AR090705A1 - PIRIDINE AND PYRIMIDINE COMPOUNDS AND THEIR USES AS 3-QUINASE PHOSPHYTIDYLINOSITOL INHIBITORS (PI3K) - Google Patents

PIRIDINE AND PYRIMIDINE COMPOUNDS AND THEIR USES AS 3-QUINASE PHOSPHYTIDYLINOSITOL INHIBITORS (PI3K)

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Publication number
AR090705A1
AR090705A1 ARP130101238A AR090705A1 AR 090705 A1 AR090705 A1 AR 090705A1 AR P130101238 A ARP130101238 A AR P130101238A AR 090705 A1 AR090705 A1 AR 090705A1
Authority
AR
Argentina
Prior art keywords
diseases
inflammatory
acute
conditions
treatment
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Bui Minna
David Cushing Timothy
Gonzalez Lopez De Turiso Felix
Hao Xiaolin
Lucas Brian
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to ARP130101238 priority Critical patent/AR090705A1/en
Publication of AR090705A1 publication Critical patent/AR090705A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Heteroarilos bicíclicos sustituidos y composiciones que los contienen, ara el tratamiento de inflamación general, artritis, enfermedades reumáticas, osteoartritis, enfermedades inflamatorias intestinales, enfermedades inflamatorias oculares, enfermedades inflamatorias de la vejiga o vejiga inestable, psoriasis, afecciones de la piel con componentes inflamatorios, condiciones inflamatorias crónicas, incluyendo, pero sin limitarse a, enfermedades autoinmunes tales como lupus eritematoso sistémico (SLE), miastenia grave, artritis reumatoidea, encefalomielitis diseminada aguda, púrpura trombocitopénica idiopática, esclerosis múltiple, síndrome de Sjoegren y anemia hemolítica autoinmune, condiciones alérgica incluyendo todas las formas de hipersensibilidad. La presente también da a conocer métodos para el tratamiento de cánceres que son mediados por, dependen de, o están asociados con, la actividad p110d, incluyendo, pero sin limitarse a, leucemias tales como leucemia mieloide aguda (AML), síndrome mielodisplásico (MDS), enfermedades mieloproliferativas (MPD), leucemia mieloide crónica (CML), leucemia linfoblástica aguda de células T (T-ALL), leucemia linfoblástica aguda de células B (B-ALL), linfoma no Hodgkins (NHL), linfoma de células B y tumores sólidos, tales como el cáncer de mama. Reivindicación 1: Un compuesto seleccionado entre las fórmulas (1), (2), (3), (4), (5), (6) y (7), o cualquier sal farmacéuticamente aceptable del mismo.Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel diseases, inflammatory eye diseases, inflammatory diseases of the bladder or unstable bladder, psoriasis, skin conditions with inflammatory components, chronic inflammatory conditions, including, but not limited to, autoimmune diseases such as systemic lupus erythematosus (SLE), myasthenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiple sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions All forms of hypersensitivity. This also discloses methods for the treatment of cancers that are mediated by, depend on, or are associated with, p110d activity, including, but not limited to, leukemias such as acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) ), myeloproliferative diseases (MPD), chronic myeloid leukemia (CML), acute lymphoblastic T-cell leukemia (T-ALL), acute lymphoblastic B-cell leukemia (B-ALL), non-Hodgkins lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer. Claim 1: A compound selected from formulas (1), (2), (3), (4), (5), (6) and (7), or any pharmaceutically acceptable salt thereof.

ARP130101238 2013-04-16 2013-04-16 PIRIDINE AND PYRIMIDINE COMPOUNDS AND THEIR USES AS 3-QUINASE PHOSPHYTIDYLINOSITOL INHIBITORS (PI3K) AR090705A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP130101238 AR090705A1 (en) 2013-04-16 2013-04-16 PIRIDINE AND PYRIMIDINE COMPOUNDS AND THEIR USES AS 3-QUINASE PHOSPHYTIDYLINOSITOL INHIBITORS (PI3K)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP130101238 AR090705A1 (en) 2013-04-16 2013-04-16 PIRIDINE AND PYRIMIDINE COMPOUNDS AND THEIR USES AS 3-QUINASE PHOSPHYTIDYLINOSITOL INHIBITORS (PI3K)

Publications (1)

Publication Number Publication Date
AR090705A1 true AR090705A1 (en) 2014-12-03

Family

ID=52145048

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130101238 AR090705A1 (en) 2013-04-16 2013-04-16 PIRIDINE AND PYRIMIDINE COMPOUNDS AND THEIR USES AS 3-QUINASE PHOSPHYTIDYLINOSITOL INHIBITORS (PI3K)

Country Status (1)

Country Link
AR (1) AR090705A1 (en)

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