AR105558A1 - ANTIBODY CONSTRUCTS FOR DLL3 AND CD3 - Google Patents

ANTIBODY CONSTRUCTS FOR DLL3 AND CD3

Info

Publication number
AR105558A1
AR105558A1 ARP160102337A ARP160102337A AR105558A1 AR 105558 A1 AR105558 A1 AR 105558A1 AR P160102337 A ARP160102337 A AR P160102337A AR P160102337 A ARP160102337 A AR P160102337A AR 105558 A1 AR105558 A1 AR 105558A1
Authority
AR
Argentina
Prior art keywords
antibody construct
dll3
polynucleotide
antibody constructs
binds
Prior art date
Application number
ARP160102337A
Other languages
Spanish (es)
Inventor
Nahrwold Elisabeth
Lutterbuese Ralf
Hoffmann Patrick
Dahlhoff Christoph
Bluemel Claudia
Pendzialek Jochen
Kufer Peter
Raum Tobias
Original Assignee
Amgen Res (Munich) Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res (Munich) Gmbh filed Critical Amgen Res (Munich) Gmbh
Publication of AR105558A1 publication Critical patent/AR105558A1/en

Links

Abstract

La presente solicitud se refiere a un constructo de anticuerpo biespecífico que comprende un primer dominio de unión que se une a DLL3 humana en la superficie de una célula diana y un segundo dominio de unión que se une a CD3 humano en la superficie de una célula T. Además, la solicitud provee un polinucleótido que codifica el constructo de anticuerpo, un vector que comprende dicho polinucleótido y una célula hospedante transformada o transfectada con dicho polinucleótido o vector. Adicionalmente, la solicitud provee un proceso para la producción del constructo de anticuerpo de la solicitud, un uso médico de dicho constructo de anticuerpo y un kit que comprende dicho constructo de anticuerpo.The present application relates to a bispecific antibody construct comprising a first binding domain that binds to human DLL3 on the surface of a target cell and a second binding domain that binds to human CD3 on the surface of a T cell In addition, the application provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Additionally, the application provides a process for the production of the antibody construct of the application, a medical use of said antibody construct and a kit comprising said antibody construct.

ARP160102337A 2015-07-31 2016-08-01 ANTIBODY CONSTRUCTS FOR DLL3 AND CD3 AR105558A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562199930P 2015-07-31 2015-07-31

Publications (1)

Publication Number Publication Date
AR105558A1 true AR105558A1 (en) 2017-10-18

Family

ID=60245273

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102337A AR105558A1 (en) 2015-07-31 2016-08-01 ANTIBODY CONSTRUCTS FOR DLL3 AND CD3

Country Status (1)

Country Link
AR (1) AR105558A1 (en)

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