preparation of 4-methyl biphenyl derivatives. |
JP51435398A JP3604702B2 (en) | 1996-09-20 | 1997-09-17 | Method for producing 4-methyl-biphenyl derivative |
AT97919122T ATE209181T1 (en) | 1996-09-20 | 1997-09-17 | METHOD FOR PRODUCING 4-METHYL-BIPHENYL DERIVATIVES |
DE69709773T DE69709773T2 (en) | 1996-09-20 | 1997-09-17 | METHOD FOR PRODUCING 4-METHYL-BIPHENYL DERIVATIVES |
PCT/FR1997/001648 WO1998012174A1 (en) | 1996-09-20 | 1997-09-17 | Method for preparing 4-methyl-biphenyl derivatives |
EP97919122A EP0931057B1 (en) | 1996-09-20 | 1997-09-17 | Method for preparing 4-methyl-biphenyl derivatives |
NO19991355A NO326192B1 (en) | 1996-09-20 | 1999-03-19 | Process for the preparation of 4-methyl-biphenyl derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9611514A FR2753705B1 (en) | 1996-09-20 | 1996-09-20 | PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2753705A1 FR2753705A1 (en) | 1998-03-27 |
FR2753705B1 true FR2753705B1 (en) | 1999-08-06 |
Family
ID=9495937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9611514A Expired - Fee Related FR2753705B1 (en) | 1996-09-20 | 1996-09-20 | PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES |
Country Status (12)
Country | Link |
---|---|
US (1) | US6407253B1 (en) |
EP (1) | EP0931057B1 (en) |
JP (1) | JP3604702B2 (en) |
AT (1) | ATE209181T1 (en) |
AU (1) | AU4306497A (en) |
BR (1) | BR9713208B1 (en) |
CA (1) | CA2265559C (en) |
DE (1) | DE69709773T2 (en) |
ES (1) | ES2166990T3 (en) |
FR (1) | FR2753705B1 (en) |
NO (1) | NO326192B1 (en) |
WO (1) | WO1998012174A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004064771A2 (en) * | 2003-01-14 | 2004-08-05 | Merck & Co., Inc. | Geminally di-substituted nsaid derivatives as abeta 42 lowering agents |
CN114733575B (en) * | 2022-04-25 | 2024-04-09 | 浙江天宇药业股份有限公司 | Palladium-supported molecular sieve catalyst and preparation method and application thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
US5270317A (en) | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
US5252753A (en) * | 1991-11-01 | 1993-10-12 | Ortho Pharmaceutical Corporation | Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof |
FR2689887B1 (en) | 1992-04-13 | 1995-06-23 | Sanofi Elf | PROCESS FOR THE PREPARATION OF A BIPHENYL DERIVATIVE. |
JPH08109143A (en) * | 1994-08-17 | 1996-04-30 | Asahi Glass Co Ltd | Production of biphenyl compound |
PT788487E (en) * | 1994-10-27 | 2001-11-30 | Novartis Ag | PROCESS FOR THE PREPARATION OF TETRAZOLES |
JP3763869B2 (en) * | 1994-12-26 | 2006-04-05 | 東ソー・ファインケム株式会社 | Method for producing biphenyl compound |
-
1996
- 1996-09-20 FR FR9611514A patent/FR2753705B1/en not_active Expired - Fee Related
-
1997
- 1997-09-17 BR BRPI9713208-0A patent/BR9713208B1/en not_active IP Right Cessation
- 1997-09-17 EP EP97919122A patent/EP0931057B1/en not_active Expired - Lifetime
- 1997-09-17 AT AT97919122T patent/ATE209181T1/en active
- 1997-09-17 AU AU43064/97A patent/AU4306497A/en not_active Abandoned
- 1997-09-17 CA CA002265559A patent/CA2265559C/en not_active Expired - Lifetime
- 1997-09-17 ES ES97919122T patent/ES2166990T3/en not_active Expired - Lifetime
- 1997-09-17 DE DE69709773T patent/DE69709773T2/en not_active Expired - Lifetime
- 1997-09-17 US US09/269,101 patent/US6407253B1/en not_active Expired - Lifetime
- 1997-09-17 JP JP51435398A patent/JP3604702B2/en not_active Expired - Lifetime
- 1997-09-17 WO PCT/FR1997/001648 patent/WO1998012174A1/en active IP Right Grant
-
1999
- 1999-03-19 NO NO19991355A patent/NO326192B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2753705A1 (en) | 1998-03-27 |
WO1998012174A1 (en) | 1998-03-26 |
ATE209181T1 (en) | 2001-12-15 |
DE69709773D1 (en) | 2002-02-21 |
ES2166990T3 (en) | 2002-05-01 |
NO991355L (en) | 1999-03-19 |
NO991355D0 (en) | 1999-03-19 |
US6407253B1 (en) | 2002-06-18 |
AU4306497A (en) | 1998-04-14 |
BR9713208A (en) | 2000-04-04 |
DE69709773T2 (en) | 2002-08-08 |
JP2000503025A (en) | 2000-03-14 |
CA2265559A1 (en) | 1998-03-26 |
CA2265559C (en) | 2003-06-03 |
EP0931057A1 (en) | 1999-07-28 |
EP0931057B1 (en) | 2001-11-21 |
BR9713208B1 (en) | 2010-06-15 |
JP3604702B2 (en) | 2004-12-22 |
NO326192B1 (en) | 2008-10-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |