AR086492A1 - Procedimientos e intermediarios para preparar agentes anti-hiv - Google Patents
Procedimientos e intermediarios para preparar agentes anti-hivInfo
- Publication number
- AR086492A1 AR086492A1 ARP120101777A ARP120101777A AR086492A1 AR 086492 A1 AR086492 A1 AR 086492A1 AR P120101777 A ARP120101777 A AR P120101777A AR P120101777 A ARP120101777 A AR P120101777A AR 086492 A1 AR086492 A1 AR 086492A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- alkyl
- cycloalkyl
- optionally substituted
- independently
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 title 1
- 229940124411 anti-hiv antiviral agent Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4434—Amides thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4449—Esters with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488133P | 2011-05-19 | 2011-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086492A1 true AR086492A1 (es) | 2013-12-18 |
Family
ID=46208163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101777A AR086492A1 (es) | 2011-05-19 | 2012-05-18 | Procedimientos e intermediarios para preparar agentes anti-hiv |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8987437B2 (OSRAM) |
| EP (3) | EP3450438A1 (OSRAM) |
| JP (4) | JP5951757B2 (OSRAM) |
| AR (1) | AR086492A1 (OSRAM) |
| AU (4) | AU2012255029B2 (OSRAM) |
| CA (1) | CA2835932C (OSRAM) |
| ES (2) | ES2629913T3 (OSRAM) |
| PT (2) | PT2710019T (OSRAM) |
| TW (1) | TWI635093B (OSRAM) |
| WO (1) | WO2012159047A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3450438A1 (en) | 2011-05-19 | 2019-03-06 | Gilead Sciences, Inc. | Processes and intermediates for preparing anti-hiv agents |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| US20180085387A1 (en) | 2016-09-27 | 2018-03-29 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
| ES2892402T3 (es) | 2017-08-01 | 2022-02-04 | Gilead Sciences Inc | Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales |
| WO2019165374A1 (en) | 2018-02-26 | 2019-08-29 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds as hbv replication inhibitors |
| CN114409706B (zh) * | 2019-07-01 | 2023-11-28 | 上海医药工业研究院 | 一种苯基氢膦酸酯及其中间体的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US599431A (en) | 1898-02-22 | Clothes-wringer | ||
| GB835785A (en) * | 1956-04-30 | 1960-05-25 | Victor Chemical Works | Method of making diaryl phosphites |
| MX3898E (es) * | 1975-12-29 | 1981-09-10 | Monsanto Co | Procedimiento mejorado para la preparacion de triesteres de n-fosfonometilglicina |
| US4198355A (en) | 1977-03-28 | 1980-04-15 | Mobil Oil Corporation | Preparation of tertiary alkylphosphorodichloridite derivatives |
| US5459256A (en) * | 1987-04-17 | 1995-10-17 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Lipophilic, aminohydrolase-activated prodrugs |
| HU906976D0 (en) | 1989-11-13 | 1991-05-28 | Bristol Myers Squibb Co | Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues |
| US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| DK1301519T4 (da) | 2000-07-21 | 2021-12-20 | Gilead Sciences Inc | Prodrugs af phosphonatnukleotidanaloger og fremgangsmåder til udvælgelse og fremstilling heraf |
| JP4942915B2 (ja) * | 2002-04-26 | 2012-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積 |
| EP1628685B1 (en) * | 2003-04-25 | 2010-12-08 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| JP2010535701A (ja) * | 2003-04-25 | 2010-11-25 | ギリアード サイエンシーズ， インコーポレイテッド | 抗癌ホスホネートアナログ |
| HRP20070043A2 (hr) * | 2004-07-16 | 2007-07-31 | Gilead Sciences | Antivirusna sredstva |
| WO2006110157A2 (en) | 2004-07-27 | 2006-10-19 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates as anti hiv agents |
| WO2007014352A2 (en) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Antiviral phosphonate conjugates for inhibition of hiv |
| CZ2008547A3 (cs) * | 2006-03-17 | 2009-06-10 | Invista Technologies S. A. R. L. | Zpusob purifikace triorganofosfitu ošetrením bazickým aditivem |
| US8324179B2 (en) * | 2007-02-09 | 2012-12-04 | Gilead Sciences, Inc. | Nucleoside analogs for antiviral treatment |
| HRP20120700T1 (hr) | 2008-07-08 | 2012-09-30 | Gilead Sciences | SOLI SPOJEVA INHIBITORA HIV-a |
| WO2011003018A2 (en) * | 2009-07-01 | 2011-01-06 | Cornell University | Halogenated 2-deoxy-lactones, 2'-deoxy--nucleosides, and derivatives thereof |
| EP3450438A1 (en) | 2011-05-19 | 2019-03-06 | Gilead Sciences, Inc. | Processes and intermediates for preparing anti-hiv agents |
-
2012
- 2012-05-18 EP EP18200819.3A patent/EP3450438A1/en not_active Withdrawn
- 2012-05-18 AR ARP120101777A patent/AR086492A1/es unknown
- 2012-05-18 PT PT127255701T patent/PT2710019T/pt unknown
- 2012-05-18 TW TW101117811A patent/TWI635093B/zh active
- 2012-05-18 AU AU2012255029A patent/AU2012255029B2/en active Active
- 2012-05-18 EP EP16204289.9A patent/EP3199537B1/en active Active
- 2012-05-18 JP JP2014511589A patent/JP5951757B2/ja active Active
- 2012-05-18 PT PT16204289T patent/PT3199537T/pt unknown
- 2012-05-18 CA CA2835932A patent/CA2835932C/en active Active
- 2012-05-18 US US13/475,569 patent/US8987437B2/en active Active
- 2012-05-18 ES ES12725570.1T patent/ES2629913T3/es active Active
- 2012-05-18 EP EP12725570.1A patent/EP2710019B1/en active Active
- 2012-05-18 ES ES16204289T patent/ES2700470T3/es active Active
- 2012-05-18 WO PCT/US2012/038615 patent/WO2012159047A1/en not_active Ceased
-
2015
- 2015-02-05 US US14/615,357 patent/US9296779B2/en active Active
-
2016
- 2016-01-15 JP JP2016005955A patent/JP6282295B2/ja active Active
- 2016-02-17 US US15/046,399 patent/US9783567B2/en active Active
- 2016-07-26 AU AU2016208292A patent/AU2016208292B2/en active Active
-
2017
- 2017-02-06 JP JP2017019959A patent/JP6621772B2/ja active Active
- 2017-09-06 US US15/697,136 patent/US10196419B2/en active Active
-
2018
- 2018-02-01 AU AU2018200776A patent/AU2018200776B2/en active Active
- 2018-12-20 US US16/226,811 patent/US20190359644A1/en not_active Abandoned
-
2019
- 2019-02-01 JP JP2019017324A patent/JP2019089808A/ja active Pending
- 2019-09-09 AU AU2019226278A patent/AU2019226278A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |