AR114683A1 - Polipéptidos inmunomoduladores e inmunoestimulantes para suministro de drogas - Google Patents

Polipéptidos inmunomoduladores e inmunoestimulantes para suministro de drogas

Info

Publication number
AR114683A1
AR114683A1 ARP190100306A ARP190100306A AR114683A1 AR 114683 A1 AR114683 A1 AR 114683A1 AR P190100306 A ARP190100306 A AR P190100306A AR P190100306 A ARP190100306 A AR P190100306A AR 114683 A1 AR114683 A1 AR 114683A1
Authority
AR
Argentina
Prior art keywords
seq
polypeptides
pharmaceutical composition
modified
polyeptides
Prior art date
Application number
ARP190100306A
Other languages
English (en)
Inventor
Mirta L Coria
Karina A Pasquevich
Juliana Cassataro
Original Assignee
Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet
Univ Nacional De General San Martin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet, Univ Nacional De General San Martin filed Critical Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet
Publication of AR114683A1 publication Critical patent/AR114683A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente se refiere a polipéptidos bacterianos modificados que tienen actividad inmunomoduladora e inmunoestimulante. Más específicamente, la presente se refiere a polipéptidos bacterianos modificados que tienen una secuencia de aminoácidos seleccionada de SEQ ID Nº 1, SEQ ID Nº 2, SEQ ID Nº 3, SEQ ID Nº 4 y SEQ ID Nº 5. Los polipéptidos modificados son los componentes adyuvantes de una composición farmacéutica para provocar una respuesta inmune contra un antígeno específico presente en la composición farmacéutica. En una forma de realización preferida, la presente provee una composición farmacéutica para una vacuna la cual comprende un componente adyuvante el cual es uno cualquiera de los polipéptidos modificados, uno o más antígenos, junto con un excipiente farmacéuticamente aceptable.
ARP190100306A 2018-02-09 2019-02-08 Polipéptidos inmunomoduladores e inmunoestimulantes para suministro de drogas AR114683A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862628724P 2018-02-09 2018-02-09

Publications (1)

Publication Number Publication Date
AR114683A1 true AR114683A1 (es) 2020-10-07

Family

ID=65818555

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190100306A AR114683A1 (es) 2018-02-09 2019-02-08 Polipéptidos inmunomoduladores e inmunoestimulantes para suministro de drogas

Country Status (5)

Country Link
US (1) US11459575B2 (es)
EP (1) EP3749364A1 (es)
CN (1) CN111936166B (es)
AR (1) AR114683A1 (es)
WO (1) WO2019155415A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112704732B (zh) * 2020-12-24 2022-02-25 华中农业大学 一种猪传染性胸膜肺炎放线杆菌亚单位疫苗
CN113144182B (zh) * 2021-04-22 2023-03-10 成都欧林生物科技股份有限公司 一种幽门螺杆菌口服缓释疫苗及其制备与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355923B1 (en) 2000-11-01 2012-03-07 The Regents of The University of California Immunomodulatory peptides derived from heat shock proteins and uses thereof
DE10208653A1 (de) * 2002-02-28 2003-09-18 Medinnova Ges Med Innovationen Mikroorganismus als Träger von Nukleotidsequenzen kodierend für Zellantigene zur Behandlung von Tumoren
AR073907A1 (es) * 2009-10-19 2010-12-09 Consejo Nac Invest Cient Tec Adyuvante para vacunas, que comprende un polipeptido no lipidado de la membrana externa (omp) de bacterias, vacunas que lo comprenden y usos
GB201017519D0 (en) * 2010-10-15 2010-12-01 Novartis Vaccines Inst For Global Health S R L Vaccines

Also Published As

Publication number Publication date
WO2019155415A1 (en) 2019-08-15
US11459575B2 (en) 2022-10-04
US20210093716A1 (en) 2021-04-01
CN111936166A (zh) 2020-11-13
EP3749364A1 (en) 2020-12-16
CN111936166B (zh) 2024-10-22

Similar Documents

Publication Publication Date Title
AR065523A1 (es) Procedimiento para fomentar una respuesta inmunitaria frente a un patogeno y composiciones
CU20190030A7 (es) Composiciones de vacunas antineumocócicas polivalentes que comprenden conjugados de polisacárido-proteína
CL2008002559A1 (es) Construccion que comprende un vector de fluorocarbono y un antigeno del virus de la influenza; composicion farmaceutica que lo comprende; y su uso para aumentar la respuesta inmunologica
RU2009126604A (ru) Вакцина против salmonella
AR114683A1 (es) Polipéptidos inmunomoduladores e inmunoestimulantes para suministro de drogas
CY1120430T1 (el) Ανασυνδυασμενες cdv συνθεσεις και χρησεις αυτων
AR081856A1 (es) Vacuna y metodos para reducir una infeccion por campylobacter
BR112016015422A2 (pt) formulações de vacina de frasco único
CO6561819A2 (es) Vectores para vacunas y método para potenciar respuestas inmunes
EA201892735A1 (ru) Состав вакцины против hiv
WO2017142843A8 (en) Novel antigen for use in malaria vaccine
AR109538A1 (es) Vacuna contra la gripe porcina
JP2013518052A5 (es)
BR112016028418A2 (pt) composição de adjuvante, vacina, anticorpo agonista cd40 ou uma parte desse, composição farmacêutica, construto, célula, e, método de mapeamento de epítopo de um polipeptídeo
EP4226938A3 (en) Coronavirus vaccine
ZA202310663B (en) Immunogenic compositions to treat and prevent microbial infections
WO2019006401A3 (en) LISTERIA-BASED IMMUNOGENIC COMPOSITIONS COMPRISING HETERICCLIENT WILMS TUMOR PROTEIN ANTIGENS AND METHODS OF USE THEREOF
NO20072705L (no) Alfa-tymosinpeptider som cancervaksineadjuvanser
CL2021000532A1 (es) Vacunas peptídicas
WO2015140172A3 (en) A medicament for use in a method of inducing or extending a cellular cytotoxic immune response
AR095425A1 (es) Vacuna, uso y procedimiento para prevenir una infección por picornavirus
WO2012174455A3 (en) Group a streptococcus multivalent vaccine
WO2013171661A3 (en) Adjuvant formulations and methods
TNSN08184A1 (en) Chimeric antigens and vaccines
MX2024007696A (es) Uso del interferon como adyuvante en vacunas.