AR097920A1 - COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF GENE SINTASA 1 OF 5-AMINOLEVULIN ACID (ALAS1) - Google Patents
COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF GENE SINTASA 1 OF 5-AMINOLEVULIN ACID (ALAS1)Info
- Publication number
- AR097920A1 AR097920A1 ARP140103699A ARP140103699A AR097920A1 AR 097920 A1 AR097920 A1 AR 097920A1 AR P140103699 A ARP140103699 A AR P140103699A AR P140103699 A ARP140103699 A AR P140103699A AR 097920 A1 AR097920 A1 AR 097920A1
- Authority
- AR
- Argentina
- Prior art keywords
- alas1
- expression
- compositions
- dsrna
- inhibit
- Prior art date
Links
Abstract
Se refiere a composiciones de ácido ribonucleico bicatenario (dsARN) opcionalmente conjugado a un ligando tal como N-acetilgalactosamina. Los dsARN están dirigidos al gen ALAS1. Métodos de uso de tales composiciones de dsARN para alterar (por ejemplo, inhibir) la expresión de ALAS1, tal como tratamientos de sujetos con porfiria. Reivindicación 1: Un ácido ribonucleico bicatenario (dsARN) para inhibir la expresión de ALAS1, en donde dicho dsARN comprende una cadena con sentido y una cadena antisentido, donde la cadena antisentido comprende una región de complementariedad con un transcripto de ARN de ALAS1 (por ejemplo, SEQ ID N º1), cuya cadena antisentido comprende al menos 20 nucleótidos contiguos de la secuencia antisentido de UAAGAUGAGACACUCUUUCUGGU (SEQ ID Nº 4153) o UAAGAUGAGACACUCTUUCUGGU (SEQ ID Nº 4154).It refers to double stranded ribonucleic acid (dsRNA) compositions optionally conjugated to a ligand such as N-acetylgalactosamine. The dsRNAs are directed to the ALAS1 gene. Methods of using such dsRNA compositions to alter (for example, inhibit) the expression of ALAS1, such as treatments of subjects with porphyria. Claim 1: A double stranded ribonucleic acid (dsRNA) for inhibiting the expression of ALAS1, wherein said dsRNA comprises a sense chain and an antisense chain, wherein the antisense chain comprises a region of complementarity with an ALAS1 RNA transcript (for example , SEQ ID No. 1), whose antisense chain comprises at least 20 contiguous nucleotides of the antisense sequence of UAAGAUGAGACACUCUUUCUGGU (SEQ ID No. 4153) or UAAGAUGAGACACUCTUUCUGGU (SEQ ID No. 4154).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361887288P | 2013-10-04 | 2013-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR097920A1 true AR097920A1 (en) | 2016-04-20 |
Family
ID=58698725
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140103699A AR097920A1 (en) | 2013-10-04 | 2014-10-03 | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF GENE SINTASA 1 OF 5-AMINOLEVULIN ACID (ALAS1) |
ARP200101035A AR118658A2 (en) | 2013-10-04 | 2020-04-13 | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF THE ALAS1 GENE |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200101035A AR118658A2 (en) | 2013-10-04 | 2020-04-13 | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF THE ALAS1 GENE |
Country Status (2)
Country | Link |
---|---|
AR (2) | AR097920A1 (en) |
MA (1) | MA39000B1 (en) |
-
2014
- 2014-10-03 MA MA39000A patent/MA39000B1/en unknown
- 2014-10-03 AR ARP140103699A patent/AR097920A1/en unknown
-
2020
- 2020-04-13 AR ARP200101035A patent/AR118658A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR118658A2 (en) | 2021-10-20 |
MA39000B1 (en) | 2018-12-31 |
MA39000A1 (en) | 2018-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2017007335A2 (en) | Suppression of the arni-induced huntingtin gene | |
AR090869A1 (en) | SERPINC1 RNAi COMPOSITIONS AND THEIR METHODS OF USE | |
CR20150493A (en) | AMRI COMPOSITIONS AGAINST COMPONENT C5 OF THE COMPLEMENT AND METHODS FOR USE | |
EA201991369A1 (en) | MODIFIED RNA GUIDES | |
PE20210921A1 (en) | ARNI AGENTS AS INHIBITORS OF SERPINE 1 TRANSCRIPTION AND COMPOSITIONS THAT INCLUDE THEM | |
CO2020015314A2 (en) | Arni compositions against angiotensinogen (agt) and methods for their use | |
PE20171763A1 (en) | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF THE HAO1 GENE (HYDROXIACIDE-OXIDASE 1 (GLYCOLATE-OXIDASE)) | |
MX2021009118A (en) | Compositions and methods for inhibiting expression of the alas1 gene. | |
CO2018006590A2 (en) | Methods and compositions for the treatment of a disorder associated with serpinc1 | |
AR100946A1 (en) | COMPOSITIONS AND METHODS TO REGULATE GENE EXPRESSION THROUGH RNA INTERFERENCE | |
MX2013011177A (en) | Compositions and methods for inhibiting expression of tmprss6 gene. | |
CO6690786A2 (en) | Polynucleotides and polypeptides encoding abc transporters and modifying their activity in vegetables | |
DOP2022000085A (en) | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF THE ALAS1 GENE | |
MX2021010716A (en) | Compositions and methods for inhibiting expression of the lect2 gene. | |
AR102777A1 (en) | COMPOSITIONS OF ARNi AGAINST TMPRSS6 AND METHODS FOR USE | |
ZA202006505B (en) | Micro rna expression constructs and uses thereof | |
CL2021002842A1 (en) | Inhibitory double-stranded nucleic acid molecules with shortened sense strands | |
BR112018070249A2 (en) | tissue specific expression modified u6 promoter system | |
AR079649A1 (en) | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF GENES IL-18 | |
AR118658A2 (en) | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF THE ALAS1 GENE | |
CL2013003466A1 (en) | Arn construction comprising a sense segment sequence and an antisense of the p0 gene of the genome of the moderate beet yellowing virus (bmyv), a method for inducing tolerance to the bmyv virus. | |
AR090582A1 (en) | METHODS AND COMPOSITIONS TO TREAT CANCER USING ARNhc SRC 3 BIFUNCTIONAL | |
CL2018000872A1 (en) | Methods of preserving the biological activity of ribonucleic acids. | |
AR127137A2 (en) | SERPINC1 ARNI COMPOSITIONS AND THEIR METHODS OF USE | |
AR121850A2 (en) | LPA RNA INTERFERENCE AGENT (RNAi), USE OF SAID AGENT AND METHOD FOR INHIBITING LPA EXPRESSION |