AR124188A1 - Antígenos nuevos - Google Patents

Antígenos nuevos

Info

Publication number
AR124188A1
AR124188A1 ARP210103313A ARP210103313A AR124188A1 AR 124188 A1 AR124188 A1 AR 124188A1 AR P210103313 A ARP210103313 A AR P210103313A AR P210103313 A ARP210103313 A AR P210103313A AR 124188 A1 AR124188 A1 AR 124188A1
Authority
AR
Argentina
Prior art keywords
fimh
amino acid
acid sequence
fragment
fusion
Prior art date
Application number
ARP210103313A
Other languages
English (en)
Inventor
Roberto Adamo
Roberta Cozzi
Adele Fantoni
Sanjay Phogat
Roberto Rosini
Maria Scarselli
Newton Wahome
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of AR124188A1 publication Critical patent/AR124188A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención está dirigida a polipéptidos FimH modificados nuevos, ácidos nucleicos que los codifican y el uso de polipéptidos y ácidos nucleicos en el tratamiento y/o la prevención de enfermedades, en particular, las infecciones del tracto urinario (UTI). Reivindicación 1: Un péptido que tiene una secuencia de aminoácidos que comprende o consiste en lo siguiente: (a) FimH; o una variante, fragmento y/o fusión de FimH y (b) una secuencia de aminoácido que complementa la cadena donante, caracterizado porque (b) está secuencia abajo de (a). Reivindicación 2: Un polipéptido que comprende o consiste en una secuencia de aminoácidos X-(a)-L-(b)-Y, caracterizado porque “(a)” es un polipéptido FimH; o una variante, fragmento y/o fusión de FimH; “L” es un primer conector; “(b)” es una secuencia de aminoácidos complementaria de la cadena donante, “X” es una secuencia opcional N-terminal; “Y es una secuencia opcional C-terminal, donde “Y” no se deriva de FimC o FimH o un fragmento de estos.
ARP210103313A 2020-12-02 2021-11-30 Antígenos nuevos AR124188A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20211337 2020-12-02

Publications (1)

Publication Number Publication Date
AR124188A1 true AR124188A1 (es) 2023-02-22

Family

ID=73694911

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210103313A AR124188A1 (es) 2020-12-02 2021-11-30 Antígenos nuevos

Country Status (1)

Country Link
AR (1) AR124188A1 (es)

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