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Application filed by Denali Therapeutics IncfiledCriticalDenali Therapeutics Inc
Publication of AR120892A1publicationCriticalpatent/AR120892A1/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
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Abstract
Se proporcionan en la presente variantes de progranulina y proteínas de fusión que comprenden una variante de progranulina y un polipéptido Fc. También se proporcionan en la presente métodos para el uso de dichas proteínas para el tratamiento de trastornos asociados con la progranulina (por ejemplo, una enfermedad neurodegenerativa, tal como demencia frontotemporal (FTD)). Una variante de progranulina que comprende una secuencia que tiene al menos 90% de identidad con la SEQ ID Nº 2 y una secuencia definida mediante X¹X²X³ en las posiciones correspondientes a los residuos 574 a 576 de la SEQ ID Nº 2, donde cada uno de X¹, X² y X³ es independientemente un aminoácido y juntos no son QLL.Progranulin variants and fusion proteins comprising a progranulin variant and an Fc polypeptide are provided herein. Also provided herein are methods of using such proteins for the treatment of progranulin-associated disorders (eg, a neurodegenerative disease, such as frontotemporal dementia (FTD)). A progranulin variant comprising a sequence having at least 90% identity to SEQ ID No. 2 and a sequence defined by X¹X²X³ at positions corresponding to residues 574 to 576 of SEQ ID No. 2, where each of X¹ , X² and X³ is independently an amino acid and together they are not QLL.
Method for producing oxalate oxidases having optical activity near physiological pH and use of such recombinant oxalate oxidases in the treatment of oxalate-related diseases
VARIOUS POLYPEPTIDES DIVIDING TOXINS FROM FUSARIUM, ADDITIVE CONTAINING THESE VARIATIONS AND THEIR USE, AS WELL AS PROCEDURES FOR DIVISION OF TOXINS FROM FUSARIUM