AR099553A1 - USPA2 PROTEIN CONSTRUCTIONS AND USES OF THE SAME - Google Patents
USPA2 PROTEIN CONSTRUCTIONS AND USES OF THE SAMEInfo
- Publication number
- AR099553A1 AR099553A1 ARP150100500A ARP150100500A AR099553A1 AR 099553 A1 AR099553 A1 AR 099553A1 AR P150100500 A ARP150100500 A AR P150100500A AR P150100500 A ARP150100500 A AR P150100500A AR 099553 A1 AR099553 A1 AR 099553A1
- Authority
- AR
- Argentina
- Prior art keywords
- uspa2
- compositions
- same
- immunogenic compositions
- immunogenic
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 6
- 230000002163 immunogen Effects 0.000 abstract 5
- 241000588655 Moraxella catarrhalis Species 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 241000606768 Haemophilus influenzae Species 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229940047650 haemophilus influenzae Drugs 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
- C07K14/212—Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente solicitud se refiere a composiciones que comprenden la proteína superficial ubicua A2 (UspA2) de Moraxella catarrhalis (M. catarrhalis). De una manera más particular, la presente solicitud se refiere a construcciones de proteína UspA2 y a composiciones inmunogénicas que comprenden las construcciones, a vacunas que comprenden estas composiciones inmunogénicas, y a los usos terapéuticos de las mismas. La solicitud se refiere además a composiciones que comprenden UspA2 en combinación con cuando menos un antígeno a partir de Haemophilus influenzae, a composiciones inmunogénicas que comprenden los antígenos, a vacunas que comprenden estas composiciones inmunogénicas, y a los usos terapéuticos de las mismas. Reivindicación 1: Una proteína de la fórmula (1): A-(R¹)ₘ-(B)ₙ (1) en donde: A es UspA2 a partir de Moraxella catarrhalis o un fragmento inmunogénico de la misma; R¹ es un aminoácido; m es 0 ó 2; B es histidina; y n es 0, 1, 2, 3, 4, 5 ó 6.The present application relates to compositions comprising the ubiquitous surface protein A2 (UspA2) of Moraxella catarrhalis (M. catarrhalis). More particularly, the present application relates to UspA2 protein constructs and immunogenic compositions comprising the constructs, to vaccines comprising these immunogenic compositions, and to therapeutic uses thereof. The application further relates to compositions comprising UspA2 in combination with at least one antigen from Haemophilus influenzae, to immunogenic compositions comprising the antigens, to vaccines comprising these immunogenic compositions, and to therapeutic uses thereof. Claim 1: A protein of the formula (1): A- (R¹) ₘ- (B) ₙ (1) wherein: A is UspA2 from Moraxella catarrhalis or an immunogenic fragment thereof; R¹ is an amino acid; m is 0 or 2; B is histidine; and n is 0, 1, 2, 3, 4, 5 or 6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461943909P | 2014-02-24 | 2014-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR099553A1 true AR099553A1 (en) | 2016-08-03 |
Family
ID=53476606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150100500A AR099553A1 (en) | 2014-02-24 | 2015-02-20 | USPA2 PROTEIN CONSTRUCTIONS AND USES OF THE SAME |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR099553A1 (en) |
-
2015
- 2015-02-20 AR ARP150100500A patent/AR099553A1/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY36006A (en) | USPA2 PROTEIN CONSTRUCTIONS AND USES OF THE SAME. | |
| CO2018004321A2 (en) | Antibody that neutralizes the human syncytial respiratory virus | |
| CY1122824T1 (en) | FUSION PROTEINS AND COMBINATION VACCINES | |
| BR112017008165A2 (en) | single domain antibodies directed against intracellular antigens | |
| BR112018011073A2 (en) | anti-myostatin antibodies, polypeptides containing variant regions and methods of use | |
| EA201790294A1 (en) | FLAGELLIN BASED MEANS AND APPLICATIONS INCLUDING EFFECTIVE VACCINATION | |
| CY1120740T1 (en) | IMPROVED BLESSING VACCINES | |
| MX2015013065A (en) | Prefusion rsv f proteins and their use. | |
| WO2014113490A3 (en) | Immunogenic wt-1 peptides and methods of use thereof | |
| EP4272750A3 (en) | Protein antigens that provide protection against pneumococcal colonization and/or disease | |
| EA201790507A1 (en) | METHODS AND COMPOSITIONS FOR STRENGTHENING IMMUNE RESPONSES | |
| DK3146042T3 (en) | Recombinant classical swine fever virus (CSFV) with substitution in the TAV epitope of the E2 protein | |
| EA201790558A1 (en) | COMPOSITION WITH REDUCED IMMUNOGENICITY | |
| EA201690115A1 (en) | COMBINED IMMUNOGENIC COMPOSITIONS | |
| MX363149B (en) | Influenza nucleoprotein vaccines. | |
| BR112014020025A8 (en) | ROTAVIRUS SUBUNIT VACCINES AND PRODUCTION METHODS AND USE THEREOF | |
| MX2019007924A (en) | Influenza vaccines. | |
| EA201990768A1 (en) | OPTIMIZED SYNTHETIC CONSENSUS IMMUNOGENIC COMPOSITIONS AIMED AT FIBROBLAST ACTIVATION PROTEIN | |
| EA201390735A1 (en) | VACCINE COMPOSITIONS WITH FRAGMENTS OF SPLITTED IMMUNOGLOBULINS | |
| AR099553A1 (en) | USPA2 PROTEIN CONSTRUCTIONS AND USES OF THE SAME | |
| WO2018066948A3 (en) | Recombinant antigen protein composed of multiple epitopes and method for producing same | |
| WO2015070207A3 (en) | Ama-1 epitopes, antibodies, compositions, and methods of making and using the same | |
| PL406631A1 (en) | Antigen, influenza vaccine, vaccine production system, method for producing antigen and application of the antigen determined above for the production of the influenza vaccine | |
| MX2015013808A (en) | Vaccine against rhipicephalus ticks. | |
| ECSP18039827A (en) | ANTIBODY THAT NEUTRALIZES THE HUMAN SYNCITIAL RESPIRATORY VIRUS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |