AR080471A1 - Participacion de la via de androgenos/receptores de androgenos en la enfermedad de fabry - Google Patents

Participacion de la via de androgenos/receptores de androgenos en la enfermedad de fabry

Info

Publication number
AR080471A1
AR080471A1 ARP110100713A ARP110100713A AR080471A1 AR 080471 A1 AR080471 A1 AR 080471A1 AR P110100713 A ARP110100713 A AR P110100713A AR P110100713 A ARP110100713 A AR P110100713A AR 080471 A1 AR080471 A1 AR 080471A1
Authority
AR
Argentina
Prior art keywords
androgen
fabry
disease
pathway
subject
Prior art date
Application number
ARP110100713A
Other languages
English (en)
Inventor
Raphael Schiffmann
Xingli Meng
Jinsong Shen
Original Assignee
Baylor Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor Res Inst filed Critical Baylor Res Inst
Publication of AR080471A1 publication Critical patent/AR080471A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Abstract

Terapias para el tratamiento de la enfermedad de Fabry que comprenden usar moléculas relacionadas con la vía de androgenos/receptores de androgenos (AR) como biomarcadores y el uso de enfoques dirigidos a la vía de androgenos/AR. La participacion de una vía de androgenos/AR aberrante en la enfermedad de Fabry no se ha descrito con anterioridad. La presente describe, (i) el uso de enfoques dirigidos a la vía de androgenos/AR como tratamientos terapéuticos para la enfermedad de Fabry y (2) el uso de los niveles de moléculas relacionadas con la vía de androgenos/AR en fluidos corporales o tejidos como biomarcadores para evaluar el avance de la enfermedad y la eficacia de los tratamientos en pacientes con Fabry. Reivindicacion 1: Un método para diagnosticar a enfermedad de Fabry en un sujeto que comprende los pasos de: recolectar una muestra del sujeto sospechado de padecer la enfermedad de Fabry; comparar un nivel de una o más moléculas seleccionadas del grupo que consiste de un androgeno, un precursor de androgeno, un metabolito de androgeno, un molécula de la vía de receptores de androgenos (AR) y uno o más genes AR de interés y metabolitos relacionados, en la muestra del sujeto sospechado de padece la enfermedad de Fabry, con el de un sujeto normal que no padece la enfermedad de Fabry determinar sí el sujeto sufre de la enfermedad de Fabry en base a un cambio estadísticamente significativo en los niveles de dichas una o más moléculas en la muestras entre el sujeto sospechado de padecer la enfermedad de Fabry y el sujeto normal.
ARP110100713A 2010-03-05 2011-03-04 Participacion de la via de androgenos/receptores de androgenos en la enfermedad de fabry AR080471A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31080210P 2010-03-05 2010-03-05
US13/038,293 US20110217288A1 (en) 2010-03-05 2011-03-01 Involvement of Androgen/Androgen Receptor Pathway in Fabry Disease

Publications (1)

Publication Number Publication Date
AR080471A1 true AR080471A1 (es) 2012-04-11

Family

ID=44531528

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100713A AR080471A1 (es) 2010-03-05 2011-03-04 Participacion de la via de androgenos/receptores de androgenos en la enfermedad de fabry

Country Status (7)

Country Link
US (1) US20110217288A1 (es)
EP (1) EP2542687A1 (es)
AR (1) AR080471A1 (es)
AU (1) AU2011223706A1 (es)
CA (1) CA2791994A1 (es)
TW (1) TW201138777A (es)
WO (1) WO2011109448A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3024463T1 (sl) * 2013-07-25 2020-08-31 Neuren Pharmaceuticals Limited Nevroprotektivne biciklične spojine in postopki za njihovo uporabo pri zdravljenju motenj avtističnega spektra in nevrorazvojnih motenj
HUE043959T2 (hu) * 2013-12-23 2019-09-30 Bcn Peptides Sa Bikalutamid analógok vagy (S)-bikalutamid, mint exocitózist aktiváló vegyületek lizoszomális tárolási zavar vagy glikogenózis kezelésében történõ alkalmazásra

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2136969C (en) * 1992-06-12 2009-03-24 Michael E. Lewis Prevention and treatment of peripheral neuropathy
WO2003086386A1 (en) * 2002-04-09 2003-10-23 Novogen Research Pty Ltd Therapeutic methods and compositions involving isoflav-3-ene and isoflavan structures
US20060269950A1 (en) * 2005-05-19 2006-11-30 Wyeth Method of identifying compounds that modulate interaction of androgen receptor with beta-catenin
EP2787345B8 (en) * 2006-05-16 2016-04-13 Amicus Therapeutics, Inc. Treatment options for fabry disease
WO2008011072A2 (en) * 2006-07-19 2008-01-24 Osurf (Ohio State University Research Foundation) Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
MX2009009936A (es) * 2007-03-20 2010-02-11 Curis Inc Amino piridina fusionada como inhibidores de hsp90.
US8956825B2 (en) * 2007-05-24 2015-02-17 The United States Of America As Represented By The Department Of Veterans Affairs Intranuclear protein transduction through a nucleoside salvage pathway
US20090282496A1 (en) * 2008-04-04 2009-11-12 University Of Rochester Medical Center Androgen Receptor Related Methods for Treating Bladder Cancer
US8541487B2 (en) * 2008-08-04 2013-09-24 Ranee Spradlin Materials, methods and compositions for a composite building material
MX2011010565A (es) * 2009-04-09 2011-10-19 Baylor Res Inst Uso de tetrahidrobiopterina como marcador y agente terapeutico para enfermedad de fabry.

Also Published As

Publication number Publication date
CA2791994A1 (en) 2011-09-09
TW201138777A (en) 2011-11-16
EP2542687A1 (en) 2013-01-09
AU2011223706A1 (en) 2012-09-20
US20110217288A1 (en) 2011-09-08
WO2011109448A1 (en) 2011-09-09

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