AR118658A2 - COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF THE ALAS1 GENE - Google Patents
COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF THE ALAS1 GENEInfo
- Publication number
- AR118658A2 AR118658A2 ARP200101035A ARP200101035A AR118658A2 AR 118658 A2 AR118658 A2 AR 118658A2 AR P200101035 A ARP200101035 A AR P200101035A AR P200101035 A ARP200101035 A AR P200101035A AR 118658 A2 AR118658 A2 AR 118658A2
- Authority
- AR
- Argentina
- Prior art keywords
- alas1
- dsrna
- expression
- compositions
- seq
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Composiciones de ácido ribonucleico bicatenario (dsARN) opcionalmente conjugados a un ligando tal como n-acetilgalactosamina. Los dsARN dirigidas al gen ALAS1. Métodos de uso de tales composiciones de dsARN para alterar (por ejemplo, inhibir) la expresión de ALAS1, tal como tratamientos de sujetos con porfiria. Reivindicación 1: Un ácido ribonucleico bicatenario (dsARN) para inhibir la expresión de ALAS1, en donde dicho dsARN comprende una cadena con sentido y una cadena antisentido, donde la cadena antisentido comprende una región de complementariedad con un transcripto de ARN de ALAS1 (por ejemplo, SEQ ID Nº 1), cuya cadena antisentido comprende al menos 20 nucleótidos contiguos de la secuencia antisentido de UAAGAUGAGACACUCUUUCUGGU (SEQ ID Nº 4153) o UAAGAUGAGACACUCTUUCUGGU (SEQ ID Nº 4154).Double stranded ribonucleic acid (dsRNA) compositions optionally conjugated to a ligand such as n-acetylgalactosamine. The dsRNAs directed to the ALAS1 gene. Methods of using such dsRNA compositions to alter (eg, inhibit) ALAS1 expression, such as treatments of subjects with porphyria. Claim 1: A double stranded ribonucleic acid (dsRNA) for inhibiting the expression of ALAS1, wherein said dsRNA comprises a sense strand and an antisense strand, where the antisense strand comprises a region of complementarity with an ALAS1 RNA transcript (for example , SEQ ID No. 1), whose antisense chain comprises at least 20 contiguous nucleotides of the antisense sequence of UAAGAUGAGACACUCUUUCUGGU (SEQ ID No. 4153) or UAAGAUGAGACACUCTUUCUGGU (SEQ ID No. 4154).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361887288P | 2013-10-04 | 2013-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR118658A2 true AR118658A2 (en) | 2021-10-20 |
Family
ID=58698725
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140103699A AR097920A1 (en) | 2013-10-04 | 2014-10-03 | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF GENE SINTASA 1 OF 5-AMINOLEVULIN ACID (ALAS1) |
ARP200101035A AR118658A2 (en) | 2013-10-04 | 2020-04-13 | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF THE ALAS1 GENE |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140103699A AR097920A1 (en) | 2013-10-04 | 2014-10-03 | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF GENE SINTASA 1 OF 5-AMINOLEVULIN ACID (ALAS1) |
Country Status (2)
Country | Link |
---|---|
AR (2) | AR097920A1 (en) |
MA (1) | MA39000B1 (en) |
-
2014
- 2014-10-03 AR ARP140103699A patent/AR097920A1/en unknown
- 2014-10-03 MA MA39000A patent/MA39000B1/en unknown
-
2020
- 2020-04-13 AR ARP200101035A patent/AR118658A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR097920A1 (en) | 2016-04-20 |
MA39000B1 (en) | 2018-12-31 |
MA39000A1 (en) | 2018-05-31 |
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