AR127877A2 - RNAi COMPOSITIONS OF COMPLEMENT C5 COMPONENT AND METHODS FOR ITS USE - Google Patents
RNAi COMPOSITIONS OF COMPLEMENT C5 COMPONENT AND METHODS FOR ITS USEInfo
- Publication number
- AR127877A2 AR127877A2 ARP220103340A ARP220103340A AR127877A2 AR 127877 A2 AR127877 A2 AR 127877A2 AR P220103340 A ARP220103340 A AR P220103340A AR P220103340 A ARP220103340 A AR P220103340A AR 127877 A2 AR127877 A2 AR 127877A2
- Authority
- AR
- Argentina
- Prior art keywords
- methods
- complement
- component
- rnai
- compositions
- Prior art date
Links
- 108091030071 RNAI Proteins 0.000 title abstract 3
- 230000009368 gene silencing by RNA Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 102100031506 Complement C5 Human genes 0.000 title 1
- 108010028773 Complement C5 Proteins 0.000 title 1
- 230000000295 complement effect Effects 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 1
- 101150069146 C5 gene Proteins 0.000 abstract 1
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 abstract 1
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- -1 for example Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 abstract 1
- 229920002477 rna polymer Polymers 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Abstract
La invención se relaciona con ARNi, por ejemplo, composiciones de ácido ribonucleico de hebra doble (ARNhd), dirigido al gen del componente del complemento C5, y métodos para usar dicho ARNi, por ejemplo, ARNhd, composiciones para inhibir la expresión de C5 y para tratar sujetos que tienen una enfermedad asociada con el componente del complemento C5, por ejemplo, hemoglobinuria paroxística nocturna.The invention relates to RNAi, for example, compositions of double-stranded ribonucleic acid (hdRNA), targeting the complement component C5 gene, and methods of using said RNAi, for example, dsRNA, compositions for inhibiting the expression of C5 and to treat subjects who have a disease associated with complement component C5, for example, paroxysmal nocturnal hemoglobinuria.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782531P | 2013-03-14 | 2013-03-14 | |
| US202061942367P | 2020-02-20 | 2020-02-20 | |
| US202061837399P | 2020-06-20 | 2020-06-20 | |
| US202061904579P | 2020-11-15 | 2020-11-15 | |
| US202061912777P | 2020-12-06 | 2020-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR127877A2 true AR127877A2 (en) | 2024-03-06 |
Family
ID=90556500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220103340A AR127877A2 (en) | 2013-03-14 | 2022-12-06 | RNAi COMPOSITIONS OF COMPLEMENT C5 COMPONENT AND METHODS FOR ITS USE |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR127877A2 (en) |
-
2022
- 2022-12-06 AR ARP220103340A patent/AR127877A2/en unknown
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