AR086738A1 - USE OF AN ANTIBODY ANTI-CD20 OF GREAT CYTOTOXICITY FOR ANTIBODY DEPENDENT CELLULAR MEDIATION (ADCC) IN THE TREATMENT OF WALDENSTRÖM DISEASE - Google Patents

USE OF AN ANTIBODY ANTI-CD20 OF GREAT CYTOTOXICITY FOR ANTIBODY DEPENDENT CELLULAR MEDIATION (ADCC) IN THE TREATMENT OF WALDENSTRÖM DISEASE

Info

Publication number
AR086738A1
AR086738A1 ARP120102258A ARP120102258A AR086738A1 AR 086738 A1 AR086738 A1 AR 086738A1 AR P120102258 A ARP120102258 A AR P120102258A AR P120102258 A ARP120102258 A AR P120102258A AR 086738 A1 AR086738 A1 AR 086738A1
Authority
AR
Argentina
Prior art keywords
antibody
waldenström
adcc
disease
treatment
Prior art date
Application number
ARP120102258A
Other languages
Spanish (es)
Inventor
Le Garf-Tavernier Magali
De Romeuf Christophe
Merle-Beral Helene
Vieillard Vincent
Leblond Veronique
Original Assignee
Lfb Biotechnologies
Univ Paris 6 Pierre Et Marie Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lfb Biotechnologies, Univ Paris 6 Pierre Et Marie Curie filed Critical Lfb Biotechnologies
Publication of AR086738A1 publication Critical patent/AR086738A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Anticuerpo monoclonal dirigido contra el antígeno CD20. Dicho anticuerpo posee una gran citotoxicidad para la mediación celular dependiente de anticuerpos (ADCC) y/o tiene capacidad para activar las células efectoras con mayor expresión de FcgRlll, y que poseen una región Fc en la cual al menos un 60% de los oligosacáridos no están fucosilados, para su uso en el tratamiento de la enfermedad de Waldenström. Reivindicación 1: Anticuerpo monoclonal dirigido contra el antígeno CD20, caracterizado porque dicho anticuerpo tiene citotoxicidad mediada por células dependiente de anticuerpos (ADCC) y/o una capacidad para activar las células efectoras que expresan FcgRlll incrementada, y posee una región Fc en donde al menos 60% de los oligosacáridos son no fucosilados, para su utilización en el tratamiento de la enfermedad de Waldenström.Monoclonal antibody directed against the CD20 antigen. Said antibody has a high cytotoxicity for antibody-dependent cell mediation (ADCC) and / or has the capacity to activate effector cells with greater FcgRlll expression, and which possess an Fc region in which at least 60% of the oligosaccharides do not are fucosylated, for use in the treatment of Waldenström disease. Claim 1: Monoclonal antibody directed against the CD20 antigen, characterized in that said antibody has antibody-dependent cell-mediated cytotoxicity (ADCC) and / or an ability to activate effector cells expressing increased FcgRlll, and possesses an Fc region where at least 60% of oligosaccharides are non-fucosylated, for use in the treatment of Waldenström disease.

ARP120102258A 2011-06-22 2012-06-22 USE OF AN ANTIBODY ANTI-CD20 OF GREAT CYTOTOXICITY FOR ANTIBODY DEPENDENT CELLULAR MEDIATION (ADCC) IN THE TREATMENT OF WALDENSTRÖM DISEASE AR086738A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1101931A FR2976811A1 (en) 2011-06-22 2011-06-22 USE OF A HIGH ADCC ANTI-CD20 ANTIBODY FOR THE TREATMENT OF WALDENSTROM'S DISEASE

Publications (1)

Publication Number Publication Date
AR086738A1 true AR086738A1 (en) 2014-01-22

Family

ID=46508094

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120102258A AR086738A1 (en) 2011-06-22 2012-06-22 USE OF AN ANTIBODY ANTI-CD20 OF GREAT CYTOTOXICITY FOR ANTIBODY DEPENDENT CELLULAR MEDIATION (ADCC) IN THE TREATMENT OF WALDENSTRÖM DISEASE

Country Status (4)

Country Link
AR (1) AR086738A1 (en)
FR (1) FR2976811A1 (en)
TW (1) TW201309728A (en)
WO (1) WO2012175874A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3012453B1 (en) 2013-10-31 2015-11-13 Lab Francais Du Fractionnement CHIMERIC PROTEIN FOR THE TREATMENT OF AMYLOSIS
CN111363043B (en) * 2020-04-09 2021-07-23 福州迈新生物技术开发有限公司 anti-CD 20 protein monoclonal antibody, cell line, preparation method and application thereof

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JP4668498B2 (en) 1999-10-19 2011-04-13 協和発酵キリン株式会社 Method for producing polypeptide
FR2807767B1 (en) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement MONOCLONAL ANTIBODIES ANTI-D
DE60139720D1 (en) 2000-06-28 2009-10-08 Glycofi Inc Process for the preparation of modified glycoproteins
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
JP4628679B2 (en) 2002-04-09 2011-02-09 協和発酵キリン株式会社 Cells in which the activity of a protein involved in GDP-fucose transport is reduced or deleted
US7425449B2 (en) 2002-04-30 2008-09-16 The Regents Of The University Of California Site specific Listeria integration vectors and methods for using the same
US20060235208A1 (en) 2002-09-27 2006-10-19 Xencor, Inc. Fc variants with optimized properties
US6994292B2 (en) 2002-10-18 2006-02-07 The Procter & Gamble Company Dispensing apparatus for web material
NZ541503A (en) 2003-01-22 2008-09-26 Glycart Biotechnology Ag Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function
US20050160485A1 (en) 2003-03-18 2005-07-21 Kyowa Hakko Kogyo Co., Ltd. Mouse in which genome is modified
US20060134105A1 (en) 2004-10-21 2006-06-22 Xencor, Inc. IgG immunoglobulin variants with optimized effector function
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RS55723B1 (en) 2003-11-05 2017-07-31 Roche Glycart Ag Antigen binding molecules with increased fc receptor binding affinity and effector function
US20060223147A1 (en) 2004-08-05 2006-10-05 Kyowa Hakko Kogyo Co., Ltd., Process for producing glycoprotein composition
US8546543B2 (en) 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
FR2879204B1 (en) 2004-12-15 2007-02-16 Lab Francais Du Fractionnement CYTOTOXIC ANTIBODY AGAINST HEMATOPOIETIC B-TYPE HEMATOPOIETIC PROLIFERATIONS
EP1888638A2 (en) 2005-06-03 2008-02-20 Genentech, Inc. Method of producing antibodies with modified fucosylation level
EP1945665B1 (en) 2005-10-21 2011-12-07 Genzyme Corporation Antibody-based therapeutics with enhanced adcc activity
AU2006304886B2 (en) 2005-10-21 2012-04-12 Genzyme Corporation Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use
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FR2915398B1 (en) * 2007-04-25 2012-12-28 Lab Francais Du Fractionnement "SET OF MEANS FOR THE TREATMENT OF MALIGNANT PATHOLOGY, AUTOIMMUNE DISEASE OR INFECTIOUS DISEASE"
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Also Published As

Publication number Publication date
FR2976811A1 (en) 2012-12-28
TW201309728A (en) 2013-03-01
WO2012175874A1 (en) 2012-12-27

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