AR108729A1 - Forma farmacéutica de unidades múltiples que comprende un núcleo con unidades centrales individuales cubiertas por un material muco-adhesivo, y un recubrimiento de núcleo entérico - Google Patents
Forma farmacéutica de unidades múltiples que comprende un núcleo con unidades centrales individuales cubiertas por un material muco-adhesivo, y un recubrimiento de núcleo entéricoInfo
- Publication number
- AR108729A1 AR108729A1 ARP170101621A ARP170101621A AR108729A1 AR 108729 A1 AR108729 A1 AR 108729A1 AR P170101621 A ARP170101621 A AR P170101621A AR P170101621 A ARP170101621 A AR P170101621A AR 108729 A1 AR108729 A1 AR 108729A1
- Authority
- AR
- Argentina
- Prior art keywords
- core
- unit
- coating layer
- multiple units
- pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una forma farmacéutica de unidades múltiples que comprende un núcleo, donde el núcleo comprende una pluralidad de unidades individuales, donde cada unidad comprende un principio farmacéuticamente activo y cada unidad está cubierta con un material muco-adhesivo, y donde la forma farmacéutica de unidades múltiples comprende, además, una capa de recubrimiento del núcleo. Además, uso de dicha forma farmacéutica de unidades múltiples en el tratamiento de trastornos inflamatorios, en especial para el tracto gastrointestinal. Reivindicación 2: La forma farmacéutica de unidades múltiples de acuerdo con la reivindicación 1, caracterizada porque el recubrimiento del núcleo (b) comprende una capa de recubrimiento adicional (b2), donde dicha capa de recubrimiento adicional (b2) está comprendida entre el núcleo (a) y la capa de recubrimiento externa (b1), y donde dicha capa de recubrimiento adicional (b2) comprende un material polimérico que es soluble en el fluido intestinal o en el fluido gástrico y que se selecciona del grupo que consiste en un polímero del ácido policarboxílico que está al menos parcialmente neutralizado y un polímero no iónico, cada uno en combinación con al menos un aditivo seleccionado de un agente buffer y/o una base y mezclas de los anteriores. Reivindicación 4: La forma farmacéutica de unidades múltiples de acuerdo con cualquiera de las reivindicaciones que anteceden, caracterizada porque al menos un material muco-adhesivo (a2) comprende chitosán o alginato, preferentemente chitosán. Reivindicación 12: La forma farmacéutica unitaria múltiple de acuerdo con cualquiera de las reivindicaciones 1 a 11, caracterizada porque el principio activo para uso farmacéutico (a1) se selecciona de metronidazol, vancomicina, ácido 5-amino-salicílico, budesonida, y anti-TNF, y es preferentemente metronidazol.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16174466.9A EP3257501A1 (en) | 2016-06-14 | 2016-06-14 | Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating |
Publications (1)
Publication Number | Publication Date |
---|---|
AR108729A1 true AR108729A1 (es) | 2018-09-19 |
Family
ID=56131433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP170101621A AR108729A1 (es) | 2016-06-14 | 2017-06-14 | Forma farmacéutica de unidades múltiples que comprende un núcleo con unidades centrales individuales cubiertas por un material muco-adhesivo, y un recubrimiento de núcleo entérico |
Country Status (9)
Country | Link |
---|---|
US (1) | US20190336449A1 (es) |
EP (2) | EP3257501A1 (es) |
JP (1) | JP2019518758A (es) |
AR (1) | AR108729A1 (es) |
CA (1) | CA3026840A1 (es) |
MA (1) | MA45240A (es) |
TW (1) | TW201742621A (es) |
UY (1) | UY37293A (es) |
WO (1) | WO2017216088A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108434109A (zh) * | 2018-04-25 | 2018-08-24 | 首都医科大学附属北京儿童医院 | 微型巯嘌呤片、微型巯嘌呤肠溶缓释片、及其制备方法 |
EP3613414A1 (de) | 2018-08-24 | 2020-02-26 | Dr. Falk Pharma Gmbh | Pellets mit mehrschichtiger struktur zur verzögerten freisetzung des wirkstoffs im distalen kolon |
CA3111353A1 (en) * | 2018-09-06 | 2020-03-12 | Fachhochschule Nordwestschweiz | Controlled drug release formulation |
CN112770730B (zh) * | 2018-09-06 | 2024-02-13 | 瑞士西北应用科学与艺术大学 | 受控的药物释放制剂 |
EP3662901A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Delayed release drug formulation comprising an outerlayer with an enzymaticyaaly degradable polymer, its composition and its method of manufacturing |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA825384B (en) | 1981-07-31 | 1983-05-25 | Tillott J B Ltd | Orally administrable pharmaceutical compositions |
US4627851A (en) | 1984-10-26 | 1986-12-09 | Alza Corporation | Colonic-therapeutic delivery system |
KR101486590B1 (ko) * | 2006-01-05 | 2015-01-26 | 벨로시스 파마슈티컬스 에이/에스 | 붕해성의 충전형 정제 |
GB0607534D0 (en) | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
SI2152250T1 (sl) | 2007-05-07 | 2020-06-30 | Evonik Operations Gmbh | Trdne dozirne oblike, ki vsebujejo enterično oplaščenje s pospešenim sproščanjem zdravila |
GB0808537D0 (en) * | 2008-05-12 | 2008-06-18 | Archimedes Dev Ltd | Compositions |
EP2168572A1 (en) | 2008-09-30 | 2010-03-31 | Omya Development Ag | New controlled release active agent carrier |
DK2264108T3 (da) | 2009-06-15 | 2012-05-29 | Omya Development Ag | Fremgangsmåde til fremstilling af et calciumcarbonat, der har reageret på overfladen, under anvendelse af en svag syre |
NO2659881T3 (es) | 2012-04-30 | 2018-04-28 | ||
AU2013404367B2 (en) | 2013-10-29 | 2020-02-27 | Tillotts Pharma Ag | A delayed release drug formulation |
-
2016
- 2016-06-14 EP EP16174466.9A patent/EP3257501A1/en not_active Ceased
-
2017
- 2017-05-19 TW TW106116604A patent/TW201742621A/zh unknown
- 2017-06-12 EP EP17732814.3A patent/EP3468538A1/en not_active Withdrawn
- 2017-06-12 WO PCT/EP2017/064250 patent/WO2017216088A1/en unknown
- 2017-06-12 MA MA045240A patent/MA45240A/fr unknown
- 2017-06-12 US US16/310,168 patent/US20190336449A1/en not_active Abandoned
- 2017-06-12 CA CA3026840A patent/CA3026840A1/en not_active Abandoned
- 2017-06-12 JP JP2018565293A patent/JP2019518758A/ja active Pending
- 2017-06-14 UY UY0001037293A patent/UY37293A/es not_active Application Discontinuation
- 2017-06-14 AR ARP170101621A patent/AR108729A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW201742621A (zh) | 2017-12-16 |
WO2017216088A1 (en) | 2017-12-21 |
MA45240A (fr) | 2019-04-17 |
JP2019518758A (ja) | 2019-07-04 |
UY37293A (es) | 2018-01-02 |
EP3257501A1 (en) | 2017-12-20 |
US20190336449A1 (en) | 2019-11-07 |
CA3026840A1 (en) | 2017-12-21 |
EP3468538A1 (en) | 2019-04-17 |
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