AR118145A1 - Compuesto inhibidor de acil-coa sintetasa 4 (acsl4) - Google Patents

Compuesto inhibidor de acil-coa sintetasa 4 (acsl4)

Info

Publication number
AR118145A1
AR118145A1 ARP200100462A ARP200100462A AR118145A1 AR 118145 A1 AR118145 A1 AR 118145A1 AR P200100462 A ARP200100462 A AR P200100462A AR P200100462 A ARP200100462 A AR P200100462A AR 118145 A1 AR118145 A1 AR 118145A1
Authority
AR
Argentina
Prior art keywords
acsl4
acil
inhibiting compound
coa synthase
compound
Prior art date
Application number
ARP200100462A
Other languages
English (en)
Inventor
Ana Fernanda Castillo
Sergio Hernn Szajnman
Angela Rosaria SOLANO
Paula Mariana MALOBERTI
Juan Bautista Rodriguez
Menna Pablo Lorenzano
Jesica Giselle Prada
Daniel E Gomez
Ernesto Jorge Podest
Ulises Daniel Orlando
Original Assignee
Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet
Univ Nacional De Quilmes Unq
Univ De Buenos Aires Uba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet, Univ Nacional De Quilmes Unq, Univ De Buenos Aires Uba filed Critical Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet
Publication of AR118145A1 publication Critical patent/AR118145A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto (N-(4-(3-(5-metilfuran-2-il)-1-fenil-1H-pirazol-4-il)-3,4-dihidrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-il)acetamida) de fórmula (1), un enantiómero, diasterómero, solvato o sal farmacéuticamente aceptable del mismo.
ARP200100462A 2019-02-21 2020-02-20 Compuesto inhibidor de acil-coa sintetasa 4 (acsl4) AR118145A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962808424P 2019-02-21 2019-02-21

Publications (1)

Publication Number Publication Date
AR118145A1 true AR118145A1 (es) 2021-09-22

Family

ID=70005651

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200100462A AR118145A1 (es) 2019-02-21 2020-02-20 Compuesto inhibidor de acil-coa sintetasa 4 (acsl4)

Country Status (4)

Country Link
US (1) US20220133731A1 (es)
EP (1) EP3927434A1 (es)
AR (1) AR118145A1 (es)
WO (1) WO2020170192A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112587664A (zh) * 2020-12-29 2021-04-02 四川大学华西医院 长链脂酰辅酶a合成酶4的抑制剂在治疗帕金森疾病中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169247B2 (en) * 2009-11-20 2015-10-27 Southern Research Institute Tetrahydro-beta-carboline derivatives, synthesis and use thereof
US9737515B2 (en) 2015-03-03 2017-08-22 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) Compositions and methods for inhibiting tumor growth
US20190269629A1 (en) 2016-11-08 2019-09-05 Ernesto Jorge PODESTÁ Compositions and methods for inhibiting growth of acsl4-overexpressing tumors
US10376495B2 (en) * 2016-11-23 2019-08-13 University Of South Florida Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)

Also Published As

Publication number Publication date
US20220133731A1 (en) 2022-05-05
EP3927434A1 (en) 2021-12-29
WO2020170192A1 (en) 2020-08-27

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