AR133025A2 - Antibody constructs for DLL3 and CD3 - Google Patents

Antibody constructs for DLL3 and CD3

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Publication number
AR133025A2
AR133025A2 ARP240101586A ARP240101586A AR133025A2 AR 133025 A2 AR133025 A2 AR 133025A2 AR P240101586 A ARP240101586 A AR P240101586A AR P240101586 A ARP240101586 A AR P240101586A AR 133025 A2 AR133025 A2 AR 133025A2
Authority
AR
Argentina
Prior art keywords
antibody construct
dll3
polynucleotide
antibody constructs
binds
Prior art date
Application number
ARP240101586A
Other languages
Spanish (es)
Inventor
Elisabeth Nahrwold
Ralf Lutterbuese
Patrick Hoffmann
Christoph Dahlhoff
Claudia Bluemel
Jochen Pendzialek
Peter Kufer
Tobias Raum
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of AR133025A2 publication Critical patent/AR133025A2/en

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Abstract

La presente invención se refiere a un constructo de anticuerpo biespecífico que comprende un primer dominio de unión que se une a DLL3 humana en la superficie de una célula diana y un segundo dominio de unión que se une a CD3 humano en la superficie de una célula T. Más aún, la invención provee un polinucleótido que codifica el constructo de anticuerpo, un vector que comprende dicho polinucleótido y una célula hospedante transformada o transfectada con dicho polinucleótido o vector. Además, la invención provee un polinucleótido que codifica el constructo de anticuerpo de la invención, un uso médico de dicho constructo de anticuerpo y un kit que comprende dicho constructo de anticuerpo.The present invention relates to a bispecific antibody construct comprising a first binding domain that binds to human DLL3 on the surface of a target cell and a second binding domain that binds to human CD3 on the surface of a T cell. Furthermore, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide, and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a polynucleotide encoding the antibody construct of the invention, a medical use of said antibody construct, and a kit comprising said antibody construct.

ARP240101586A 2015-07-31 2024-06-19 Antibody constructs for DLL3 and CD3 AR133025A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562199930P 2015-07-31 2015-07-31
US202062290896P 2020-02-03 2020-02-03

Publications (1)

Publication Number Publication Date
AR133025A2 true AR133025A2 (en) 2025-08-20

Family

ID=96877967

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP240101586A AR133025A2 (en) 2015-07-31 2024-06-19 Antibody constructs for DLL3 and CD3
ARP240101587A AR133026A2 (en) 2015-07-31 2024-06-19 Antibody constructs for DLL3 and CD3

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP240101587A AR133026A2 (en) 2015-07-31 2024-06-19 Antibody constructs for DLL3 and CD3

Country Status (1)

Country Link
AR (2) AR133025A2 (en)

Also Published As

Publication number Publication date
AR133026A2 (en) 2025-08-20

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