AR106542A1 - Inhibidor del receptor p2x7 - Google Patents

Inhibidor del receptor p2x7

Info

Publication number
AR106542A1
AR106542A1 ARP160103326A ARP160103326A AR106542A1 AR 106542 A1 AR106542 A1 AR 106542A1 AR P160103326 A ARP160103326 A AR P160103326A AR P160103326 A ARP160103326 A AR P160103326A AR 106542 A1 AR106542 A1 AR 106542A1
Authority
AR
Argentina
Prior art keywords
inhibitor
receiver
morpholinoethyl
thiazol
pyrimidin
Prior art date
Application number
ARP160103326A
Other languages
English (en)
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of AR106542A1 publication Critical patent/AR106542A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporciona (S)-N-(2-(4-clorofenil)-2-morfolinoetil)-2-(pirimidin-2-il)-4-(trifluorometil)tiazol-5-carboxamida como inhibidor de P2X7, su uso como medicamento y un protocolo de síntesis enantiomérica conveniente para la preparación de (S)-N-(2-(4-clorofenil)-2-morfolinoetil)-2-(pirimidin-2-il)-4-(trifluorometil)tiazol-5-carboxamida.
ARP160103326A 2015-11-02 2016-11-01 Inhibidor del receptor p2x7 AR106542A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201500678 2015-11-02

Publications (1)

Publication Number Publication Date
AR106542A1 true AR106542A1 (es) 2018-01-24

Family

ID=57241072

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103326A AR106542A1 (es) 2015-11-02 2016-11-01 Inhibidor del receptor p2x7

Country Status (16)

Country Link
US (1) US20180319786A1 (es)
EP (1) EP3371180A1 (es)
JP (1) JP2018532751A (es)
CN (1) CN108137571A (es)
AR (1) AR106542A1 (es)
AU (1) AU2016348487A1 (es)
BR (1) BR112017014117A2 (es)
CA (1) CA3001766A1 (es)
EA (1) EA201890806A1 (es)
IL (1) IL258573A (es)
MX (1) MX2018005251A (es)
PH (1) PH12018500898A1 (es)
RU (1) RU2018114986A (es)
SG (1) SG11201803477VA (es)
TW (1) TW201722432A (es)
WO (1) WO2017076825A1 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2178865T1 (sl) 2007-07-19 2015-11-30 Lundbeck, H., A/S 5-členski heterociklični amidi in sorodne spojine

Also Published As

Publication number Publication date
BR112017014117A2 (pt) 2018-03-06
IL258573A (en) 2018-05-31
TW201722432A (zh) 2017-07-01
JP2018532751A (ja) 2018-11-08
CA3001766A1 (en) 2017-05-11
CN108137571A (zh) 2018-06-08
WO2017076825A1 (en) 2017-05-11
EP3371180A1 (en) 2018-09-12
MX2018005251A (es) 2018-08-01
AU2016348487A1 (en) 2018-05-10
RU2018114986A (ru) 2019-12-05
PH12018500898A1 (en) 2018-10-29
SG11201803477VA (en) 2018-05-30
US20180319786A1 (en) 2018-11-08
EA201890806A1 (ru) 2018-10-31

Similar Documents

Publication Publication Date Title
ECSP17016797A (es) Indazoles sustituidos con benzilo como inhibidores de bub1
EP3181559B8 (en) 2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof
ECSP17030878A (es) Formas cristalinas de 5-cloro-n4-[2-(dimetilfosforil)fenil]-n2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidina-2,4-diamina
DK3174875T3 (da) Fremgangsmåde til fremstilling af (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid og dets oprensning til anvendelse som farmaceutisk aktivstof
CL2017003107A1 (es) Derivados de 2-(pirazolopiridin-3-il)pirimidina como inhibidores de jak
PH12016502461A1 (en) N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide hydrochloride salts
BR112016025910A2 (pt) uso de uma quantidade eficaz de glyx-13, uso de glyx-13 e um antagonista de nmdar e composição farmaceuticamente aceitável compreendendo os mesmos
IL271726A (en) Compositions and methods of use of 2-(4-chlorophenyl)-N-((2-(2, 6-doxopyridin-3-yl)-1-oxoisoinodolin-5-yl)methyl)2-2-difluoroacetamide
BR112017002060A2 (pt) novo uso
EP3399981A4 (en) SOLID FORMS OF 2- (4-CHLOROPHENYL) -N - ((2-2,6-DIOXOPIPERIDIN-3-YL) -1-OXOISOINDOLIN-5-YL) METHYL) -2,2-DIFLUOROACETAMIDE, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF THEM
ZA201804482B (en) Formulations of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
CL2021003498A1 (es) Compuesto de pirazolona y pirimidina, y método de preparación y uso del mismo
SG11201600996UA (en) Formulations of (s)-3-(4-((4-(morpholinomethyl)benzyloxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
MX2018015872A (es) Derivados de benzodioxano y su uso farmaceutico.
DK3303323T3 (da) Heterocykliske forbindelser af 3,3-difluorpiperidincarbamat som NR2B-NMDA-receptorantagonister
DK3962601T3 (da) 5-HT2A-agonister til anvendelse til behandling af depression
TW201613843A (en) Process for preparing 1-indanols and 1-indanamines
BR112018012095A2 (pt) formas sólidas de compostos substituidos de 5,6-di-hidro-6-fenilbenzo[f]isoquinolin-2-amina
DK3417294T3 (da) Fremgangsmåder, som omfatter fast intermitterende dosering af cediranib
PH12018501302A1 (en) Emulsion concentrates of lipophilic compounds
DOP2018000032A (es) Composición herbicida y proceso para prepararla
PL2986593T3 (pl) Herbicydowo aktywne związki 2-(podstawione-fenylo)-cyklopentano-1,3-dionu i ich pochodne
AR106542A1 (es) Inhibidor del receptor p2x7
DK3324736T3 (da) Hidtil ukendt spot-on-aktivstofformulering
PE20180503A1 (es) 2-tiopirimidinonas

Legal Events

Date Code Title Description
FB Suspension of granting procedure