AR109887A1 - Inhibidores de lsd1 y usos de los mismos - Google Patents

Inhibidores de lsd1 y usos de los mismos

Info

Publication number
AR109887A1
AR109887A1 ARP170102971A ARP170102971A AR109887A1 AR 109887 A1 AR109887 A1 AR 109887A1 AR P170102971 A ARP170102971 A AR P170102971A AR P170102971 A ARP170102971 A AR P170102971A AR 109887 A1 AR109887 A1 AR 109887A1
Authority
AR
Argentina
Prior art keywords
alkyl
nhc1
halo
same
alkoxy
Prior art date
Application number
ARP170102971A
Other languages
English (en)
Inventor
Victor S Gehling
Avinash Khanna
Francois Brucelle
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of AR109887A1 publication Critical patent/AR109887A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems

Abstract

Reivindicación 1: Un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo, en donde n es 1 ó 2; m es 1 ó 2; o es 0 ó 1; q es 0, 1, 2 ó 3; R¹ es hidrógeno o C₁₋₆ alquilo; R² es hidrógeno o C₁₋₆ alquilo opcionalmente sustituido con OH o C₁₋₆ alcoxilo; R³ y R⁴, si están presentes, cada uno se selecciona en forma independiente de hidrógeno, halo, OH, y C₁₋₆ alquilo; R⁵ se selecciona de NH₂, -NH(SO₂)C₁₋₆ alquilo, -NH(SO₂)C₁₋₆ alquil-OC₁₋₆ alquilo, -NHC(O)C₁₋₆ alquilo, -NH(SO₂)C₃₋₆ cicloalquilo, OH, -O-C₁₋₆ alquilo, -SO₂NH₂, -C(O)NH₂, -C(O)NHC₁₋₆ alquilo, -C(O)N[C₁₋₆ alquilo]₂, -C(O)NH(SO₂)C₁₋₆ alquilo, -C(O)NHC₁₋₆ alquil(SO₂)C₁₋₆ alquilo, -C(O)NH(SO₂)C₃₋₆ cicloalquilo, -C(O)NHC₁₋₆ alquil-OH, -C(O)NHC₁₋₆ alquil-OC₁₋₆ alquilo, y C₁₋₄ alquilo sustituido con OH; R⁶, si está presente, se selecciona de C₁₋₆ alquilo, halo C₁₋₆ alquilo, C₁₋₆ alcoxilo, halo C₁₋₆ alcoxilo, halo, y ciano; con la condición de que el compuesto no sea el compuesto de fórmula (2) ó (3); o una sal del mismo.
ARP170102971A 2016-10-26 2017-10-26 Inhibidores de lsd1 y usos de los mismos AR109887A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662413162P 2016-10-26 2016-10-26

Publications (1)

Publication Number Publication Date
AR109887A1 true AR109887A1 (es) 2019-01-30

Family

ID=65351698

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170102971A AR109887A1 (es) 2016-10-26 2017-10-26 Inhibidores de lsd1 y usos de los mismos

Country Status (2)

Country Link
AR (1) AR109887A1 (es)
MA (1) MA46625B1 (es)

Also Published As

Publication number Publication date
MA46625B1 (fr) 2023-11-30
MA46625A (fr) 2019-09-04

Similar Documents

Publication Publication Date Title
AR110405A1 (es) Compuestos
AR116315A1 (es) Compuestos de triazolo-pirimidina y usos de los mismos
AR108130A1 (es) Derivados de pirazolopirimidina
AR093598A1 (es) Compuestos y sus metodos de empleo
AR112687A1 (es) Agonistas del receptor tipo toll 7 (tlr7) que tienen una porción tricíclica, conjugados de estos y métodos y usos de estos
AR121044A1 (es) Inhibidores de egfr
AR096684A1 (es) Compuestos para tratar atrofia muscular espinal
AR090868A1 (es) Composiciones plaguicidas y procesos relacionados con ellas
AR100975A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
UY36121A (es) ?pirazolopiridinas y pirazolopirimidinas?.
AR100058A1 (es) DERIVADOS DE PIRIMIDIN-PIRAZINAS FUSIONADAS MODULADORES DE RORg
AR100809A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
AR097866A1 (es) Derivados de 4-azaindol
AR100233A1 (es) Composición de limpieza
AR100808A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
AR093758A1 (es) Inhibidores de aril lactama quinasa
AR089623A1 (es) Inhibidores de iap
AR109711A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
AR095351A1 (es) Inhibidores de histona desacetilasa (hdac)
AR102957A1 (es) Combinaciones de compuestos activos
AR089814A1 (es) Compuestos que modulan la actividad de los proteasomas
AR102258A1 (es) Compuestos de quinolina y quinazolina
AR113931A1 (es) Tratamientos de combinación que comprenden la administración de 1h-pirazolo[4,3-b]piridinas
AR093738A1 (es) Formas solidas que comprenden inhibidores de ns5a de hcv, sus composiciones y sus usos
AR109712A1 (es) Inhibidores de fosfatidilinositol 3-quinasa