AR124626A1 - A SCREENING METHOD FOR DIAGNOSING GROWTH HORMONE DEFICIENCY IN PEDIATRIC PATIENTS USING MACIMORELIN - Google Patents
A SCREENING METHOD FOR DIAGNOSING GROWTH HORMONE DEFICIENCY IN PEDIATRIC PATIENTS USING MACIMORELINInfo
- Publication number
- AR124626A1 AR124626A1 ARP210102035A ARP210102035A AR124626A1 AR 124626 A1 AR124626 A1 AR 124626A1 AR P210102035 A ARP210102035 A AR P210102035A AR P210102035 A ARP210102035 A AR P210102035A AR 124626 A1 AR124626 A1 AR 124626A1
- Authority
- AR
- Argentina
- Prior art keywords
- growth hormone
- macimorelin
- pediatric patients
- blood sample
- hormone deficiency
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/61—Growth hormones [GH] (Somatotropin)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Physiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se relaciona con un método de detección para diagnosticar una deficiencia en la hormona del crecimiento en pacientes pediátricos utilizando macimorelina. La presente invención proporciona además la sustancia macimorelina para su utilización en el diagnóstico de la deficiencia de la hormona del crecimiento en pacientes pediátricos. El método comprende proporcionar al menos una muestra de sangre, tomada de un sujeto dentro de un intervalo de aproximadamente 15 a aproximadamente 100 minutos después de una administración de una cantidad de macimorelina eficaz para inducir la secreción de la hormona del crecimiento, medir el nivel de la hormona del crecimiento de cada muestra de sangre, comparar el nivel medido de la hormona del crecimiento con un valor umbral único, diagnosticar si el sujeto sufre de deficiencia de la hormona del crecimiento o no en función de la comparación del nivel de la hormona del crecimiento con dicho valor umbral único en dicha al menos una muestra de sangre. El método de la invención es una prueba independiente y no necesita ser repetida y no se requiere ninguna prueba alternativa de estimulación de la hormona del crecimiento para realizar un diagnóstico confiable en pacientes pediátricos.The present invention relates to a detection method for diagnosing growth hormone deficiency in pediatric patients using macimorelin. The present invention further provides the substance macimorelin for use in the diagnosis of growth hormone deficiency in pediatric patients. The method comprises providing at least one blood sample, taken from a subject within an interval of about 15 to about 100 minutes after administration of an amount of macimorelin effective to induce growth hormone secretion, measuring the level of growth hormone from each blood sample, comparing the measured level of growth hormone to a single threshold value, diagnosing whether or not the subject is growth hormone deficient based on comparison of growth hormone level growth with said single threshold value in said at least one blood sample. The method of the invention is a standalone test and does not need to be repeated and no alternative growth hormone stimulation test is required to make a reliable diagnosis in pediatric patients.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2020/070691 WO2022017599A1 (en) | 2020-07-22 | 2020-07-22 | A screening method for diagnosing growth hormone deficiency in pediatric patients by using macimorelin |
Publications (1)
Publication Number | Publication Date |
---|---|
AR124626A1 true AR124626A1 (en) | 2023-04-19 |
Family
ID=71784051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210102035A AR124626A1 (en) | 2020-07-22 | 2021-07-20 | A SCREENING METHOD FOR DIAGNOSING GROWTH HORMONE DEFICIENCY IN PEDIATRIC PATIENTS USING MACIMORELIN |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP4185866A1 (en) |
JP (1) | JP2023535000A (en) |
KR (1) | KR102635025B1 (en) |
CN (1) | CN114258492A (en) |
AR (1) | AR124626A1 (en) |
AU (1) | AU2020460118A1 (en) |
CA (1) | CA3185680A1 (en) |
IL (1) | IL299918A (en) |
MX (1) | MX2023000935A (en) |
TW (1) | TW202219511A (en) |
WO (1) | WO2022017599A1 (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK287169B6 (en) | 2000-06-13 | 2010-02-08 | Zentaris Ag | Compounds increased growth hormone secretion, pharmaceutical compositions comprising thereof and their use |
GB0603295D0 (en) | 2006-02-18 | 2006-03-29 | Ardana Bioscience Ltd | Methods and kits |
CN105209055A (en) * | 2013-03-11 | 2015-12-30 | 阿穆尼克斯运营公司 | Treatment of pediatric growth hormone deficiency with human growth hormone analogues |
CN106310229A (en) * | 2015-06-30 | 2017-01-11 | 深圳翰宇药业股份有限公司 | Macimorelin film coated tablet and preparation method thereof |
US10288629B1 (en) | 2017-12-19 | 2019-05-14 | Aeterna Zentaris, Inc. | Method of assessing growth hormone deficiency in humans by a macimorelin containing composition |
-
2020
- 2020-07-22 JP JP2023504173A patent/JP2023535000A/en active Pending
- 2020-07-22 CN CN202080006891.5A patent/CN114258492A/en active Pending
- 2020-07-22 AU AU2020460118A patent/AU2020460118A1/en active Pending
- 2020-07-22 IL IL299918A patent/IL299918A/en unknown
- 2020-07-22 MX MX2023000935A patent/MX2023000935A/en unknown
- 2020-07-22 CA CA3185680A patent/CA3185680A1/en active Pending
- 2020-07-22 EP EP20745175.8A patent/EP4185866A1/en active Pending
- 2020-07-22 KR KR1020217043189A patent/KR102635025B1/en active IP Right Grant
- 2020-07-22 WO PCT/EP2020/070691 patent/WO2022017599A1/en unknown
-
2021
- 2021-06-23 TW TW110122905A patent/TW202219511A/en unknown
- 2021-07-20 AR ARP210102035A patent/AR124626A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN114258492A (en) | 2022-03-29 |
AU2020460118A1 (en) | 2023-02-02 |
WO2022017599A1 (en) | 2022-01-27 |
KR102635025B1 (en) | 2024-02-07 |
KR20220015466A (en) | 2022-02-08 |
TW202219511A (en) | 2022-05-16 |
JP2023535000A (en) | 2023-08-15 |
EP4185866A1 (en) | 2023-05-31 |
CA3185680A1 (en) | 2022-01-27 |
MX2023000935A (en) | 2023-02-22 |
IL299918A (en) | 2023-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Cosquéric et al. | Sarcopenia is predictive of nosocomial infection in care of the elderly | |
Reid | Evaluation of model systems for study of airway epithelium, cilia, and mucus | |
Sasano et al. | Application of umami taste stimulation to remedy hypogeusia based on reflex salivation | |
EP3232910A1 (en) | Method and apparatus for use in allergy testing | |
Pollock et al. | Peripheral nerve morphometry in myotonic dystrophy | |
Puonti et al. | How to assess sensory recovery after breast reconstruction surgery? | |
Sharma et al. | Comparison of accuracy of age estimation in Indian children by measurement of open apices in teeth with the London Atlas of tooth development | |
Kempf et al. | Evaluation of esophageal high-resolution manometry in awake and sedated dogs | |
Schwitzer et al. | Commentary: Anatomical constitution of sense organs as a marker of mental disorders | |
Prince et al. | Evaluation of the risk of noise-induced hearing loss among unscreened male industrial workers | |
AR124626A1 (en) | A SCREENING METHOD FOR DIAGNOSING GROWTH HORMONE DEFICIENCY IN PEDIATRIC PATIENTS USING MACIMORELIN | |
Manley | Frequency response of the ear of the Tokay gecko | |
MD3729100T2 (en) | Method of assessing growth hormone deficiency in humans by a macimorelin containing composition | |
Bourne et al. | The permeability of the corneal endothelium to fluorescein in the normal human eye | |
Maurer et al. | A rat in vitro model for the measurement of multiple excitability properties of cutaneous axons | |
Sordillo et al. | A novel approach to Paget's disease diagnosis and monitoring using near-infrared absorption spectroscopy | |
Pincus et al. | A quantitative method for the bioassay of progestin | |
Chemaitilly et al. | Assessing short-statured children for growth hormone deficiency | |
Moëll et al. | Blunted pubertal growth after leukemia: a new pattern of growth hormone insufficiency | |
Palmer et al. | Endocrine analysis of childhood monorchism | |
Abbas et al. | Salivary Cortisol Level Pre and Post MRI Scanning | |
Caballero et al. | Placement of pH-monitoring probes using height-related formulas. Is it an applicable method to adults? | |
Aykal et al. | Assessment of Ovarian Reserve in Patients with Migraine | |
Ragavan et al. | Evaluation of shunt flow through a hydrocephalic shunt: a controlled model for evaluation of the performance using Shuntcheck. 1–4 | |
Miah | PWE-094 Achalasia subtype classification based on liquid swallow and solid swallow |