AR085276A1 - P2X7R ANTAGONISTS AND ITS USE - Google Patents

P2X7R ANTAGONISTS AND ITS USE

Info

Publication number
AR085276A1
AR085276A1 ARP120100542A ARP120100542A AR085276A1 AR 085276 A1 AR085276 A1 AR 085276A1 AR P120100542 A ARP120100542 A AR P120100542A AR P120100542 A ARP120100542 A AR P120100542A AR 085276 A1 AR085276 A1 AR 085276A1
Authority
AR
Argentina
Prior art keywords
acetamide
p2x7r
azaindole
indole
halogen
Prior art date
Application number
ARP120100542A
Other languages
Spanish (es)
Inventor
Michael Boes
Original Assignee
Affectis Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affectis Pharmaceuticals Ag filed Critical Affectis Pharmaceuticals Ag
Publication of AR085276A1 publication Critical patent/AR085276A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a antagonistas de P2X7R que son compuestos de N-indol-3-il-acetamida y N-azaindol-3-il-acetamida, a composiciones farmacéuticas que los comprenden y a su uso para el tratamiento preventivo o terapéutico de enfermedades mediadas por la actividad de P2X7R.Reivindicación 1: Un compuesto de N-indol-3-il-acetamida y N-azaindol-3-il-acetamida representado por la fórmula general (1), en donde, R1 es un resto de fórmula (2) ó (3); R2 es un grupo mono- o bicicloalquilo; R3 está seleccionado del alquilo C1-5 lineal o ramificado que puede estar opcionalmente sustituido con -OH, -CH2-OH, alcoxi C1-5, CN-, CF3, halógeno (es decir, Cl, F, Br o I), piperidino, morfolino, pirrolidino, 5H-tetrazolilpropilo, metilcarbamoilo, dimetilcarbamoilo o etilcarbamoilo, en donde Ra es alquilo C1-5; R4, R5, R6, R7 están seleccionados en cada aparición, de modo independiente, de hidrógeno, halógeno (es decir, Cl, F, Br o I), metilo, metoxi, ciano o trifluorometilo, o, de ser necesario por valencia, puede estar ausente; a, b, c, d, x están seleccionados en cada aparición, de modo independiente, de carbono o nitrógeno; o una de sus sales o solvatos farmacéuticamente aceptables (en donde x debe tener un sustituyente de hidrógeno si es carbono).This refers to P2X7R antagonists that are compounds of N-indole-3-yl-acetamide and N-azaindole-3-yl-acetamide, pharmaceutical compositions that comprise them and their use for preventive or therapeutic treatment of mediated diseases by the activity of P2X7R. Claim 1: A compound of N-indole-3-yl-acetamide and N-azaindole-3-yl-acetamide represented by the general formula (1), wherein R1 is a moiety of formula ( 2 or 3); R2 is a mono- or bicycloalkyl group; R3 is selected from the linear or branched C1-5 alkyl which may be optionally substituted with -OH, -CH2-OH, C1-5 alkoxy, CN-, CF3, halogen (ie, Cl, F, Br or I), piperidine , morpholino, pyrrolidino, 5H-tetrazolylpropyl, methylcarbamoyl, dimethylcarbamoyl or ethylcarbamoyl, wherein Ra is C1-5 alkyl; R4, R5, R6, R7 are selected at each occurrence, independently, from hydrogen, halogen (ie, Cl, F, Br or I), methyl, methoxy, cyano or trifluoromethyl, or, if necessary by valence, may be absent; a, b, c, d, x are selected at each occurrence, independently, of carbon or nitrogen; or one of its pharmaceutically acceptable salts or solvates (where x must have a hydrogen substituent if it is carbon).

ARP120100542A 2011-02-17 2012-02-17 P2X7R ANTAGONISTS AND ITS USE AR085276A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11154877 2011-02-17
US201161444479P 2011-02-18 2011-02-18

Publications (1)

Publication Number Publication Date
AR085276A1 true AR085276A1 (en) 2013-09-18

Family

ID=45558013

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120100542A AR085276A1 (en) 2011-02-17 2012-02-17 P2X7R ANTAGONISTS AND ITS USE

Country Status (2)

Country Link
AR (1) AR085276A1 (en)
WO (1) WO2012110190A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103819479B (en) * 2014-03-10 2017-01-04 东华大学 A kind of containing pyrimidine group rigidity Conjugate macrocycle compound and its preparation method and application
WO2020150417A2 (en) * 2019-01-17 2020-07-23 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN113233958B (en) * 2021-01-18 2023-09-19 阜阳欣奕华材料科技有限公司 Preparation method of 2- (trans-4-n-propylcyclohexyl) propane-1, 3-diol

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019386A1 (en) 1997-02-26 2000-07-19 Glaxo Group Limited Reverse hydroxamate derivatives as metalloprotease inhibitors
ZA988967B (en) 1997-10-03 2000-04-03 Du Pont Pharm Co Lactam metalloprotease inhibitors.
SE9704546D0 (en) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704545D0 (en) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704544D0 (en) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
WO1999065867A1 (en) 1998-06-17 1999-12-23 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
US6239151B1 (en) 1998-06-26 2001-05-29 Hoffmann-La Roche Inc. Compounds as inhibitor of tumor necrosis factor alpha release
UA59453C2 (en) 1998-08-12 2003-09-15 Пфайзер Продактс Інк. HYDROXYPIPECOLATE HYDROXAMIC ACID DERIVATIVES AS matrix metalloproteinase inhibitors
US20040122011A1 (en) 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
US6225311B1 (en) 1999-01-27 2001-05-01 American Cyanamid Company Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
SK13422001A3 (en) 1999-04-09 2002-05-09 Astrazeneca Ab Adamantane derivatives
SE9901875D0 (en) 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
SE9904505D0 (en) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
SE9904652D0 (en) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
SE9904738D0 (en) 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
GB0013737D0 (en) 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds
AU2001280167A1 (en) 2000-08-31 2002-03-13 Wakunaga Pharmaceutical Co.,Ltd Novel propenohydroxamic acid derivatives
JP2004535411A (en) 2001-05-25 2004-11-25 ブリストルーマイヤーズ スクイブ カンパニー Hydantoins and related heterocyclic compounds as inhibitors of matrix metalloproteinases and / or TNF-α convertases (TACE)
AU2002324716A1 (en) 2001-08-17 2003-03-03 Bristol-Myers Squibb Company Patent Department Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace)
AU2002341715A1 (en) 2001-09-17 2003-04-01 Bristol-Myers Squibb Company Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace)
WO2003031431A1 (en) 2001-10-09 2003-04-17 Bristol-Myers Squibb Company Cyclic sulfone derivatives as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace)
WO2003055856A2 (en) 2001-10-17 2003-07-10 Bristol-Myers Squibb Company BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE)
WO2003040103A1 (en) 2001-11-02 2003-05-15 Bristol-Myers Squibb Company β-SULFONE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE)
WO2003042190A1 (en) 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
PA8557501A1 (en) 2001-11-12 2003-06-30 Pfizer Prod Inc BENZAMIDA, HETEROARILAMIDA AND INVESTED AMIDAS
SE0103836D0 (en) 2001-11-16 2001-11-16 Astrazeneca Ab Novel compounds
WO2003047515A2 (en) 2001-11-30 2003-06-12 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services P2x7 receptor antagonists
AU2002357312A1 (en) 2001-12-20 2003-07-09 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-alpha converting enzyme (tace) and/or matrix metalloproteinases
IL162653A0 (en) 2001-12-21 2005-11-20 King Pharmaceuticals Reserch & Tyrosyl derivatives and their use as p2x7 receptormodulators
AU2003220401A1 (en) 2002-03-18 2003-10-08 Bristol-Myers Squibb Company Uracil derivatives as inhibitors of tnf-alpha converting enzyme (tace) and matrix metalloproteinases
SE0200920D0 (en) 2002-03-25 2002-03-25 Astrazeneca Ab Novel compounds
GB0216379D0 (en) 2002-07-13 2002-08-21 Astrazeneca Ab Compounds
WO2004012663A2 (en) 2002-08-01 2004-02-12 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
EP1546109A4 (en) 2002-10-04 2005-11-09 Bristol Myers Squibb Co Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace)
WO2004032846A2 (en) 2002-10-07 2004-04-22 Bristol-Myers Squibb Company Triazolone and triazolethione derivatives
WO2004043349A2 (en) 2002-11-06 2004-05-27 Bristol-Myers Squibb Company Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
PA8591801A1 (en) 2002-12-31 2004-07-26 Pfizer Prod Inc BENZAMID INHIBITORS OF THE P2X7 RECEIVER.
EP1581507A1 (en) 2002-12-31 2005-10-05 Pfizer Products Inc. Benzamide inhibitors of the p2x7 receptor
SE0300480D0 (en) 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
ES2281801T3 (en) 2003-05-12 2007-10-01 Pfizer Products Inc. BENZAMIDE INHIBITORS OF THE P2X7 RECEIVER.
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
US7132432B2 (en) 2003-06-05 2006-11-07 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
GB0324498D0 (en) 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
SE0302139D0 (en) 2003-07-28 2003-07-28 Astrazeneca Ab Novel compounds
SE0302192D0 (en) 2003-08-08 2003-08-08 Astrazeneca Ab Novel compounds
WO2005019182A1 (en) 2003-08-20 2005-03-03 Bayer Healthcare Ag Pyrazolylmethylbenzamide derivatives as p2xt-receptor antagonists
JP2007509180A (en) 2003-10-21 2007-04-12 インスパイアー ファーマシューティカルズ，インコーポレイティド Non-nucleotide compositions and methods for treating pain
WO2005111003A1 (en) 2004-04-29 2005-11-24 Abbott Laboratories Amino-tetrazoles analogues and methods of use
EP1768965A1 (en) 2004-06-29 2007-04-04 Pfizer Products Incorporated Method for preparing 5-¬4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3h-¬1,2,4|-triazin-2-yl|benzamide derivatives with p2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid
AU2005258911A1 (en) 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3H`1,2,4!triazin-2-YL!-benzamide derivatives by deprotecting the hydroxyl-protected precursers
US7241776B2 (en) 2004-08-02 2007-07-10 Abbott Laboratories Cyanoamidine P2X7 antagonists for the treatment of pain
SA05260265A (en) 2004-08-30 2005-12-03 استرازينيكا ايه بي Novel compounds
SE0402925D0 (en) 2004-11-30 2004-11-30 Astrazeneca Ab Novel Compounds
MX2007007424A (en) 2004-12-24 2007-07-17 Astrazeneca Ab Amide derivatives.
US20080146612A1 (en) 2005-01-27 2008-06-19 Astrazeneca Ab Novel Biaromatic Compounds, Inhibitors of the P2X7-Receptor
US20060211739A1 (en) 2005-02-08 2006-09-21 Arturo Perez-Medrano Use of selective P2X7 receptor antagonists
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
WO2006110516A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories Acylhydrazide p2x7 antagonists and uses thereof
WO2006136004A1 (en) 2005-05-05 2006-12-28 Medicure International Inc. Inhibition of atp-mediated, p2x7 dependent pathways by pyridoxal-5-phosphaste and vitamin b6 related compounds
WO2007016597A2 (en) 2005-07-29 2007-02-08 The Regents Of The University Of California Targeting tnf-alpha converting enzyme (tace)-dependent growth factor shedding in cancer therapy
CA2625940A1 (en) 2005-08-29 2007-03-08 Irma Bernatchez-Lemaire Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents
WO2007028022A2 (en) 2005-09-01 2007-03-08 Renovis, Inc. Novel compounds as p2x7 modulators and uses thereof
WO2007056046A1 (en) 2005-11-07 2007-05-18 Abbott Laboratories P2x7 receptor antagonists and methods of use
CA2628260A1 (en) 2005-11-09 2007-05-18 Abbott Laboratories 2-phenyl-2h-pyraz0le derivatives as p2x7 receptor antagonists and uses thereof
CA2645652A1 (en) 2006-03-16 2007-09-27 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
US20100298285A1 (en) 2006-03-16 2010-11-25 Kelly Michael G Biclycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof
US20100184802A1 (en) 2006-03-16 2010-07-22 Kelly Michael G Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof
CA2645556C (en) 2006-03-16 2016-05-24 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
TWI464148B (en) 2006-03-16 2014-12-11 Evotec Us Inc Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2007109160A2 (en) 2006-03-16 2007-09-27 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2007141267A1 (en) 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration
GB0611154D0 (en) 2006-06-06 2006-07-19 Glaxo Group Ltd Novel receptor antagonists and their methods of use
US20080076924A1 (en) 2006-06-30 2008-03-27 Patrick Betschmann Piperazines as P2X7 antagonists
CA2655675A1 (en) 2006-07-06 2008-01-10 Glaxo Group Limited Substituted n-phenylmethyl -5-oxo-proline-2-amides as p2x7-receptor antagonists and their methods of use
US20080058309A1 (en) 2006-07-27 2008-03-06 Astrazeneca Ab Novel Compounds 171
JP2010523524A (en) 2007-04-03 2010-07-15 グラクソ グループ リミテッド Imidazolidinecarboxamide derivatives as P2X7 modulators
EP2155744A1 (en) 2007-04-10 2010-02-24 Lundbeck, H., A/S Heteroaryl amide analogues as p2x7 antagonists
JP2010523623A (en) 2007-04-11 2010-07-15 グラクソ グループ リミテッド Pyrazole derivatives as P2X7 modulators
DE602008005582D1 (en) 2007-05-10 2011-04-28 Glaxo Group Ltd PYRAZONE DERIVATIVES AS P2X7 MODULATORS
WO2009019503A2 (en) 2007-08-03 2009-02-12 Astrazeneca Ab P2x7 antagonists for use in the treatment of mood disorders
EP2185560A4 (en) * 2007-08-10 2011-10-05 Lundbeck & Co As H Heteroaryl amide analogues
JP2011500767A (en) 2007-10-26 2011-01-06 グラクソ グループ リミテッド 4-Benzoyl-1-substituted piperazin-2-one derivatives as P2X7 modulators
PE20091036A1 (en) 2007-11-30 2009-08-15 Astrazeneca Ab QUINOLINE DERIVATIVE AS ANTAGONIST OF THE P2X7 RECEPTOR
EP2231153A2 (en) 2007-12-18 2010-09-29 Glaxo Group Limited 5-oxo-3-pyrrolidinecarboxamide derivatives as p2x7 modulators
EP2105164B1 (en) 2008-03-25 2011-01-12 Affectis Pharmaceuticals AG Novel P2X7R antagonists and their use
ES2376092T3 (en) 2008-04-22 2012-03-08 Janssen Pharmaceutica, N.V. P2X7 ANTAGONISTS REPLACED WITH QUINOLINE OR ISOQUINOLINE.
MX2011010810A (en) 2009-04-14 2012-01-12 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use.
GB0907425D0 (en) 2009-04-29 2009-06-10 Glaxo Group Ltd Compounds

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