AR128719A1 - PRODUCCIÓN CROMATOGRÁFICA DE AFINIDAD DE PRODUCTOS CLÍNICOS DE IgG HUMANA - Google Patents
PRODUCCIÓN CROMATOGRÁFICA DE AFINIDAD DE PRODUCTOS CLÍNICOS DE IgG HUMANAInfo
- Publication number
- AR128719A1 AR128719A1 ARP230100562A ARP230100562A AR128719A1 AR 128719 A1 AR128719 A1 AR 128719A1 AR P230100562 A ARP230100562 A AR P230100562A AR P230100562 A ARP230100562 A AR P230100562A AR 128719 A1 AR128719 A1 AR 128719A1
- Authority
- AR
- Argentina
- Prior art keywords
- igg
- affinity
- subclass
- bound
- protein
- Prior art date
Links
- 239000003446 ligand Substances 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 239000012501 chromatography medium Substances 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 108010074864 Factor XI Proteins 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Se proporciona un método cromatográfico de afinidad para preparar a partir de un material de partida que contiene IgG una formulación de IgG que incluye una o más de IgG1, IgG2, IgG3 e IgG4. Un método de la invención incluye poner en contacto el material de partida que contiene IgG con un primer medio cromatográfico que incluye un primer soporte sólido que tiene proteína A unida al mismo, formando una fracción unida a proteína A de una subclase de IgG con afinidad de unión a proteína A y formando un primer flujo continuo incluyendo una subclase de IgG que no se une a la proteína A; y poner en contacto el primer flujo continuo con un primer medio cromatográfico de ligando de afinidad que incluye un segundo soporte sólido que tiene un primer ligando de afinidad con afinidad de unión a IgG unido al mismo, formando una primera subclase de IgG unida a ligando de afinidad y un segundo flujo continuo que incluye una subclase de IgG no unida a la primera subclase de IgG unida a ligando de afinidad. Reivindicación 43: Una solución de IgG acuosa que comprende al menos aproximadamente 99,5% de IgG y menos de aproximadamente 0,5% de impurezas donde la solución de IgG acuosa comprende Factor XI como una impureza en una actividad de menos de aproximadamente 0,0025 E/mg de IgG total, preferentemente menos de aproximadamente 0,0020 E/mg de IgG total, más preferentemente menos de aproximadamente 0,0015 E/mg de IgG total y con la máxima preferencia menos de aproximadamente 0,0012 E/mg de IgG total.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263317456P | 2022-03-07 | 2022-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR128719A1 true AR128719A1 (es) | 2024-06-05 |
Family
ID=85726553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230100562A AR128719A1 (es) | 2022-03-07 | 2023-03-07 | PRODUCCIÓN CROMATOGRÁFICA DE AFINIDAD DE PRODUCTOS CLÍNICOS DE IgG HUMANA |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR128719A1 (es) |
| AU (1) | AU2023230335A1 (es) |
| TW (1) | TW202342522A (es) |
| WO (1) | WO2023170553A1 (es) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US477A (en) | 1837-11-23 | Coitstbttctiost | ||
| US9782A (en) | 1853-06-14 | george frederick | ||
| SE348942B (es) | 1970-06-02 | 1972-09-18 | Statens Bakteriologiska Labor | |
| EP1027439B1 (en) | 1997-10-27 | 2010-03-17 | Bac Ip B.V. | Multivalent antigen-binding proteins |
| DE60013767T3 (de) | 1999-01-19 | 2009-07-09 | Unilever N.V. | Verfahren zur herstellung von antikörperfragmenten |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| WO2008113589A1 (en) | 2007-03-20 | 2008-09-25 | Csl Behring Gmbh | Methods for industrial scale production of therapeutic complement factor h preparations from human plasma |
| SG176256A1 (en) | 2009-05-27 | 2012-01-30 | Baxter Int | A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use |
| WO2011011753A1 (en) | 2009-07-23 | 2011-01-27 | Baxter International Inc. | Manufacture of factor h (fh) and fh-derivatives from plasma |
| US8945895B2 (en) | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
| AU2010202125B1 (en) | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| US8772462B2 (en) | 2010-05-26 | 2014-07-08 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
| EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| SG10201709131UA (en) | 2013-03-08 | 2017-12-28 | Genzyme Corp | Continuous purification of therapeutic proteins |
| CA3084827A1 (en) | 2017-12-29 | 2019-07-04 | Baxalta Incorporated | Adeno-associated virus purification methods |
-
2023
- 2023-03-06 WO PCT/IB2023/052096 patent/WO2023170553A1/en active Application Filing
- 2023-03-06 TW TW112108082A patent/TW202342522A/zh unknown
- 2023-03-06 AU AU2023230335A patent/AU2023230335A1/en active Pending
- 2023-03-07 AR ARP230100562A patent/AR128719A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW202342522A (zh) | 2023-11-01 |
| AU2023230335A1 (en) | 2024-08-29 |
| WO2023170553A1 (en) | 2023-09-14 |
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