AR079849A1 - DERIVATIVES OF THIOCHROMAN, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, PROCEDURE FOR PREPARATION AND USE OF THE SAME IN THE TREATMENT OF DISEASES OF THE NERVOUS CENTRAL SYSTEM, SUCH AS ALZHEIMER AND PARKINSON, AMONG OTHERS. - Google Patents

DERIVATIVES OF THIOCHROMAN, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, PROCEDURE FOR PREPARATION AND USE OF THE SAME IN THE TREATMENT OF DISEASES OF THE NERVOUS CENTRAL SYSTEM, SUCH AS ALZHEIMER AND PARKINSON, AMONG OTHERS.

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Publication number
AR079849A1
AR079849A1 ARP110100041A ARP110100041A AR079849A1 AR 079849 A1 AR079849 A1 AR 079849A1 AR P110100041 A ARP110100041 A AR P110100041A AR P110100041 A ARP110100041 A AR P110100041A AR 079849 A1 AR079849 A1 AR 079849A1
Authority
AR
Argentina
Prior art keywords
branched
linear
substituted
unsubstituted
nitrogen atom
Prior art date
Application number
ARP110100041A
Other languages
Spanish (es)
Inventor
Laurence Danober
Pierre Lestage
Pierre Francotte
Tullio Pascal De
Bernard Pirotte
Iuliana Botez
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR079849A1 publication Critical patent/AR079849A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicacion 1: Compuestos de formula (1): en la que R1, R2, R3 y R4 idénticos o diferentes, representan cada uno un átomo de hidrogeno, un átomo de halogeno, o un grupo ciano ; hidroxi ; tio ; nitro; alquilo C1-6 lineal o ramificado sustituido opcionalmente ; arilo ; alcoxi C1-6 lineal o ramificado no sustituido o sustituido con uno o varios átomos de halogeno ; ariloxi ; alquiltio C1-6 lineal o ramificado ; ariltio; carboxi; alcoxicarbonilo C1-6 lineal o ramificado ariloxicarbonilo ; aciloxi C1-6 lineal o ramificado ; arilcarboniloxi; acilo C1-6 lineal o ramificado ; arilcarbonilo; amino no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; arilamino no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; acilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; arilcarbonilamino no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; aminocarbonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes arilaminocarbonilo no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; alquilsulfonilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; o arilsulfonilamino no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; sus enantiomeros y sus diastereoisomeros, así como sus sales de adicion con un ácido o una base farmacéuticamente aceptable, entendiéndose que: el término ½arilo y el término ½aril contenido en los grupos ariloxi, ariltio, ariloxicarbonilo, arilcarboniloxi, arilcarbonilo, arilamino, arilcarbonilamino, arilaminocarbonilo, y arilsulfonilamino, representan el grupo fenilo no sustituido o sustituido con uno o varios grupos, idénticos o diferentes, elegidos entre un átomo de halogeno, o un grupo ciano ; hidroxi; tio; nitro; alquilo C1-6 lineal o ramificado sustituido opcionalmente ; alcoxi C1-6 lineal o ramificado no sustituido o sustituido con uno o varios átomos de halogeno ; alquiltio C1-6 lineal o ramificado ; carboxi; alcoxicarbonilo C1-6 lineal o ramificado ; amino no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; aciloxi C1-6 lineal o ramificado ; acilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; aminocarbonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes aminosulfonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; alquilsulfonilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; o N-hidroxicarboximidamida; la expresion ½sustituido opcionalmente destinada al término alquilo significa que este grupo puede estar sustituido con uno o varios átomos de halogeno, o con un grupo ciano; hidroxi; tio; nitro; arilo ; alcoxi C1-6 lineal o ramificado no sustituido o sustituido con uno o varios átomos de halogeno ; alquiltio C1-6 lineal o ramificado ; carboxi; alcoxicarbonilo C1-6 lineal o ramificado ; aciloxi C1-6 lineal o ramificado ; amino no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; acilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; aminocarbonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes aminosulfonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; alquilsulfonilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; o N-hidroxicarboximidamida.Claim 1: Compounds of formula (1): wherein R1, R2, R3 and R4 identical or different, each represent a hydrogen atom, a halogen atom, or a cyano group; hydroxy; uncle ; nitro; linear or branched C1-6 alkyl optionally substituted; aryl; linear or branched C1-6 alkoxy not substituted or substituted with one or more halogen atoms; aryloxy; linear or branched C1-6 alkylthio; arylthio; carboxy; linear or branched C 1-6 alkoxycarbonyl aryloxycarbonyl; linear or branched C1-6 acyloxy; arylcarbonyloxy; linear or branched C1-6 acyl; arylcarbonyl; amino unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; unsubstituted or substituted arylamino in the nitrogen atom with a linear or branched C1-6 alkyl group; linear or branched C1-6 acylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; unsubstituted or substituted arylcarbonylamino in the nitrogen atom with a linear or branched C1-6 alkyl group; aminocarbonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different arylaminocarbonyl unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; linear or branched C1-6 alkylsulfonylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; or unsubstituted or substituted arylsulfonylamino in the nitrogen atom with a linear or branched C1-6 alkyl group; their enantiomers and their diastereoisomers, as well as their addition salts with a pharmaceutically acceptable acid or base, it being understood that: the term ½aryl and the term ½aryl contained in the aryloxy, arylthio, aryloxycarbonyl, arylcarbonyloxy, arylcarbonyl, arylamino, arylcarbonylamino, arylaminocarbonylamino groups , and arylsulfonylamino, represent the phenyl group unsubstituted or substituted with one or more groups, identical or different, chosen from a halogen atom, or a cyano group; hydroxy; uncle; nitro; linear or branched C1-6 alkyl optionally substituted; linear or branched C1-6 alkoxy not substituted or substituted with one or more halogen atoms; linear or branched C1-6 alkylthio; carboxy; linear or branched C1-6 alkoxycarbonyl; amino unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 acyloxy; linear or branched C1-6 acylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; aminocarbonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different aminosulfonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 alkylsulfonylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; or N-hydroxycarboximidamide; the term "substituted" optionally intended for the term "alkyl" means that this group may be substituted with one or more halogen atoms, or with a cyano group; hydroxy; uncle; nitro; aryl; linear or branched C1-6 alkoxy not substituted or substituted with one or more halogen atoms; linear or branched C1-6 alkylthio; carboxy; linear or branched C1-6 alkoxycarbonyl; linear or branched C1-6 acyloxy; amino unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 acylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; aminocarbonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different aminosulfonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 alkylsulfonylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; or N-hydroxycarboximidamide.

ARP110100041A 2010-01-08 2011-01-07 DERIVATIVES OF THIOCHROMAN, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, PROCEDURE FOR PREPARATION AND USE OF THE SAME IN THE TREATMENT OF DISEASES OF THE NERVOUS CENTRAL SYSTEM, SUCH AS ALZHEIMER AND PARKINSON, AMONG OTHERS. AR079849A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1000070A FR2955107B1 (en) 2010-01-08 2010-01-08 NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

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AR079849A1 true AR079849A1 (en) 2012-02-22

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Application Number Title Priority Date Filing Date
ARP110100041A AR079849A1 (en) 2010-01-08 2011-01-07 DERIVATIVES OF THIOCHROMAN, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, PROCEDURE FOR PREPARATION AND USE OF THE SAME IN THE TREATMENT OF DISEASES OF THE NERVOUS CENTRAL SYSTEM, SUCH AS ALZHEIMER AND PARKINSON, AMONG OTHERS.

Country Status (3)

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AR (1) AR079849A1 (en)
FR (1) FR2955107B1 (en)
WO (1) WO2011083264A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1088945A (en) 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
FR2722502B1 (en) 1994-07-12 1996-08-23 Adir NOVEL BENZOTHIADIAZINE DERIVATIVE, ITS PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
WO1998012185A1 (en) * 1996-09-17 1998-03-26 The Regents Of The University Of California Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor
EE200000468A (en) * 1998-02-18 2002-04-15 Neurosearch A/S The compounds, their use and the pharmaceutical composition
JP2005508352A (en) * 2001-10-10 2005-03-31 ニューロサーチ、アクティーゼルスカブ Novel benzothiazine derivative, method for producing the same and method for using the same

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FR2955107B1 (en) 2012-03-02
FR2955107A1 (en) 2011-07-15
WO2011083264A1 (en) 2011-07-14

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